scholarly journals Effect of altering the regime of oral rifampicin therapy in the treatment of persistent central serous chorioretinopathy

2019 ◽  
Vol 35 (6) ◽  
Author(s):  
Hina Loya ◽  
Hunain Ghoghari ◽  
Syed Fawad Rizvi ◽  
Abdullah Khan
Keyword(s):  
Comparative Study ◽  
Central Serous Chorioretinopathy ◽  
P Value ◽  
Drug Induced ◽  
Chronic Central Serous Chorioretinopathy ◽  
Once Daily ◽  
Reduced Dose ◽  
Group A ◽  
Pre Treatment ◽  
Group B

Objective: To study the effect of reducing the duration of rifampicin therapy in the treatment of Chronic Central Serous Chorioretinopathy. Methods: This is interventional study conducted in Layton Rahmatullah Benevolent Trust, Free Base Eye Hospital Korangi, Karachi from February 2017 - December 2018. This randomized controlled comparative study included two groups, Groups-A comprised of 48 eyes of 40 cases with Chronic Central Serous Chorioretinopathy who were given reduced dose of oral rifampicin i.e. 600mg for one month, and Group-B consisted of 43 eyes of 40 controls with Chronic Central Serous Chorioretinopathy who were given reduced dose of oral rifampicin i.e. 300mg once daily for three months as previously stated in literature. To access the effect of therapy in both the groups, pre-treatment visual acuity on the logMAR and Optical Coherent Tomography (OCT, Heidelberg spectralis) for CMT were performed and repeated on the 1st and 3rd month post-treatment. Patients were also followed for 6 months to access any recurrence. Results: On comparing the two groups, Group-A had improvement in VA and CMT after one month therapy of Rifampicin, Pre-treatment mean VA in Group-A was 0.85 ± 0.19 as compared to the pre-treatment mean VA in Group-B i.e. 0.74+/- 0.208, while the pre-treatment mean CMT was 609.0 ± 178.29 µm in Group-A, and 600.0 +/- 155.09 µm in Group-B respectively. After 1 month of therapy, the visual status, and CMT in Group-A was 0.29+/- 0.21 and 311.6 +/- 89.9, while Group-B, VA was 0.598 +/- 0.23 (p value 0.001%) and CMT was 512.30 +/- 148.37 (p-value 0.001%). Rifampicin was continued in Group-B till three months, and patients were re-accessed but there was no difference in VA and CMT statically. During the 3rd and 6th months of follow up no relapses were reported. Conclusion: This comparative study showed that the group receiving oral rifampicin 600mg for one month showed better outcome at one month and third month than the group receiving oral rifampicin at a dose of 300mg once daily for three months. This gives a better compliance and lower the risk of drug induced side effects. doi: https://doi.org/10.12669/pjms.35.6.990 How to cite this:Loya H, Ghoghari H, Rizvi SF, Khan A. Effect of altering the regime of oral rifampicin therapy in the treatment of persistent central serous chorioretinopathy. Pak J Med Sci. 2019;35(6):1687-1690. doi: https://doi.org/10.12669/pjms.35.6.990 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Comparison of Tamoxifen and Clomiphene Citrate for Ovulation Induction in Women with Polycystic Ovarian Syndrome: A Prospective Study

2021 ◽  
Author(s):  
Sangita Sharma ◽  
Manisha Choudhary ◽  
Vikas Swarankar ◽  
Vaibhav Vaishnav
Keyword(s):  
Endometrial Thickness ◽  
Clomiphene Citrate ◽  
P Value ◽  
Ovulatory Cycle ◽  
Chi Square ◽  
Once Daily ◽  
Induction Of Ovulation ◽  
Group A ◽  
Group B ◽  
Estradiol Levels

Background: The purpose of this study was to compare the efficacy of tamoxifen and clomiphene citrate in induction of ovulation in women with PCOS and anovulation. Methods: In this prospective cohort study, 104 women with PCOS and primary infertility were enrolled after fulfilling the inclusion and exclusion criteria. The patients were allocated in two groups; group A (n=54) received tamoxifen 40 mg once daily (Days 3-7) and group B (n=50) received clomiphene citrate 100 mg once daily (Days 3-7). Serial ultrasounds were done till the administration of human chorionic gonadotropin (hCG). The ovulation and pregnancy rates in both groups were compared. The number of dominant follicles, estradiol levels, and endometrial thickness were also studied. Comparison was done using chi-square and student’s t-test and a p-value of less than 0.05 was considered statistically significant. Results: The number of dominant follicles and serum estradiol levels were significantly higher in group B (p<0.05), whereas the endometrial thickness was significantly more in group A (p<0.05). The ovulation rates were similar in both groups (66.6% vs. 70%, p=0.715). Pregnancy rate per treatment cycle and per ovulatory cycle was marginally higher in group A (14.81% and 22.22%, respectively), as compared to group B (14% and 20%, respectively), but the difference was not statistically significant (p>0.05). Conclusion: Tamoxifen and clomiphene citrate are both equally effective in induction of ovulation and achieving a pregnancy in women with PCOS.

