ULTRASOUND CHARACTERISTIC OF THYMUS GLAND IN MATURE NEWBORNS FROM MOTHERS WITH INFLUENZA A(H3N2) IN THE FIRST TRIMESTER OF PREGNANCY

2016 ◽  
Vol 1 (62) ◽  
pp. 68-71
Author(s):  
Игорь Гориков ◽  
Igor Gorikov ◽  
Михаил Луценко ◽  
Mikhail Lutsenko
Keyword(s):  
Influenza Virus ◽  
Antibody Titer ◽  
Influenza A ◽  
First Trimester ◽  
Thymus Gland ◽  
Fourth Group ◽  
Influenza Virus A ◽  
The Third ◽  
Early Stages ◽  
First Trimester Of Pregnancy

Ultrasound characteristic of thymus gland was studied in 109 mature newborns at the 3-5th days of life. All the examined patients were divided into 4 groups. The first group (control) included 30 healthy newborns of 38-40 weeks from mothers with physiologic course of pregnancy. The second group had 28 newborns whose mothers at early stages of gestation suffered influenza virus А(Н3N2) with antibody titer 1:4-1:16; in the third group there were 26 children of 38-40 weeks from mothers who suffered in the first trimester of pregnancy influenza virus A(H3N2) with antibody titer 1:8-1:32; the fourth group consisted of 25 newborns from mothers who suffered at early stages of gestation influenza virus A(H3N2) with antibody titer 1:32-1:128. The children in the second and the third group in comparison with the first one did not have any changes of organometric parameters of the immune organ. In the newborns of the fourth group the length of the thymus gland decreased till 3.8±0.11 cm, the width till 2.4±0.06 cm, the mass till 8.6±0.53 g and the volume of the organ till 6.0±0.37 sm3. In the first group these parameters were 4.2±0.09 cm (р<0.05), 2.8±0.05 cm (р<0.001), 10.5±0.37 g (р<0.01), 7.4±0.25 sm3 (р<0.01), respectively. This suggests the suppression of organogenesis of thymus in children with antenatal anamnesis burdened with influenza virus А(Н3N2) with antibody titer 1:32-1:128 in their mothers at early stages of gestation

THE CHANGES IN CYTOKINS LEVEL AT THE EXACERBATION OF CHRONIC SIMPLE BRONCHITIS CAUSED BY VIRUS OF PARAINFLUENZA OF THE THIRD TYPE IN WOMEN IN THE FIRST TRIMESTER OF PREGNANCY

2016 ◽  
Vol 1 (62) ◽  
pp. 64-67
Author(s):  
Артем Колосов ◽  
Artem Kolosov ◽  
Татьяна Смирнова ◽  
Tatyana Smirnova ◽  
Вадим Резник ◽  
...  
Keyword(s):  
Antibody Titer ◽  
First Trimester ◽  
Interleukin 4 ◽  
Control Group ◽  
Fourth Group ◽  
The Third ◽  
Early Stages ◽  
Tnf Α ◽  
First Trimester Of Pregnancy ◽  
Ifn Γ

The contents of interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the blood serum were studied in 89 women in the first trimester of pregnancy. The first group (control) was made out of 25 women with uncomplicated pregnancy; the second had 23 women with the exacerbation of chronic simple bronchitis caused by parainfluenza of the 3rd type with antibody titer 1:16-1:64; the third one consisted of 21 patients with the exacerbation of chronic simple bronchitis induced by parainfluenza infection with antibody titers 1:32-1:128; the fourth group had 20 women with exacerbation of chronic simple bronchitis of parainfluenza etiology with antibody titer 1:64-1:256 at early stages of gestation. In the second group in comparison with the first one there were higher contents of IL-4: 21.1±2.00 pg/ml and INF-γ: 29.5±2.31 pg/ml than in the control group: 12.9±1.16 pg/ml (р<0.001) and 22.3±2.08 pg/ml (р<0.05), respectively. In the third group in comparison with the first one there were higher values of IL-4 (the growth by 132.6%, р<0.001), TNF-α (by 36%, p<0.01) and IFN-γ (by 43%, p<0.01). The patients in the fourth group in comparison with the third one did not have significant differences in TNF-α and IFN-γ. Buy there was the decrease of the level of IL-4 by 11.3% (р<0.05) that shows the imbalance of cytokines in women with exacerbation of chronic simple bronchitis caused by parainfluenza of the third type with antibody titer 1:64-1:256 at early stages of gestation. This may lead to persistent course of infectious-inflammatory process as well as to autoimmune damage of vital organs and the formation of initial placental insufficiency.

