Bold Does a High Fat Diet or Succinic Acid Treatment Affect Adipose Mitochondrial Function?

2016 ◽  
Vol 48 ◽  
pp. 386
Author(s):  
Gabriel H. O’Brien
Keyword(s):  
Succinic Acid ◽  
Mitochondrial Function ◽  
High Fat Diet ◽  
Acid Treatment ◽  
High Fat

scholarly journals Berberine elevates cardiolipin in heart of offspring from mouse dams with high fat diet-induced gestational diabetes mellitus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Laura K. Cole ◽  
Genevieve C. Sparagna ◽  
Marilyne Vandel ◽  
Bo Xiang ◽  
Vernon W. Dolinsky ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Mitochondrial Function ◽  
High Fat Diet ◽  
Fatty Acid Uptake ◽  
Isoquinoline Alkaloid ◽  
Acid Uptake ◽  
High Fat ◽  
Low Fat

AbstractBerberine (BBR) is an isoquinoline alkaloid from plants known to improve cardiac mitochondrial function in gestational diabetes mellitus (GDM) offspring but the mechanism is poorly understood. We examined the role of the mitochondrial phospholipid cardiolipin (CL) in mediating this cardiac improvement. C57BL/6 female mice were fed either a Lean-inducing low-fat diet or a GDM-inducing high-fat diet for 6 weeks prior to breeding. Lean and GDM-exposed male offspring were randomly assigned a low-fat, high-fat, or high-fat diet containing BBR at weaning for 12 weeks. The content of CL was elevated in the heart of GDM offspring fed a high fat diet containing BBR. The increase in total cardiac CL was due to significant increases in the most abundant and functionally important CL species, tetralinoleoyl-CL and this correlated with an increase in the expression of the CL remodeling enzyme tafazzin. Additionally, BBR treatment increased expression of cardiac enzymes involved in fatty acid uptake and oxidation and electron transport chain subunits in high fat diet fed GDM offspring. Thus, dietary BBR protection from cardiac dysfunction in GDM exposed offspring involves improvement in mitochondrial function mediated through increased synthesis of CL.

scholarly journals Estradiol treatment or modest exercise improves hepatic health and mitochondrial outcomes in female mice following ovariectomy

2021 ◽  
Author(s):  
Kelly N. Z. Fuller ◽  
Colin S. McCoin ◽  
Alex T. Von Schulze ◽  
Claire J. Houchen ◽  
Michael A. Choi ◽  
...  
Keyword(s):  
Bile Acid ◽  
Mitochondrial Function ◽  
High Fat Diet ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
High Fat ◽  
Estradiol Treatment ◽  
Respiratory Capacity ◽  
Female Mice ◽  
Mitochondrial Respiratory

We recently reported that compared to males, female mice have increased hepatic mitochondrial respiratory capacity and are protected against high-fat diet-induced steatosis. Here we sought to determine the role of estrogen in hepatic mitochondrial function, steatosis, and bile acid metabolism in female mice, as well as investigate potential benefits of exercise in the absence or presence of estrogen via ovariectomy (OVX). Female C57BL mice (n=6 per group) were randomly assigned to sham surgery (Sham), ovariectomy (OVX), or OVX plus estradiol replacement therapy (OVX+Est). Half of the mice in each treatment group were sedentary (SED) or had access to voluntary wheel running (VWR). All mice were fed a high-fat diet (HFD) and were housed at thermoneutral temperatures. We assessed isolated hepatic mitochondrial respiratory capacity using the Oroboros O2k with both pyruvate and palmitoylcarnitine as substrates. As expected, OVX mice presented with greater hepatic steatosis, weight gain, and fat mass gain compared to Sham and OVX+Est animals. Hepatic mitochondrial coupling (Basal/State 3 respiration) with pyruvate was impaired following OVX, but both VWR and estradiol treatment rescued coupling to levels greater than or equal to Sham animals. Estradiol and exercise also had different effects on liver electron transport chain protein expression depending on OVX status. Markers of bile acid metabolism and excretion were also impaired by ovariectomy but rescued with estradiol add-back. Together our data suggest that estrogen depletion impairs hepatic mitochondrial function and liver health, and that estradiol replacement and modest exercise can aid in rescuing this phenotype.

