scholarly journals The Effect of Improved Serum 25-Hydroxyvitamin D Status on Glycemic Control in Diabetic Patients: A Meta-Analysis

2017 ◽  
Vol 102 (9) ◽  
pp. 3097-3110 ◽  
Author(s):  
Naghmeh Mirhosseini ◽  
Hassanali Vatanparast ◽  
Mohsen Mazidi ◽  
Samantha M Kimball
Keyword(s):  
Glycemic Control ◽  
Meta Analysis ◽  
Diabetic Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Correlational study on the levels of 25-hydroxyvitamin D and non-alcoholic fatty liver disease in type 2 diabetic patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yuanyuan Zhang ◽  
Juyi Li ◽  
Yingqun Ni ◽  
Yan Wang ◽  
Huaizhen Liu
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Type 2 Diabetic

Abstract Background It is widely acknowledged that nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus(T2DM) are all chronic metabolic diseases. The objective of this study is to retrospectively probe the association between the 25-hydroxyvitamin D (25-(OH)D) and NAFLD in type 2 diabetic patients. Methods Three hundred thirty-nine T2DM patients participated in this research and from November 2018 to September 2019 and were divided into simple T2DM group (108 cases) and T2DM with NAFLD group (231 cases) in conformity with abdominal ultrasound diagnosis. The NAFLD fibrosis score (NFS) ≥0.676 was defined as progressive liver fibrosis.231 T2DM with NAFLD patients were categorized into two subgroups: progressive liver fibrosis subgroup (48 cases) and without progressive liver fibrosis subgroup (183 cases). Results The prevalence of NAFLD by Abdominal ultrasonography was 68%.The results indicated that the levels of 25-(OH) D were significantly lower in T2DM with NAFLD group than that in simple T2DM group(P < 0.01). The levels of 25-(OH) D were significantly lower in progressive liver fibrosis subgroup than that in patients without progressive liver fibrosis and simple T2DM,and 25-(OH) D levels were lower in without progressive liver fibrosis subgroup than that in simple T2DM group(p < 0.01 or p < 0.05). Multivariate logistic regression analysis showed that levels of 25-(OH) D were negative correlation with risk of NAFLD and progressive liver fibrosis(p = 0.011、p = 0.044,respectively). Conclusions we could come to a conclusion that low levels of 25-(OH) D was a risk factor for NAFLD and progressive liver fibrosis in T2DM patients.

Circulating 25-hydroxyvitamin D level and prognosis of lung cancer patients: A systematic review and meta-analysis

2017 ◽  
Vol 104 (7-8) ◽  
pp. 675-682 ◽  
Author(s):  
Jian-Da Huang ◽  
Chao-Hui Dong ◽  
Sheng-Wen Shao ◽  
Tong-Jie Gu ◽  
Zhi-Lin Hu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Lung Cancer Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Mohammad Rizki Akbar ◽  
Arief Wibowo ◽  
Raymond Pranata ◽  
Budi Setiabudiawan
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Secondary Outcome ◽  
Control Group ◽  
Hydroxyvitamin D ◽  
Literature Searches ◽  
25 Hydroxyvitamin D ◽  
Meta Regression Analysis ◽  
Embase Database ◽  
Low Serum

Background: This systematic review and meta-analysis aimed to assess whether low serum 25-hydroxyvitamin D (25-OHD) level is associated with susceptibility to COVID-19, severity, and mortality related to COVID-19.Methods: Systematic literature searches of PubMed, Scopus, and Embase database up until 9 December 2020. We include published observational prospective and retrospective studies with information on 25-OHD that reported main/secondary outcome. Low serum 25-OHD refers to participants with serum 25-OHD level below a cut-off point ranging from 20 to 30 ng/mL. Other cut-off values were excluded to reduce heterogeneity. The main outcome was mortality defined as non-survivor/death. The secondary outcome was susceptibility and severe COVID-19.Results: There were 14 studies comprising of 999,179 participants. Low serum 25-OHD was associated with higher rate of COVID-19 infection compared to the control group (OR = 2.71 [1.72, 4.29], p &lt; 0.001; I2: 92.6%). Higher rate of severe COVID-19 was observed in patients with low serum 25-OHD (OR = 1.90 [1.24, 2.93], p = 0.003; I2: 55.3%), with a sensitivity of 83%, specificity of 39%, PLR of 1.4, NLR of 0.43, and DOR of 3. Low serum 25-OHD was associated with higher mortality (OR = 3.08 [1.35, 7.00], p = 0.011; I2: 80.3%), with a sensitivity of 85%, specificity of 35%, PLR of 1.3, NLR of 0.44, and DOR of 3. Meta-regression analysis showed that the association between low serum 25-OHD and mortality was affected by male gender (OR = 1.22 [1.08, 1.39], p = 0.002), diabetes (OR = 0.88 [0.79, 0.98], p = 0.019).Conclusion: Low serum 25-OHD level was associated with COVID-19 infection, severe presentation, and mortality.

