scholarly journals Salivary Interleukin 1-beta levels and clinical periodontal parameters in habitual naswar users and non-users

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Zaeem Arif Abbasi ◽  
Naila Irum Hadi ◽  
Adnan Mustafa Zubairi ◽  
Mervyn Hosein
Keyword(s):  
Original Work ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Missing Teeth ◽  
Clinical Attachment Loss ◽  
Creative Commons ◽  
Inflammatory Conditions ◽  
Probing Depth ◽  
Significant Difference ◽  
Open Access Article

Objectives: Aim of our study was to assess the expression of salivary Interleukin 1-beta (IL-1β) and clinical periodontal parameters in naswar users and non-users (controls). Methods: Eighty four individuals (forty-two naswar users and forty-two controls) were included in the study which was conducted between August 2017 and May 2018. Salivary IL-1β levels, plaque index (PI), bleeding on probing (BOP), probing depth (PD) and clinical attachment loss (CAL) was assessed in all the participants. Results: PD of 4mm (p<0.05), PD of 5-6mm (p<0.05), CAL (p<0.001) and levels of salivary IL1β (p<0.05) were significantly higher among naswar users as compared to controls while PI, BOP and number of missing teeth showed no significant difference among the two groups (p>0.05). Conclusion: Periodontal inflammatory conditions were worse and salivary IL-1β levels were elevated in naswar users as compared to controls. doi: https://doi.org/10.12669/pjms.35.3.10 How to cite this:Abbasi ZA, Hadi NI, Zubairi AM, Hosein M. Salivary Interleukin 1-beta levels and clinical periodontal parameters in habitual naswar users and non-users. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.10 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Examination of differences in health indicators between efficient and inefficient countries

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Gozde Yesilaydin
Keyword(s):  
Original Work ◽  
Important Determinant ◽  
Health Indicators ◽  
Data Envelopment ◽  
Fuzzy Data ◽  
Creative Commons ◽  
Fuzzy Data Envelopment Analysis ◽  
Significant Difference ◽  
Input Variables ◽  
Open Access Article

Objective: This study determined whether there is a statistically significant difference between efficient and inefficient Organization for Economic Co-operation and Development (OECD) countries in terms of health indicators using fuzzy data envelopment analysis (FDEA). Methods: In the study, FDEA was performed with three input variables directly affecting health, four environmental factors considered to indirectly affect health, and two output variables. Literature research was used to determine appropriate variables. In FDEA, three different α-cut levels were used. The hypotheses regarding whether there was a statistically significant difference between efficient and inefficient countries in input and output variables were tested for all α-cut levels of upper bound efficiency values. Results: In terms of health indicators, 17 countries were efficient at α-cut 0 and 0.5. At α-cut 1, 18 countries were efficient. There was only a statistically significant difference between the efficient and inefficient countries in “the number of physicians.” Conclusion: This study shows the number of physicians was the most important determinant affecting the efficiency of a country’s healthcare system. Inefficient countries had a greater mean for number of physicians. Thus, inefficient countries consume more resources than efficient ones. How to cite this:Yesilaydin G. Examination of differences in health indicators between efficient and inefficient countries. Pak J Med Sci. 2019;35(1):---------. doi: https://doi.org/10.12669/pjms.35.1.255 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Association between Hemoglobin Level and Severity of Chronic Periodontitis

2010 ◽  
Vol 17 (1) ◽  
pp. 53-64 ◽  
Author(s):  
Hind A. Aljohani
Keyword(s):  
Chronic Periodontitis ◽  
Hemoglobin Level ◽  
Missing Teeth ◽  
Clinical Attachment Loss ◽  
Bleeding On Probing ◽  
Attachment Loss ◽  
Probing Depth ◽  
Significant Difference ◽  
King Abdulaziz University ◽  
The Mean