Acerola polysaccharides ameliorate high-fat diet-induced non-alcoholic fatty liver disease through reduction of lipogenesis and improvement of mitochondrial functions in mice

2020 ◽  
Vol 11 (1) ◽  
pp. 1037-1048 ◽  
Author(s):  
Yuanyuan Hu ◽  
Fawen Yin ◽  
Zhongyuan Liu ◽  
Hongkai Xie ◽  
Yunsheng Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Fatty Liver ◽  
Mitochondrial Function ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Mitochondrial Functions ◽  
Alcoholic Fatty Liver Disease

Acerola polysaccharides ameliorate HFD-induced NAFLD by inhibiting lipogenesis, reducing oxidative stress and inflammation, and promoting the mitochondrial function in C57BL/6 mice.

scholarly journals Effects of monobutyrin and tributyrin on liver lipid profile, caecal microbiota composition and SCFA in high-fat diet-fed rats

2017 ◽  
Vol 6 ◽  
Author(s):  
Thao Duy Nguyen ◽  
Olena Prykhodko ◽  
Frida Fåk Hållenius ◽  
Margareta Nyman
Keyword(s):  
Succinic Acid ◽  
High Fat Diet ◽  
Intestinal Tract ◽  
Liver Lipid ◽  
Microbiota Composition ◽  
Risk Markers ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets ◽  
Caecal Microbiota

AbstractButyric acid has been shown to have suppressive effects on inflammation and diseases related to the intestinal tract. The aim of the present study was to investigate whether supplementation of two glycerol esters, monobutyrin (MB) and tributyrin (TB), would reach the hindgut of rats, thus having an effect on the caecal profile of SCFA, microbiota composition and some risk markers associated with chronic inflammation. For this purpose, rats were fed high-fat diets after adding MB (1 and 5 g/kg) and TB (5 g/kg) to a diet without any supplementation (high-fat control; HFC). A low-fat (LF) diet was also included. In the liver, total cholesterol concentrations, LDL-cholesterol concentrations, LDL:HDL ratio, and succinic acid concentrations were reduced in rats given the MB and TB (5 g/kg) diets, compared with the group fed the HFC diet. These effects were more pronounced in MB than TB groups as also expressed by down-regulation of the gene Cyp8b1. The composition of the caecal microbiota in rats fed MB and TB was separated from the group fed the HFC diet, and also the LF diet, as evidenced by the absence of the phylum TM7 and reduced abundance of the genera Dorea (similar to LF-fed rats) and rc4-4. Notably, the caecal abundance of Mucispirillum was markedly increased in the MB group compared with the HFC group. The results suggest that dietary supplementation of MB and TB can be used to counteract disturbances associated with a HFC diet, by altering the gut microbiota, and decreasing liver lipids and succinic acid concentrations.

scholarly journals Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice

2020 ◽  
Vol 128 (5) ◽  
pp. 1251-1261
Author(s):  
Kelly N. Z. Fuller ◽  
Colin S. McCoin ◽  
Julie Allen ◽  
Shelby Bell-Glenn ◽  
Devin C. Koestler ◽  
...  
Keyword(s):  
Protein Expression ◽  
Mitochondrial Function ◽  
Mitochondrial Respiration ◽  
High Fat Diet ◽  
Wild Type ◽  
High Fat ◽  
Interacting Protein ◽  
Female Mice ◽  
Complex Protein ◽  
Respiratory Outcomes

