scholarly journals Effects of daily handling and other factors on weight gain of mice from birth to six weeks of age

1969 ◽  
Vol 3 (1) ◽  
pp. 7-16 ◽  
Author(s):  
G. Porter ◽  
M. Festing

The results of this experiment show that growth rate in mice is so sensitive to environmental factors that any change in the environment such as handling or diet could cause short-term changes in the rate of growth. It is also shown that if there is a period of restricted growth due to an environmental factor such as either handling or diet, this may be followed by a period of compensating rapid growth.

1946 ◽  
Vol 22 (3-4) ◽  
pp. 130-144
Author(s):  
MARGARET E. BROWN

1. Two-year-old trout were grown in environments where the following factors were controlled: temperature, amount and intensity of illumination, rate of flow, composition and aeration of the water, quality and quantity of food and amount of living space. 2. The specific growth rate of an individual depended on its size relative to that of the others in the group. It is suggested that subgroups of four or five individuals existed within the size hierarchy and were reorganized at intervals of about 3 months. 3. There was an optimum degree of crowding for rapid growth, and overcrowding led to lower appetite and efficiency of utilization of food, while under-crowded trout ate and grew erratically. 4. In spite of constant environmental conditions, all the fish had an annual growth-rate cycle, with an autumn check, a spring maximum, rapid summer growth and another autumn check, which coincided with maturation of the gonads when they became 3 years old. 5. Individual specific growth rates fluctuated over periods of 4-6 weeks, and rapid growth in length alternated with rapid growth in weight. The specific rate of growth in length was directly proportional to the condition factor. The amount of food eaten, the efficiency of utilization of food and the specific rate of growth in weight varied with the condition factor and were maximal for a factor of about 1·10. 6. The growth-rate fluctuations were exaggerated and the efficiency was greater when the food supply was restricted. At the maintenance level the change in weight was directly proportional to the amount of food eaten. The maintenance requirement decreased, relatively, with increase in body weight. 7. The mean specific growth rate was higher with less than 12 hr. per diem of the standard illumination.


1955 ◽  
Vol 12 (5) ◽  
pp. 768-780 ◽  
Author(s):  
W. A. Fuller

Material for this study was gathered by field parties of the Fisheries Research Board in the summers of 1944, 1945 and 1946. A description of the subspecies is given, based on measurements of 26 specimens. The distribution of Stenodus in Great Slave Lake, and in northern North America is outlined. The rate of growth was determined from an examination of scale samples from 298 fish, and it was found that the inconnu has a rapid growth rate, even in this highly oligotrophic lake. Inconnu spawn mainly in the rivers which enter Great Slave Lake from the Mackenzie Lowlands. The upstream run apparently occupies most of the summer but evidence is presented which indicates a major movement in late August. The post-spawning, downstream run takes place in late September or early October. Residents take advantage of it to put up inconnu for winter dog feed. The food of young inconnu in the spawning streams was found to be mainly invertebrates, whereas in Great Slave Lake the species is almost entirely piscivorous. A list of parasites is given, among which Triaenophorus crassus is considered of major importance. The rate of infestation with the larvae of this worm is high—88 per cent of 49 fish examined, at a rate of 64 cysts per 100 pounds. At present the major use of the inconnu is in the domestic fishery where it serves local trappers, and others, as dog feed.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Manit Srisurapanont ◽  
Sirijit Suttajit ◽  
Surinporn Likhitsathian ◽  
Benchalak Maneeton ◽  
Narong Maneeton

AbstractThis study compared weight and cardiometabolic changes after short-term treatment of olanzapine/samidorphan and olanzapine. Eligible criteria for an included trial were ≤ 24 weeks, randomized controlled trials (RCTs) that compared olanzapine/samidorphan and olanzapine treatments in patients/healthy volunteers and reported weight or cardiometabolic outcomes. Three databases were searched on October 31, 2020. Primary outcomes included weight changes and all-cause dropout rates. Standardized mean differences (SMDs) and risk ratios (RRs) were computed and pooled using a random-effect model. This meta-analysis included four RCTs (n = 1195). The heterogeneous data revealed that weight changes were not significantly different between olanzapine/samidorphan and olanzapine groups (4 RCTs, SDM = − 0.19, 95% CI − 0.45 to 0.07, I2 = 75%). The whole-sample, pooled RR of all-cause dropout rates (4 RCTs, RR = 1.02, 95% CI 0.84 to 1.23, I2 = 0%) was not significant different between olanzapine/samidorphan and olanzapine groups. A lower percentage of males and a lower initial body mass index were associated with the greater effect of samidorphan in preventing olanzapine-induced weight gain. Current evidence is insufficient to support the use of samidorphan to prevent olanzapine-induced weight gain and olanzapine-induced cardiometabolic abnormalities. Samidorphan is well accepted by olanzapine-treated patients.


2021 ◽  
Vol 10 (4) ◽  
pp. 196
Author(s):  
Julio Manuel de Luis-Ruiz ◽  
Benito Ramiro Salas-Menocal ◽  
Gema Fernández-Maroto ◽  
Rubén Pérez-Álvarez ◽  
Raúl Pereda-García

The quality of human life is linked to the exploitation of mining resources. The Exploitability Index (EI) assesses the actual possibilities to enable a mine according to several factors. The environment is one of the most constraining ones, but its analysis is made in a shallow way. This research is focused on its determination, according to a new preliminary methodology that sets the main components of the environmental impact related to the development of an exploitation of industrial minerals and its weighting according to the Analytic Hierarchy Process (AHP). It is applied to the case of the ophitic outcrops in Cantabria (Spain). Twelve components are proposed and weighted with the AHP and an algorithm that allows for assigning a normalized value for the environmental factor to each deposit. Geographic Information Systems (GISs) are applied, allowing us to map a large number of components of the environmental factors. This provides a much more accurate estimation of the environmental factor, with respect to reality, and improves the traditional methodology in a substantial way. It can be established as a methodology for mining spaces planning, but it is suitable for other contexts, and it raises developing the environmental analysis before selecting the outcrop to be exploited.