A COMPARATIVE STUDY OF MIFEPRISTONE AND MISOPROSTOL VERSUS MISOPROSTOL ALONE IN INDUCTION OF LABOUR IN LATE INTRAUTERINE FETAL DEATH

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Shivpal Moond ◽  
K.P. Banerjee ◽  
Rakhi Arya
Keyword(s):  
Single Dose ◽  
Comparative Study ◽  
Fetal Death ◽  
Induction Of Labour ◽  
Labour Induction ◽  
Intrauterine Fetal Death ◽  
P Value ◽  
Group A ◽  
The Mean ◽  
Group B

Objective: To compare efficacy, safety and tolerance of combination of Mifepristone and Misoprostol versus Misoprostol alone in induction of labour in late intrauterine fetal death (>24 weeks). Methods: This prospectively study included 160 women with late intrauterine fetal death (IUFD) after 24 weeks of gestation and divided the women randomly into two groups each containing 80 women. In Group-A : Mifepristone 200 mg single dose was given and after 24 hrs Tab Misoprostol (intravaginally) administered and repeated 4 hourly upto a maximum of 5 doses, while in Group-B : Only Tab Misoprostol administered intravaginally 4 hourly upto maximum 5 doses. Induction-delivery interval and number of doses of Misoprostol was calculated.    Results: The mean induction-delivery interval in Group-A was 13.02 ± 3.74 hours and in Group-B was 16.09 ± 2.99 hours (p-value <0.0001). Mean doses of Misoprostol required in Group-A was 3.36 ± 1.08 hours and in Group-B was 4.32 ± 0.65 hours (p-value <0.0001). Conclusion: Combination of Mifepristone and Misoprostol is more effective as comparison to Misoprostol in terms of induction-delivery interval and number of doses of misoprostol required.    Keywords: IUFD, mifepristone, misoprostol, induction of labour, induction-delivery interval.

scholarly journals Morphologic Changes in the Foveal Photoreceptor Layer before and after Laser Treatment in Acute and Chronic Central Serous Chorioretinopathy Documented in Spectral-Domain Optical Coherence Tomography

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Dominik Odrobina ◽  
Iwona Laudańska-Olszewska ◽  
Piotr Gozdek ◽  
Mariusz Maroszyński ◽  
Michael Amon
Keyword(s):  
Laser Treatment ◽  
Central Serous Chorioretinopathy ◽  
Subretinal Fluid ◽  
Chronic Central Serous Chorioretinopathy ◽  
Microstructural Changes ◽  
Photoreceptor Layer ◽  
Before And After ◽  
Group A ◽  
Group B

Purpose. To analyze microstructural changes in the external limiting membrane (ELM) and photoreceptor layer before and after early and late conventional laser treatment in central serous chorioretinopathy (CSC) in 12 months follow-up study.Methods. A retrospective observational study included Group A: 19 patients (19 eyes) with symptomatic acute CSC and Group B: 16 patients (16 eyes) with symptomatic chronic CSC. Retinal microstructural changes were analyzed with SD-OCT paying a particular role in examining the photoreceptor layer and ELM.Results. The length of the photoreceptors, prior to treatment, was approximately 84 μm in Group A and 82,5 μm in Group B. Twelve months after laser treatment, photoreceptor length was approximately 49 μm in Group A and 43 μm (range 20–55 μm) in Group B. No patients in Group A had noticeable photoreceptor defects nor ELM defects, but in 15 eyes in Group B photoreceptor and ELM defects were detected ().Conclusions. When analyzing the photoreceptor layer and ELM during active CSC, it is not possible to evaluate any irreversible changes which have already occurred in this layer. Damage to the photoreceptor layer and ELM in patients with chronic CSC was only found after laser treatment and the absorption of subretinal fluid.

