Protective role of garlic against malathion induced oxidative stress in male albino rats

2016 ◽  
Vol 50 (3) ◽  
Author(s):  
Gamila A. M. Kotb ◽  
Farag A.A. Gh ◽  
Kholoud S Ramadan ◽  
Hoda E.A. Farid
Keyword(s):  
Oxidative Stress ◽  
Ache Activity ◽  
Protein Pattern ◽  
Experimental Period ◽  
Protective Role ◽  
Oxidative Stress Marker ◽  
Albino Rats ◽  
Stress Markers ◽  
Therapeutic Properties

The garlic has been widely used as medicinal plant for its therapeutic properties This study was aimed to investigate the antioxidant role of garlic (G) against oxidative stress induced by malathion (M) in male albino rats. After experimental period (28 days), the study investigated some biochemical parameters and oxidative stress markers in plasma rats. The results revealed that, malathion induced significant increase in plasma Tri-iodothyronine (T<sub>3</sub>), Thyroxin (T<sub>4</sub>), glucose values and malondialdehyde (MDA) as oxidative stress marker was noticed. However, significant decrease was recorded in cholesterol, total protein (T. Protein) contents and in defense system biomarker total SH- protein. Acetylcholinesterase (AChE) activity was inhibited by malathion treatment and cause alteration in non-specific esterase and protein pattern. Finally, these results concluded that garlic has significant protection against malathion intoxication demonstrated inhibition in acetyl cholinesterase (AChE) activity and reduced in cholesterol, T. protein and total SH- protein. Further studies are necessary to investigate the significant effect of garlic on thyroid gland, brain and neurotransmitters.

Effects of erdosteine on cyclosporin-A-induced nephrotoxicity

2011 ◽  
Vol 31 (6) ◽  
pp. 565-573 ◽  
Author(s):  
M Tutanc ◽  
V Arica ◽  
N Yılmaz ◽  
A Nacar ◽  
I Zararsiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cyclosporin A ◽  
Protective Role ◽  
Control Group ◽  
Albino Rats ◽  
Protective Mechanism ◽  
Antioxidant Parameters ◽  
Group 2 ◽  
Wistar Albino Rats

Aim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a potential responsible mechanism. Therefore, we aimed to investigate the protective role of erdosteine against CsA-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Materials and methods: Wistar albino rats were randomly separated into four groups. Group 1 rats treated with sodium chloride served as the control, group 2 rats were treated with CsA, group 3 with CsA plus erdosteine, and group 4 with erdosteine alone. Animals were killed and blood samples were analyzed for blood urea nitrogen (BUN), serum creatinine (Cr), uric acid (UA), total protein (TP), and albumin (ALB) levels. Kidney sections were analyzed for malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as for histopathological changes. Results: In the CsA group, MDA, GSH-Px, BUN, and Cr levels were increased. The TP and ALB levels were decreased. These changes had been improved by erdosteine administration. Other biochemical parameters did not show any significant change. Conclusion: These results indicate that erdosteine produces a protective mechanism against CsA-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.

scholarly journals Indium Titanium Oxide Nanoparticles Induced Hepatic Damage: Hepatoprotective Role of Novel 2-Imino-4-methyl-1, 2-Dihydropyrimido [5, 4C] Quinoline-5(6H)-one

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Dinesh Bheeman ◽  
Sinjula Cheerothsahajan ◽  
Sathish Sugumaran ◽  
Sankaran Mathan ◽  
Ramesh Mathan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Titanium Oxide ◽  
Total Protein ◽  
Total Bilirubin ◽  
Protective Role ◽  
Albino Rats ◽  
Oxide Nanoparticles ◽  
Histopathological Changes ◽  
Titanium Oxide Nanoparticles

Protective role of 2-imino-4-methyl-1, 2-dihydropyrimido [5, 4C] quinoline-5(6H)-one (IMDHPQ) in indium titanium oxide nanoparticles (InTiO NPs) induced hepatotoxicity was analyzed. InTiO NPs were synthesized and given orally to albino rats to assess their hepatotoxicity. NPs mediated oxidative stress and liver tissue pathology were analyzed. Altered antioxidants (GSH, GPx, and catalase) and, biochemical (SGOT, SGPT, ALP, total protein, and total bilirubin) and histopathological changes were observed due to the oxidative stress caused by InTiO NPs. Varying effects of IMDHPQ on each parameter were observed in the present study. The altered parameters of InTiO NPs exposed rats might be due to the oxidative stress caused by NPs and hepatoprotective or ameliorative efficacy of quinoline compound IMDHPQ on signaling and molecular mechanism needs further study.

scholarly journals Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: The protective role of selenium

2010 ◽  
Vol 62 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Ivana Trbojevic ◽  
Branka Ognjanovic ◽  
Natasa Djordjevic ◽  
Snezana Markovic ◽  
A.S. Stajn ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Membrane Lipids ◽  
Redox Status ◽  
Protective Role ◽  
Male Rats ◽  
Albino Rats ◽  
Wistar Albino Rats ◽  
Glutathione Redox

The role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.) alone or in combination. The results suggest that CP intoxication induces oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats.

scholarly journals Bisphenol-A induced oxidative stress, inflammatory gene expression, and metabolic and histopathological changes in male Wistar albino rats: protective role of boron

2019 ◽  
Vol 8 (2) ◽  
pp. 262-269 ◽  
Author(s):  
Ulas Acaroz ◽  
Sinan Ince ◽  
Damla Arslan-Acaroz ◽  
Zeki Gurler ◽  
Hasan Huseyin Demirel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Bisphenol A ◽  
Protective Role ◽  
Albino Rats ◽  
Histopathological Changes ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene ◽  
Wistar Albino Rats