SYSTEM INFLAMMATORY RESPONSE AT THE EXACERBATION OF CHRONIC SIMPLE BRONCHITIS CAUSED BY INFLUENZA VIRUS B IN WOMEN IN THE FIRST TRIMESTER OF PREGNANCY

2016 ◽  
Vol 1 (60) ◽  
pp. 67-69
Author(s):  
Смирнова ◽  
Tatyana Smirnova ◽  
Резник ◽  
Vadim Reznik ◽  
Одиреев ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Inflammatory Cytokines ◽  
First Trimester ◽  
Fourth Group ◽  
The Third ◽  
Early Stages ◽  
Tnf Α ◽  
Antibody Titers ◽  
Anti Inflammatory ◽  
Pro Inflammatory Cytokines

The contents of anti-inflammatory and pro-inflammatory cytokines in 95 women in the first trimester of gestation were studied. The first (control) group included 25 women with physiologic course of pregnancy; the second group consisted of 25 patients with exacerbation of chronic simple bronchitis caused by influenza virus B (antibody titers were 1:16-1:64); the third group consisted of 24 pregnant women with exacerbation of chronic simple bronchitis under influenza virus В (antibody titers were 1:32-1:128); the fourth group consisted of 21 women with exacerbation of chronic simple bronchitis induced by influenza virus B (antibody titers were 1:64-1:256) at early stages of gestation. In the patients of the second group in comparison with the patients of the first group there was an increase of IL-4 till 19.7±2.17 pg/ml, of TNF-α till 33.4±3.09 pg/ml and of INF-γ till 30.9±2.64 pg/ml (in the control it was 12.9±1.16 pg/ml, р<0.01; 24.7±2.27 pg/ml, р<0.05 and 22.3±2.08 pg/ml, р<0.05, respectively). In the third group in comparison with the second group there was no growth of anti-inflammatory and pro-inflammatory cytokines. In the fourth group in comparison with the second group there was the biggest increase of IL-4 till 27.7±2.42 pg/ml (р<0.05), of TNF-α till 43.6±2.79 pg/ml (p<0.05) and of INF-γ till 40.7±2.96 pg/ml (p<0.05). This suggest the paramount importance of the growth of anti-virus antibodies titers in the pathogenesis of exacerbation of chronic simple bronchitis under influenza virus B in women at early stages of gestation.

THE STATE OF HUMORAL IMMUNITY IN PAIRS “MOTHER-CHILD” AT INFLUENZA A(H3N2) IN THE FIRST TRIMESTER OF PREGNANCY

2016 ◽  
Vol 1 (61) ◽  
pp. 66-68
Author(s):  
Луценко ◽  
Mikhail Lutsenko ◽  
Гориков ◽  
Igor Gorikov ◽  
Андриевская ◽  
...  
Keyword(s):  
Antibody Titer ◽  
Influenza A ◽  
Influenza Infection ◽  
First Trimester ◽  
Full Term ◽  
Fourth Group ◽  
The Third ◽  
Umbilical Blood ◽  
Antibody Titers ◽  
Somatic Diseases

