Corrigendum to: “The Use of Morning Urinary Gonadotropins and Sex Hormones in the Management of Early Puberty in Chinese Girls”

Although early sexual initiation and childbearing are major barriers against the upward social mobility of American adolescents, particularly those who belong to a low socioeconomic status (SES) and racial minorities such as Blacks, less is known on how SES and race correlate with adolescents’ sex hormones. An understanding of the associations between race and SES with adolescents’ sex hormones may help better understand why racial, and SES gaps exist in sexual risk behaviors and teen pregnancies. To extend the existing knowledge on social patterning of adolescents’ sex hormones, in the current study, we studied social patterning of sex hormones in a national sample of male and female American adolescents, with a particular interest in the role of race and SES. For this cross-sectional study, data came from the baseline data (wave 1) of the Adolescent Brain Cognitive Development (ABCD) study, a national longitudinal prospective study of American adolescents. This analysis included 717 male and 576 female non-Hispanic White or Black adolescents ages 9–10. The dependent variables were sex hormones (testosterone for males and estradiol for females). Independent variables were age, race, family marital status, parental education, and financial difficulties. For data analysis, linear regression models were used. Age, race, parental education, and financial difficulties were associated with estradiol in female and testosterone levels in male adolescents. Associations were not identical for males and females, but the patterns were mainly similar. Low SES explained why race is associated with higher estradiol in female adolescents. Marital status of the family did not correlate with any of the sex hormones. Being Black and low SES were associated with a higher level of sex hormones in male and female adolescents. This information may help us understand the social patterning of sexual initiation and childbearing. Addressing racial and economic inequalities in early puberty, sexual initiation, and childbearing is an essential part of closing the racial and economic gaps in the US.

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Obesity‐related genetic polymorphisms are associated with the risk of early puberty in Han Chinese girls

Clinical Endocrinology ◽

10.1111/cen.14631 ◽

2021 ◽

Author(s):

Di Li ◽

Boxian Zhang ◽

Jinquan Cheng ◽

Dingyan Chen ◽

Yu Wu ◽

...

Keyword(s):

Genetic Polymorphisms ◽

Han Chinese ◽

Early Puberty ◽

Chinese Girls

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The Effectiveness of Genistein on Early Puberty of the Arabi Female Lambs: The Concentration of Sex Hormones and Development of Reproductive Organs

Basrah Journal of Agricultural Sciences ◽

10.37077/25200860.2019.135 ◽

2019 ◽

Vol 32 ◽

pp. 1-7

Author(s):

Maysaa M. A. Al-Rsitmawi ◽

Waleed Y. Kassim

Keyword(s):

Sex Hormones ◽

Reproductive Organs ◽

Reproductive Organ ◽

Control Group ◽

Early Puberty ◽

Sheep Farm ◽

Genistein Treatment ◽

Different Levels ◽

Average Body ◽

Average Body Weight

This study was undertaken at special sheep farm in Missan province. The study began at the 1st of September 2016 and ended at the 29th of December 2016. Sixteen female Arabi lambs, with an average age 210±5 days, and average body weight (23.88) Kg, were randomly divided into four groups as follows:. T1 as a control group, T2 treated with a dose of 0.5g genistein.head-1, T3 treated with a dose of 1g genistein.head-1. T4 treated with a dose of 2g genistein.head-1. All treatments were given genistein orally three times a week to investigate the effect of genistein treatment on sex hormones and reproductive organ development. The results showed significant (P<0.05) increase in concentrations of sex hormones (FSH, LH and estrogen) in female lambs treated 1g genistein for three times a week compared with control, T2 and T4 during the whole study period. The weights of the uterus, right ovary and ovary duct length of T3 group increased significantly (P<0.05) in comparison with TI group. There were no significant (P<0.05) differences observed between treated groups in left ovary weight. Treated of Arabi female lambs with different levels of genistein improved the development of uterus during puberty.

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Association of Obesity with Onset of Puberty and Sex Hormones in Chinese Girls: A 4-Year Longitudinal Study

PLoS ONE ◽

10.1371/journal.pone.0134656 ◽

2015 ◽

Vol 10 (8) ◽

pp. e0134656 ◽

Cited By ~ 25

Author(s):

Lingling Zhai ◽

Jihong Liu ◽

Jian Zhao ◽

Junxiu Liu ◽

Yinglong Bai ◽

...