Boron reversed Bisphenol-A induced alterations.

scholarly journals Diosmin Mitigates Cyclophosphamide Induced Premature Ovarian Insufficiency in Rat Model

2021 ◽  
Vol 22 (6) ◽  
pp. 3044
Author(s):  
Noha M. Abogresha ◽  
Sally S. Mohammed ◽  
Marwa M. Hosny ◽  
Hoda Y. Abdallah ◽  
Ahmed M. Gadallah ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Target Genes ◽  
Histopathological Examination ◽  
Protective Role ◽  
Premature Ovarian Insufficiency ◽  
Albino Rats ◽  
High Dose ◽  
Ovarian Insufficiency ◽  
Stress Markers ◽  
Intraperitoneal Dose

The current study was designed to investigate the protective role of diosmin against cyclophosphamide-induced premature ovarian insufficiency (POI). Female Swiss albino rats received a single intraperitoneal dose of cyclophosphamide (200 mg/kg) followed by 8 mg/kg/day for the next 15 consecutive days either alone or in combination with oral diosmin at 50 or 100 mg/kg. Histopathological examination of ovarian tissues, hormonal assays for follicle stimulating hormone (FSH), estradiol (E2), and anti-Mullerian hormone (AMH), assessment of the oxidative stress status, as well as measurement of the relative expression of miRNA-145 and its target genes [vascular endothelial growth factor B (VEGF-B) and regulator of cell cycle (RGC32)] were performed. Diosmin treatment ameliorated the levels of E2, AMH, and oxidative stress markers. Additionally, both low and high diosmin doses significantly reduced the histopathological alterations and nearly preserved the normal ovarian reserve. MiRNA-145 expression was upregulated after treatment with diosmin high dose. miRNA-145 target genes were over-expressed after both low and high diosmin administration. Based on our findings, diosmin has a dose-dependent protective effect against cyclophosphamide-induced ovarian toxicity in rats.

scholarly journals Changes in reproductive organs, semen characteristics and intra-testicular oxidative stress in adult male rats caused by azithromycin

2017 ◽  
Vol 5 (2) ◽  
pp. 72 ◽  
Author(s):  
Mossad El-Sayed ◽  
Mohamed Kandiel ◽  
Dalia Ebied
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cells ◽  
Experimental Period ◽  
Reproductive Organs ◽  
Post Treatment ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
Albino Rats ◽  
Stress Markers ◽  
Vascular Congestion

This study aimed to evaluate the numerous azithromycin (as a member of macrolides) effects on the male reproductive organs, spermio-gram, testicular oxidative stress markers of adults’ male albino rats. Azithromycin was administered orally once daily to male rats (200-250 b.wt.) at a dose of 45 mg (therapeutic) or 90 mg/kg b.wt. (double-therapeutic) for three or six days and scarified at the first, thirty and sixty days after the last dose of administration. A significant decrease as the index weight of the reproductive organs as well as sperm motility, livability and cell concentration, but sperm abnormalities increased at varying times post-treatment with azithromycin administration. Testosterone hormone level did not vary significantly after azithromycin dosing for three days along the experimental period. However, it differed at the first day after the end of azithromycin dosing for six days. The intra-testicular oxidative stress alteration mostly occurred at the thirty-day post-treatment in the three- and six-days protocols. In the three-days protocol, there was a significant decrease in malondialdehyde level and superoxide dismutase enzyme activity in a double-therapeutic group. In the six-days regimen, there was an increased activity of catalase enzyme, accompanied with a significant decrease in malondialdehyde levels as well as glutathione peroxidase enzymes. Double therapeutic dose for six days’ treatment was associated with vascular congestion and perivascular inflammatory cells and ho-mogenous eosinophilic material infiltration into the stroma of testes. The lumen of seminiferous tubules and epididymis showed azoo-spermia. From these results, it could be concluded that azithromycin administration has hazard effects on male adult’s rats’ fertility governed with the spermiogram, oxidative stress and the histopathological alternations during the post-treatment period.

scholarly journals Polychlorinated Biphenyls-Induced Oxidative Stress on Rat Hippocampus: A Neuroprotective Role of Quercetin

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Kandaswamy Selvakumar ◽  
Senthamilselvan Bavithra ◽  
Gunasekaran Krishnamoorthy ◽  
Prabhu Venkataraman ◽  
Jagadeesan Arunakaran
Keyword(s):  
Oxidative Stress ◽  
Corn Oil ◽  
Protective Role ◽  
Rat Hippocampus ◽  
Functional Markers ◽  
Group Iii ◽  
Stress Markers ◽  
Group I ◽  
Brain Oxidative Stress

Present study is aimed to evaluate the ameliorative role of quercetin on PCBs-induced oxidative stress in hippocampus of Wistar rats.Group Irats received vehicle (corn oil) intraperitoneally (i.p);Group IIreceived quercetin 50 mg/kg bwt/day (gavage);Group IIIreceived PCB 2 mg/kg bwt/day (i.p);Group IVreceived PCB (i.p) and simultaneously quercetin through gavage. After 30 days, rats were euthanized and hippocampus was dissected from each rat brain. Oxidative stress was assessed by determining the levels of H2O2, LPO, Pcc, and alteration in the functional markers such as CK, AchE, and ATPases activities in the hippocampus of control and experimental animals. A significant increase in the levels of stress markers and decrease in level of functional markers were observed in PCBs-treated rats. Moreover DNA fragmentation and histological studies were ascertained to confirm PCBs toxicity. In conclusion, quercetin shows a protective role against PCBs-induced oxidative damage in rat hippocampus.

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