Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia

Objective: There are limited studies in Latin America regarding the chronic consequences of the Chikungunya virus (CHIK), such as post-CHIK chronic inflammatory rheumatism (pCHIK-CIR). We assessed the largest cohort so far of pCHIK-CIR in Latin America, at the municipality of La Virginia, Risaralda, a new endemic area of CHIK in Colombia.Methods: We conducted a cohort retrospective study in Colombia of 283 patients diagnosed with CHIK that persisted with pCHIK-CIR after a minimum of 6 weeks and up to a maximum of 26.1 weeks. pCHIK cases were identified according to validated criteria via telephone.Results: Of the total CHIK-infected subjects, 152 (53.7%) reported persistent rheumatological symptoms (pCHIK-CIR). All of these patients reported joint pains (chronic polyarthralgia, pCHIK-CPA), 49.5% morning stiffness, 40.6% joint edema, and 16.6% joint redness. Of all patients, 19.4% required and attended for care prior to the current study assessment (1.4% consulting rheumatologists). Significant differences in the frequency were observed according to age groups and gender. Patients aged >40 years old required more medical attention (39.5%) than those ≤40 years-old (12.1%) (RR=4.748, 95%CI 2.550-8.840).Conclusions: According to our results, at least half of the patients with CHIK developed chronic rheumatologic sequelae, and from those with pCHIK-CPA, nearly half presented clinical symptoms consistent with inflammatory forms of the disease. These results support previous estimates obtained from pooled data of studies in La Reunion (France) and India and are consistent with the results published previously from other Colombian cohorts in Venadillo (Tolima) and Since (Sucre).

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Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia

F1000Research ◽

10.12688/f1000research.8235.2 ◽

2016 ◽

Vol 5 ◽

pp. 360 ◽

Cited By ~ 7

Author(s):

Alfonso J. Rodriguez-Morales ◽

Andrés F. Gil-Restrepo ◽

Valeria Ramírez-Jaramillo ◽

Cindy P. Montoya-Arias ◽

Wilmer F. Acevedo-Mendoza ◽

...

Keyword(s):

Latin America ◽

Clinical Symptoms ◽

Morning Stiffness ◽

Age Groups ◽

Medical Attention ◽

La Réunion ◽

Pooled Data ◽

Follow Up Study ◽

And Gender

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Concentrations of canine prostate specific esterase, CPSE, at baseline are associated with the relative size of the prostate at three-year follow-up

BMC Veterinary Research ◽

10.1186/s12917-021-02874-1 ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Bodil S. Holst ◽

Sofia Carlin ◽

Virginie Fouriez-Lablée ◽

Sofia Hanås ◽

Sofie Ödling ◽

...

Keyword(s):

Clinical Symptoms ◽

Specific Antigen ◽

Relative Size ◽

Clinical Signs ◽

Serum Concentrations ◽

Prostatic Disease ◽

Follow Up Study ◽

Prostate Size ◽

Prostate Growth

Abstract Background Enlargement of the prostate is associated with prostatic diseases in dogs, and an estimation of prostatic size is a central part in the diagnostic workup. Ultrasonography is often the method of choice, but biomarkers constitute an alternative. Canine prostate specific esterase (CPSE) shares many characteristics with human prostate specific antigen (PSA) and is related to prostate size. In men with clinical symptoms of prostatic disease, PSA concentrations are related to prostate growth. The aims of the present follow-up study were to evaluate if the concentration of CPSE is associated with future growth of the prostate, and if analysis of a panel of 16 steroids gives further information on prostatic growth. Owners of dogs included in a previous study were 3 years later contacted for a follow-up study that included an interview and a clinical examination. The prostate was examined by ultrasonography. Serum concentrations of CPSE were measured, as was a panel of steroids. Results Of the 79 dogs included at baseline, owners of 77 dogs (97%) were reached for an interview, and 22 were available for a follow-up examination. Six of the 79 dogs had clinical signs of prostatic disease at baseline, and eight of the remaining 73 dogs (11%) developed clinical signs between baseline and follow-up, information was lacking for two dogs. Development of clinical signs was significantly more common in dogs with a relative prostate size of ≥2.5 at baseline (n = 20) than in dogs with smaller prostates (n = 51). Serum concentrations of CPSE at baseline were not associated with the change in prostatic size between baseline and follow-up. Serum concentrations of CPSE at baseline and at follow-up were positively associated with the relative prostatic size (Srel) at follow-up. Concentrations of corticosterone (P = 0.024), and the class corticosteroids (P = 0.0035) were positively associated with the difference in Srel between baseline and follow-up. Conclusions The results support the use of CPSE for estimating present and future prostatic size in dogs ≥4 years, and the clinical usefulness of prostatic size for predicting development of clinical signs of prostatic disease in the dog. The association between corticosteroids and prostate growth warrants further investigation.

