Possible Protective Role of Date (Phoenix Dactylifera) against Flusilazole Induced Oxidative Stress in Male Albino Rats

Aim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a potential responsible mechanism. Therefore, we aimed to investigate the protective role of erdosteine against CsA-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Materials and methods: Wistar albino rats were randomly separated into four groups. Group 1 rats treated with sodium chloride served as the control, group 2 rats were treated with CsA, group 3 with CsA plus erdosteine, and group 4 with erdosteine alone. Animals were killed and blood samples were analyzed for blood urea nitrogen (BUN), serum creatinine (Cr), uric acid (UA), total protein (TP), and albumin (ALB) levels. Kidney sections were analyzed for malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as for histopathological changes. Results: In the CsA group, MDA, GSH-Px, BUN, and Cr levels were increased. The TP and ALB levels were decreased. These changes had been improved by erdosteine administration. Other biochemical parameters did not show any significant change. Conclusion: These results indicate that erdosteine produces a protective mechanism against CsA-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.

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Indium Titanium Oxide Nanoparticles Induced Hepatic Damage: Hepatoprotective Role of Novel 2-Imino-4-methyl-1, 2-Dihydropyrimido [5, 4C] Quinoline-5(6H)-one

Advances in Toxicology ◽

10.1155/2014/641813 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Dinesh Bheeman ◽

Sinjula Cheerothsahajan ◽

Sathish Sugumaran ◽

Sankaran Mathan ◽

Ramesh Mathan ◽

...

Keyword(s):

Oxidative Stress ◽

Titanium Oxide ◽

Total Protein ◽

Total Bilirubin ◽

Protective Role ◽

Albino Rats ◽

Oxide Nanoparticles ◽

Histopathological Changes ◽

Titanium Oxide Nanoparticles

Protective role of 2-imino-4-methyl-1, 2-dihydropyrimido [5, 4C] quinoline-5(6H)-one (IMDHPQ) in indium titanium oxide nanoparticles (InTiO NPs) induced hepatotoxicity was analyzed. InTiO NPs were synthesized and given orally to albino rats to assess their hepatotoxicity. NPs mediated oxidative stress and liver tissue pathology were analyzed. Altered antioxidants (GSH, GPx, and catalase) and, biochemical (SGOT, SGPT, ALP, total protein, and total bilirubin) and histopathological changes were observed due to the oxidative stress caused by InTiO NPs. Varying effects of IMDHPQ on each parameter were observed in the present study. The altered parameters of InTiO NPs exposed rats might be due to the oxidative stress caused by NPs and hepatoprotective or ameliorative efficacy of quinoline compound IMDHPQ on signaling and molecular mechanism needs further study.

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Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: The protective role of selenium

Archives of Biological Sciences ◽

10.2298/abs1001075t ◽

2010 ◽

Vol 62 (1) ◽

pp. 75-82 ◽

Cited By ~ 1

Author(s):

Ivana Trbojevic ◽

Branka Ognjanovic ◽

Natasa Djordjevic ◽

Snezana Markovic ◽

A.S. Stajn ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Membrane Lipids ◽

Redox Status ◽

Protective Role ◽

Male Rats ◽

Albino Rats ◽

Wistar Albino Rats ◽

Glutathione Redox

The role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.) alone or in combination. The results suggest that CP intoxication induces oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats.

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Protective role of garlic against malathion induced oxidative stress in male albino rats

Indian Journal of Animal Research ◽

10.18805/ijar.10712 ◽

2016 ◽

Vol 50 (3) ◽

Cited By ~ 1

Author(s):

Gamila A. M. Kotb ◽

Farag A.A. Gh ◽

Kholoud S Ramadan ◽

Hoda E.A. Farid

Keyword(s):

Oxidative Stress ◽

Ache Activity ◽

Protein Pattern ◽

Experimental Period ◽

Protective Role ◽

Oxidative Stress Marker ◽

Albino Rats ◽

Stress Markers ◽

Therapeutic Properties

The garlic has been widely used as medicinal plant for its therapeutic properties This study was aimed to investigate the antioxidant role of garlic (G) against oxidative stress induced by malathion (M) in male albino rats. After experimental period (28 days), the study investigated some biochemical parameters and oxidative stress markers in plasma rats. The results revealed that, malathion induced significant increase in plasma Tri-iodothyronine (T<sub>3</sub>), Thyroxin (T<sub>4</sub>), glucose values and malondialdehyde (MDA) as oxidative stress marker was noticed. However, significant decrease was recorded in cholesterol, total protein (T. Protein) contents and in defense system biomarker total SH- protein. Acetylcholinesterase (AChE) activity was inhibited by malathion treatment and cause alteration in non-specific esterase and protein pattern. Finally, these results concluded that garlic has significant protection against malathion intoxication demonstrated inhibition in acetyl cholinesterase (AChE) activity and reduced in cholesterol, T. protein and total SH- protein. Further studies are necessary to investigate the significant effect of garlic on thyroid gland, brain and neurotransmitters.

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