Effect of the Age at Menarche and Menopause Status Interaction on Type 2 Diabetes: The Henan Rural Cohort Study

2020 ◽  
Vol 105 (3) ◽  
pp. e139-e147 ◽  
Author(s):  
Lulu Zhang ◽  
Yuqian Li ◽  
Xiaokang Dong ◽  
Wen Zhou ◽  
Chongjian Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Interaction Effect ◽  
Lower Risk ◽  
Significant Interaction ◽  
Age At Menarche ◽  
Homa Index ◽  
Significant Interaction Effect ◽  
Multiple Variables ◽  
Menarche Age

Abstract Purpose The aims of this study were to evaluate the effect of age at menarche (AM) on type 2 diabetes mellitus (T2DM) and to assess whether the fasting plasma glucose (FPG) and homeostasis model assessment (HOMA) index responses to AM and menopause status interact in Chinese rural adults. Methods A cross-sectional, population-based study including 23 138 participants was performed. Logistic regression and multivariable linear regression were performed to investigate the relationship between AM and glucose status. Generalized linear model was used to calculate the interaction term of AM and menopause status on FPG and the HOMA index. Interaction plot was used to interpret the significant interaction effect. Results Women in the later menarche age group (≥18 years) had a 17.7% lower risk of T2DM (95% confidence interval [CI]: 0.712-0.951, P = .008), after adjusting for multiple variables. Further adjustment for body mass index (BMI) completely attenuated this association (odds ratio = 0.884, 95% CI: 0.764-1.024, P = .099). A significant interaction effect of AM and menopause status on T2DM (P = .004) was observed. The adverse effects of menopausal status on FPG and HOMA-2 of insulin resistance decreased with increasing menarche age, and the age ranges were limited to <18 and 9 to 19 years, respectively. Conclusions Later menarche was associated with a lower risk of T2DM, and the association appears to be mediated by BMI. More importantly, the adverse effect of menopause status on T2DM was decreased along with increasing menarche age.

Abstract MP038: Age at Menarche is Associated with Type 2 Diabetes in Young Adulthood: the CARDIA Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Jill Dreyfus ◽  
Pamela J Schreiner ◽  
Mercedes R Carnethon ◽  
Hilary Whitham ◽  
Richard Maclehose ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Black Women ◽  
Young Women ◽  
White Women ◽  
Age At Menarche ◽  
Family History Of Diabetes ◽  
History Of ◽  
Baseline Bmi ◽  
Menarche Age

Introduction: Recent studies report an association between early age at menarche and risk of type 2 diabetes (T2D). However, information in young women is limited to self-reported diabetes in primarily white populations. We explored the association of age at menarche and clinically-defined T2D among young black and white women (mean age 25 at baseline) in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort. Hypothesis: We assessed the hypothesis that the rate for T2D will decrease with each 1 year increase in age at menarche. Methods: Our analysis included 1,258 white and 1,341 black women (total=2,599) who participated in CARDIA during 1985-2006. We used Cox proportional hazards models to estimate hazard ratios (HR) for T2D (yes/no as determined at clinic visits) by continuous age at menarche. We excluded women with diabetes at baseline, missing age at menarche, or menarche <8 or >18 years. T2D was defined cumulatively from baseline among non-pregnant women as fasting blood glucose ≥ 126 mg/dl, A1C ≥ 6.5%, 2-hour oral glucose tolerance ≥ 200 mg/dl, or use of diabetes medication. Adjusted models included race (except race stratified models) and parental history of diabetes, as well as baseline age, education, and BMI as covariates. Results: Mean age at menarche was 12.6 years (SD=1.5; black=12.5, white=12.7). We identified 176 cases of T2D over 20 years of follow-up (cumulative incidence=6.8%). Among all women, the rate for T2D decreased by 16% for each 1 year increase in menarche age ( Table 1 ); we found no evidence of nonlinearity. HRs remained protective, but no longer statistically significant after adjustment for BMI. HRs were lower for white women compared to black women, although a test for race by menarche age interaction was not significant (p=0.26). Conclusions: We found evidence to support the hypothesis that early menarche increases the rate for T2D among young women. Higher baseline BMI among women with earlier menarche appears to attenuate the association of age at menarche and future glucose metabolism. Table 1. Hazard Ratio (HR) of Type 2 Diabetes for Each One Year Increase in Age at Menarche in the CARDIA Study, 1985-2006 Crude Model 1 Model 2 # T2D HR 95% CI HR 95% CI HR 95% CI All Women 176 0.84 0.76, 0.93 0.88 0.79, 0.98 0.94 0.85, 1.04 White 46 0.78 0.64, 0.96 0.83 0.68, 1.02 0.93 0.76, 1.16 Black 130 0.90 0.80, 1.01 0.90 0.80, 1.02 0.96 0.85, 1.08 Model 1: adjusted for race (except for race-stratified models), family history of diabetes, baseline age, and participant level of education at baseline (<HS, HS, >HS) Model 2: adjusted for variables in Model 1 plus baseline BMI

scholarly journals Is There an Association Between Metformin Exposure and Frailty?