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Human Milk Antibodies Against SARS-CoV-2: A Longitudinal Follow-Up Study

Journal of Human Lactation ◽

10.1177/08903344211030171 ◽

2021 ◽

pp. 089033442110301

Author(s):

Hannah G. Juncker ◽

M. Romijn ◽

Veerle N. Loth ◽

Tom G. Caniels ◽

Christianne J.M. de Groot ◽

...

Keyword(s):

Human Milk ◽

Clinical Symptoms ◽

Immunoglobulin A ◽

Spike Protein ◽

Enzyme Linked Immunosorbent Assay ◽

Follow Up Study ◽

Lactating Mothers ◽

Milk Antibodies ◽

Over Time

Background: Human milk contains antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) following Coronavirus Disease 2019 (COVID-19). These antibodies may serve as protection against COVID-19 in infants. However, the evolution of these human milk antibodies over time is unclear. Research Aim: To elucidate the evolution of immunoglobulin A (IgA) against SARS-CoV-2 in human milk after a SARS-CoV-2 infection. Methods: This longitudinal follow-up study included lactating mothers ( N = 24) who had participated in the COVID MILK study. To assess the evolution of SARS-CoV-2 antibodies, serum and human milk samples were collected 14–143 days after the onset of clinical symptoms related to COVID-19. Enzyme-Linked ImmunoSorbent Assay was used to detect antibodies against the ectodomain of the SARS-CoV-2 spike protein. Results: SARS-CoV-2 antibodies remain present up to 5 months (143 days) in human milk after onset of COVID-19 symptoms. Overall, SARS-CoV-2 IgA in human milk seems to gradually decrease over time. Conclusion: Human milk from SARS-CoV-2 convalescent lactating mothers contains specific IgA antibodies against SARS-CoV-2 spike protein up to at least 5 months post-infection. Passive viral immunity can be transferred via human milk and may serve as protection for infants against COVID-19. Dutch Trial Register on May 1st, 2020, number: NL 8575, URL: https://www.trialregister.nl/trial/8575 .

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Use of antidepressants among Finnish family caregivers: a nationwide register-based study

Social Psychiatry and Psychiatric Epidemiology ◽

10.1007/s00127-021-02049-1 ◽

2021 ◽

Author(s):

Tuija M. Mikkola ◽

Hannu Kautiainen ◽

Minna Mänty ◽

Mikaela B. von Bonsdorff ◽

Hannu Koponen ◽

...

Keyword(s):

Relative Risk ◽

Family Caregivers ◽

High Intensity ◽

Matched Control ◽

Age Groups ◽

Control Population ◽

Defined Daily Doses ◽

Male Caregivers ◽

And Gender

Abstract Purpose The purpose of this study was to compare the use of antidepressants over 6 years between family caregivers providing high-intensity care and a matched control population using register-based data. Methods The study includes all individuals, who received family caregiver’s allowance in Finland in 2012 (n = 29,846 females, mean age 66 years; n = 12,410 males, mean age 71 years) and a control population matched for age, sex, and municipality of residence (n = 59,141 females; n = 24,477 males). Information on purchases of antidepressants, including the number of defined daily doses (DDD) purchased, between 2012 and 2017 was obtained from the national drugs reimbursement register. Results During the follow-up, 28.5% of female caregivers and 23.5% of the female controls used antidepressants, while the numbers for males were 21.1% and 16.4%, respectively. Adjusted for socioeconomic status, female caregivers used 43.7 (95% confidence interval 42.4–45.0) and their controls used 36.2 (35.3–37.2) DDDs of antidepressants per person-year. Male caregivers used 29.6 (27.6–31.6) and their controls used 21.6 (20.2–23.0) DDDs of antidepressants per person-year. Among female caregivers, the relative risk for use of antidepressants was similar (about 1.3) from 20 to 70 years, after which the relative risk declined. In male caregivers, the relative risk was highest (about 1.4–1.5) between 45 and 65 years. Conclusions Family caregivers providing high-intensity care use more antidepressants and hence, are likely to have poorer mental health than the age-matched general population in virtually all age groups. However, the magnitude of the higher use varies as a function of age and gender.

