Dietary Sodium Intake and Incidence of Diabetes Complications in Japanese Patients with Type 2 Diabetes: Analysis of the Japan Diabetes Complications Study (JDCS)

2014 ◽  
Vol 99 (10) ◽  
pp. 3635-3643 ◽  
Author(s):  
Chika Horikawa ◽  
Yukio Yoshimura ◽  
Chiemi Kamada ◽  
Shiro Tanaka ◽  
Sachiko Tanaka ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Complications ◽  
Sodium Intake ◽  
Japanese Patients ◽  
Dietary Sodium

scholarly journals Sodium Intake and Incidence of Diabetes Complications in Elderly Patients with Type 2 Diabetes—Analysis of Data from the Japanese Elderly Diabetes Intervention Study (J-EDIT)

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 689
Author(s):  
Chika Horikawa ◽  
Rei Aida ◽  
Shiro Tanaka ◽  
Chiemi Kamada ◽  
Sachiko Tanaka ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Elderly Patients ◽  
Diabetes Complications ◽  
Vegetable Intake ◽  
Sodium Intake ◽  
Food Groups ◽  
High Sodium ◽  
Increased Risk

This study investigates the associations between sodium intake and diabetes complications in a nationwide cohort of elderly Japanese patients with type 2 diabetes aged 65–85. Data from 912 individuals regarding their dietary intake at baseline is analyzed and assessed by the Food Frequency Questionnaire based on food groups. Primary outcomes are times to diabetic retinopathy, overt nephropathy, cardiovascular disease (CVD), and all-cause mortality during six years. We find that mean sodium intake in quartiles ranges from 2.5 g to 5.9 g/day. After adjustment for confounders, no significant associations are observed between sodium intake quartiles and incidence of diabetes complications and mortality, except for a significant trend for an increased risk of diabetic retinopathy (p = 0.039). Among patients whose vegetable intake was less than the average of 268.7 g, hazard ratios (HRs) for diabetic retinopathy in patients in the second, third, and fourth quartiles of sodium intake compared with the first quartile were 0.87 (95% CI, 0.31–2.41), 2.61 (1.00–6.83), and 3.70 (1.37–10.02), respectively. Findings indicate that high sodium intake under conditions of low vegetable intake is associated with an elevated incidence of diabetic retinopathy in elderly patients with type 2 diabetes.

scholarly journals Dietary intake in Japanese patients with type 2 diabetes: Analysis from Japan Diabetes Complications Study

2013 ◽  
Vol 5 (2) ◽  
pp. 176-187 ◽  
Author(s):  
Chika Horikawa ◽  
Yukio Yoshimura ◽  
Chiemi Kamada ◽  
Shiro Tanaka ◽  
Sachiko Tanaka ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Diabetes Complications ◽  
Japanese Patients

scholarly journals Dietary Sodium Intake in Type 2 Diabetes

2014 ◽  
Vol 32 (3) ◽  
pp. 106-112 ◽  
Author(s):  
L. F. Provenzano ◽  
S. Stark ◽  
A. Steenkiste ◽  
B. Piraino ◽  
M. A. Sevick
Keyword(s):  
Type 2 Diabetes ◽  
Sodium Intake ◽  
Dietary Sodium

Sodium Intake, Circulating Microvesicles and Cardiovascular Outcomes in Type 2 Diabetes

2019 ◽  
Vol 15 (6) ◽  
pp. 435-445
Author(s):  
Dorothy Liu ◽  
Sara Baqar ◽  
Lisa L. Lincz ◽  
Elif I. Ekinci
Keyword(s):  
Type 2 Diabetes ◽  
Endothelial Dysfunction ◽  
Sodium Intake ◽  
Cardiovascular Outcomes ◽  
Dietary Sodium ◽  
Ongoing Debate ◽  
Cellular Activation ◽  
Cardiovascular Morbidity And Mortality ◽  
Increased Activity

There is ongoing debate surrounding the complex relationship between dietary sodium intake and cardiovascular morbidity and mortality. The existing literature consists largely of observational studies that have demonstrated positive, negative, U-/J-shaped or unclear associations between sodium intake and cardiovascular outcomes. Our group and others have previously demonstrated an inverse relationship between dietary sodium intake and cardiovascular outcomes in people with type 2 diabetes. Increased activity of the renin-angiotensin-aldosterone system and sympathetic nervous system is postulated to contribute to these paradoxical findings through endothelial dysfunction, a precursor to the development of cardiovascular disease. Microvesicles are submicron (0.1 – 1.0μm) vesicles that form during cellular activation, injury or death with endothelial microvesicles being recognized markers of endothelial dysfunction. They are pathologically elevated in a variety of vascular-related conditions including type 2 diabetes. Lower habitual sodium intake in type 2 diabetes has been associated with higher pro-coagulant platelet microvesicles levels but not with endothelial microvesicles. Research utilizing endothelial microvesicles to evaluate the mechanistic relationship between dietary sodium intake and adverse cardiovascular outcomes in type 2 diabetes remains scarce.

scholarly journals Clinical Features in Japanese Patients with Type 2 Diabetes: Interim Results of Japan Diabetes Complications Study (JDCS)

2007 ◽  
Vol 65 (6) ◽  
pp. 269-279
Author(s):  
Hirohito Sone ◽  
Yukio Yoshimura ◽  
Akira Tanaka ◽  
Nobuhiro Yamada ◽  
Japan Diabetes Complications Study
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Features ◽  
Diabetes Complications ◽  
Japanese Patients
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