scholarly journals Longitudinal Metabolic Impacts of Perinatal Exposure to Phthalates and Phthalate Mixtures in Mice

Endocrinology ◽  
2019 ◽  
Vol 160 (7) ◽  
pp. 1613-1630 ◽  
Author(s):  
Kari Neier ◽  
Drew Cheatham ◽  
Leah D Bedrosian ◽  
Brigid E Gregg ◽  
Peter X K Song ◽  
...  
Keyword(s):  
Body Fat ◽  
Animal Studies ◽  
Metabolic Effects ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Diethylhexyl Phthalate ◽  
Metabolic Outcomes ◽  
Lactating Females ◽  
Developmental Exposures

Abstract Developmental exposures to phthalates are suspected to contribute to risk of metabolic syndrome. However, findings from human studies are inconsistent, and long-term metabolic impacts of early-life phthalate and phthalate mixture exposures are not fully understood. Furthermore, most animal studies investigating metabolic impacts of developmental phthalate exposures have focused on diethylhexyl phthalate (DEHP), whereas newer phthalates, such as diisononyl phthalate (DINP), are understudied. We used a longitudinal mouse model to evaluate long-term metabolic impacts of perinatal exposures to three individual phthalates, DEHP, DINP, and dibutyl phthalate (DBP), as well as two mixtures (DEHP+DINP and DEHP+DINP+DBP). Phthalates were administered to pregnant and lactating females through phytoestrogen-free chow at the following exposure levels: 25 mg of DEHP/kg of chow, 25 mg of DBP/kg of chow, and 75 mg of DINP/kg of chow. One male and female per litter (n = 9 to 13 per sex per group) were weaned onto control chow and followed until 10 months of age. They underwent metabolic phenotyping at 2 and 8 months, and adipokines were measured in plasma collected at 10 months. Longitudinally, females perinatally exposed to DEHP only had increased body fat percentage and decreased lean mass percentage, whereas females perinatally exposed to DINP only had impaired glucose tolerance. Perinatal phthalate exposures also modified the relationship between body fat percentage and plasma adipokine levels at 10 months in females. Phthalate-exposed males did not exhibit statistically significant differences in the measured longitudinal metabolic outcomes. Surprisingly, perinatal phthalate mixture exposures were statistically significantly associated with few metabolic effects and were not associated with larger effects than single exposures, revealing complexities in metabolic effects of developmental phthalate mixture exposures.

scholarly journals Whole-Food Plant-Based Lifestyle Program and Decreased Obesity: A 10-Year Follow-up

2019 ◽  
Author(s):  
Boštjan Jakše ◽  
Barbara Jakše ◽  
Stanislav Pinter ◽  
Jernej Pajek ◽  
Nataša Fidler Mis
Keyword(s):  
Body Composition ◽  
Body Mass ◽  
Body Fat ◽  
Food Plant ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Total Body Mass ◽  
Lifestyle Program ◽  
Composition Changes

Failure of various weight-loss programs and long-term maintenance of favorable body composition in all kinds of people is high, since the majority go back to old dietary patterns. Many studies have documented the efficacy of a plant-based diet (PBD) for body mass management, but there are opinions that maintaining a PBD is difficult. We aimed to evaluate the long-term success of a whole-food plant-based (WFPB) lifestyle program. We investigated the differences in the obesity indices and lifestyle of 151 adults (39.6 ± SD 12.5 years), who were on our program for short (0.5–<2 years), medium (2–<5 years), or long term (5–10 years). Body-composition changes were favourable for all three groups, both genders and all participants. There were no differences in relative body-composition changes (BMI, body fat percentage and muscle mass index (MMI)) between the three groups. All participants improved their BMI (baseline mean pre-obesity BMI range (kg/m2): 26.4 ± 5.6 to normal 23.9 ± 3.8, p < 0.001), decreased body mass (–7.1 ± 8.3 kg, p < 0.001) and body fat percentage (–6.4 ± 5.6 % points, p < 0.001). 85.6% (101 out of 118) of parents of underage children (< 18 years), introduced WFPB lifestyle to their children. Those with the highest BMI at baseline lost the most of: a) BMI units, b) total body mass and c) body fat (a) (kg/m2) (–5.6 ± SD 2.9, –2.4 ± 1.8 and –0.9 ± 1.5), b) (kg) (–16.1 ± SD 8.8, –7.1 ± 5.4 and –2.5 ± 4.5) and c) (% points) (–9.5 ± SD 5.7, –6.6 ± 4.6 and –4.7 ± 5.3) for participants who had baseline BMI in obese, overweight and normal range, respectively; pbaseline vs. current < 0.001 for all). WFPB lifestyle program provides long-term lifestyle changes for reversal of obesity and is effective transferred to the next generation.