scholarly journals Comparison of 532 nm Micropulse Green Laser versus Continuous-Wave 532 nm Green Laser in Chronic Central Serous Chorioretinopathy: Long-Term Follow-Up

2020 ◽  
Vol 2020 ◽  
pp. 1-5 ◽  
Author(s):  
Katarzyna Piasecka ◽  
Piotr Gozdek ◽  
Mariusz Maroszyński ◽  
Dominik Odrobina
Keyword(s):  
Central Serous Chorioretinopathy ◽  
Continuous Wave ◽  
Subretinal Fluid ◽  
Green Laser ◽  
Chronic Central Serous Chorioretinopathy ◽  
Micropulse Laser ◽  
Group A ◽  
Group B ◽  
532 Nm

The aim of this study was to analyze the efficacy of micropulse laser treatment (MLT) compared with the continuous-wave laser (CL) in treating eyes with chronic central serous chorioretinopathy (CSC) in a 12-month follow-up study. Methods: A retrospective observational study included 51 eyes with chronic CSC; 35 eyes were treated with MLT (Group A), and 16 eyes were treated with CL (Group B). We analyzed the best corrected visual acuity (BCVA) and retinal microstructural changes in spectral optical coherence tomography before the treatment, one and twelve months after the laser procedure. Results: The final mean BCVA was 0.89 ± 0.13 in Group A and 0.71 ± 0.17 in Group B. Photoreceptor length decreased significantly in both groups and amounted 61.2 μm in Group A and 42.9 μm in Group B one year after the treatment. Complete absorption of subretinal fluid twelve months after the laser procedure was noted in 74.3% eyes in Group A and in 87.5% eyes in group B. Hyper-reflective subretinal deposits were observed in 10/35 eyes in Group A but in 15/16 eyes in Group B on the final follow-up visit. Conclusion. MLT-treated patients showed better functional and microstructural results than patients treated with CL.

scholarly journals Comparison of Effects of Low Level Laser and Ultrasound Therapy in Plantar Fasciitis

2020 ◽  
Vol 5 (11) ◽  
pp. 510-515
Author(s):  
Fatima Mehmood ◽  
Dr. Aiesha Malik ◽  
Muhammad Zeeshan
Keyword(s):  
Plantar Fasciitis ◽  
Post Treatment ◽  
P Value ◽  
Ultrasound Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Group A ◽  
Pre Treatment ◽  
Group B

Plantar Fasciitis is among the major causes of heel pain. Mechanical stress of plantar aponeurosis usually causes inflammation thus result in problem with weight bearing and difficulty in walking. Pain often exacerbates and may stick at for months with unremitting activity, limiting the activities of daily living and the functional status. The objective of the study was to compare the effects of low level laser and ultrasound therapy in patients for pain and their functional status presents with plantar fasciitis. This study was a Quasi-experimental trial and conducted at Physical therapy Center for Arthritis & Rehabilitation Excellence (PT CARE), Gulberg III Lahore. The study completed in the time duration of six months (Aug 2019 – Jan 2020). Consecutive sampling technique was used to collect the data. A sample size of `total 28 patients were taken in this study; patients were divided into two groups. Conventional Physiotherapy protocol was given to both groups as baseline treatment. (Group A patients were treated with low level laser protocol whereas Group B was treated with ultrasound therapy protocol). Functional Foot Index (FFI) score was used to ask some questions related to patients symptoms and daily activities and to measure the intensity of pain Numeric Pain Rating Scale (NPRS) was used. All participants of the study filled the FFI & NPRS score and Numeric pain rating scale on day 1 in first cycle as pretreatment values and at the end of 5th session and 10th session as first and second cycles as post treatment values respectively. Data was analyzed on SPSS 21.The means of pre-treatment NPRS in group A was 7.78 and in group B means of pre-treatment NPRS was 7.35 with p value <0.05. Means difference of NPRS for group A was 4.07 and in group B the post treatment-1 means difference 4.85 with p value <0.05. Means of post treatment-2 in group A was 1.71 and in group B was 2.64 with p value <0.05. While means of pre-treatment in group A for FFI was 77.66 in group A and group B was 73.35 with p value <0.05. Means of post treatment-1 for group A for FFI was 54.50 and for group B 58.27 with p value <0.05. And means of post treatment-2 in FFI for group-A was 28.22 and for group B was 35.88 with p values <0.05. Low Level Laser Therapy is more effective than Ultrasound Therapy in reducing pain and improving functions in patients with plantar fasciitis and vice versa.

