The human fatigue under static and dynamic physical activity And adaptation mechanisms

10.12737/7590 ◽  
2015 ◽  
Vol 9 (1) ◽  
pp. 0-0 ◽  
Author(s):  
Зилов ◽  
V. Zilov ◽  
Еськов ◽  
V. Eskov ◽  
Борисова ◽  
...  

This review focuses on spinal and central mechanisms of fatigue associated with the implementation of adaptation programs. The morpho-functional correlations of the moto-neurons activity of the spinal cord, the activities of the functional systems of the human body, neurotransmitter systems, serotonergic, dopaminergic and noradrenergic systems in the mechanisms of fatigue were considered. The phases of the process of adaptation to physical loads as well as cumulative training effect were identified. The authors have identified and described the participation of the autonomic nervous system, glucocorticoids and other hormones and mediators in long-term adaptation to physical loads, in the transition from carbohydrate to fat type of energy metabolism. The stages of disadaptation and re-adaptation to physical activities (a manifestation of stress, rate adaptation, cybernetic principles of homeostasis) have been identified and described. The two-circuit system homeostasis: the autonomic (controlling) and myocardial-hemodynamic (controlled) was demonstrated and an hierarchy of control has been defined.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Robert F. Hoey ◽  
Daniel Medina-Aguiñaga ◽  
Fahmi Khalifa ◽  
Beatrice Ugiliweneza ◽  
Sharon Zdunowski ◽  
...  

AbstractSpinal cord epidural stimulation (scES) mapping at L5-S1 was performed to identify parameters for bladder and bowel inhibition and/or contraction. Using spinally intact and chronic transected rats of both sexes in acute urethane-anesthetized terminal preparations, scES was systematically applied using a modified Specify 5–6–5 (Medtronic) electrode during bladder filling/emptying cycles while recording bladder and colorectal pressures and external urethral and anal sphincter electromyography activity. The results indicate frequency-dependent effects on void volume, micturition, bowel peristalsis, and sphincter activity just above visualized movement threshold intensities that differed depending upon neurological intactness, with some sex-dependent differences. Thereafter, a custom-designed miniature 15-electrode array designed for greater selectivity was tested and exhibited the same frequency-dependent urinary effects over a much smaller surface area without any concurrent movements. Thus, select activation of autonomic nervous system circuitries with scES is a promising neuromodulation approach for expedient translation to individuals with SCI and potentially other neurologic disorders.


2021 ◽  
Vol 13 (5) ◽  
pp. 2439
Author(s):  
Alexis Espinoza-Salinas ◽  
Edgardo Molina-Sotomayor ◽  
Johnattan Cano-Montoya ◽  
Jose Antonio Gonzalez-Jurado

Autonomic nervous system function is an important predictor of physical fitness. The objective of this study was to find out the associations of autonomic activity parameters, lipid profile, insulin concentrations, and insulin resistance in overweight men with the level of physical activity. A descriptive and correlational study was carried out in 28 overweight men: 14 physically active (PA) and 14 physically inactive (PI). The following variables were assessed: Level of physical activity, HRV (heart rate variability), basal insulin, HOMA-IR index (Homeostasis Model Assessment Insulin-Resistance), and lipid profile. The main results show a positive correlation between the spectral parameters of the HRV and total cholesterol (r = 0.24), LDL (r = 0.59), VLDL (r = 0.86), and insulin (r = 0.88) of sedentary people, evidencing a directly proportional correlation with BMI. We conclude that weight gain and a sedentary lifestyle are associated with an increase in sympathetic discharge, which, in turn, is associated with an increase in lipid profile and insulin levels.


2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Guojia Du ◽  
Yandong Li ◽  
Pan Wu ◽  
Xin Wang ◽  
Riqing Su ◽  
...  

Abstract Background To explore central nervous system (CNS) involvement in this disease, from the perspectives of diagnosis, treatment, and misdiagnosis Methods Twenty-eight patients with CNS echinococcosis were included in this retrospective study, including 18 males (64.3%) and 10 (35.7%) females. The average age of all the patients were 23.5 years (ranged 4–60 years). Twenty-three (23) patients (82.1%) received the first surgical resection in our hospital. Five (5) patients (17.9%) gave up surgical treatment for multiple-organ hydatidosis and previous surgery history at other hospitals, and albendazole was applied for a long-term (3–6 months) adjunct therapy for the 5 patients. The average follow-up time was 8 years. Results For the 28 patients, 23 cases received surgical treatments, and the diagnosis was confirmed by pathological examinations. The diagnosis of 4 cases of brain echinococcosis and 2 cases of spinal cord echinococcosis could not be confirmed, resulting in a misdiagnosis rate of 21.4% (6/28). For the pathological examination, a total of 17 cases were infected with Echinococcus granulosus (including 2 cases of spinal cord echinococcosis), and 6 cases were infected with Echinococcus alveolaris. Conclusion The diagnosis should be specifically considered in endemic regions. The clinical features of CNS hydatidosis were intracranial space-occupying lesions. For the treatment, the surgical removal of cysts should be necessary. In addition, the adjuvant therapy with drug and intraoperative prophylaxis is also suggested. The misdiagnosis may have resulted from atypical clinical features and radiographic manifestations, as well as the accuracy of hydatid immunologic test.