2020 ◽  
Vol 6 ◽  
pp. 233372142092495
Author(s):  
Dhanya Baskaran ◽  
Raquel Aparicio-Ugarriza ◽  
Juliana Ferri-Guerra ◽  
Raneem Milyani ◽  
Hermes Florez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Logistic Regression ◽  
Lower Risk ◽  
Frailty Index ◽  
Community Dwelling ◽  
Outcome Variable ◽  
Deficit Accumulation ◽  
Binomial Logistic Regression ◽  
Multiple Variables

Frailty is a state of vulnerability to stressors resulting in higher morbidity, mortality, and utilization in older adults. Frailty and type 2 diabetes mellitus share similar pathophysiological mechanisms which metformin may target. The purpose of this study was to determine whether exposure to metformin is associated with frailty in veterans. This is a cross-sectional study of veterans 65 years and older with type 2 diabetes who were screened for frailty between January 2016 and August 2017. We constructed a 44-item Frailty Index including multiple variables using a deficit accumulation framework. After adjustment for covariates, the association was calculated using binomial logistic regression models with frailty status as the outcome variable, and metformin exposure as the independent variable. Patients were 98.3% male and 56.7% White with a mean age of 72.9 ( SD = 6.8) years. The proportion of robust, prefrail and frail patients was 2.9% ( n = 22), 46.7 % ( n = 356) and 50.5% ( n = 385), respectively. In binomial logistic regression, exposure to metformin was associated with lower risk for frailty, adjusted odds ratio (OR) = .55 (95% confidence interval [CI] = .39–.77), p ≤ .001. This study shows that exposure to metformin was associated with lower risk for frailty in community-dwelling veterans.

EFFECT OF SOWING DATE ON GRAIN YIELD OF CRAB GRASS

2001 ◽  
Vol 49 (3) ◽  
pp. 293-297
Author(s):  
S. O. Bakare ◽  
M. G. M. Kolo ◽  
J. A. Oladiran
Keyword(s):  
Grain Yield ◽  
Interaction Effect ◽  
Significant Interaction ◽  
Sowing Date ◽  
Yield Data ◽  
Significant Interaction Effect ◽  
Sowing Dates

There was a significant interaction effect between the variety and the sowing date for the number of productive tillers, indicating that the response to sowing date varied with the variety. A significant reduction in the number of productive tillers became evident when sowing was delayed till 26 June in the straggling variety as compared to sowing dates in May. Lower numbers of productive tillers were also recorded when the sowing of the erect variety was further delayed till 10 July. The grain yield data showed that it is not advisable to sow the straggling variety later than 12 June, while sowing may continue till about 26 June for the erect variety in the study area.

Novel glucose lowering agents are associated with a lower risk of cardiovascular and adverse events in type 2 diabetes: A population based analysis

2020 ◽  
Vol 310 ◽  
pp. 147-154 ◽  
Author(s):  
Malik Elharram ◽  
Cristiano S. Moura ◽  
Michal Abrahamowicz ◽  
Sasha Bernatsky ◽  
Hassan Behlouli ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adverse Events ◽  
Lower Risk ◽  
Population Based ◽  
Glucose Lowering

Is HOMA index a predictor of nocturnal nondipping in hypertensives with newly diagnosed type 2 diabetes mellitus?

2007 ◽  
Vol 12 (3) ◽  
pp. 133-139 ◽  
Author(s):  
Baris Afsar ◽  
Siren Sezer ◽  
Rengin Elsurer ◽  
Fatma Nurhan Ozdemir
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Homa Index ◽  
Newly Diagnosed

Family environment of eating disordered patients with and without self-injurious behaviors

2004 ◽  
Vol 19 (8) ◽  
pp. 494-498 ◽  
Author(s):  
Laurence Claes ◽  
Walter Vandereycken ◽  
Hans Vertommen
Keyword(s):  
Psychiatric Disorders ◽  
Family Environment ◽  
Interaction Effect ◽  
Significant Interaction ◽  
Family Context ◽  
Hair Pulling ◽  
Significant Interaction Effect ◽  
Eating Disordered ◽  
Significant Difference ◽  
The Family

AbstractObjective.– The family environment is known to be an important contributor to the course of psychiatric disorders. In this study, we examined the family context of eating disordered (ED) patients with and without self-injurious behaviors (SIB).Method.– A Dutch adaptation of the Family Environment Scale ‘Sci Eng 57(9-B):1997;5927’ was completed by 131 ED patients of whom 47% showed at least one form of SIB (e.g., cutting, burning, hair pulling, etc.).Results– Results showed a significant difference in family environment between patients with and without SIB. The family environment of self-injuring ED patients was less cohesive, expressive and socially oriented, and more conflictual and disorganized than the family environment of those without SIB. No significant differences in perceived family environment were found with respect to the number or form of SIB and the subtype of ED. Neither did we find a significant interaction effect between ED subtype and presence/absence of SIB.

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