Cone Snail Venom Peptides and Future Biomedical Applications of Natural Products

2017 ◽  
pp. 425-489
Keyword(s):  
Natural Products ◽  
Biomedical Applications ◽  
Cone Snail ◽  
Venom Peptides

scholarly journals Marine Natural Products from Microalgae: An -Omics Overview

Marine Drugs ◽  
2019 ◽  
Vol 17 (5) ◽  
pp. 269 ◽  
Author(s):  
Chiara Lauritano ◽  
Maria Immacolata Ferrante ◽  
Alessandra Rogato
Keyword(s):  
Natural Products ◽  
Metabolic Pathways ◽  
Marine Natural Products ◽  
Biomedical Applications ◽  
Bioactive Metabolites ◽  
Future Perspectives ◽  
Genome Sequences ◽  
Comprehensive Overview ◽  
Wide Range ◽  
Broad Variety

Over the last decade, genome sequences and other -omics datasets have been produced for a wide range of microalgae, and several others are on the way. Marine microalgae possess distinct and unique metabolic pathways, and can potentially produce specific secondary metabolites with biological activity (e.g., antipredator, allelopathic, antiproliferative, cytotoxic, anticancer, photoprotective, as well as anti-infective and antifouling activities). Because microalgae are very diverse, and adapted to a broad variety of environmental conditions, the chances to find novel and unexplored bioactive metabolites with properties of interest for biotechnological and biomedical applications are high. This review presents a comprehensive overview of the current efforts and of the available solutions to produce, explore and exploit -omics datasets, with the aim of identifying species and strains with the highest potential for the identification of novel marine natural products. In addition, funding efforts for the implementation of marine microalgal -omics resources and future perspectives are presented as well.

scholarly journals Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome

2012 ◽  
Vol 5 ◽  
pp. 43-51 ◽  
Author(s):  
Arturo O. Lluisma ◽  
Brett A. Milash ◽  
Barry Moore ◽  
Baldomero M. Olivera ◽  
Pradip K. Bandyopadhyay
Keyword(s):  
Next Generation Sequencing ◽  
Cone Snail ◽  
Next Generation ◽  
Venom Peptides ◽  
Generation Sequencing

Conopeptides, Marine Natural Products from Venoms: Biomedical Applications and Future Research Applications

2015 ◽  
pp. 463-496 ◽  
Author(s):  
Baldomero Olivera ◽  
Helena Safavi-­Hemami ◽  
Martin Horvath ◽  
Russell Teichert
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Biomedical Applications ◽  
Future Research

scholarly journals A phylogeny-aware approach reveals unexpected venom components in divergent lineages of cone snails

2021 ◽  
Vol 288 (1954) ◽  
pp. 20211017
Author(s):  
Alexander Fedosov ◽  
Paul Zaharias ◽  
Nicolas Puillandre
Keyword(s):  
Biomedical Applications ◽  
De Novo ◽  
Toxin Gene ◽  
Cone Snail ◽  
Marine Gastropods ◽  
Venom Composition ◽  
Signal Region ◽  
Rare Gene ◽  
Cone Snails ◽  
First Time

Marine gastropods of the genus Conus are renowned for their remarkable diversity and deadly venoms. While Conus venoms are increasingly well studied for their biomedical applications, we know surprisingly little about venom composition in other lineages of Conidae. We performed comprehensive venom transcriptomic profiling for Conasprella coriolisi and Pygmaeconus traillii , first time for both respective genera. We complemented reference-based transcriptome annotation by a de novo toxin prediction guided by phylogeny, which involved transcriptomic data on two additional ‘divergent’ cone snail lineages, Profundiconus , and Californiconus . We identified toxin clusters (SSCs) shared among all or some of the four analysed genera based on the identity of the signal region—a molecular tag present in toxins. In total, 116 and 98 putative toxins represent 29 and 28 toxin gene superfamilies in Conasprella and Pygmaeconus , respectively; about quarter of these only found by semi-manual annotation of the SSCs. Two rare gene superfamilies, originally identified from fish-hunting cone snails, were detected outside Conus rather unexpectedly, so we further investigated their distribution across Conidae radiation. We demonstrate that both these, in fact, are ubiquitous in Conidae, sometimes with extremely high expression. Our findings demonstrate how a phylogeny-aware approach circumvents methodological caveats of similarity-based transcriptome annotation.

scholarly journals Editorial to the Special Issue—“Technology for Natural Products Research”

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 327
Author(s):  
Brendan M. Duggan
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Biomedical Applications ◽  
Special Issue ◽  
Natural Product Research

Natural product research continues to be a productive source of unusual chemistry, producing novel compounds for biomedical applications and, increasingly, sustainably providing commercially useful compounds [...]

Structural characterisation of defensive cone snail venom peptides

Toxicon ◽  
2019 ◽  
Vol 158 ◽  
pp. S6
Author(s):  
David Wilson ◽  
Paramjit Bansal ◽  
Sebastien Dutertre ◽  
Norelle L. Daly
Keyword(s):  
Cone Snail ◽  
Venom Peptides ◽  
Structural Characterisation

Applications of Scanning Microscopy in Biomedical Research

1968 ◽  
Vol 26 ◽  
pp. 354-355
Author(s):  
T. L. Hayes
Keyword(s):  
Information Content ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
Three Dimensional ◽  
Dental Enamel ◽  
Resolving Power ◽  
Whole Mount ◽  
Two Parameters ◽  
Content Information ◽  
Sectioned Tissue

Biomedical applications of the scanning electron microscope (SEM) have increased in number quite rapidly over the last several years. Studies have been made of cells, whole mount tissue, sectioned tissue, particles, human chromosomes, microorganisms, dental enamel and skeletal material. Many of the advantages of using this instrument for such investigations come from its ability to produce images that are high in information content. Information about the chemical make-up of the specimen, its electrical properties and its three dimensional architecture all may be represented in such images. Since the biological system is distinctive in its chemistry and often spatially scaled to the resolving power of the SEM, these images are particularly useful in biomedical research.In any form of microscopy there are two parameters that together determine the usefulness of the image. One parameter is the size of the volume being studied or resolving power of the instrument and the other is the amount of information about this volume that is displayed in the image. Both parameters are important in describing the performance of a microscope. The light microscope image, for example, is rich in information content (chemical, spatial, living specimen, etc.) but is very limited in resolving power.

How SIMS microscopy can be used in medicine

1992 ◽  
Vol 50 (2) ◽  
pp. 1602-1603
Author(s):  
Philippe Fragu
Keyword(s):  
Mass Spectrometry ◽  
Biomedical Applications ◽  
Secondary Ion Mass Spectrometry ◽  
Chemical Elements ◽  
Biological Applications ◽  
The Past ◽  
Potential Source ◽  
Secondary Ion ◽  
Chemical Integrity ◽  
Scientific Endeavour

The identification, localization and quantification of intracellular chemical elements is an area of scientific endeavour which has not ceased to develop over the past 30 years. Secondary Ion Mass Spectrometry (SIMS) microscopy is widely used for elemental localization problems in geochemistry, metallurgy and electronics. Although the first commercial instruments were available in 1968, biological applications have been gradual as investigators have systematically examined the potential source of artefacts inherent in the method and sought to develop strategies for the analysis of soft biological material with a lateral resolution equivalent to that of the light microscope. In 1992, the prospects offered by this technique are even more encouraging as prototypes of new ion probes appear capable of achieving the ultimate goal, namely the quantitative analysis of micron and submicron regions. The purpose of this review is to underline the requirements for biomedical applications of SIMS microscopy.Sample preparation methodology should preserve both the structural and the chemical integrity of the tissue.

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