THE CHANGE OF HORMONAL STATUS IN WOMEN WITN INFLUENZA VIRUS A(H3N2) IN THE FIRST TRIMESTER OF PREGNANCY

The contents of β-subunit of chorionic gonadotropin (β-CG), estriol, progesterone, dehydroepiandrosterone (DEAS), placental lactogen and cortisol were studied in 164 women of child-bearing age at the 7-9th weeks of pregnancy. The first group (control) consisted of 30 women with physiologic course of pregnancy. The second group (comparison) had 32 patients with the threat of premature delivery of non-infectious etiology. The third group included 36 patients with influenza virus А(Н3N2) (anti-virus antibody titers were 1:4-1:16); the fourth group had 34 women with influenza virus А(Н3N2) (antibody titers were 1:8-1:32); in the fifth group there were 32 patients with influenza virus А(Н3N2) (antibody titers were 1:32-1:128) and the threat of premature delivery in the period of reconvalescence. The patients of the fifth group had the decrease of the level of β-CG till 40.5±2.0 mМЕ/ml, of estriol till 3.4±0.21 nmole/l, of progesterone till 35.1±3.13 nmole/l, of DEAS till 7.3±0.68 nmole/l, of placental lactogen till 12.1±1.0 nmole/l, as well as the increase of cortisol till 738.7±22.08 nmole/l in comparison with 73.0±2.0 mМЕ/ml (р<0.001), 5.9±0.33 nmole/l (р<0.001), 70.6±4.14 nmole/l (р<0.001); 7.3±0.68 nmole/l (р<0.001), 12.1±1.0 nmole/l (р<0.001) and 567.8±24.02 nmole/l (р<0.001) in the first group, respectively. The differences of hormonal status in the fifth and third group consisted of the drop of concentration of β-CG by 22.8% (р<0.001), of estriol by 26.1% (р<0.01), of progesterone by 32.1% (р<0.001) and placental lactogen by 32.4% (р<0.001). At the same time there were no significant changes in the concentration of DEAS and there were registered higher indicators of cortisol, i.e. the increase by 11.5% (р<0.05), which suggested the significance of the growth of antivirus antibody titers in the suppression of synthesis of hormones in ovaries and in syncytiotrophoblast as a result of direct and indirect negative influence of influenza infection.

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EFFECT OF CYTOMEGALOVIRUS INFECTION ON PROGESTERONE CONVERSION INTO A METABOLITE 5α-PREGNAN-3.20-DIONE IN THE PLACENTA IN EARLY PREGNANCY

Bulletin physiology and pathology of respiration ◽

10.12737/article_5a9f265a108f03.54183370 ◽

2018 ◽

Vol 1 (67) ◽

pp. 50-54

Author(s):

Инна Довжикова ◽

Inna Dovzhikova ◽

Ирина Андриевская ◽

Irina Andrievskaya ◽

Ксения Петрова ◽

...

Keyword(s):

Nervous System ◽

Cytomegalovirus Infection ◽

First Trimester ◽

Control Group ◽

Reaction Products ◽

Latent Stage ◽

Hardware Complex ◽

Enzyme Method ◽

Antibody Titers ◽

First Trimester Of Pregnancy

The aim was to study the activity of progesterone and 5α-pregnan-3.20-dione conversion in the placenta at the exacerbation of cytomegalovirus infection (CMVI) during the first trimester of pregnancy. The study material included 50 villous chorions taken during medical abortions in the period of 8-10 weeks from women with exacerbation of chronic CMVI during pregnancy. The control group had 35 villous chorions of pregnant women of the same gestation period with chronic CMVI in the latent stage. Diagnosis of CMVI was performed taking into account the activity of CMVI with the immune-enzyme method by the level of antibodies of IgM and antibody titers of IgG in the paired serums in dynamics in 10 days. The progesterone content was determined at the “Stat Fax-2100ˮ spectrophotometer. The activity of 4-pregnene-3.20-dione dehydrogenase and 5α-pregnane-3.20-dione dehydrogenase was assessed by the histochemical method. Quantitative evaluation of the reaction products was carried out on sections under the microscope “Meiji Technoˮ connected to the software-hardware complex “SCION Corporationˮ. It was found out that progesterone content in villous chorions of women with reactivation of CMVI during pregnancy was reduced to 21.5±2.73 nmol/L in comparison with the control group (53.4±3.70 nmol/L, p<0.001). The disturbance of progesterone inversion intensiveness in placenta was proved by the decrease of enzyme activity: of 4-pregnene-3.20-dione dehydrogenase till 15.9±0.47 standard units (in control it was 28.6±0.58 standard units, p<0.001) and of 5α-pregnan-3.20-dione till 16.2±1.11 standard units (in control it was 25.0±1.91 standard units, p<0.001). Reduction in the intensity of progesterone conversion into 5α-dihydroprogesterone (5α-pregnan-3.20-dione) in the placenta with the exacerbation of CMVI can negatively affect the formation and functioning of the fetal nervous system.