At full-term pregnancy the level of anti-influenza antibodies in 126 pairs “mother-child” at influenza A(H3N2) in the first trimester of gestation was studied. The first group (comparison) was made of 40 pairs “mother-child” at pregnancy not complicated with acute respiratory virus infection, but with exacerbation of somatic diseases as well as moderate and severe somatic and obstetric pathology. The second group consisted of 43 pairs “mother-child” with influenza infection with antibody titer 1:4-1:16; the third group had 41 pairs “mother-child” with influenza А(Н3N2) with antibody titer 1:8-1:32; the fourth group had 42 pairs “mother-child” with influenza infection (antibody titers were 1:32-1:128) associated with the threat of miscarriage at early stages of gestation. It was found out that in the second group in 80% of cases mothers had higher titers of anti-virus antibodies in comparison with the titers of their children; in 12.5% of cases there were equal titers of antibodies in maternal and umbilical blood. In the second and the third groups unlike the first one there was a tendency to the decrease of a number of pairs that had higher titers of antibodies in mothers and there was an increase of pairs with equal titers of anti-virus antibodies. In the fourth group the number of pairs with domination of titers of anti-influenza antibodies increased till 28.6% in children in comparison with the titers in their mothers (in the second group it was in 4.7%, р<0.05), which suggested antenatal infecting of full term newborns.

Correlations Between the Values of Maternal Glycemia from the Last Trimester of Pregnancy and Fetal Birth Weight

2013 ◽  
Vol 20 (3) ◽  
pp. 259-265
Author(s):  
Monica Vereş ◽  
Aurel Babeş ◽  
Szidonia Lacziko
Keyword(s):  
First Trimester ◽  
Mean Value ◽  
Fetal Macrosomia ◽  
Entire Group ◽  
Third Trimester ◽  
The Third ◽  
Group I ◽  
Fetal Birth Weight ◽  
First Trimester Of Pregnancy ◽  
The Mean

Abstract Background and aims: Gestational diabetes represents a form of diabetes diagnosed during pregnancy that is not clearly overt diabetes. In the last trimester of gestation the growth of fetoplacental unit takes place, thus maternal hyperglycemia will determine an increased transplacental passage, hyperinsulinemia and fetal macrosomia. The aim of our study was that o analyzing the effect of maternal glycemia from the last trimester of pregnancy over fetal weight. Material and method: We run an observational study on a group of 46 pregnant women taken into evidence from the first trimester of pregnancy, separated in two groups according to blood glucose determined in the third trimester (before birth): group I normoglycemic and group II with hyperglycemia (>92mg/dl). Results: The mean value of third trimester glycemia for the entire group was of 87.13±22.03. The mean value of the glycemia determined in the third trimester of pregnancy was higher in the second group (109.17 mg/dl) in comparison to the first group (74.,21 mg/dl). The ROC curve for third trimester glycemia as fetal macrosomia appreciation test has an AUC of 0.517. Conclusions: Glycemia determined in the last trimester of pregnancy cannot be used alone as the predictive factor for fetal macrosomia.

scholarly journals A Lower Level of Post-Vaccinal Antibody Titer against Influenza Virus A H1N1 May Protect Patients with Autoimmune Rheumatic Diseases from Respiratory Viral Infections

Medicina ◽  
2022 ◽  
Vol 58 (1) ◽  
pp. 76
Author(s):  
Milomir S. Milanovic ◽  
Djordje M. Kadijevich ◽  
Ljudmila Stojanovich ◽  
Branislav Milovanovic ◽  
Aleksandra Djokovic
Keyword(s):  
Logistic Regression ◽  
Influenza Virus ◽  
Antibody Titer ◽  
Rheumatic Diseases ◽  
Disease Duration ◽  
Viral Infections ◽  
Binary Logistic Regression ◽  
Influenza Virus A ◽  
Autoimmune Rheumatic Diseases ◽  
Respiratory Viral Infections

