scholarly journals SUN-417 Long Working Hours Are Associated with Hypothyroidism: A Cross-Sectional Study with Population-Representative Data

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Young Ki Lee ◽  
Dong-eun Lee ◽  
Yul Hwangbo ◽  
You Jin Lee ◽  
Eun Kyung Lee

Abstract Background: Studies have highlighted the adverse effects of long working hours on workers’ health; however, the association of long working hours with thyroid function has not been studied. This study aimed to assess long working hours as a risk factor for thyroid dysfunction. Methods: This cross-sectional study was based on data obtained from the Korea National Health and Nutrition Examination Survey conducted from 2013 to 2015. A total of 2,160 adults who worked 36–83 hours per week were included. Thyroid function was defined based on the population thyroid-stimulating hormone reference ranges, after excluding individuals with positive results for thyroid peroxidase antibody. The association between working hours and thyroid function was confirmed via multinomial logistic regression. Results: Hypothyroidism was more prevalent among those with longer working hours (3·5% vs. 1·4% for 53–83 and 36–42 working hours per week, respectively). Individuals who worked longer hours had an increased odds for hypothyroidism (odds ratio 1·46, 95% confidence interval 1·12−1·90, per 10 hour increase in working hours per week), after adjustment for age, sex, body mass index, urine iodine concentration, smoking status, shift work, and socioeconomic characteristics such as occupation, income level, and educational attainment. The association between working hours and hypothyroidism was consistent in various subgroups stratified by sex or socioeconomic characteristics. Conclusions: To our knowledge, this study is the first to show that long working hours are associated with hypothyroidism. Our findings suggest that appropriate monitoring and treatment of hypothyroidism are necessary among individuals who work long hours.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sangsoo Han ◽  
Yujin Ko ◽  
Ji Eun Moon ◽  
Young Soon Cho

AbstractLong working hours have been presumed to negatively influence health. However, evidence is lacking regarding any associations of working hours with depressive mood or suicidal ideation. We investigated the relationships of working hours with depressive mood and suicidal ideation in a representative sample of the Korean general population. We analyzed data collected by the Korea National Health and Nutrition Examination Surveys VI and VII (2013–2018). Depressive mood and suicidal ideation were identified through self-reporting. We divided participants into four groups according to weekly working hours: 30–40, 41–50, 51–60, and > 60 h/week. Sampling weights were applied to obtain estimates for the general Korean population. We analyzed 14,625 participants, of whom 5383 (36.8%), 4656 (31.8%), 2553 (17.5%), and 2033 (13.9%) worked 30–40, 41–50, 51–60, and > 60 h/week, respectively. In these groups, 3.6%, 4.4%, 5.2%, and 6.3% of the participants reported depressive mood, while 1.8%, 1.9%, 2.2%, and 3.6% reported suicidal ideation. In multiple regression analyses, compared with the 30–40 h/week group, the adjusted odds ratios of the 41–50, 51–60, and > 60 h/week groups for depressive mood were 1.35 (1.08–1.69), 1.5 (1.14–1.97), and 1.6 (1.19–2.14). A similar trend was evident for suicidal ideation (odds ratios 1.16 [0.82–1.63], 1.48 [0.99–2.21], and 2.29 [1.53–3.42]). Long working hours are significantly associated with depressive mood and suicidal ideation.


Author(s):  
Farahnaz Farzaneh ◽  
Farzaneh Khastehfekr

Background: Thyroid dysfunction is associated with negative pregnancy outcomes. There is a lack of reliable information on thyroid hormones in Iranian pregnant women, especially in Yazd. Objective: To determine the safe thyroid hormone levels in women of Yazd and also the first trimester-specific reference ranges for serum thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3). Materials and Methods: In this cross-sectional study, the serum of 1,148 women in the first trimester of pregnancy was analyzed. Thyroid function tests (TSH, T4, T3) were measured through radioimmunoassay (RIA) [immunoradiometric (IRMA) for TSH]. The study was conducted in Yazd, from September 2018 to November 2019. Reference intervals were defined as the 5th, 50th, and 95th percentiles. Results: The mean age of the participants was 28.78 (± 5.86 yr) (range: 15-45 yr). The thyroid hormones reference intervals in the first trimester were TSH (0.2-3.8 mIU/l), T4 (7.45-12.75, μg/dl), and T3 (100-217 ng/dl). Conclusion: The results of the present study determined a local thyroid function measurement in the first trimester of pregnancy at a center of Yazd, Iran. This could facilitate the decision-making of maternal TSH level during the first trimester of pregnancy. Key words: First pregnancy trimester, Thyrotropin, Thyroxine, Triiodothyronine.


BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e049996
Author(s):  
Yosuke Inoue ◽  
Shohei Yamamoto ◽  
Ami Fukunaga ◽  
Dong Van Hoang ◽  
Takako Miki ◽  
...  

ObjectivesTo examine whether engagement in COVID-19-related work was associated with an increased prevalence of depressive symptoms among the staff members working in a designated medical institution for COVID-19 in Tokyo, Japan.DesignA cross-sectional study.SettingData were obtained from a health survey conducted in July 2020 among the staff members of a designated medical institution for COVID-19 in Tokyo, Japan.ParticipantsA total of 1228 hospital workers.Exposure of interestEngagement in COVID-19-related work (qualitatively (ie, the risk of SARS-CoV-2 infection at work or affiliation to related departments) as well as quantitatively (ie, working hours)) and job categories.Outcome measuresDepressive symptoms.ResultsThere was no significant association between depressive symptoms and engagement in work with potential exposure to SARS-CoV-2 or affiliation to COVID-19-related departments. However, working for longer hours in March/April, when Japan witnessed a large number of infected cases, was significantly associated with depressive symptoms (≥11 hours/day: prevalence ratio (PR)=1.45, 95% CI=1.06 to 1.99, compared with ≤8 hours/day). Nurses were more likely to exhibit depressive symptoms than did doctors (PR=1.70, 95% CI=1.14 to 2.54).ConclusionsThis study suggests that the risk of SARS-CoV-2 infection at work or having an affiliation to related departments might not be linked with a higher prevalence of depressive symptoms among Japanese hospital workers; contrarily, long working hours appeared to increase the prevalence of depressive symptoms.


PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0253841
Author(s):  
Yuji Shimizu ◽  
Shin-Ya Kawashiri ◽  
Yuko Noguchi ◽  
Yasuhiro Nagata ◽  
Takahiro Maeda ◽  
...  

Anti-thyroid peroxidase antibody (TPO-Ab) is revealed to be inversely associated with thyroid cysts among euthyroid population. TPO-Ab causes autoimmune thyroiditis by bolstering thyroid inflammation. Therefore, at least partly, absence of thyroid cysts could indicate latent thyroid damage. Since participants with subclinical hypothyroidism are reported to have higher HbA1c than normal healthy controls, HbA1c could be inversely associated with thyroid cysts through a mechanism reflecting latent thyroid damage. To investigate the association between HbA1c and thyroid cysts among a euthyroid population, a cross-sectional study was conducted on 1,724 Japanese individuals who were within the normal range of thyroid function [i.e., normal range of free triiodothyronine (T3) and free thyroxine (T4)] and aged 40–74 years. Among this study population, 564 were diagnosed with thyroid cysts. Independently of thyroid related hormones [thyroid stimulating hormone (TSH), free T3, and free T4] and known cardiovascular risk factors, HbA1c was found to be significantly inversely associated with the presence of thyroid cysts. This association remained significant even after this analysis was limited to participants within a normal range of TSH. The fully adjusted odds ratios (ORs) of thyroid cysts for 1 standard deviation (SD) increment of HbA1c were 0.84 (0.74, 0.95) for total participants and 0.80 (0.70, 0.92) for participants within a normal range of TSH. Among participants with normal thyroid function, HbA1c was inversely associated with the presence of thyroid cysts. The absence of thyroid cysts and higher levels of HbA1c could indicate the latent functional damage of the thyroid.


2020 ◽  
Author(s):  
Hyunil Kim ◽  
Woncheol Lee ◽  
Soyoung Park ◽  
Hyeongcheol Kim

Abstract Background: This study investigated the association between parental long working hours and the depression of adult children living with them in South Korea. Methods: Data from two years of the Korean National Health and Nutrition Examination Survey (KNHANES) in 2014 and 2016 were analyzed using a cross-sectional study. Study samples included 1334 adult children aged ≥ 19 and 2486 parents (1483 mothers and 1003 fathers). Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). Logistic regression analyses were performed to determine the association between parental long working hours and their adult children’s depression. Results: Odds ratio (OR) of adult children’s depression for maternal working > 60 hours/week was 4.88 (95% confidential interval (CI): 1.95 – 12.2) when maternal working ≤ 40 hours/week was considered as a reference in the crude model. After considering parental and adult children’s socio-demographic characteristics and occupational characteristics, and parental depression, OR of adult children’s depression for maternal working was found to be 10.2 (95% CI: 2.47 – 42.0). The association between paternal long working hours and adult children’s depression was not statistically significant. Conclusions: Mothers’ long working hours were associated with the greater risk of their adult children’s depression in South Korea. Comprehending aging mothers’ weekly working hours is an important factor when developing strategies for addressing adult children’s depression using family-based interventions.


Sign in / Sign up

Export Citation Format

Share Document