Keyword(s):

Longitudinal Study ◽

Sex Hormones ◽

Chinese Girls

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Associations of waking cortisol with DHEA and testosterone across the pubertal transition: Effects of threat-related early life stress

10.1101/691279 ◽

2019 ◽

Cited By ~ 1

Author(s):

Lucy S. King ◽

Madelaine G. Graber ◽

Natalie L. Colich ◽

Ian H. Gotlib

Keyword(s):

Sex Hormones ◽

Hpa Axis ◽

Life Stress ◽

Early Life ◽

Early Life Stress ◽

Subsequent Development ◽

Tanner Stage ◽

Early Puberty ◽

Pubertal Stage ◽

Mental And Physical Health

AbstractAtypical regulation of the hypothalamic-pituitary-adrenal (HPA) axis is a putative mechanism underlying the association between exposure to early life stress (ELS) and the subsequent development of mental and physical health difficulties. Recent research indicates that puberty is a period of HPA-axis plasticity during which the effects of exposure to ELS on cortisol regulation may change. In particular, increases in the sex hormones that drive pubertal maturation, including dehydroepiandrosterone (DHEA) and testosterone, may be implicated in pubertal recalibration of cortisol regulation. In the current study, we examined the associations among levels of objectively-rated threat-related ELS and salivary waking cortisol, DHEA, and testosterone in a sample of 178 adolescents (55% female) who were in early puberty at baseline (Tanner stages 1-3; mean Tanner stage[SD]=1.93[0.64]; mean age[SD]=11.42[1.04]) and were followed up approximately two years later (mean Tanner stage[SD]=3.46[0.86]; mean age[SD]=13.38[1.06]). Using multi-level modeling, we disaggregated the effects of between-individual levels and within-individual increases in pubertal stage and sex hormones on change in cortisol. Controlling for between-individual differences in average pubertal stage, the association between levels of cortisol and DHEA was more strongly positive among adolescents who evidenced greater within-individual increases in pubertal stage across time. Both higher average levels and greater within-individual increases in DHEA and testosterone were associated with increases in cortisol across time, indicating positive coupling of developmental changes in these hormones; however, coupling was attenuated in adolescents who were exposed to more severe threat-related ELS prior to puberty. These findings advance our understanding of the development of the HPA-axis and its association with childhood environmental risk during puberty.

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Association of Polymorphisms in the Kisspeptin/GPR54 Pathway Genes With Risk of Early Puberty in Chinese Girls

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgz229 ◽

2020 ◽

Vol 105 (4) ◽

pp. e1458-e1467 ◽

Cited By ~ 1

Author(s):

Di Li ◽

Yu Wu ◽

Jinquan Cheng ◽

Liegang Liu ◽

Xiaoheng Li ◽

...

Keyword(s):

Positive Association ◽

Central Precocious Puberty ◽

Recessive Model ◽

Additive Models ◽

Nucleotide Polymorphism ◽

Early Puberty ◽

Chinese Han ◽

Single Nucleotide ◽

Chinese Girls ◽

Control Study

Abstract Context and Objective This case control study was designed to investigate the association between mutation of 10 single nucleotide polymorphism (SNP) loci (rs1132506, rs5780218, rs192636495, rs4889, rs184749, rs12985070, rs708910, rs932491, rs8074995, and rs2306877) in all 5 genes (KISS1, GPR54, PLCB1, PRKCA, and ITPR1) in the kisspeptin/GPR54 pathway and the risk of early puberty in Chinese Han girls. Design and Participants A total of 314 pairs of early puberty girls on their first visit to hospital and age-matched controls (± 3 months) were recruited. The genotypes of each SNP were determined and the effect of loci variation on early puberty was investigated. Results rs5780218 was significantly associated with early puberty in additive, dominant, and recessive models of inheritance after adjusting for confounding factors (Pr < .05). After stratification, rs5780218 variation (odds ratio [OR], 1.650, 95% confidence interval [CI], 1.155-2.355 in additive models and OR, 2.116; 95% CI, 1.187-3.770 in recessive models) increased the risk of central precocious puberty (CPP); mutation in rs708910 (OR, 2.768; 95% CI, 1.305-5.872 in recessive model) had a positive association with the risk of CPP; and rs932491 variation was negatively associated with early and fast puberty (EFP) (OR, 0.309; 95% CI, 0.144-0.661 in additive models and OR, 0.317; 95% CI, 0.141-0.713 in dominant models). Conclusions Our study suggests that mutation in rs5780218 and rs708910 increases the risk of CPP. rs932491 variation may have a protective effect on the risk of EFP. Further studies in larger populations or with people from different regions are needed to verify our findings.

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