A new concentration result for regularized risk minimizers

2006 ◽  
pp. 260-275 ◽  
Author(s):  
Ingo Steinwart ◽  
Don Hush ◽  
Clint Scovel
Keyword(s):  
Concentration Result

scholarly journals ANTIFUNGAL ACTIVITY OF MANGIFERA INDICA LEAF EXTRACT ON FUNGI ISOLATED FROM BREAD VENDED WITHIN BAKORI, NIGERIA

2021 ◽  
pp. 1-4
Author(s):  
ABDULAZIZ BASHIR KUTAWA ◽  
SALMAN SADA BAKORI ◽  
HABU MUSA
Keyword(s):  
Antifungal Activity ◽  
Room Temperature ◽  
Inhibitory Concentration ◽  
Mangifera Indica ◽  
Morphological Characteristics ◽  
Diffusion Method ◽  
Leaf Extracts ◽  
Chemical Test ◽  
Concentration Result ◽  
Powdered Form

Objective: The present study was carried out to determine the antifungal activity of Mangifera indica leaves extract on fungi isolated from bread vended within Bakori. Methods: The powdered form of M. indica leaves was used to prepare the extract using ethanol, the leaves were air dried at room temperature for 10 days. Results: The chemical test was carried out to identify the secondary metabolites, some of the metabolites that were present include alkaloids, saponins, flavonoids, steroids, and tannins. Both fungal isolates were identified on the basis of morphological characteristics as Aspergillus niger, Aspergillus flavus, and Mucor spp. The antifungal activity of M. indica leaves extract was determined using agar well diffusion method on Aspergillus and Mucor spp. The results showed that the extract was found to inhibit A. niger at 100 mg/ml, 50 mg/ml, and 25 mg/ml with 13.9 mm, 11.5 mm, and 8.0 mm, respectively, and A. flavus at 100 mg/ml, 50 mg/ml, and 25 mg/ml with 13.6 mm, 11.2 mm, and 8.1 mm, respectively, while Mucor spp. was found to be resistant at 25 mg/ml while 100 mg/ml and 50 mg/ml showed an activity. Minimum inhibitory concentration result showed a promising activity against Aspergillus spp. at 25 mg/ml while Mucor spp. at 50 mg/ml. Conclusion: Therefore, M. indica leaf extracts can be used in the treatment of diseases or illness caused by Aspergillus and Mucor spp.

Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides

1988 ◽  
Vol 8 (3) ◽  
pp. 1224-1235
Author(s):  
T J Yen ◽  
D A Gay ◽  
J S Pachter ◽  
D W Cleveland
Keyword(s):  
Amino Acids ◽  
Animal Cells ◽  
Beta Tubulin ◽  
Coding Sequence ◽  
Tubulin Subunit ◽  
Concentration Result ◽  
Necessary And Sufficient ◽  
Specific Degradation ◽  
Autoregulatory Mechanism

The expression of tubulin polypeptides in animal cells is controlled by an autoregulatory mechanism whereby increases in the tubulin subunit concentration result in rapid and specific degradation of tubulin mRNAs. We have now determined that the sequences that are necessary and sufficient to specify mouse beta-tubulin mRNAs as substrates for this autoregulated instability reside within the first 13 translated nucleotides (which encode the first four beta-tubulin amino acids Met-Arg-Glu-Ile). This domain has been functionally conserved throughout evolution, inasmuch as sequences isolated from the analogous region of human, chicken, and yeast beta-tubulin mRNAs also confer autoregulation. Further, for an RNA to be a substrate for regulation, not only must it carry the 13-nucleotide coding sequence, but it must also be ribosome bound and its translation must proceed 3' to codon 41.

scholarly journals Singularly Perturbed Fractional Schrödinger Equation Involving a General Critical Nonlinearity

2018 ◽  
Vol 18 (3) ◽  
pp. 487-499 ◽  
Author(s):  
Hua Jin ◽  
Wenbin Liu ◽  
Jianjun Zhang
Keyword(s):  
Variational Approach ◽  
Bound State ◽  
Singularly Perturbed ◽  
Critical Nonlinearity ◽  
Bound State Solution ◽  
Critical Nonlinearities ◽  
Concentration Phenomena ◽  
Fractional Schrödinger Equations ◽  
Concentration Result ◽  
Made In

AbstractIn this paper, we are concerned with the existence and concentration phenomena of solutions for the following singularly perturbed fractional Schrödinger problem:\varepsilon^{2s}(-\Delta)^{s}u+V(x)u=f(u)\quad\text{in }\mathbb{R}^{N},where{N>2s}and the nonlinearityfhas critical growth. By using the variational approach, we construct a localized bound-state solution concentrating around an isolated component of the positive minimum point ofVas{\varepsilon\rightarrow 0}. Our result improves the study made in [X. He and W. Zou, Existence and concentration result for the fractional Schrödinger equations with critical nonlinearities, Calc. Var. Partial Differential Equations 55 2016, 4, Article ID 91], in the sense that, in the present paper, theAmbrosetti–Rabinowitzcondition and themonotonicitycondition on{f(t)/t}are not required.

