Association between Visit-to-Visit Fasting Plasma Glucose Variability and Osteoporotic Fractures in nondiabetic subjects

Abstract Context Although long-term glucose variability has been reported to be a risk factor associated with osteoporosis, there have been no previous studies between the relationship of glucose variability and fractures in people without diabetes. Objective We assessed visit-to-visit variations in fasting plasma glucose (FPG) as a prognostic factor in predicting osteoporotic fractures in individuals without diabetes. Design, Setting, and Subjects Using a nationwide cohort database, we examined the impact of FPG on the development of osteoporotic fractures in men and women (aged ≥50 years). Main Outcomes The primary outcomes were the number of total fractures and vertebral fractures. FPG variability was measured using standard deviation (FPG-SD), coefficient of variation (FPG-CV), and variation independent of the mean (FPG-VIM). Results Of the 92,929 participants, 5,262 (5.7%) developed osteoporotic fractures during the mean follow-up of 8.4 years. Individuals in the highest quartile of FPG-SD showed an 11% and 16% increase in risk of total and vertebral fractures, respectively, compared with those in the lowest quartile after adjustment for mean FPG and other risk factors. Analyses using FPG-CV and FPG-VIM demonstrated similar results. Subgroup analyses and sensitivity analyses to explore potential heterogeneity showed consistent results. Conclusions FPG variability may be a novel risk factor for osteoporotic fractures independent of risk factors in the general population without diabetes.

Download Full-text

Prevalence and risk factors of undiagnosed diabetes mellitus among gastroenterological patients: a HbA1c-based single center experience

Zeitschrift für Gastroenterologie ◽

10.1055/a-1482-8840 ◽

2021 ◽

Author(s):

Thorben Fründt ◽

Niko Schröder ◽

Angelique Hölzemer ◽

Hans Pinnschmidt ◽

Jocelyn de Heer ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Liver Cirrhosis ◽

Risk Factor ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Medication Use ◽

Undiagnosed Diabetes ◽

Diabetes Screening ◽

Fasting Plasma

Abstract Background Diabetes mellitus is a major risk factor for microvascular disease, leading to chronic kidney injury or cardiovascular disease, but there is a tremendous proportion of patients worldwide who suffer from undiagnosed diabetes. Until now, little is known about the prevalence of undiagnosed diabetes in gastroenterology inpatients. Objective To improve detection of undiagnosed diabetes, a routine screening procedure for gastroenterology inpatients, based on hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) measurement, was established. Methods We conducted a retrospective analysis of the implemented diabetes screening. Diabetes mellitus was diagnosed according to the guideline of the German Diabetes Association in patients with an HbA1c of ≥6.5% anld/or fasting plasma glucose (FPG) ≥126 mg/dL. Univariate and multivariate analyses were performed to identify independent risk factors for undiagnosed diabetes. Results Within a 3-month period, 606 patients were eligible for a diabetes screening. Pre-existing diabetes was documented in 120 patients (19.8 %), undiagnosed diabetes was found in 24 (3.9%), and 162 patients (26.7%) met the definition for prediabetes. Steroid medication use, age, and liver cirrhosis due to primary sclerosing cholangitis (PSC) were identified as risk factors for undiagnosed diabetes. Conclusion The prevalence of undiagnosed diabetes in gastroenterology inpatients is markedly elevated in comparison to the general population, and a substantial number of inpatients are in a prediabetic status, underlining the need for diabetes screening. In addition to previously described risk factors of patient age and steroid medication use, we identified PSC-related liver cirrhosis (but not liver cirrhosis due to another etiology) as an independent risk factor for undiagnosed diabetes.

Download Full-text

Fifteen years of GH replacement improves body composition and cardiovascular risk factors

Acta Endocrinologica ◽

10.1530/eje-12-1083 ◽

2013 ◽

Vol 168 (5) ◽

pp. 745-753 ◽

Cited By ~ 57

Author(s):

Mariam Elbornsson ◽

Galina Götherström ◽

Ingvar Bosæus ◽

Bengt-Åke Bengtsson ◽

Gudmundur Johannsson ◽

...