2001 ◽  
Vol 5 (1) ◽  
pp. 146-156
Author(s):  
Giuseppe Riva

The paper presents an overview of the ergonomic/design issues of a VR-enhanced orthopaedic appliance to be used in rehabilitation of patients with Spinal Cord Injury. First, some design considerations are described and an outline of aims which the tool should pursue are given. Finally, the design issues are described focusing both on the development of a test-bed rehabilitation device and on the description of a preliminary study detailing the use of the device with a long-term SCI patient. The basis for this approach is that physical therapy and motivation are crucial for maintaining flexibility and muscle strength and for reorganizing the nervous system after SCIs.


Neurosurgery describes the surgical treatment and management of various disease processes that target the brain, spinal cord, and peripheral nervous system. The specialty is wide and varied as increasing numbers of neurological conditions can now be improved following neurosurgery; for example, some types of epilepsy respond to the insertion of a vagal nerve stimulator, Parkinson’s disease symptoms can be diminished with a deep brain stimulator, and intractable back pain may be improved following spinal surgery. Practitioners must be equipped with the knowledge and skills to care for these patients and meet their immediate and long-term needs.


Sensors ◽  
2019 ◽  
Vol 19 (12) ◽  
pp. 2820 ◽  
Author(s):  
Lucia Billeci ◽  
Alessandro Tonacci ◽  
Elena Brunori ◽  
Rossella Raso ◽  
Sara Calderoni ◽  
...  

Anorexia nervosa (AN) is associated with a wide range of disturbances of the autonomic nervous system. The aim of the present study was to monitor the heart rate (HR) and the heart rate variability (HRV) during light physical activity in a group of adolescent girls with AN and in age-matched controls using a wearable, minimally obtrusive device. For the study, we enrolled a sample of 23 adolescents with AN and 17 controls. After performing a 12-lead electrocardiogram and echocardiography, we used a wearable device to record a one-lead electrocardiogram for 5 min at baseline for 5 min during light physical exercise (Task) and for 5 min during recovery. From the recording, we extracted HR and HRV indices. Among subjects with AN, the HR increased at task and decreased at recovery, whereas among controls it did not change between the test phases. HRV features showed a different trend between the two groups, with an increased low-to-high frequency ratio (LF/HF) in the AN group due to increased LF and decreased HF, differently from controls that, otherwise, slightly increased their standard deviation of NN intervals (SDNN) and the root mean square of successive differences (RMSSD). The response in the AN group during the task as compared to that of healthy adolescents suggests a possible sympathetic activation or parasympathetic withdrawal, differently from controls. This result could be related to the low energy availability associated to the excessive loss of fat and lean mass in subjects with AN, that could drive to autonomic imbalance even during light physical activity.


2015 ◽  
Vol 3 (3) ◽  
pp. 197-205 ◽  
Author(s):  
Jill M. Wecht ◽  
Michael F. La Fountaine ◽  
John P. Handrakis ◽  
Christopher R. West ◽  
Aaron Phillips ◽  
...  

2019 ◽  
Vol 30 (8) ◽  
pp. 379-384
Author(s):  
Clare Gordon

Practice nurses are equipped to care for patients with long-term conditions such as diabetes, asthma and obesity. Therefore, says Clare Gordon, they are well placed to advise pregnant women on common physical activities they may undertake to maintain health and wellbeing It has long been recognised that regular physical activity and exercise enhance both physical and psychological wellbeing. The benefits of physical activity throughout the life span of an individual cannot be underestimated and it is no less important when a woman is planning to become, or is, pregnant. The World Health Organization (2010) note that physical inactivity is the fourth leading risk factor for global mortality and is attributed to 6% of deaths globally. This article explores the guidance for physical activity for the general population and how it then relates to the guidance available for women who are pregnant. This article considers some of the key benefits to a range of common physical activities that pregnant women may undertake. It also explores some of the information that practice nurses should be aware of and how physical activity may impact on several long-term health conditions such as asthma, diabetes and obesity.


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