High Intensity Interval Training is Superior to Continuous Training in a Pulmonary Hypertension Rat Model

2016 ◽  
Vol 48 ◽  
pp. 204-205
Author(s):  
Mary Beth Brown ◽  
Evandro Neves ◽  
Gary Long ◽  
Rachel Novack ◽  
Amanda Fisher ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Rat Model ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
High Intensity Interval

Abstract 15949: High Intensity Interval Training is Superior to Continuous Training and Reverses RV Remodeling and Dysfunction in a Rat Model of Pulmonary Hypertension

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Mary Beth Brown ◽  
Evandro Neves ◽  
Rachel Novack ◽  
Amanda Fisher ◽  
Robert Presson ◽  
...  
Keyword(s):  
Rat Model ◽  
High Intensity ◽  
Systolic Pressure ◽  
Interval Training ◽  
Wall Stress ◽  
High Intensity Interval Training ◽  
Sprague Dawley ◽  
Continuous Training ◽  
Sheer Stress ◽  
High Intensity Interval

Exercise appears to have overall benefit in pulmonary arterial hypertension (PAH); however, studies to date indicate little effect on the elevated pulmonary pressure or RV hypertrophy (RVH) and dysfunction associated with the disease. High intensity interval training (HIIT) is reported to be superior to the more customary prolonged continuous exercise training (CExT) protocol for chronic heart failure but has not been tested for PAH. Therefore, we investigated impact of a 6 wk HIIT vs. CExT treadmill program in a monocrotaline rat model of mild PAH (MCT, 40 mg/kg) on indicators of disease progression. Methods: Treadmill training was performed 5x/wk in male Sprague-Dawley MCT rats (250-300g), following a protocol of either HIIT (5 cycles of 2 min at ~90% VO 2 reserve [VO 2 R] + 3 min at 30% VO 2 R; n=8), or low intensity CExT (60 min at 50% VO 2 R; n=7). Statistical analysis was performed by one-way ANOVA. Results: MCT-induced decrements in VO 2 max were ameliorated by both HIIT and CExT (p < 0.01 vs. sedentary MCT rats, MCT-SED, n=6), and were similar to healthy controls (CON, n=6). Most importantly, RV systolic pressure (RVSP, in mmHg; via Millar catheter) and RVH (ratio of RV to LV+S mass) were lowered (p<0.05) only by HIIT (28.7±2, and 0.32±0.02) and not by CExT (44.1±3, and 0.43±0.01) vs. MCT-SED (40.2±3.2, and 0.41±0.02). Cardiac output (Δ from baseline in μl, via RV echocardiography) was also improved by HIIT (117±28) vs. MCT-SED (6±42, p=0.04). Additional hemodynamic recordings during running, via novel implantable telemetry (DSI), were obtained serially at pre- and 2, 4, 6, and 8 wks post-MCT, and revealed ‘surges’ in RVSP during HIIT, vs. a steady RVSP pattern during CExT. Pulmonary eNOS (per immunoblotting) was increased (p<0.05) with HIIT, consistent with greater endothelial stimulation. Conclusions: HIIT is superior to CExT for improving hemodynamics and RV remodeling and dysfunction in MCT rats and warrants further investigation in other models and in patients. More favorable outcomes may be explained by greater sheer-stress mediated vascular endothelial adaptation to HIIT stimulus, or lower cumulative training-induced RV wall stress with the briefer HIIT session duration.

scholarly journals High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension

2017 ◽  
Vol 312 (2) ◽  
pp. R197-R210 ◽  
Author(s):  
Mary Beth Brown ◽  
Evandro Neves ◽  
Gary Long ◽  
Jeremy Graber ◽  
Brett Gladish ◽  
...  
Keyword(s):  
Rat Model ◽  
High Intensity ◽  
Systolic Pressure ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Maximal Aerobic Capacity ◽  
High Intensity Interval ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Exercise is beneficial in pulmonary arterial hypertension (PAH), although studies to date indicate little effect on the elevated pulmonary pressures or maladaptive right ventricle (RV) hypertrophy associated with the disease. For chronic left ventricle failure, high-intensity interval training (HIIT) promotes greater endothelial stimulation and superior benefit than customary continuous exercise training (CExT); however, HIIT has not been tested for PAH. Therefore, here we investigated acute and chronic responses to HIIT vs. CExT in a rat model of monocrotaline (MCT)-induced mild PAH. Six weeks of treadmill training (5 times/wk) were performed, as either 30 min HIIT or 60 min low-intensity CExT. To characterize acute hemodynamic responses to the two approaches, novel recordings of simultaneous pulmonary and systemic pressures during running were obtained at pre- and 2, 4, 6, and 8 wk post-MCT using long-term implantable telemetry. MCT-induced decrement in maximal aerobic capacity was ameliorated by both HIIT and CExT, with less pronounced pulmonary vascular remodeling and no increase in RV inflammation or apoptosis observed. Most importantly, only HIIT lowered RV systolic pressure, RV hypertrophy, and total pulmonary resistance, and prompted higher cardiac index that was complemented by a RV increase in the positive inotrope apelin and reduced fibrosis. HIIT prompted a markedly pulsatile pulmonary pressure during running and was associated with greater lung endothelial nitric oxide synthase after 6 wk. We conclude that HIIT may be superior to CExT for improving hemodynamics and maladaptive RV hypertrophy in PAH. HIIT’s superior outcomes may be explained by more favorable pulmonary vascular endothelial adaptation to the pulsatile HIIT stimulus.

Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men

2021 ◽  
Author(s):  
Neumir Sales de Lima ◽  
Ricardo Augusto Leoni De Sousa ◽  
Fabiano Trigueiro Amorim ◽  
Fernando Gripp ◽  
Caíque Olegário Diniz e Magalhães ◽  
...  
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Middle Aged ◽  
Continuous Training ◽  
High Intensity Interval

scholarly journals The Effects of High-Intensity Interval Training vs. Moderate-Intensity Continuous Training on Heart Rate Variability in Physically Inactive Adults

2018 ◽  
Vol 15 (7) ◽  
pp. 1508 ◽  
Author(s):  
Abdullah Alansare ◽  
Ken Alford ◽  
Sukho Lee ◽  
Tommie Church ◽  
Hyun Jung
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Significant Interaction Effect ◽  
High Intensity Interval ◽  
Physically Inactive

Physically inactive adults are prevalent worldwide. This study compared the effects of short-term high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on heart rate variability (HRV) in physically inactive adults as a preliminary study. Thirteen physically inactive male adults (27.5 ± 3.80 years) were randomly assigned to HIIT (N = 7) or MICT (N = 6). The HIIT program consisted of 20 min of interval training with cycling to rest ratio of 10/50 s at ≥90% HRpeak, while the MICT program consisted of 40 min of continuous cycling at 60–75% HRpeak. Both groups completed eight sessions of training within two weeks. Time and frequency domains of HRV were measured for 20 min with Actiwave-Cardio monitor (CamNtech, UK). The number of R-R interval and inter-beat interval (IBI) were significantly improved (p < 0.05) in both HIIT and MICT programs following eight sessions of training. A significant interaction effect for group by time was found in the lnLF/HF ratio (p < 0.05) where it was only improved in the HIIT group from pre- to post-test. The HIIT program is superior to MICT in improving HRV in physically inactive adults. The HIIT program can be applied as a time-efficient program for improving cardiac-autoregulation.

High-intensity interval training is more effective than continuous training to reduce inflammation markers in female rats with cisplatin nephrotoxicity

Life Sciences ◽  
2021 ◽  
Vol 266 ◽  
pp. 118880
Author(s):  
Allyne Baía Leite ◽  
Hernando Nascimento Lima ◽  
Caleb de Oliveira Flores ◽  
Caroline Assunção Oliveira ◽  
Larissa Esterfanne Cavalcante Cunha ◽  
...  
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
Female Rats ◽  
High Intensity Interval Training ◽  
Inflammation Markers ◽  
Continuous Training ◽  
Cisplatin Nephrotoxicity ◽  
High Intensity Interval

Comparison of High-Intensity Interval Training to Moderate-Intensity Continuous Training in Older Adults: A Systematic Review

2020 ◽  
Vol 28 (5) ◽  
pp. 798-807
Author(s):  
Christopher J. Keating ◽  
Juan Á. Párraga Montilla ◽  
Pedro Á. Latorre Román ◽  
Rafael Moreno del Castillo
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Cardiorespiratory Fitness ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Female Population ◽  
High Intensity Interval

High-intensity interval training (HIIT) is emerging as a safe and effective means to combat chronic diseases. The objective of this work was to perform a systematic review of the effect of HIIT interventions in an aging population. Three electronic databases were searched for randomized trials comparing the effect of HIIT and moderate-intensity continuous training in older adults. After a thorough screening process, 15 articles were identified as meeting the inclusion criteria. All studies expressed a comparable or superior effect of HIIT in cardiorespiratory fitness measures. No studies reported a lessened effect of HIIT in comparison with moderate-intensity continuous training. This systematic review demonstrates that HIIT is a useful exercise regimen, which can be used in older adults to increase cardiorespiratory fitness. More research is needed to determine the effects of HIIT in an aging, predominately female population.

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