Keyword(s):

Risk Factors ◽

Body Composition ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Baseline Level ◽

Gh Replacement ◽

Fasting Plasma ◽

The Mean

ObjectiveFew studies have determined the effects of more than 5–10 years of GH replacement in adults on body composition and cardiovascular risk factors.Design/patientsIn this prospective, single-center, open-label study, the effects of 15 years of GH replacement on body composition and cardiovascular risk factors were determined in 156 hypopituitary adults (93 men) with adult-onset GH deficiency (GHD). Mean age was 50.5 (range 22–74) years at study start. Body composition was measured using dual-energy X-ray absorptiometry.ResultsThe mean initial GH dose of 0.55 (s.e.m. 0.03) mg/day was gradually lowered to 0.40 (0.01) mg/day after 15 years. The mean serum IGF1 SDS increased from −1.53 (0.10) at baseline to 0.74 (0.13) at study end (P<0.001 vs baseline). Lean soft tissue (LST) increased to 3% above the baseline level at study end (P<0.001). After a 9% decrease during the first year of treatment (P<0.001 vs baseline), body fat (BF) started to increase and had returned to the baseline level after 15 years. Serum levels of total cholesterol and LDL-cholesterol decreased and serum HDL-cholesterol level increased. Fasting plasma glucose increased from 4.4 (0.1) at baseline to 4.8 (0.1) mmol/l at study end (P<0.001). However, blood HbA1c decreased from 5.0 (0.1) to 4.6 (0.1) % (P<0.001).ConclusionsFifteen-year GH replacement in GHD adults induced a transient decrease in BF and sustained improvements of LST and serum lipid profile. Fasting plasma glucose increased whereas blood HbA1c was reduced.

Download Full-text

Fasting plasma glucose variability as a risk factor of retinopathy in Type 2 diabetic patients

Journal of Diabetes and its Complications ◽

10.1016/s1056-8727(02)00197-6 ◽

2003 ◽

Vol 17 (2) ◽

pp. 78-81 ◽

Cited By ~ 46

Author(s):

José A Gimeno-Orna ◽

Francisco J Castro-Alonso ◽

Beatriz Boned-Juliani ◽

Luis M Lou-Arnal

Keyword(s):

Risk Factor ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Glucose Variability ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Fasting Plasma ◽

Type 2 Diabetic

Download Full-text

Prevalence of Metabolic Syndrom in Three Urban Communities of Dhaka City

Ibrahim Medical College Journal ◽

10.3329/imcj.v2i2.2936 ◽

1970 ◽

Vol 2 (2) ◽

pp. 44-48 ◽

Cited By ~ 5

Author(s):

Shurovi Sayeed ◽

Akhter Banu ◽

Parvin Akter Khanam ◽

Sharmina Alauddin ◽

Sabrina Makbul ◽

...

Keyword(s):

Metabolic Syndrome ◽

Urban Communities ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Urban Population ◽

Population Characteristics ◽

Dhaka City ◽

Fasting Plasma ◽

Prevalence Of Obesity ◽

The Mean

Bangladeshis are prone to develop type 2 diabetes mellitus (T2DM), hypertension (sHTN and dHTN) and atherosclerotic heart diseases, observed more predominantly in the urban population. Though metabolic syndrome (MetS) is a related disorder, there are few studies in this regard. The prevalence of obesity, T2DM and MetS in three urban communities of Bangladesh were addressed in this study. Nine hundred non-slum urban households in three Dhaka City Wards were randomly selected. One member (age ≥ 25y) from each household was invited for investigation with an overnight fast. Socio-demographic information as well as height, weight, waist-girth, hip-girth and blood pressure were measured. Fasting plasma glucose (FPG), total cholesterol (chol), triglycerides (TG) and high-density lipoproteins-c (HDL) were estimated. A total of 705 (m / f = 239 / 466) subjects volunteered for the study. The mean value with 95% confidence interval (CI) of age was 42.4 (40.9 - 43.1) years for men and 37.8 (36.8 - 38.7) for women. The mean (CI) body mass index (BMI) was 21.0 (20.6 - 21.5) and 22.6 (22.2 - 22.9) and waist hip ratio (WHR) was 0.84 (0.83 - 0.84) and 0.82 (0.81 - 0.83), respectively for men and women. The mean (CI) FPG (fasting plasma glucose) was 5.5 (5.2 - 5.7) for men and 5.2 (5.0 - 5.4) for women. The prevalence of obesity (BMI ≥ 25.0) was 21%, T2DM (FPG ≥ 6.1 mmol/l) was 22.2%, triglyceridemia (TG ≥ 150mg/dl) was 45.1% and low HDL-c (HDL<40mg/ dl) was 43.8%. The crude prevalence of MetS varied based on different cluster combinations, being the lowest (0.3%) recommended by WHO cluster (FPG + BMI + SBP/DBP) and the highest (8.7%) by International Diabetes Federation (IDF) cluster (waist + FPG + HDL). The MetS was found higher in male than female by NCEP criteria and higher in female than male by IDF criteria. The study revealed an increased prevalence of obesity, T2DM and MetS in the urban communities. It also revealed that T2DM and MetS are moderately common and of growing healthcare burden in the rapidly growing urban population. Additionally, the study observed the wide ranging prevalence rates of MetS in the same study population indicating the need to establish a consistent and useful MetS-cluster depending on population characteristics. Ibrahim Med. Coll. J. 2008; 2(2): 44-48 Key Words: Metabolic syndrome, urban, diabetes, hypertension, dyslipidemia doi: 10.3329/imcj.v2i2.2936

