scholarly journals First person – Dipanjana Ghosh

2021 ◽  
Vol 134 (18) ◽  
Keyword(s):  
Leading Edge ◽  
Early Career ◽  
Woman Scientist ◽  
First Person ◽  
Collective Cell Migration ◽  
Cytoskeletal Remodeling ◽  
Cell Metastasis ◽  
Colorectal Cancer Cells ◽  
Indian Institute Of Science ◽  
Human Colorectal Cancer Cells

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Dipanjana Ghosh is first author on ‘ PLP2 drives collective cell migration via ZO-1-mediated cytoskeletal remodeling at the leading edge in human colorectal cancer cells’, published in JCS. Dipanjana is an independent DST Woman Scientist-A researcher at the Indian Institute of Science Education and Research, Bhopal, India, investigating cancer cell metastasis at the proteome-wide level.

scholarly journals First person – Komaki Ninomiya

2021 ◽  
Vol 134 (2) ◽  
pp. jcs258384
Keyword(s):  
Epithelial Cell ◽  
Spatiotemporal Dynamics ◽  
Early Career ◽  
Cellular Structures ◽  
Cell Junction ◽  
First Person ◽  
Cytoskeletal Remodeling ◽  
Early Career Researchers ◽  
Junction Formation ◽  
Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Komaki Ninomiya is first author on ‘PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell–cell junction formation’, published in JCS. Komaki is a PhD student in the lab of Kazumasa Ohashi at Tohoku University, Sendai, Japan, investigating the mechanisms and spatiotemporal dynamics of cytoskeletal and cellular structures driven by Rho-GEFs.

scholarly journals First person – Bharti Nawalpuri

2021 ◽  
Vol 134 (16) ◽  
Keyword(s):  
Synaptic Plasticity ◽  
Brain Research ◽  
Indian Institute ◽  
Early Career ◽  
Translation Regulation ◽  
First Person ◽  
Temporal Expression ◽  
Early Career Researchers ◽  
Indian Institute Of Science ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Bharti Nawalpuri is first author on ‘ Distinct temporal expression of the GW182 paralog TNRC6A in neurons regulates dendritic arborization’, published in JCS. Bharti is a PhD student in the lab of Dr Ravi S. Muddashetty at the Centre for Brain Research, Indian Institute of Science, Bangalore, India, investigating mechanisms of translation regulation in neurodevelopment and synaptic plasticity.

scholarly journals First person – Sutirtha Lahiri

Biology Open ◽  
2021 ◽  
Vol 10 (6) ◽  
Keyword(s):  
Community Structure ◽  
South Asian ◽  
Grassland Birds ◽  
Early Career ◽  
First Person ◽  
Research Assistant ◽  
Early Career Researchers ◽  
Acoustic Community ◽  
Indian Institute Of Science ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Sutirtha Lahiri is first author on ‘Convergent acoustic community structure in South Asian dry and wet grassland birds’, published in BiO. Sutirtha is a research assistant in the lab of Dr Anand Krishnan at the Indian Institute of Science Education and Research (IISER) Pune, India, investigating whether biogeographically distinct grasslands display convergent acoustic community structure.

scholarly journals First person – Neha Khetan

2021 ◽  
Vol 134 (10) ◽  
Keyword(s):  
Early Career ◽  
Self Organization ◽  
First Person ◽  
Optimal Packing ◽  
Evolutionary Forces ◽  
Early Career Researchers ◽  
Self Organized ◽  
Postdoctoral Research ◽  
Indian Institute Of Science ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Neha Khetan is first author on ‘Self-organized optimal packing of kinesin-5-driven microtubule asters scales with cell size’, published in JCS. Neha is a CEFIPRA postdoctoral research fellow in the lab of Chaitanya A. Athale at the Indian Institute of Science Education and Research, Pune, India, investigating the interplay of self-organization and evolutionary forces in cytoskeletal patterns and collective behaviour.

scholarly journals Pals1 prevents Rac1-dependent colorectal cancer cell metastasis by inhibiting Arf6

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Simona Mareike Lüttgenau ◽  
Christin Emming ◽  
Thomas Wagner ◽  
Julia Harms ◽  
Justine Guske ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Scaffolding Protein ◽  
Migration And Invasion ◽  
Tight Junction Formation ◽  
Cell Metastasis ◽  
Colorectal Cancer Cells

AbstractLoss of apical-basal polarity and downregulation of cell-cell contacts is a critical step during the pathogenesis of cancer. Both processes are regulated by the scaffolding protein Pals1, however, it is unclear whether the expression of Pals1 is affected in cancer cells and whether Pals1 is implicated in the pathogenesis of the disease.Using mRNA expression data and immunostainings of cancer specimen, we show that Pals1 is frequently downregulated in colorectal cancer, correlating with poorer survival of patients. We further found that Pals1 prevents cancer cell metastasis by controlling Rac1-dependent cell migration through inhibition of Arf6, which is independent of the canonical binding partners of Pals1. Loss of Pals1 in colorectal cancer cells results in increased Arf6 and Rac1 activity, enhanced cell migration and invasion in vitro and increased metastasis of transplanted tumor cells in mice. Thus, our data reveal a new function of Pals1 as a key inhibitor of cell migration and metastasis of colorectal cancer cells. Notably, this new function is independent of the known role of Pals1 in tight junction formation and apical-basal polarity.

scholarly journals Morphodynamic signatures of MDA-MB-231 single cells and cell doublets undergoing invasion in confined microenvironments

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xingjian Zhang ◽  
Trevor Chan ◽  
Michael Mak
Keyword(s):  
Single Cell ◽  
Single Cells ◽  
Leading Edge ◽  
Cell Group ◽  
Collective State ◽  
Long Term Effects ◽  
Cell Metastasis ◽  
Geometric Confinement ◽  
Short And Long Term ◽  
The Impact

AbstractCancer cell metastasis is a major factor in cancer-related mortality. During the process of metastasis, cancer cells exhibit migratory phenotypes and invade through pores in the dense extracellular matrix. However, the characterization of morphological and subcellular features of cells in similar migratory phenotypes and the effects of geometric confinement on cell morphodynamics are not well understood. Here, we investigate the phenotypes of highly aggressive MDA-MB-231 cells in single cell and cell doublet (an initial and simplified collective state) forms in confined microenvironments. We group phenotypically similar single cells and cell doublets and characterize related morphological and subcellular features. We further detect two distinct migratory phenotypes, fluctuating and non-fluctuating, within the fast migrating single cell group. In addition, we demonstrate an increase in the number of protrusions formed at the leading edge of cells after invasion through geometric confinement. Finally, we track the short and long term effects of varied degrees of confinement on protrusion formation. Overall, our findings elucidate the underlying morphological and subcellular features associated with different single cell and cell doublet phenotypes and the impact of invasion through confined geometry on cell behavior.

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