Background and Objectives: The concentration of antibodies against virus influenza A H1N1 in the titer (≥1:32) positively correlates with resistance to flu in healthy persons. In elderly and immune-compromised patients, an influenza vaccine may be less immunogenic. Hypothesis: A lower post-vaccinal antibody titer (≥1:16) may be sero-protective against respiratory viral infections in patients with autoimmune rheumatic diseases. Materials and Methods: Fifty patients with autoimmune rheumatic diseases (Systemic Lupus Erythematosus—24; Rheumatoid Arthritis—15; and Sjögren’s Syndrome—11), who were at least 65 years old or whose relative disease duration (disease duration/age) was greater than 1/8, were examined. Thirty-four of them were vaccinated with a trivalent inactivated non-adjuvant influenza vaccine. The antibody concentration against influenza virus A H1N1 was measured using the standardized hemagglutination inhibition test and patients who got any respiratory viral infection were registered. To test the hypothesis, a correlative analysis was applied, followed by a binary logistic regression that included potential confounding variables, such as age, disease duration and therapy (personal/health-related conditions). Results: Vaccinated patients were significantly less affected by respiratory viral infections (21% vs. 75%). The lower titer considered (≥1:16) was significantly present more often among vaccinated patients (68% vs. 6%). The correlation between its presence/absence and that of respiratory viral infections was –0.34 (p < 0.05). The binary logistic regression evidenced the relevance of this correlation, confirming the hypothesis. Vaccination was associated with the 87.3% reduction in the likelihood of getting respiratory viral infections, whereas the lower antibody titer (≥1:16) was associated with the 77.6% reduction in the likelihood of getting respiratory viral infections. The vaccine was well tolerated by all patients and after vaccination no exacerbation of the underlying disease was observed. Conclusions: A lower antibody titer (≥1:16) against influenza virus A H1N1 could be protective against respiratory viral infections for certain autoimmune rheumatic diseases patients, which confirms the clinical effectiveness of influenza vaccination.

scholarly journals The model of prediction of the inhibition of neuraminidases of influenza A and B based on a reduced set of energy terms

2019 ◽  
Vol 65 (6) ◽  
pp. 520-525 ◽  
Author(s):  
A.V. Mikurova ◽  
V.S. Skvortsov
Keyword(s):  
Influenza Virus ◽  
Potential Energy ◽  
Correlation Coefficient ◽  
Influenza A ◽  
Protein Complexes ◽  
Computation Time ◽  
Inhibitor Protein ◽  
Data Set ◽  
Influenza Virus A ◽  
Calculation Procedures

The overall model for prediction of IC₅₀ values for inhibitors of neuraminidase influenza virus A and B has been created. It combines data about IC₅₀ values of complexes of 40 variants of neuraminidases of influenza A (7 serotypes) and B and three known inhibitors (oseltamivir, zanamivir, peramivir). The model also uses only data of enthalpy contributions to the potential energy of inhibitor/protein and substrate (MUNANA)/protein complexes. The calculation procedures are ported to use software with support of GPU accelerators, that significant decrease the computation time. The corresponding correlation coefficient (R²) for pIC₅₀ prediction was within 0.45-0.58, the SEM values of around 0.7 (the range of used pIC₅₀ data set is from 4.55 to 10.22).

scholarly journals Detection of severe acute respiratory syndrome coronavirus 2 and influenza viruses based on CRISPR-Cas12a

2020 ◽  
pp. 153537022096379
Author(s):  
Oraphan Mayuramart ◽  
Pattaraporn Nimsamer ◽  
Somruthai Rattanaburi ◽  
Naphat Chantaravisoot ◽  
Kritsada Khongnomnan ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Severe Acute Respiratory Syndrome ◽  
Influenza A ◽  
Limit Of Detection ◽  
Cross Reactivity ◽  
Influenza Viruses ◽  
Influenza B Virus ◽  
Influenza B ◽  
Influenza Virus A ◽  
B Virus