The aim of this study is to investigate the association between hemoglobin level and the severity of chronic periodontitis. Data were collected from 124 systemically healthy chronic periodontitis patients, referred to the Division of Periodontology, Faculty of Dentistry, King Abdulaziz University. Medical history, dental history, and periodontal parameters such as bleeding on probing. Plus probing depth, clinical attachment loss and distance from cement-enamel junction to gingival margin, furcations, mobility and number of missing teeth] were recorded. Blood samples were collected to measure the hemoglobin level. The correlation between hemoglobin and the means of clinical attachment loss and bleeding on probing was insignificant. There was no significant difference in the mean hemoglobin level for individuals with different severity of periodontitis among male and females. The mean hemoglobin found to be insignificantly correlated with the number of missing teeth. No association between hemoglobin levels and periodontal status was found. Further longitudinal studies with larger sample size are needed to investigate this association, and the effect of periodontal treatment on hemoglobin level.

scholarly journals Research on the Correlation of Serum PCT and Plasma GSN Levels with the Prognosis of Urosepsis Patients

2020 ◽  
Vol 36 (5) ◽  
Author(s):  
Na Cui ◽  
Zhanbiao Yu ◽  
Zhi Chen ◽  
Ning Chen
Keyword(s):  
Poor Prognosis ◽  
Original Work ◽  
Protective Factor ◽  
Good Prognosis ◽  
Control Group ◽  
Creative Commons ◽  
The Poor ◽  
Prognosis Group ◽  
Good Prognosis Group ◽  
Open Access Article

Objective: To explore the correlation of procalcitonin (PCT) and gelsolin (GSN) with the prognosis of urosepsis patients. Method: The data of 71 urosepsis patients from March 2015 to April 2019 who were admitted to and treated in Affiliated Hospital of Hebei University were analyzed and compared with those of 92 healthy persons. Serum PCT and plasma GSN levels at different times after treatment were detected. According to prognosis, patients were classified into the good prognosis group or the poor prognosis group. The serum PCT and plasma GSN levels of both groups were compared. Result: The serum PCT level of the urosepsis group on the 1st, 3rd, 5th and 7th days was obviously higher than that of the control group (P<0.05). The plasma GSN levels of the urosepsis group on the 1st, 3rd, 5th and 7th days were obviously lower than those of the control group (P<0.05).The serum PCT level of the poor prognosis group on the 1st, 3rd, 5th and 7th days was obviously higher than that of the good prognosis group (P<0.05). The plasma GSN level of the poor prognosis group on the 1st, 3rd, 5th and 7th days was obviously lower than that of the good prognosis group (P<0.05). PCT was an independent risk factor influencing the prognosis of urosepsis patients and that GSN was a protective factor (P<0.05). Conclusion: The serum PCT and plasma GSN levels can accurately predict the severity and prognosis of urosepsis patients and reflect the disease state of early urosepsis patients. High PCT levels and low GSN levels indicate poor prognosis, and clinicians should consider these values. doi: https://doi.org/10.12669/pjms.36.5.2143 How to cite this:Cui N, Yu Z, Chen Z, Chen N. Research on the Correlation of Serum PCT and Plasma GSN Levels with the Prognosis of Urosepsis Patients. Pak J Med Sci. 2020;36(5):---------. doi: https://doi.org/10.12669/pjms.36.5.2143 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Promoting Research Culture at Indus Health Network

2019 ◽  
Vol 36 (ICON-Suppl) ◽  
Author(s):  
Shaukat Ali Jawaid
Keyword(s):  
Open Access ◽  
Original Work ◽  
Research Culture ◽  
Health Network ◽  
Creative Commons ◽  
Special Supplement ◽  
Open Access Article

doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1861 How to cite this:Jawaid SA. Promoting Research Culture at Indus Health Network. Pak J Med Sci. Special Supplement ICON 2020. 2020;36(1):S2. doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1861 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals A Framework for Protecting Pregnant Women in the Era of COVID-19 Pandemic

2021 ◽  
Vol 10 (1) ◽  
pp. 109-112
Author(s):  
Deepa Dongarwar ◽  
Veronica Ajewole ◽  
Kiydra Harris ◽  
Emmanuella Oduguwa ◽  
Theresa Ofili ◽  
...  
Keyword(s):  
Open Access ◽  
Severe Acute Respiratory Syndrome ◽  
Best Practices ◽  
Global Health ◽  
Pregnant Women ◽  
Original Work ◽  
Creative Commons ◽  
New Challenges ◽  
Work First ◽  
Open Access Article