scholarly journals Single Layer Extra-Mucosal Interrupted Anastomoses; Revalidated

2015 ◽  
Vol 2 (1) ◽  
pp. 22-26
Author(s):  
Bilal Khattak ◽  
Faiz -Ur- Rahman ◽  
Irfan -Ul-Islam Nasir ◽  
Muhammad Iftikhar ◽  
Imtiaz Ahmad Khattak ◽  
...  
Keyword(s):  
Comparative Study ◽  
Double Layer ◽  
Intestinal Anastomosis ◽  
Single Layer ◽  
P Value ◽  
Burst Abdomen ◽  
Group A ◽  
Prospective Comparative Study ◽  
Anastomosis Leakage ◽  
Group B

Objective:To evaluate the safety regarding anastomotic failure of single layer interrupted extra mucosal intestinal anastomosis in comparison with double layer intestinal anastomosisMethodology:This prospective comparative study was conducted in surgical A unit of Lady reading Hospital Peshawar from 1st June 2007 to 1st February 2008 (8 months).Patients were divided into two groups, each comprising 60 patients. First 60 consecutive patients were included in Group A, for single layer extra mucosal anastomosis while Group B included last 60 consecutive patients for double layer inverting anastomosis (continuous inner and interrupted outer Lambert sutures). All the cases were admitted through OPD and emergency. The safety of two techniques of anastomosis was analyzed by comparing the outcome in terms of complications.Results:In this study, anastomosis leakage occurred only in 4 (3.33%) patients, one (1.67%) in group A and three (5%) in group B with a P-Value 0.138. Mean age of patient in group A was 36.15 years (+/- 6.0 years) and in group B was 33.25 years (+/- 5.5 years).Conclusion:Single layer extra-mucosal anastomosis has least anastomotic leakage and other complication like wound infection, septicemia, and collection and burst abdomen than in patients with double layer investing anastomosis.

scholarly journals APGAR SCORE OF NEONATE

2006 ◽  
Vol 13 (02) ◽  
pp. 175-177
Author(s):  
ANEEL ASLAM ◽  
FAWAD ALAM ◽  
ADEEL ASLAM
Keyword(s):  
Comparative Study ◽  
Apgar Score ◽  
P Value ◽  
Induction Agent ◽  
Mask Ventilation ◽  
Significant Difference ◽  
Group A ◽  
Group B

A comparative study was conducted in CMH, Malir, CMH, Kharian andWT (Pvt) Ltd. Gynaecology and Obstetrics, Multan from April 2001 to March 2004. The Apgar score of neonate wascompared for thiopentone or propofol in C-section patients. Two groups of patients were made. Group-A was inducedwith thiopentone and group-B was induced with propofol. Each group had 100 patients. In group-A 13 neonatesrequired manipulation and 2 neonates in group-B also required manipulation like mask ventilation or endotrachealintubation and one of drugs like atropine to improve apgar score. 13% neonates in group-A and 1% neonates in group-B required manipulation. This clearly shows the superiority of propofol over thiopentone as an induction agent in Csection.The P value of group-A was 0.13 and for group B was 0.02 and had had a statistically significant difference.

scholarly journals A comparative study of 25µg versus 50µg vaginal misoprostol for induction of labour at term premature rupture of membrane

2017 ◽  
Vol 6 (4) ◽  
pp. 1511
Author(s):  
Renu K. Sinha ◽  
Santoshi Gupta
Keyword(s):  
Comparative Study ◽  
Induction Of Labour ◽  
P Value ◽  
Premature Rupture ◽  
Spontaneous Vaginal Delivery ◽  
Misoprostol Group ◽  
Group A ◽  
Vaginal Misoprostol ◽  
Group B ◽  
Foetal Infection