Download Full-text

Fasting plasma glucose variability levels and risk of adverse outcomes among patients with type 2 diabetes: A systematic review and meta-analysis

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2018.12.010 ◽

2019 ◽

Vol 148 ◽

pp. 23-31 ◽

Cited By ~ 8

Author(s):

Qian Zhao ◽

Fan Zhou ◽

Yusheng Zhang ◽

Xiaoyan Zhou ◽

Changjiang Ying

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Meta Analysis ◽

Glucose Variability ◽

Adverse Outcomes ◽

Fasting Plasma

Download Full-text

The Global, Regional, and National Burden and Trends of Breast Cancer From 1990 to 2019: Results From the Global Burden of Disease Study 2019

Frontiers in Oncology ◽

10.3389/fonc.2021.689562 ◽

2021 ◽

Vol 11 ◽

Author(s):

Shangbo Xu ◽

Yiyuan Liu ◽

Taofeng Zhang ◽

Jiehua Zheng ◽

Weixun Lin ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Burden Of Disease ◽

Global Burden Of Disease ◽

Global Burden ◽

Fasting Plasma ◽

Life Years ◽

High Fasting Plasma Glucose

BackgroundThe burden of breast cancer has been increasing globally. The epidemiology burden and trends need to be updated. This study aimed to update the burden and trends of breast cancer incidences, deaths, and disability-adjusted life-years (DALYs) from 1990 to 2019, using the Global Burden of Disease 2019 study.MethodsThe data of incidences, deaths, DALYs, and age-standardized rates were extracted. Estimated annual percentage changes were used to quantify the trends of age-standardized rates. Besides, the population attributable fractions of the risk factors of breast cancer were also estimated.ResultsGlobally, the incidences of breast cancer increased to 2,002,354 in 2019. High social-development index (SDI) quintiles had the highest incidence cases with a declining trend in age-standardized incidence rate. In 2019, the global deaths and DALYs of breast cancer increased to 700,660 and 20,625,313, respectively. From 1990 to 2019, the age-standardized mortality rates and age-standardized DALY rates declined globally, especially in high and high-middle SDI quintiles. Besides, the trends varied from different regions and countries. The proportion of the patients in the 70+ years age group increased globally. Deaths of breast cancer attributable to high fasting plasma glucose and high body mass index increased globally, and high fasting plasma glucose was the greatest contributor to the global breast cancer deaths.ConclusionThe burden of breast cancer in higher SDI quintiles had gone down while the burden was still on the rise in lower SDI quintiles. It is necessary to appeal to the public to decrease the exposure of the risk factors.

Download Full-text

Risk factors for Type 2 Diabetes Mellitus in college students: association with sociodemographic variables

Revista Latino-Americana de Enfermagem ◽

10.1590/0104-1169.3053.2441 ◽

2014 ◽

Vol 22 (3) ◽

pp. 484-490 ◽

Cited By ~ 20

Author(s):

Adman Câmara Soares Lima ◽

Márcio Flávio Moura Araújo ◽

Roberto Wagner Júnior Freire de Freitas ◽

Maria Lúcia Zanetti ◽

Paulo César de Almeida ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

College Students ◽

Type 2 Diabetes ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Central Obesity ◽

Fasting Plasma ◽

High Fasting Plasma Glucose

OBJECTIVE: identify the modifiable risk factors for type 2 diabetes mellitus in college students and associate these factors with their sociodemographic variables.METHOD: cross-sectional study, involving 702 college students from Fortaleza-CE, Brazil. Sociodemographic, anthropometric, physical exercise data and blood pressure and fasting plasma glucose levels were collected.RESULTS: the most prevalent risk factor was sedentariness, followed by overweight, central obesity, high fasting plasma glucose and arterial hypertension. A statistically significant association was found between overweight and sex (p=0.000), age (p=0.004) and marital status (p=0.012), as well as between central obesity and age (p=0.018) and marital status (p=0.007) and between high fasting plasma glucose and sex (p=0.033).CONCLUSION: distinct risk factors were present in the study population, particularly sedentariness and overweight.

Download Full-text