scholarly journals Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4260
Author(s):  
Liana Najjar ◽  
Joshua Sutherland ◽  
Ang Zhou ◽  
Elina Hyppönen
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Meta Analysis ◽  
Low Frequency ◽  
Nucleotide Polymorphisms ◽  
Hydroxyvitamin D ◽  
Quantitative Synthesis ◽  
25 Hydroxyvitamin D

Several observational studies have examined vitamin D pathway polymorphisms and their association with type 1 diabetes (T1D) susceptibility, with inconclusive results. We aimed to perform a systematic review and meta-analysis assessing associations between selected variants affecting 25-hydroxyvitamin D [25(OH)D] and T1D risk. We conducted a systematic search of Medline, Embase, Web of Science and OpenGWAS updated in April 2021. The following keywords “vitamin D” and/or “single nucleotide polymorphisms (SNPs)” and “T1D” were selected to identify relevant articles. Seven SNPs (or their proxies) in six genes were analysed: CYP2R1 rs10741657, CYP2R1 (low frequency) rs117913124, DHCR7/NADSYN1 rs12785878, GC rs3755967, CYP24A1 rs17216707, AMDHD1 rs10745742 and SEC23A rs8018720. Seven case-control and three cohort studies were eligible for quantitative synthesis (n = 10). Meta-analysis results suggested no association with T1D (range of pooled ORs for all SNPs: 0.97–1.02; p > 0.01). Heterogeneity was found in DHCR7/NADSYN1 rs12785878 (I2: 64.8%, p = 0.02). Sensitivity analysis showed exclusion of any single study did not alter the overall pooled effect. No association with T1D was observed among a Caucasian subgroup. In conclusion, the evidence from the meta-analysis indicates a null association between selected variants affecting serum 25(OH)D concentrations and T1D.

scholarly journals Poor glycemic control and associated factors among diabetic patients in Ethiopia; A Systemic review and meta-analysis

2019 ◽  
Author(s):  
Berhane Fseha Teklehaimanot ◽  
Abadi kidanemariam Berhe ◽  
Gebrehiwot Gebremariam Welearegawi
Keyword(s):  
Glycemic Control ◽  
Low Income ◽  
Associated Factors ◽  
Meta Analysis ◽  
Group Analysis ◽  
Poor Glycemic Control ◽  
Systemic Review ◽  
Cochrane Library ◽  
Diabetic Patients ◽  
Optimum Level

AbstractIntroductionThe major global public health problems now days are diabetes especially the burden is high in low income countries including Ethiopia due to the limited resource for screening and early diagnosis of the diabetes. To prevent diabetic complications including organ damage and micro vascular complications blood glucose level should be maintained at an optimum level. However there was no pooled national picture on poor glycemic control and its associated factors.MethodsDifferent data base searching engine including PubMed, Google scholar, the Cochrane library, MEDLINE,, HINARY and African journal online (AJOL) were used. The Joanna Briggs Critical Appraisal Tools and Newcastle Ottawa scale for assessing the quality of cross sectional studies were used for quality assessment. The meta-analysis was conducted using STATA 14 software. I2 statistic and egger weighted regression were used to assess heterogeneity and publication bias.ResultsA total of 134 studies were identified from different database searching engines and other sources. After removing for duplication, absence of abstract and review of the full text 12 studies were including in the meta-analysis. The pooled prevalence of poor glycemic control among diabetic patients in Ethiopia is 64.72% with 95% confidence interval 63.16-66.28%. The sub group analysis of poor glycemic control among diabetic patients in different region of the country shows consistent and high prevalence of poor glycemic control ranging from 62.5% in Tigray region to 65.6% in Oromia region of the country. Residence, dyslipidemia and diet adherence were significantly association with poor glycemic control among diabetic patients in Ethiopia.ConclusionThe prevalence of poor glycemic control among diabetic patients was high in Ethiopia and consistent across different regions of the country. The most important factors associated with poor glycemic factor among diabetic patients were being rural residence, having dyslipidemia and not adhering to dietary plan.

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