Background: At term, infection remains the most serious complication associated with PROM for the mother and the neonate Induction of labour significantly reduces the risk of maternal and foetal infection. This randomized comparative study has been done to compare the effectiveness and safety of low and high dosage (25 mcg and 50mcg) regimen of vaginal misoprostol for induction in term PROM patients.Methods: At term, infection remains the most serious complication associated with PROM for the mother and the neonate Induction of labour significantly reduces the risk of maternal and foetal infection. This randomized comparative study has been done to compare the effectiveness and safety of low and high dosage (25 mcg and 50mcg) regimen of vaginal misoprostol for induction in term PROM patients.Results: PROM to delivery interval was significantly shorter with 50mcg vaginal misoprostol as compared to 25 mcg vaginal misoprostol (15.71±3.29 hours vs. 18.23±3.23 hours, (p value = 0.0023) Number of doses required was less with 50mcg vaginal misoprostol group as compared to 25mcg vaginal misoprostol (1.22±0.42 vs. 1.91±0.80, p value <0.05). 83.6% women in group A and 69.09% women in group B underwent spontaneous vaginal delivery within 24 hours. 3.64% women in group A and 7.27% in group B had instrumental delivery. Caesarean section was performed in 12.27% cases in group A and 23.64% cases in group B. The complication rate was comparable.Conclusions: 50mcg vaginal misoprostol is more effective and safe for induction of labour at term PROM as compared to 25 mcg vaginal misoprostol 

scholarly journals Comparative study of linear closure technique versur purse string closure technique of skin closure in stoma reversal.

2020 ◽  
Vol 27 (05) ◽  
pp. 1038-1042
Author(s):  
M. Rehman Gulzar ◽  
Faiqa Aslam ◽  
Muhammad Umar Farooq ◽  
Shahbaz Ahmad ◽  
Sabeen Adil ◽  
...  
Keyword(s):  
Wound Healing ◽  
Comparative Study ◽  
Surgical Site Infection ◽  
P Value ◽  
Site Infection ◽  
Closure Technique ◽  
Purse String ◽  
Group A ◽  
Group B ◽  
Wound Length

Objectives: To compare the results of linear closure technique with purse string closure technique in terms of surgical site infection, wound healing (scar cosmesis) and wound length. Study Design: Comparative Study. Setting: Surgical Unit V, Faisalabad Medical University, Faisalabad. Period: January 2016 to January 2019. Material & Methods: A total of 100 patients were operated in our unit during the study period & were allocated into two groups randomly: Group A (Linear closure) Group B (Purse string closure) included 50 patients in each group. The primary outcome measures were, surgical site infection, wound healing (scar cosmesis) and wound length. Results: During follow up period Surgical site infection was noted in 17 patients out of 100 with 14 patients in Group A and 03 Patients in Group B (p value 0.002). Regarding wound healing 60% patients were having good scar and 20% patients were having satisfactory and 20% having poor scar in Group A. while in Group B 82% patients were having good scar and 18% patients were having satisfactory scar (p value 0.00). Mean wound length in Group A was 5.14 with SD 1.2978 while in Group B mean length was 3.8 with SD 1.3095. Conclusion: Our study concludes that purse string closure is superior to linear closure technique in terms of surgical site infection, wound healing (scar cosmesis) and wound length.

A Comparative Study between Apamarga Pratisaraniya Kshara and Shireesha Beejadi Lepa in the management of Arsha

2018 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. Chandrashekhar . ◽  
Dr. Pallavi A. Hegde
Keyword(s):  
Comparative Study ◽  
Clinical Features ◽  
P Value ◽  
Inclusion Criteria ◽  
Group A ◽  
Bleeding Per Rectum ◽  
Group B

Background: Arsha is fleshy projection that pains like an enemy and creates obstruction in Guda Marga which can be compared with haemorrhoids and one among the Astamahagada. Arsha presents with clinical features as bleeding per rectum, prolapse, feeling of mass, pain, anaemia. Peak age is 4rd to 6th decade while majority of patients report regarding onset of disease in 5th decade of life and increased prevalence in women compared with men. Objectives of the Study: To compare the efficacy of Shireesha Beejadi Lepa over Apamarga Pratisaraniya Kshara in the management of Arsha with special refence to Internal Haemorrhoids. Methods: 30 patients were selected on the basis of inclusion criteria and divided into 2 groups with 15 patients in each group by computerized random technique. Group A was treated with Apamarga Pratisaraniya Kshara, while Group B was treated with Shireesha Beejadi Lepa. Results: It was found that the main clinical features like Pain were reduced 84.09% in Group A and 90.90% in Group B, Bleeding per Rectum were 68.18% in Group A and 86.36% in Group B. Colour of Pile mass changes of 75% in Group A and 81.81% in Group B. Size of Pilemass reduced 70.45% in Group A and 68.18% in group B after 7th day of treatment. Conclusion: Apamarga Pratisaraniya Kshara had significant result over Shireesha Beejadi Lepa Yoga in both subjective and objective parameters with P value less than 0.0001

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