scholarly journals Editorial: Final Musings on the Impact of Molecular Endocrinology

2016 ◽  
Vol 30 (10) ◽  
pp. 1027-1028
Keyword(s):  
Molecular Endocrinology ◽  
The Impact

scholarly journals Editorial

2008 ◽  
Vol 40 (1) ◽  
pp. 1
Author(s):  
Evan Simpson ◽  
Anna Spada
Keyword(s):  
Impact Factor ◽  
Molecular Mechanisms ◽  
Good Deal ◽  
Structural Features ◽  
Official Journal ◽  
Endocrine Disorders ◽  
Wide Range ◽  
Molecular Endocrinology ◽  
The Impact

Dear Readers, Having served as Editor-in-Chief of Journal of Molecular Endocrinology for seven years, I would like to take this opportunity to thank all those who have contributed to the journal's success – the Editorial Board, authors and referees.Following a great increase in the journal's impact factor in the early part of my term of office, submissions to the journal began to increase significantly, approaching a remarkable 250% of what they had been previously. This gave us the opportunity to build upon the journal's established reputation by improving its high quality standards even further. One of the ways of achieving this was to increase the rejection rate. Prior to 2000, the acceptance rate of the journal had typically been around 60% for many years. In recent years, this percentage has often been in the thirties. Despite this, the number of papers published in a year has frequently been more than it was historically, and rapid growth from one year to the next has sometimes had the effect of temporarily decreasing the journal's impact factor compared with the heights we had previously achieved, because of the way it is calculated. We have also increased the journal's online frequency to monthly, ensuring that the journal is poised ready for the rapid publication of greater numbers of higher quality papers.With this legacy, I am pleased to hand over the reins of the journal to Professor Anna Spada, and I wish her well in taking the journal to new heights.As the incoming Editor-in-Chief of the Journal of Molecular Endocrinology, I feel proud to be associated with a major international journal dedicated to publishing excellent science in the field of molecular endocrinology. Together with the new members of the Editorial Board, we are committed to continue the tradition of excellence established by our predecessors. We would like to take this opportunity to thank the outgoing Editor-in-Chief, Professor Evan Simpson, who contributed greatly to the development and prestige of the journal during his tenure. We would also like to acknowledge with gratitude the efforts of all the other members of the Editorial Board who are retiring.As we enter the year 2008, the journal begins its 20th year of serving the global endocrine community as a vital forum for research on molecular endocrinology. Moreover, the journal recently became an official journal of the European Society of Endocrinology, a fact that confirms its increasing significance and importance. The journal has an active Editorial Board who represent both the global reach of the journal and the breadth of expertise needed to build upon its current subject coverage.Journal of Molecular Endocrinology has undergone substantial developments recently, including full migration to an electronic manuscript handling system and monthly online publication, together with immediate publication of authors' accepted manuscripts. These changes, together with the hard work of the staff of the Society for Endocrinology, the journal's publisher, have had a major impact on the efficiency of manuscript handling, with rapid and careful decisions on submitted manuscripts. High-profile review articles are freely available to all on the web and the improved features of the new platform, including toll-free reference linking and ‘This article has been cited by…’ links to and from other major journals, have increased JME's online visibility.We are committed to publishing the best endocrine research at the molecular level, and we believe that the journal has a particular role in integrating basic molecular mechanisms towards understanding the physiological and pathological processes of the endocrine system. We want to encourage the submission of manuscripts that expand our knowledge of the molecular mechanisms underlying hormone action; examples of potential topics include proteomics, structural features of RNA and the impact on mRNA regulation and processing, DNA repair mechanisms underlying endocrine disorders and cancers, DNA–protein complexes and chromatin structures and the accessibility of promoter–regulatory regions, molecular chaperones, etc. Articles on molecular endocrinology with potential translational/clinical significance, methodology and bioinformatics tools are especially welcome. We also want to attract papers from leaders in other fields who are investigating endocrine-related aspects but do not traditionally publish in our journal. A series of mini-reviews will address a wide range of provocative and updated topics that we believe will extend our range of interest and will aim to anticipate the future direction of many specific research areas. As many of the mini-reviews will be invited, we welcome suggestions of topics and authors as well as outlines of potential mini-reviews from interested authors.It is with a good deal of humility that I take over the reins of the journal. It is my intention to ensure that it remains at the forefront of endocrine research and, along with the Editorial Board, we are hopeful that we can raise JME's standards even higher.

