scholarly journals Determination of End Point of Primary Drying in Freeze-Drying Process Control

2010 ◽  
Vol 11 (1) ◽  
pp. 73-84 ◽  
Author(s):  
Sajal M. Patel ◽  
Takayuki Doen ◽  
Michael J. Pikal
2011 ◽  
Vol 204-210 ◽  
pp. 2083-2086
Author(s):  
Yun Feng Hu ◽  
Han Yan Hu ◽  
Chang Jie Jiang ◽  
Yan Hua Zhu ◽  
Jian Ming Wang

Lycium barbarum as raw materials, after press, enzymatic hydrolysis, separation and drying process to a series of different Lycium barbarum products, through determination of effective ingredients content, such as carotenoid, amino acid, crude protein, crude fat, tried to explore the influence of effective component on different processing methods. The result showed that after pressing, enzymatic hydrolysis, separation technology, a large number of carotenoid, amino acid was retained in original slurry, juice, clear juice only have little. The carotenoid content of freeze-drying fruit were lost obiously during the different course of drying, such as air-drying, mechanical-drying, freeze-drying. Spray drying can destroy crude protein and fat activity, but it can be used to improve free amino acid in Lycium barbarum.


Cryobiology ◽  
2009 ◽  
Vol 59 (3) ◽  
pp. 400
Author(s):  
Guo-Yan Zhou ◽  
Wei-Yue Wang ◽  
Jin Zhang ◽  
Fei Xu ◽  
Baolin Liu ◽  
...  

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1835
Author(s):  
Bhaskar Pandya ◽  
Geoff Smith ◽  
Irina Ermolina ◽  
Evgeny Polygalov

Models for ice sublimation from a freeze-drying vial rely on the assumption of a planar ice interface up to ~25% loss of ice mass (which is difficult to qualify) whereas single-vial determinations of the sublimation endpoint (by temperature sensors) are based on the point when the observed temperature reaches a plateau, which cannot differentiate between sublimation and desorption-drying. In this work, the real part capacitance of TVIS vial(s) containing frozen water (during sublimation drying) was measured at 100 kHz. This parameter C′(100 kHz) was shown to be highly sensitive to the shape and volume of the ice mass and is therefore a useful parameter for monitoring ice sublimation. By placing a digital camera in front of an isolated TVIS vial containing ice, it was possible to relate the changes in the shape of the ice mass with the changes in the trajectory of the time profile of C′(100 kHz) and determine the point of deviation from a planar ice interface and ultimately determine the point when the last vestiges of ice disappear. Thereafter, the same characteristics of the C′(100 kHz) time-profile were identified for those TVIS vials located out of sight of the camera in a separate full-shelf lyo study, thereby obviating the need for photographic examination.


1997 ◽  
Vol 32 (2) ◽  
pp. 133-154 ◽  
Author(s):  
Chokri Hammami ◽  
Frédéric René

2018 ◽  
Vol 40 (3) ◽  
Author(s):  
Nguyen Thi Oanh ◽  
Ha Danh Duc ◽  
Tran Dat Huy ◽  
Nguyen Gia Hien ◽  
Nguyen Thi Huynh Nhu

Pseudomonas fluorescens HH isolated from soil utilized 2,4-Dichlorophenoxyacetic acid (2,4D) as a sole carbon and energy source. The strain completely utilized 1.0 mM of 2,4D within 30 hr. The immobilized Pseudomonas fluorescens HH degraded 2,4D with higher rates compared to the rates of free-suspension cells. The determination of degradation and cell growth kinetics in exponential growth phase of bacteria showed that both fitted with the Edwards model, in which the maximal utilization rates and inhibition coefficient were 0.079 ± 0.008 mM/h and 0.820 ± 0.03 mM, respectively. The addition of glycerol as a cryoprotectant into alginate increased the survival of bacteria in beads during freeze-drying process, which resulted in reducing the adverse effects of bead lyophilization.


2017 ◽  
Vol 532 (1) ◽  
pp. 185-193 ◽  
Author(s):  
Laurens De Meyer ◽  
Joris Lammens ◽  
Séverine Thérèse F.C. Mortier ◽  
Brecht Vanbillemont ◽  
Pieter Jan Van Bockstal ◽  
...  

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