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SYSTEM INFLAMMATORY RESPONSE AT THE EXACERBATION OF CHRONIC SIMPLE BRONCHITIS CAUSED BY INFLUENZA VIRUS B IN WOMEN IN THE FIRST TRIMESTER OF PREGNANCY

Bulletin physiology and pathology of respiration ◽

10.12737/20123 ◽

2016 ◽

Vol 1 (60) ◽

pp. 67-69

Author(s):

Смирнова ◽

Tatyana Smirnova ◽

Резник ◽

Vadim Reznik ◽

Одиреев ◽

...

Keyword(s):

Influenza Virus ◽

Inflammatory Cytokines ◽

First Trimester ◽

Fourth Group ◽

The Third ◽

Early Stages ◽

Tnf Α ◽

Antibody Titers ◽

Anti Inflammatory ◽

Pro Inflammatory Cytokines

The contents of anti-inflammatory and pro-inflammatory cytokines in 95 women in the first trimester of gestation were studied. The first (control) group included 25 women with physiologic course of pregnancy; the second group consisted of 25 patients with exacerbation of chronic simple bronchitis caused by influenza virus B (antibody titers were 1:16-1:64); the third group consisted of 24 pregnant women with exacerbation of chronic simple bronchitis under influenza virus В (antibody titers were 1:32-1:128); the fourth group consisted of 21 women with exacerbation of chronic simple bronchitis induced by influenza virus B (antibody titers were 1:64-1:256) at early stages of gestation. In the patients of the second group in comparison with the patients of the first group there was an increase of IL-4 till 19.7±2.17 pg/ml, of TNF-α till 33.4±3.09 pg/ml and of INF-γ till 30.9±2.64 pg/ml (in the control it was 12.9±1.16 pg/ml, р<0.01; 24.7±2.27 pg/ml, р<0.05 and 22.3±2.08 pg/ml, р<0.05, respectively). In the third group in comparison with the second group there was no growth of anti-inflammatory and pro-inflammatory cytokines. In the fourth group in comparison with the second group there was the biggest increase of IL-4 till 27.7±2.42 pg/ml (р<0.05), of TNF-α till 43.6±2.79 pg/ml (p<0.05) and of INF-γ till 40.7±2.96 pg/ml (p<0.05). This suggest the paramount importance of the growth of anti-virus antibodies titers in the pathogenesis of exacerbation of chronic simple bronchitis under influenza virus B in women at early stages of gestation.

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THE STATE OF HUMORAL IMMUNITY IN PAIRS “MOTHER-CHILD” AT INFLUENZA A(H3N2) IN THE FIRST TRIMESTER OF PREGNANCY

Bulletin physiology and pathology of respiration ◽

10.12737/21456 ◽

2016 ◽

Vol 1 (61) ◽

pp. 66-68

Author(s):

Луценко ◽

Mikhail Lutsenko ◽

Гориков ◽

Igor Gorikov ◽

Андриевская ◽

...