Whole-Food Plant-Based Lifestyle Program and Decreased Obesity

2020 ◽  
pp. 155982762094920
Author(s):  
Boštjan Jakše ◽  
Barbara Jakše ◽  
Stanislav Pinter ◽  
Jernej Pajek ◽  
Nataša Fidler Mis
Keyword(s):  
Body Composition ◽  
Body Mass ◽  
Body Fat ◽  
Food Plant ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Lifestyle Program ◽  
Obesity Indices ◽  
Baseline Bmi

Failure of weight-loss programs is high. We evaluated a whole-food plant-based (WFPB) lifestyle program. We investigated the obesity indices of 151 healthy adults who were on our ongoing, community-based program for the short (0.5 to ≤2 years), medium (2 to ≤5 years), or long term (5 to 10 years). Body composition indices were measured by medically approved bioimpedance. Body composition changes were favorable for all 3 groups and both genders. There were no differences in body composition between the males for all 3 groups, while there were lower body mass (BM), body mass index (BMI), and muscle mass in females on long-term versus short-term programs. All participants experienced a decrease in BMI (−2.5 kg/m2), BM (−7.1 kg), and body fat percentage (−6.4%; P < .001 for all). The reductions for those with a baseline BMI of obese, overweight, and normal were −5.6, −2.4, and −0.9 kg/m2 for BMI, −16.1, −7.1, and −2.5 kg for total BM, and −9.5%, −6.6%, and −4.8% for body fat percentage (baseline vs current; P < .001 for all). A total of 86% of parents of underage children introduced the WFPB lifestyle to children. Our WFPB lifestyle program provides a long-term reversal of obesity.

scholarly journals Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247049
Author(s):  
Amber Hillaert ◽  
Daisy J. X. Liu ◽  
Sylvie Daminet ◽  
Bart J. G. Broeckx ◽  
Emmelie Stock ◽  
...  
Keyword(s):  
Body Fat ◽  
Weight Change ◽  
Filtration Rate ◽  
Control Group ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Symmetric Dimethylarginine ◽  
Association Coefficient ◽  
Healthy Dogs

Symmetric dimethylarginine (SDMA) is a promising renal marker that correlates well with the glomerular filtration rate and could allow earlier detection of impaired renal function. The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the influence of an increased body fat percentage on the level of SDMA. Sixteen lean Beagles were randomly assigned to the control group or weight-change group in age- and gender-matched pairs. The energy intake of the control group (n = 8) was strictly regulated to maintain an ideal body weight for 83 weeks, while the weight-change group (n = 8) was fed to induce weight gain (week 0–47), to maintain stable excessive body weight (week 47–56) and to lose weight (week 56–83), consecutively. At 8 specified time points, the body condition score, body composition, glomerular filtration rate, serum concentration of SDMA and creatinine were analyzed. In the control group, the within-subject coefficient of variation, between-subject coefficient of variation, reference change value (type I error = 5%) and index of individuality were 0.16, 0.22, 0.43 and 0.73, respectively. The control group and weight-change group did not differ significantly in SDMA concentration. SDMA showed a significant negative association (coefficient = -0.07) with body fat percentage (p<0.01) in the weight-change group and a significant positive association (coefficient = 7.79) with serum creatinine (p<0.01) in the entire study population. In conclusion, SDMA concentration has high long-term stability in healthy adult dogs. For the evaluation of SDMA concentrations, subject-specific reference values are preferred over a population-based reference value seen their higher sensitivity. Moreover, an increased body fat percentage does seem to affect the serum SDMA concentration of otherwise healthy dogs, but its clinical relevance has to be clarified in further research.

Effect of long-term oral administration of a low dosage of clenbuterol on body fat percentage in working and nonworking adult horses

2015 ◽  
Vol 76 (5) ◽  
pp. 460-466 ◽  
Author(s):  
Rose D. Nolen-Walston ◽  
Caitlin M. Moore ◽  
Ciara A. Barr ◽  
Joy E. Tomlinson ◽  
Raymond C. Boston ◽  
...  
Keyword(s):  
Oral Administration ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Low Dosage

scholarly journals Long-Term Effects of Placental Growth on Overweight and Body Composition

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Johan G. Eriksson ◽  
Jill Gelow ◽  
Kent L. Thornburg ◽  
Clive Osmond ◽  
Markku Laakso ◽  
...  
Keyword(s):  
Body Composition ◽  
Surface Area ◽  
Body Fat ◽  
Odds Ratio ◽  
Adult Life ◽  
Nutrient Supply ◽  
Body Fat Percentage ◽  
Long Term Effects ◽  
Fat Percentage

Obesity is programmed in utero and small babies generally have small placentas. In some circumstances, an undernourished fetus can expand its placental surface to extract more nutrients. We hypothesize that this results in an imbalanced nutrient supply to the fetus leading to obesity. To determine whether placental size determines overweight and body composition, we studied 2003 subjects in adult life. Associations between placental surface area and indices of overweight were restricted to people who carried the Pro12Pro genotype of thePPARγ2gene. For every 1 SD increase in placental surface area, the odds ratio for overweight was 1.37 (95% CI 1.10 to 1.71;P=0.005). Expansion of the placental surface in compensation for fetal undernutrition increases the risk of overweight and a higher body fat percentage in people carrying the Pro12Pro genotype. We suggest that similar underlying multifactorial mechanisms affect the development of obesity in general.

Subjective Sleep Debt Is Correlated with Body Fat Percentage Independent of Sleep Duration

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1675-P
Author(s):  
XIAO TAN ◽  
CHRISTIAN BENEDICT
Keyword(s):  
Sleep Duration ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Subjective Sleep ◽  
Sleep Debt
Sign in / Sign up

Export Citation Format

Share Document