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An Evaluation of Survival of Space Maintainers: A Six-year Follow-up Study

The Journal of Contemporary Dental Practice ◽

10.5005/jcdp-6-1-74 ◽

2005 ◽

Vol 6 (1) ◽

pp. 74-84 ◽

Cited By ~ 9

Author(s):

Ozlem Tulunoglu ◽

Tezer Ulusu ◽

Yasemin Genç

Keyword(s):

Survival Time ◽

Success Rate ◽

Median Survival ◽

Median Survival Time ◽

Age Groups ◽

Age Group ◽

Follow Up Study ◽

Different Types ◽

Lost To Follow Up

Abstract The aim of this study was to evaluate the median survival time of fixed and removable space maintainers related to age groups, gender, and their distribution in upper and lower dental arches. The adherence of patients to a periodic recall program and the success rate of different types of space maintainers related to different arches were also evaluated. This study included 663 patients aged between 4-15 years old that were treated between the years of 1997 and 2002. The patients were categorized into four main groups: lost to follow-up, failed, successful, and censored at the end of study. Three hundred forty-five space maintainers were considered lost to follow-up, 83 were considered failed, 206 successful, and 20 censored-at-end. The overall median survival time of the appliances was 6.51 months. Median survival time was 7.25 months in the 4-6 age group, 6.35 months in the 7-12 age group, and 7.0 months in the 13+ age groups. Median survival time was 5.76 months in girls and 7.11 months in boys. Median survival time of space maintainers was 7.17 months for maxilla and 6.69 months in the mandible. Median survival time was 5.25 months for space maintainers fabricated in both arches. Citation Tulunoglu Ö, Ulusu T, Genç Y. An Evaluation of Survival of Space Maintainers: A Six-year Follow-up Study J Contemp Dent Pract 2005 February;(6)1:074-084.

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Working memory performance in relation to clinical symptoms in schizophrenia patients: A4-month follow-up study

Schizophrenia Research ◽

10.1016/s0920-9964(97)82384-5 ◽

1997 ◽

Vol 24 (1-2) ◽

pp. 135

Author(s):

Sohee Park ◽

Jörg Püschel ◽

David A. Moore ◽

Ann Ragin ◽

Christine Hooker ◽

...

Keyword(s):

Working Memory ◽

Clinical Symptoms ◽

Memory Performance ◽

Follow Up Study

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A Longitudinal Study of Atlanto-Dens Relationships in Asymptomatic Individuals with Down Syndrome

PEDIATRICS ◽

10.1542/peds.89.6.1194 ◽

1992 ◽

Vol 89 (6) ◽

pp. 1194-1198 ◽

Cited By ~ 1

Author(s):

Siegfried M. Pueschel ◽

Francis H. Scola ◽

John C. Pezzullo

Keyword(s):

Down Syndrome ◽

Clinical Symptoms ◽

Age Groups ◽

Atlantoaxial Instability ◽

History Of ◽

Child Development Center ◽

Asymptomatic Individuals ◽

Development Center ◽

Over Time

This study was designed to investigate the natural history of atlantoaxial instability in individuals with Down syndrome and to determine whether significant changes in C1-C2 relationship are taking place over time. Although more than 400 patients with Down syndrome who are presently followed at the Child Development Center had cervical spine radiographic examinations in the past, only 141 patients who had serial radiological examinations and whose radiographs were available for reevaluation participated in this study. The results of our investigations revealed that there were only minor changes (1 to 1.5 mm) of atlanto-dens interval measurements over time in 130 (92%) patients with Down syndrome. Eleven patients (8%) had changes of atlanto-dens interval measurements between 2 and 4 mm over time; however, none of these patients had any clinical symptoms. The analyses of data obtained from several subgroups (males and females, various age groups, and patients with and without atlantoaxial instability) did not show any significant changes of atlanto-dens interval measurements of successively obtained radiographs. Our recommendations for and rationale of routine screening for atlantoaxial instability and follow-up examinations are discussed in detail.

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Follow-up Study of Recurrent Parotitis in Children

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948809700403 ◽

1988 ◽

Vol 97 (4) ◽

pp. 341-346 ◽

Cited By ~ 46

Author(s):

Åke Geterud ◽

Ann-Marie Lindvall ◽

Olle Nyléan

Keyword(s):

Clinical Symptoms ◽

Rare Condition ◽

Follow Up Study ◽

Age Independent

Recurrent parotitis in children is a well-described but rare condition of unknown cause. In this follow-up investigation the long-term course of the disease was studied both clinically and radiographically. In 23 of 25 patients investigated, the clinical symptoms disappeared before the patients were 22 years of age, independent of a given therapy. However, sialographic changes, mostly in the form of sialectasis, were seen on follow-up in the majority of cases, in spite of the fact that the patients were clinically symptom free.

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