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for the coronavirus disease 2019 (COVID-19) pandemic, highlighted and compounded problems while posing new challenges for the pregnant population. Although individual organizations have provided disparate information, guidance, and updates on managing the pregnant population during the current COVID-19 pandemic, it is important to develop a collective model that highlights all the best practices needed to protect the pregnant population during the pandemic. To establish a standard for ensuring safety during the pandemic, we present a framework that describes best practices for the management of the pregnant population during the ongoing COVID-19pandemic.   Copyright © 2021 Dongarwar, et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.

scholarly journals Problems faced by Researchers and pressure on Impact Factor Journal Editors

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Shaukat Ali Jawaid
Keyword(s):  
Open Access ◽  
Impact Factor ◽  
Original Work ◽  
Impact Factor Journal ◽  
Creative Commons ◽  
Journal Editors ◽  
Open Access Article

doi: https://doi.org/10.12669/pjms.37.3.4296 How to cite this:Jawaid SA. Problems faced by Researchers and pressure on Impact Factor Journal Editors. Pak J Med Sci. 2021;37(3):616-620.  doi: https://doi.org/10.12669/pjms.37.3.4296 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Spontaneous Detorsion of Sigmoid Volvulus in a patient with Nineteen-Volvulus episode history: A rare outcome of an extremely rare clinical entity

2021 ◽  
Vol 37 (7) ◽  
Author(s):  
Sabri Selcuk Atamanalp ◽  
Esra Disci ◽  
Cansu Tatar Atamanalp ◽  
Refik Selim Atamanalp
Keyword(s):  
Open Access ◽  
Original Work ◽  
Sigmoid Volvulus ◽  
Clinical Entity ◽  
Rare Clinical Entity ◽  
Creative Commons ◽  
Multiple Episode ◽  
Open Access Article

Sigmoid volvulus (SV) recurrence more than 10 times is an extremely rare clinical entity and spontaneous detorsion is a rare outcome of SV. In this paper, we report a case with 19 previous SV attacks, in last of which spontaneous detorsion occurred. Such a multiple-episode history as well as an unexpected recovery was unique in a 1,036-case clinical profession of Ataturk University with SV over a 54.5-year period. doi: https://doi.org/10.12669/pjms.37.7.4703 How to cite this:Atamanalp SS, Disci E, Tatar Atamanalp C, Atamanalp RS. Spontaneous Detorsion of Sigmoid Volvulus in a patient with Nineteen-Volvulus episode history: A rare outcome of an extremely rare clinical entity. Pak J Med Sci. 2021;37(7):---------.  doi: https://doi.org/10.12669/pjms.37.7.4703 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals 2019 Health Equity Summer Research Summit Organized by the Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas 77030, USA on June 18th, 2019

2020 ◽  
Vol 9 (2s) ◽  
pp. S1-S46
Author(s):  
A Uribe-Gomez ◽  
Abraham A. Salinas-Miranda ◽  
Acara E. Turner ◽  
Adriana M. Strutt ◽  
Adrienne Joseph ◽  
...  
Keyword(s):  
Open Access ◽  
Health Equity ◽  
Original Work ◽  
Baylor College ◽  
Creative Commons ◽  
Center Of Excellence ◽  
Training And Research ◽  
Open Access Article

Copyright © 2020 Harris. This is an open-access article distributed under the terms of the Creative Commons At - tribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Exploration of constructs of professionalism identified in the ABIM framework as perceived by the faculty fitting the Pakistani context

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Humaira Fayyaz Khan ◽  
Raheela Yasmeen
Keyword(s):  
Open Access ◽  
Focus Group ◽  
Original Work ◽  
Group Discussion ◽  
Local Context ◽  
Ethnographic Research ◽  
Professional Conduct ◽  
Medical College ◽  
Creative Commons ◽  
Open Access Article