This is the first study focusing on hepatic mitochondrial respiratory outcomes in response to lipid overload via a high-fat diet (HFD) combined with intralipid injection. Novel findings include no effect of intralipid injection on mitochondrial outcomes of interest, despite increased circulating lipid concentrations. However, we report pronounced differences in hepatic mitochondrial respiration, complex protein expression, and H2O2 production by sex and BCL-2/adenovirus EIB 19-kDa interacting protein (BNIP3) genotype. Specifically, female mice had lower H2O2 emission globally and on an acute HFD, females had greater hepatic mitochondrial respiration than males, whereas BNIP3 knockout (KO) animals had greater mitochondrial coupling and complex protein expression than wild-type (WT) animals.

scholarly journals Perinatal Protein Malnutrition Affects Mitochondrial Function in Adult and Results in a Resistance to High Fat Diet-Induced Obesity

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104896 ◽  
Author(s):  
Céline Jousse ◽  
Yuki Muranishi ◽  
Laurent Parry ◽  
Christophe Montaurier ◽  
Patrick Even ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
High Fat Diet ◽  
Protein Malnutrition ◽  
High Fat ◽  
Diet Induced Obesity

scholarly journals Effects of three different conjugated linoleic acid preparations on insulin signalling, fat oxidation and mitochondrial function in rats fed a high-fat diet

2007 ◽  
Vol 98 (2) ◽  
pp. 264-275 ◽  
Author(s):  
Joo Sun Choi ◽  
In-Uk Koh ◽  
Myeong Ho Jung ◽  
Jihyun Song
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Mitochondrial Function ◽  
High Fat Diet ◽  
Insulin Signalling ◽  
Fat Oxidation ◽  
Acid Oxidation ◽  
High Fat ◽  
Cla Isomers

To investigate the effects of three different conjugated linoleic acid (CLA) preparations containing different ratios of CLA isomers on insulin signalling, fatty acid oxidation and mitochondrial function, Sprague–Dawley rats were fed a high-fat diet either unsupplemented or supplemented with one of three CLA preparations at 1 % of the diet for 8 weeks. The first CLA preparation contained approximately 30 % cis-9, trans-11 (c9, t11)-CLA isomer and 40 % trans-10, cis-12 (t10, c12)-CLA isomer (CLA-mix). The other two preparations were an 80:20 mix (c9, t11-CLA-mix) or a 10:90 mix of two CLA isomers (t10, c12-CLA-mix). Insulin resistance was decreased in all three supplemented groups based on the results of homeostasis model assessment and the revised quantitative insulin-sensitivity check index. The phosphorylation of insulin receptor substrate-1 on serine decreased in the livers of all three supplemented groups, while subsequent Akt phosphorylation increased only in the t10, c12-CLA-mix group. Both the c9, t11-CLA-mix and the t10, c12-CLA-mix increased the expression of hepatic adiponectin receptors R1 and 2, which are thought to enhance insulin sensitivity and fat oxidation. The c9, t11-CLA-mix increased protein and mRNA levels of PPARα, acyl-CoA oxidase and uncoupling protein, which are involved in fatty acid oxidation and energy dissipation. The c9, t11-CLA-mix enhanced mitochondrial function and protection against oxidative stress by increasing the activities of cytochrome c oxidase, manganese-superoxide dismutase, glutathione peroxidase, and glutathione reductase and the level of GSH. In conclusion, all three CLA preparations reduced insulin resistance. Among them, the c9, t11-CLA-mix was the most effective based on the parameters reflecting insulin resistance and fat oxidation, and mitochondrial antioxidative enzyme activity in the liver.

T1851 Changes in Liver Mitochondrial Function Induced By a High-Fat Diet Enriched withω-3 PUFAS Are Associated with Reduction of Hepatic Lesions Secondary to Ischemia/Reperfusion

2009 ◽  
Vol 136 (5) ◽  
pp. A-923
Author(s):  
Ana Maria M. Coelho ◽  
Rui Curi ◽  
Sandra N. Sampietre ◽  
Nilza A. Molan ◽  
Hilton Takahashi ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
High Fat Diet ◽  
Ischemia Reperfusion ◽  
High Fat ◽  
Hepatic Lesions
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