Formation of Lunar Craters and Bright Rays as a Result of Meteorite Impacts

1962 ◽  
Vol 14 ◽  
pp. 415-418
Author(s):  
K. P. Stanyukovich ◽  
V. A. Bronshten
Keyword(s):  
Explosive Charge ◽  
The Moon ◽  
Meteorite Impacts ◽  
The Earth ◽  
Lunar Craters ◽  
The Impact

The phenomena accompanying the impact of large meteorites on the surface of the Moon or of the Earth can be examined on the basis of the theory of explosive phenomena if we assume that, instead of an exploding meteorite moving inside the rock, we have an explosive charge (equivalent in energy), situated at a certain distance under the surface.

The Geosciences Applied to Lunar Exploration

1962 ◽  
Vol 14 ◽  
pp. 169-257 ◽  
Author(s):  
J. Green
Keyword(s):  
Lunar Surface ◽  
Probable Mechanism ◽  
Point Of View ◽  
Lunar Exploration ◽  
Geological Model ◽  
Apply Geophysics ◽  
Surface Features ◽  
The Impact

The term geo-sciences has been used here to include the disciplines geology, geophysics and geochemistry. However, in order to apply geophysics and geochemistry effectively one must begin with a geological model. Therefore, the science of geology should be used as the basis for lunar exploration. From an astronomical point of view, a lunar terrain heavily impacted with meteors appears the more reasonable; although from a geological standpoint, volcanism seems the more probable mechanism. A surface liberally marked with volcanic features has been advocated by such geologists as Bülow, Dana, Suess, von Wolff, Shaler, Spurr, and Kuno. In this paper, both the impact and volcanic hypotheses are considered in the application of the geo-sciences to manned lunar exploration. However, more emphasis is placed on the volcanic, or more correctly the defluidization, hypothesis to account for lunar surface features.

Asteroid and Comet Impact Speeds upon Mars: Significance for Panspermia and the Supply of Organics

1997 ◽  
Vol 161 ◽  
pp. 197-201 ◽  
Author(s):  
Duncan Steel
Keyword(s):  
Probability Distributions ◽  
Regions Of Interest ◽  
Significant Fraction ◽  
Organic Chemicals ◽  
Impact Speed ◽  
The Mean ◽  
The Impact

AbstractWhilst lithopanspermia depends upon massive impacts occurring at a speed above some limit, the intact delivery of organic chemicals or other volatiles to a planet requires the impact speed to be below some other limit such that a significant fraction of that material escapes destruction. Thus the two opposite ends of the impact speed distributions are the regions of interest in the bioastronomical context, whereas much modelling work on impacts delivers, or makes use of, only the mean speed. Here the probability distributions of impact speeds upon Mars are calculated for (i) the orbital distribution of known asteroids; and (ii) the expected distribution of near-parabolic cometary orbits. It is found that cometary impacts are far more likely to eject rocks from Mars (over 99 percent of the cometary impacts are at speeds above 20 km/sec, but at most 5 percent of the asteroidal impacts); paradoxically, the objects impacting at speeds low enough to make organic/volatile survival possible (the asteroids) are those which are depleted in such species.

Organic Syntheses During the Impact of a Comet with a Gaseous Planet

1997 ◽  
Vol 161 ◽  
pp. 189-195
Author(s):  
Cesare Guaita ◽  
Roberto Crippa ◽  
Federico Manzini
Keyword(s):  
Polymeric Material ◽  
Molecular Form ◽  
Parent Compound ◽  
Blue Filter ◽  
Organic Syntheses ◽  
The Impact

AbstractA large amount of CO has been detected above many SL9/Jupiter impacts. This gas was never detected before the collision. So, in our opinion, CO was released from a parent compound during the collision. We identify this compound as POM (polyoxymethylene), a formaldehyde (HCHO) polymer that, when suddenly heated, reformes monomeric HCHO. At temperatures higher than 1200°K HCHO cannot exist in molecular form and the most probable result of its decomposition is the formation of CO. At lower temperatures, HCHO can react with NH3 and/or HCN to form high UV-absorbing polymeric material. In our opinion, this kind of material has also to be taken in to account to explain the complex evolution of some SL9 impacts that we observed in CCD images taken with a blue filter.