Early diagnosis of acute myocardial infarction with use of a rapid immunochemical assay of creatine kinase MB isoenzyme

1993 ◽  
Vol 39 (8) ◽  
pp. 1725-1728 ◽  
Author(s):  
D R Collins ◽  
D J Wright ◽  
M G Rinsler ◽  
P Thomas ◽  
S Bhattacharya ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Creatine Kinase ◽  
Thrombolytic Therapy ◽  
Efficiency Evaluation ◽  
Diagnostic Efficiency ◽  
Potential Influence ◽  
Immunochemical Method ◽  
Creatine Kinase Mb ◽  
Concentration Result

Abstract In 195 patients presenting with chest pain and referred acutely for cardiological assessment, blood was taken immediately for assay of creatine kinase (CK; EC 2.7.3.2) MB isoenzyme by an immunochemical method and results [mass units of enzyme per liter of plasma (microgram/L)] were obtained within 30 min of sampling. Diagnosis of acute myocardial infarction in the patients was made independently, based on electrocardiograms and conventional cardiac enzyme profiles. The administration of any thrombolytic therapy in response to the CK-MB concentration result was also noted, allowing assessment of the assay's potential influence on patient management in addition to the diagnostic efficiency evaluation. The study demonstrated that, when blood samples were collected on admission to hospital and the decision level suggested by the manufacturers was utilized, the assay had an immediate sensitivity of 52% and a specificity of 97%. Of the 81 patients who were shown by conventional means to have had acute myocardial infarction, 8 (10%) had equivocal electrocardiograms but positive CK-MB concentration results. In four of these patients (5%), thrombolytic therapy was given on the basis of the clinical features and a positive CK-MB concentration result alone.

scholarly journals Comparison between Sevoflurane/Remifentanil and Propofol/Remifentanil Anaesthesia in Providing Conditions for Somatosensory Evoked Potential Monitoring during Scoliosis Corrective Surgery

2008 ◽  
Vol 36 (6) ◽  
pp. 779-785 ◽  
Author(s):  
N. Y. Fung ◽  
Y. Hu ◽  
M. G. Irwin ◽  
B. F. M. Chow ◽  
M. Y. Yuen
Keyword(s):  
Evoked Potential ◽  
Somatosensory Evoked Potential ◽  
Corrective Surgery ◽  
Quality Of Recovery ◽  
Physiological Variables ◽  
Suppressant Effect ◽  
Concentration Result ◽  
Latency Variability ◽  
Eye Opening ◽  
Evoked Potential Monitoring

Somatosensory evoked potential (SSEP) monitoring is an important tool in spinal corrective surgery. Anaesthesia has a significant influence on SSEP monitoring and a technique which has the least and shortest suppressant effect on SSEP while facilitating a fast recovery from anaesthesia is ideal. We compared the effect of sevoflurane/remifentanil and propofol/remifentanil anaesthesia on SSEPs during scoliosis corrective surgery and assessed patients’ clinical recovery profiles. Twenty patients with idiopathic scoliosis receiving surgical correction with intraoperative SSEP monitoring were prospectively randomised to receive sevoflurane/remifentanil anaesthesia or propofol/remifentanil anaesthesia. During surgery, changes in anaesthesia dose and physiological variables were recorded, while SSEP was continuously monitored. A simulated ‘wake-up’ test was performed postoperatively to assess speed and quality of recovery from anaesthesia. The effects of propofol and sevoflurane resulted in SSEP amplitude variability between 18.0% ± 3.5% to 28.7% ± 5.9% and SSEP latency variability within 1.3% ± 0.4% to 2.6% ± 1.2%. Patients receiving sevoflurane had faster suppression and faster recovery of SSEP amplitude compared to propofol (P <0.05), although propofol anaesthesia showed less within-patient variability in Cz amplitude and latency (P <0.05). On cessation of anaesthesia, time to eye-opening (5.2 vs. 16.5 minutes) and toe movement (5.4 vs. 17.4 minutes) was shorter following sevoflurane (all P <0.05). These findings indicate that propofol produces a better SSEP signal than sevoflurane. However, adjustments in sevoflurane concentration result in faster changes in the SSEP signal than propofol. Assessment of neurological function was facilitated more rapidly after sevoflurane anaesthesia.