Keyword(s):

Antibody Titer ◽

Influenza A ◽

Influenza Infection ◽

First Trimester ◽

Full Term ◽

Fourth Group ◽

The Third ◽

Umbilical Blood ◽

Antibody Titers ◽

Somatic Diseases

At full-term pregnancy the level of anti-influenza antibodies in 126 pairs “mother-child” at influenza A(H3N2) in the first trimester of gestation was studied. The first group (comparison) was made of 40 pairs “mother-child” at pregnancy not complicated with acute respiratory virus infection, but with exacerbation of somatic diseases as well as moderate and severe somatic and obstetric pathology. The second group consisted of 43 pairs “mother-child” with influenza infection with antibody titer 1:4-1:16; the third group had 41 pairs “mother-child” with influenza А(Н3N2) with antibody titer 1:8-1:32; the fourth group had 42 pairs “mother-child” with influenza infection (antibody titers were 1:32-1:128) associated with the threat of miscarriage at early stages of gestation. It was found out that in the second group in 80% of cases mothers had higher titers of anti-virus antibodies in comparison with the titers of their children; in 12.5% of cases there were equal titers of antibodies in maternal and umbilical blood. In the second and the third groups unlike the first one there was a tendency to the decrease of a number of pairs that had higher titers of antibodies in mothers and there was an increase of pairs with equal titers of anti-virus antibodies. In the fourth group the number of pairs with domination of titers of anti-influenza antibodies increased till 28.6% in children in comparison with the titers in their mothers (in the second group it was in 4.7%, р<0.05), which suggested antenatal infecting of full term newborns.

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ULTRASOUND CHARACTERISTIC OF THYMUS GLAND IN MATURE NEWBORNS FROM MOTHERS WITH INFLUENZA A(H3N2) IN THE FIRST TRIMESTER OF PREGNANCY

Bulletin physiology and pathology of respiration ◽

10.12737/23254 ◽

2016 ◽

Vol 1 (62) ◽

pp. 68-71

Author(s):

Игорь Гориков ◽

Igor Gorikov ◽

Михаил Луценко ◽

Mikhail Lutsenko

Keyword(s):

Influenza Virus ◽

Antibody Titer ◽

Influenza A ◽

First Trimester ◽

Thymus Gland ◽

Fourth Group ◽

Influenza Virus A ◽

The Third ◽

Early Stages ◽

First Trimester Of Pregnancy

Ultrasound characteristic of thymus gland was studied in 109 mature newborns at the 3-5th days of life. All the examined patients were divided into 4 groups. The first group (control) included 30 healthy newborns of 38-40 weeks from mothers with physiologic course of pregnancy. The second group had 28 newborns whose mothers at early stages of gestation suffered influenza virus А(Н3N2) with antibody titer 1:4-1:16; in the third group there were 26 children of 38-40 weeks from mothers who suffered in the first trimester of pregnancy influenza virus A(H3N2) with antibody titer 1:8-1:32; the fourth group consisted of 25 newborns from mothers who suffered at early stages of gestation influenza virus A(H3N2) with antibody titer 1:32-1:128. The children in the second and the third group in comparison with the first one did not have any changes of organometric parameters of the immune organ. In the newborns of the fourth group the length of the thymus gland decreased till 3.8±0.11 cm, the width till 2.4±0.06 cm, the mass till 8.6±0.53 g and the volume of the organ till 6.0±0.37 sm3. In the first group these parameters were 4.2±0.09 cm (р<0.05), 2.8±0.05 cm (р<0.001), 10.5±0.37 g (р<0.01), 7.4±0.25 sm3 (р<0.01), respectively. This suggests the suppression of organogenesis of thymus in children with antenatal anamnesis burdened with influenza virus А(Н3N2) with antibody titer 1:32-1:128 in their mothers at early stages of gestation

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Catheter Directed Thrombolysis for Deep Vein Thrombosis during the First Trimester of Pregnancy: Two Case Reports

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2008.58.2.127 ◽

2008 ◽

Vol 58 (2) ◽

pp. 127

Author(s):

Kum Rae Kim ◽

Won Kyu Park ◽

Jae Woon Kim ◽

Woo Hyung Kwun ◽

Bo Yang Suh ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Case Reports ◽

First Trimester ◽

Vein Thrombosis ◽

Catheter Directed Thrombolysis ◽

First Trimester Of Pregnancy ◽

Deep Vein

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FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

Acta Endocrinologica ◽

10.1530/acta.0.0410123 ◽

1962 ◽

Vol 41 (1) ◽

pp. 123-128 ◽

Cited By ~ 6

Author(s):

Pentti A. Järvinen ◽

Sykkö Pesonen ◽

Pirkko Väänänen

Keyword(s):

Hyperemesis Gravidarum ◽

First Trimester ◽

Control Group ◽

Before And After ◽

Daily Urine ◽

First Trimester Of Pregnancy ◽

The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

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