Objective: Domains of professionalism are well-described in the literature. Examining the elements of Professionalism in the local context have received less attention from education experts. The aim of the study was to explore the construct of professionalism as perceived by the faculty that fitted the Pakistani context identified in the ABIM framework of professionalism. Methods: This qualitative ethnographic research was conducted involving nine participants from Islamic International Medical College in Riphah University Islamabad. A four hours Focus Group Discussion was undertaken to explore the views of the faculty. The focus group session was audiotaped, transcribed and technique of triangulation was employed. Shortened meaningful unit (SMU) were identified from the transcribed data and analyzed to make codes for themes for the behaviors. Forty-six meaningful units were categorized and codes were identified. The themes were identified under the domains of the ABIM frameworks for the Pakistani context. Results: The participants listed 2-8 elements for each domain of the framework describing the professional conduct which lead to 140 shortened meaningful units. These were organized into 46 higher order codes. Conclusions: The study concludes that that ABIM framework can be used to build consensus regarding the domains of professionalism. No difference was found cross contextually regarding the domains of ABIM framework of professionalism. doi: https://doi.org/10.12669/pjms.36.3.1573 How to cite this:Khan HF, Yasmeen R. Exploration of constructs of professionalism identified in the ABIM framework as perceived by the faculty fitting the Pakistani context. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.1573 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Interleukin-1-beta concentration and neutrophil-lymphocyte ratio as possible predicting biomarkers of response to therapy with checkpoint inhibitors.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 3024-3024
Author(s):  
Rashida Orlova ◽  
Natalia V. Zhukova ◽  
Anna Malkova ◽  
Ekaterina Kaledina ◽  
Anna Gubal ◽  
...  
Keyword(s):  
Checkpoint Inhibitors ◽  
Immune Therapy ◽  
Interleukin 1 ◽  
Anticancer Therapy ◽  
Response To Therapy ◽  
Interleukin 1 Beta ◽  
Group I ◽  
Significant Difference ◽  
The Mean ◽  
Group Ii

3024 Background: One of the discussed predictive markers of the immune therapy efficacy is the index of neutrophils to lymphocytes ratio in peripheral blood (NLr), which reflects the activity of adaptive immunity and correlates with the level of tumor-infiltrating lymphocytes (TILs). High NLr and low TILs are associated with disease progression. Interleukin-1-beta (IL-1β) is one of the main cytokines produced by the tumor microenvironment (TMO). Overexpression of the cytokine leads to a local immunosuppression. For some tumors, elevated serum IL-1β levels have been associated with a poor prognosis. The aim of this work is to analyze the serum IL-1β level as a marker of TMO activity and the NLr as a marker of adaptive immunity activity in relation to the response to therapy with checkpoint inhibitors in patients with various solid tumors. Methods: The study involved 63 patients with various solid tumors who were treated at the City Oncological Dispensary and were prescribed checkpoint inhibitors (nivolumab (n = 33), pembrolizumab (n = 23), ipilimumab + nivolumab (n = 7)). The determination of the level of IL-1β was performed using the ELISA method ("Interleukin-1-beta, ELISA-best", Novosibirsk), a clinical blood test was performed in a dispensary. The response to treatment was assessed 3-6 months after the start of therapy. Statistical analysis was carried out in GraphPad Prism. Results: Among the examined patients 49.21% (31/63) achieved partial regression or stabilization of the process (group I), and 50.79% (32/63) progressed (group II). The mean concentration of IL-1β before treatment in group I was 2.21±0.3 pg/ml, in group II - 0.98±0.2 pg/ml. NLr was increased in 7 patients from group I and in 9 patients from group II, with the mean index level being 2.9±0.39 and 3.2±0.5, respectively. There was no statistically significant difference in the concentration of IL-1β and the NLr between the studied groups. In group II, the number of patients undergoing systemic anticancer therapy before immune therapy (n = 18) was statistically significantly higher than in group I (n = 8), p = 0.033. There was no statistically significant difference in IL-1β concentration and NLr relative to previous treatment. Conclusions: Our study showed that the level of IL-1β corresponds to that of healthy donors and its isolated determination has no prognostic value. The NLr in most patients from the progression group was higher than normal, in contrast to group I, which is confirmed in the literature. The presence of previous systemic anticancer therapy was found to be associated with disease progression. The described feature can be explained by the fact that patients who received therapy before, already have a longer period of illness, a more severe clinical condition. The presence of systemic anticancer therapy does not affect the level of IL-1β and NLr.

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