Existence and Concentration Result for the Kirchhoff Type Equations with General Nonlinearities

2014 ◽  
Vol 213 (3) ◽  
pp. 931-979 ◽  
Author(s):  
Giovany M. Figueiredo ◽  
Norihisa Ikoma ◽  
João R. Santos Júnior
Keyword(s):  
Kirchhoff Type ◽  
Concentration Result

scholarly journals Combined Laser Blood Illumination by Red (635 nm) and UV (365-405 nm) Light in the Treatment of Small Domestic Animals with Allergic Dermatitis

2017 ◽  
Author(s):  
Tatiana L. Yatskevich ◽  
Olga N. Semenova ◽  
Sergey V. Moskvin
Keyword(s):  
Clinical Status ◽  
Domestic Animals ◽  
Treatment Session ◽  
Chemotherapeutic Agents ◽  
Low Level Laser Therapy ◽  
Physiological Concentration ◽  
Standard Drug ◽  
Allergic Dermatitis ◽  
Concentration Result ◽  
Blood Transport

Background: The prevalence of atopic dermatitis in domestic animals is one of the problems of modern veterinary. Treating with standard techniques using chemotherapeutic agents not always leads to a positive result of therapy; moreover, many drugs produce adverse side effects. Methods: Low level laser therapy, in particular, intravenous laser blood illumination (ILBI) has a pronounced and long-lasting impact on the immune system of animals. The combined technique including ILBI-635 (635 nm, 2 mW, 5 min) and LUVBI&reg; (365 nm, 2 mW, 3 min) every other day provides a positive change in clinical status of cats with allergic dermatitis after the 3rd-4th treatment session. Results: The increased level of erythrocytes and hemoglobin was identified in the course of treatment, and it indirectly indicates increased blood transport activity, which improves trophic provision and microcirculation. A double reduction of leukocytes and a significant decrease of neutrophil cells indicate the immunomodulatory effect of LILI (low-intensity laser illumination). The increase in the percentage of lymphocytes and the decrease of eosinophils and monocytes against the background of basophil concentrations deviations within physiological concentration result in the reduction of inflammatory mediators expression that induce itching. The reduction of total IgE concentration 32 times against control on the 7th day of treatment correlates with the decrease in the quantitative content of peripheral blood eosinophils, indicating the decrease in severity of an allergic process. Conclusion: LLLT is recommended against the background of standard drug therapy to achieve quick clinical outcome together with a long-lasting prolonged effect.

scholarly journals A peptide of a type I toxin−antitoxin system inducesHelicobacter pylorimorphological transformation from spiral shape to coccoids

2020 ◽  
Vol 117 (49) ◽  
pp. 31398-31409
Author(s):  
Lamya El Mortaji ◽  
Alejandro Tejada-Arranz ◽  
Aline Rifflet ◽  
Ivo G. Boneca ◽  
Gérard Pehau-Arnaudet ◽  
...  
Keyword(s):  
Antisense Rna ◽  
Type I ◽  
Morphological Transformation ◽  
Bacterial Chromosomes ◽  
Concentration Result ◽  
Expression Activity ◽  
Spiral Shape ◽  
H Pylori ◽  
Plasmid Stabilization

Toxin−antitoxin systems are found in many bacterial chromosomes and plasmids with roles ranging from plasmid stabilization to biofilm formation and persistence. In these systems, the expression/activity of the toxin is counteracted by an antitoxin, which, in type I systems, is an antisense RNA. While the regulatory mechanisms of these systems are mostly well defined, the toxins’ biological activity and expression conditions are less understood. Here, these questions were investigated for a type I toxin−antitoxin system (AapA1−IsoA1) expressed from the chromosome of the human pathogenHelicobacter pylori. We show that expression of the AapA1 toxin inH. pyloricauses growth arrest associated with rapid morphological transformation from spiral-shaped bacteria to round coccoid cells. Coccoids are observed in patients and during in vitro growth as a response to different stress conditions. The AapA1 toxin, first molecular effector of coccoids to be identified, targetsH. pyloriinner membrane without disrupting it, as visualized by cryoelectron microscopy. The peptidoglycan composition of coccoids is modified with respect to spiral bacteria. No major changes in membrane potential or adenosine 5′-triphosphate (ATP) concentration result from AapA1 expression, suggesting coccoid viability. Single-cell live microscopy tracking the shape conversion suggests a possible association of this process with cell elongation/division interference. Oxidative stress induces coccoid formation and is associated with repression of the antitoxin promoter and enhanced processing of its transcript, leading to an imbalance in favor of AapA1 toxin expression. Our data support the hypothesis of viable coccoids with characteristics of dormant bacteria that might be important inH. pyloriinfections refractory to treatment.

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