2021 ◽  
Vol 9 (1) ◽  
pp. e002035
Author(s):  
Merel M Ruissen ◽  
Hannah Regeer ◽  
Cyril P Landstra ◽  
Marielle Schroijen ◽  
Ingrid Jazet ◽  
...  

IntroductionLockdown measures have a profound effect on many aspects of daily life relevant for diabetes self-management. We assessed whether lockdown measures, in the context of the COVID-19 pandemic, differentially affect perceived stress, body weight, exercise and related this to glycemic control in people with type 1 and type 2 diabetes.Research design and methodsWe performed a short-term observational cohort study at the Leiden University Medical Center. People with type 1 and type 2 diabetes ≥18 years were eligible to participate. Participants filled out online questionnaires, sent in blood for hemoglobin A1c (HbA1c) analysis and shared data of their flash or continuous glucose sensors. HbA1c during the lockdown was compared with the last known HbA1c before the lockdown.ResultsIn total, 435 people were included (type 1 diabetes n=280, type 2 diabetes n=155). An increase in perceived stress and anxiety, weight gain and less exercise was observed in both groups. There was improvement in glycemic control in the group with the highest HbA1c tertile (type 1 diabetes: −0.39% (−4.3 mmol/mol) (p<0.0001 and type 2 diabetes: −0.62% (−6.8 mmol/mol) (p=0.0036). Perceived stress was associated with difficulty with glycemic control (p<0.0001).ConclusionsAn increase in perceived stress and anxiety, weight gain and less exercise but no deterioration of glycemic control occurs in both people with relatively well-controlled type 1 and type 2 diabetes during short-term lockdown measures. As perceived stress showed to be associated with glycemic control, this provides opportunities for healthcare professionals to put more emphasis on psychological aspects during diabetes care consultations.


2000 ◽  
Vol 18 (4) ◽  
pp. 339-342 ◽  
Author(s):  
Cynthia S Pomerleau ◽  
Ovide F Pomerleau ◽  
Rebecca J Namenek ◽  
Ann M Mehringer
Keyword(s):  

2003 ◽  
Vol 28 (3) ◽  
pp. 519-526 ◽  
Author(s):  
Wesley K Kroeze ◽  
Sandra J Hufeisen ◽  
Beth A Popadak ◽  
Sean M Renock ◽  
SeAnna Steinberg ◽  
...  

1974 ◽  
Vol 11 (03) ◽  
pp. 437-444 ◽  
Author(s):  
Benoit Mandelbrot

Luria and Delbrück (1943) have observed that, in old cultures of bacteria that have mutated at random, the distribution of the number of mutants is extremely long-tailed. In this note, this distribution will be derived (for the first time) exactly and explicitly. The rates of mutation will be allowed to be either positive or infinitesimal, and the rate of growth for mutants will be allowed to be either equal, greater or smaller than for non-mutants. Under the realistic limit condition of a very low mutation rate, the number of mutants is shown to be a stable-Lévy (sometimes called “Pareto Lévy”) random variable, of maximum skewness ß, whose exponent α is essentially the ratio of the growth rates of non-mutants and of mutants. Thus, the probability of the number of mutants exceeding the very large value m is proportional to m –α–1 (a behavior sometimes referred to as “asymptotically Paretian” or “hyperbolic”). The unequal growth rate cases α ≠ 1 are solved for the first time. In the α = 1 case, a result of Lea and Coulson is rederived, interpreted, and generalized. Various paradoxes involving divergent moments that were encountered in earlier approaches are either absent or fully explainable. The mathematical techniques used being standard, they will not be described in detail, so this note will be primarily a collection of results. However, the justification for deriving them lies in their use in biology, and the mathematically unexperienced biologists may be unfamiliar with the tools used. They may wish for more details of calculations, more explanations and Figures. To satisfy their needs, a report available from the author upon request has been prepared. It will be referred to as Part II.


2014 ◽  
Vol 34 (1) ◽  
pp. 48-53
Author(s):  
K Thapa

Childhood obesity is a global epidemic and a major public health challenge. There has been increasing evidence that intrauterine exposures, such as alcohol, smoking, and maternal nutritional status, may affect both the long and short term health consequences of the mother and offspring. Childhood adiposity may be affected by the mother’s pre-pregnancy weight and her weight gain during pregnancy. Consequently, interventions may need to start before conception of the child to prevent childhood obesity. In 2009, the Institute of Medicine updated its gestational weight gain recommendations by incorporating rates of gestational weight gain in the second and third trimesters based on the mother’s pre-pregnancy Body Mass Index. There is extensive research on the association between total gestational weight gain and short-term offspring adiposity. However, this review focuses on the association between trimester-specific gestational weight gain and childhood adiposity for singleton pregnancies with respect to the Institute of Medicine’s newly defined weight gain recommendations as very few studies have examined the association between the gestational weight gain during each trimester and childhood adiposity. Identifying the trimester that is most associated with childhood adiposity may help in the development of targeted interventions, guide physician’s nutritional and weight-gain recommendations for child-bearing mothers, and direct future research. DOI: http://dx.doi.org/10.3126/jnps.v34i1.8429   J Nepal Paediatr Soc 2014;34(1):48-53


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