Hydrogen Cyanide Polymers from the Impact of Comet P/Shoemaker-Levy 9 on Jupiter

1997 ◽  
Vol 161 ◽  
pp. 179-187
Author(s):  
Clifford N. Matthews ◽  
Rose A. Pesce-Rodriguez ◽  
Shirley A. Liebman
Keyword(s):  
Amino Acids ◽  
Solar System ◽  
Hydrogen Cyanide ◽  
Nitrogen Heterocycles ◽  
Laboratory Studies ◽  
Heterogeneous Solids ◽  
The Many ◽  
Comet Halley ◽  
The Impact ◽  
By Products

AbstractHydrogen cyanide polymers – heterogeneous solids ranging in color from yellow to orange to brown to black – may be among the organic macromolecules most readily formed within the Solar System. The non-volatile black crust of comet Halley, for example, as well as the extensive orangebrown streaks in the atmosphere of Jupiter, might consist largely of such polymers synthesized from HCN formed by photolysis of methane and ammonia, the color observed depending on the concentration of HCN involved. Laboratory studies of these ubiquitous compounds point to the presence of polyamidine structures synthesized directly from hydrogen cyanide. These would be converted by water to polypeptides which can be further hydrolyzed to α-amino acids. Black polymers and multimers with conjugated ladder structures derived from HCN could also be formed and might well be the source of the many nitrogen heterocycles, adenine included, observed after pyrolysis. The dark brown color arising from the impacts of comet P/Shoemaker-Levy 9 on Jupiter might therefore be mainly caused by the presence of HCN polymers, whether originally present, deposited by the impactor or synthesized directly from HCN. Spectroscopic detection of these predicted macromolecules and their hydrolytic and pyrolytic by-products would strengthen significantly the hypothesis that cyanide polymerization is a preferred pathway for prebiotic and extraterrestrial chemistry.

Unusual Microstructure in Shock-Compacted Graphite

1970 ◽  
Vol 28 ◽  
pp. 474-475
Author(s):  
Lucien F. Trueb
Keyword(s):  
Mechanical Characteristic ◽  
Compression Wave ◽  
Gray Zone ◽  
Flyer Plate ◽  
Compacted Graphite ◽  
The Impact

Crushed and statically compressed Madagascar graphite that was explosively shocked at 425 kb by means of a planar flyer-plate is characterized by a black zone extending for 2 to 3 nun below the impact plane of the driver. Beyond this point, the material assumes the normal gray color of graphite. The thickness of the black zone is identical with the distance taken by the relaxation wave to overtake the compression wave.The main mechanical characteristic of the black material is its great hardness; steel scalpels and razor blades are readily blunted during attempts to cut it. An average microhardness value of 95-3 DPHN was obtained with a 10 kg load. This figure is a minimum because the indentations were usually cracked; 14.8 DPHN was measured in the gray zone.

Drug Induced Changes in Cell Organelles

1968 ◽  
Vol 26 ◽  
pp. 110-111
Author(s):  
Sarah A. Luse
Keyword(s):  
Clinical Medicine ◽  
Cell Organelles ◽  
Riboflavin Deficiency ◽  
Drug Induced ◽  
New Era ◽  
Health And Disease ◽  
In The Beginning ◽  
Cellular Pathology ◽  
Induced Changes ◽  
The Impact

In the mid-nineteenth century Virchow revolutionized pathology by introduction of the concept of “cellular pathology”. Today, a century later, this term has increasing significance in health and disease. We now are in the beginning of a new era in pathology, one which might well be termed “organelle pathology” or “subcellular pathology”. The impact of lysosomal diseases on clinical medicine exemplifies this role of pathology of organelles in elucidation of disease today.Another aspect of cell organelles of prime importance is their pathologic alteration by drugs, toxins, hormones and malnutrition. The sensitivity of cell organelles to minute alterations in their environment offers an accurate evaluation of the site of action of drugs in the study of both function and toxicity. Examples of mitochondrial lesions include the effect of DDD on the adrenal cortex, riboflavin deficiency on liver cells, elevated blood ammonia on the neuron and some 8-aminoquinolines on myocardium.

Fluorescent potentiometric dyes for membrane-potential imaging

1994 ◽  
Vol 52 ◽  
pp. 166-167
Author(s):  
Leslie M. Loew
Keyword(s):  
Membrane Potential ◽  
Single Cells ◽  
Quantitative Imaging ◽  
Optical Recording ◽  
Biological Processes ◽  
Major Focus ◽  
The Past ◽  
Excitable Systems ◽  
Major Application ◽  
The Impact

A major application of potentiometric dyes has been the multisite optical recording of electrical activity in excitable systems. After being championed by L.B. Cohen and his colleagues for the past 20 years, the impact of this technology is rapidly being felt and is spreading to an increasing number of neuroscience laboratories. A second class of experiments involves using dyes to image membrane potential distributions in single cells by digital imaging microscopy - a major focus of this lab. These studies usually do not require the temporal resolution of multisite optical recording, being primarily focussed on slow cell biological processes, and therefore can achieve much higher spatial resolution. We have developed 2 methods for quantitative imaging of membrane potential. One method uses dual wavelength imaging of membrane-staining dyes and the other uses quantitative 3D imaging of a fluorescent lipophilic cation; the dyes used in each case were synthesized for this purpose in this laboratory.

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