Due to the common symptoms of COVID-19, patients are similar to influenza-like illness. Therefore, the detection method would be crucial to discriminate between SARS-CoV-2 and influenza virus-infected patients. In this study, CRISPR-Cas12a-based detection was applied for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus, and influenza B virus which would be a practical and attractive application for screening of patients with COVID-19 and influenza in areas with limited resources. The limit of detection for SARS-CoV-2, influenza A, and influenza B detection was 10, 103, and 103 copies/reaction, respectively. Moreover, the assays yielded no cross-reactivity against other respiratory viruses. The results revealed that the detection of influenza virus and SARS-CoV-2 by using RT-RPA and CRISPR-Cas12a technology reaches 96.23% sensitivity and 100% specificity for SARS-CoV-2 detection. The sensitivity for influenza virus A and B detections was 85.07% and 94.87%, respectively. In addition, the specificity for influenza virus A and B detections was approximately 96%. In conclusion, the RT-RPA with CRISPR-Cas12a assay was an effective method for the screening of influenza viruses and SARS-CoV-2 which could be applied to detect other infectious diseases in the future.

scholarly journals Antigenicity and immunogenicity of equine influenza vaccines containing a Carbomer adjuvant

1994 ◽  
Vol 112 (2) ◽  
pp. 421-437 ◽  
Author(s):  
J. A. Mumford ◽  
H. Wilson ◽  
D. Hannant ◽  
D. M. Jessett
Keyword(s):  
Influenza Virus ◽  
Inverse Correlation ◽  
Clinical Disease ◽  
Influenza Vaccines ◽  
Aluminium Phosphate ◽  
Influenza Virus A ◽  
Equine Influenza ◽  
The Third ◽  
Virus Excretion ◽  
Antibody Levels

SUMMARYEquine influenza vaccines containing inactivated whole virus and Carbomer adjuvant stimulated higher levels and longer lasting antibody to haemagglutinin in ponies than vaccines of equivalent antigenic content containing aluminium phosphate adjuvants. Five months after the third dose of vaccine containing Carbomer adjuvant, ponies were protected against clinical disease induced by an aerosol of virulent influenza virus (A/equine/Newmarket/79, H3N8). In contrast ponies which received vaccine containing aluminium phosphate adjuvant were susceptible to infection and disease. There was an inverse correlation between prechallenge levels of antibody detected by single radial haemolysis (SRH) and duration of virus excretion, pyrexia and coughing. All ponies with antibody levels equivalent to SRH zones of ≥ 154 mm2 were protected against infection and all those with levels ≤ 85 mm2 were protected from disease.

scholarly journals EVALUATION OF THE RATIONALE OF NEFRECTOMY IN PREGNANT WOMEN WITH PURULENT GESTATIONAL PYELONEPHRITIS

2019 ◽  
Vol 19 (1-2) ◽  
pp. 157-162 ◽  
Author(s):  
A. N Zhdanova ◽  
M. B Pryanichnikova
Keyword(s):  
Urinary Tract ◽  
Caesarean Section ◽  
Pregnant Women ◽  
First Trimester ◽  
The Other ◽  
The Third ◽  
First Trimester Of Pregnancy

During the last 2 years, an increase in cases of purulent gestational pyelonephritis with severe course and 20 such cases have been revealed and reported. The average age of the patients was 25 years. The first trimester of pregnancy accounted for 10% of cases, the second - 40%; on the third - 50%. In 30% of women there were bilateral defects of kidneys. All patients were operated on. On the first day 12 of them underwent nephrectomy for carbunculosis; 8 women underwent pre-drainage of the urinary tract, which did not improve their condition, and also resulted in nephrectomy. Two patients had to terminate the pregnancy by Caesarean section at a later date, the children were alive; one of these women performed extirpation of the uterus with appendages, the other was subject to supravaginal amputation of the uterus.

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