Association Between Serum Vitamin D Level and Lipid Profile in a Jordanian Adult Cohort

2020 ◽  
Vol 27 (2) ◽  
pp. 59-65
Author(s):  
Saidat , Sana’a ◽  
Al-zghoul , Areen ◽  
Abu-alkeshek , Alaa ◽  
Ogeilat , Tania ◽  
Khasawneh , Rame
Keyword(s):  
Vitamin D ◽  
Lipid Profile ◽  
Serum Vitamin ◽  
Serum Vitamin D

Correlation between vitamin D and lipid profile in multiple sclerosis patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Azza AbdelNaser AbdelAziz ◽  
Prof Dr. Rasha Mamdouh Saleh ◽  
Mahmoud Saad Swelam ◽  
Janet Masoud Ayad
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Disease Activity ◽  
Lipid Profile ◽  
Serum Vitamin ◽  
Density Lipoprotein ◽  
P Value ◽  
Serum Vitamin D ◽  
The Mean ◽  
Multiple Sclerosis Patients

Abstract Background Studies have suggested that vitamin D and lipid profile have been linked to the etiology of multiple sclerosis and have an impact on the activity and progression of the disease. Objectives The aim of the present study was to determine correlation between vitamin D level and lipid profile in multiple sclerosis (MS) patients and their effect on disease activity and progression for better management and control of risk factors. Patients and Methods It is a cross-sectional hospital based study carried on clinically definite 111 Relapsing Remitting MS (RRMS) patients according to McDonald criteria 2010 recruited from Multiple sclerosis unit at Ain Shams University Hospitals, both genders included and aged from 18 to 50 years old. All subjects were assessed regarding their basic demographic data, serum vitamin D level and lipid profile and correlated these data with their state of disease activity and degree of disability. Results The mean level of serum vitamin D was 18.93 ± 9.85 ng/mL. Serum vitamin D level was insufficient (< 30 ng/mL) in 81.08% of patients and sufficient (≥ 30 ng/mL) in 18.92% of patients. The mean level of total cholesterol (TC) was 204.9 ± 50.9 mg/dL, of tri-glycerides (TG) was 105.4 ± 44.6 mg/dL, of low density lipoprotein (LDL) was 122.2 ± 38.8 mg/dL and of high density lipoprotein (HDL) level was 56.2 ± 16.6 mg/dL. High relapse frequency was found to be significantly related to low serum vitamin D level with P-value 0.005. Near all lipid related variables were positively correlated to disease duration. TC and TG were positively related to EDSS while HDL was negatively related with it. Number of brain T2 lesions was significantly correlated with TC and TG levels with P-value 0.001 and 0.002 respectively. Fingolimod was found to be associated with dyslipidemia. We found that each 1 ng/mL increase in vitamin D was associated with decrease in TC of 1.48 mg/dL (95% CI: -2.42 to -0.54, P-value 0.002) and increase in HDL of 0.35 mg/dL (95% CI: 0.04 to -0.66, P-value 0.028). Conclusion Vitamin D deficiency is predominant among Egyptian MS patients. Patients with insufficient vitamin D were found to have higher annualized relapse rate (ARR). Patients with dyslipidemia found to have longer duration, more disability and higher brain T2 lesion load. Vitamin D was correlated positively with HDL and negatively with TC.

scholarly journals Effects of Five-Year Treatment with Testosterone Undecanoate on Metabolic and Hormonal Parameters in Ageing Men with Metabolic Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Davide Francomano ◽  
Andrea Lenzi ◽  
Antonio Aversa
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Lipid Profile ◽  
Glycosylated Hemoglobin ◽  
Serum Vitamin ◽  
Mineral Density ◽  
Testosterone Undecanoate ◽  
Cholesterol Ratio ◽  
Serum Vitamin D

Metabolic and hormonal modifications after long-term testosterone (T) treatment have never been investigated. 20 hypogonadal men (mean T = 241 ng/dL–8.3 nmol/L) with metabolic syndrome (MS, mean age 58) were treated with T-undecanoate injections every 12 weeks for 60 months. 20 matched subjects in whom T was unaccepted or contraindicated served as controls. Primary endpoints were variations from baseline of metabolic and hormonal parameters. In T-group, significant reductions in waist circumference (−9.6±3.8 cm,P<0.0001), body weight (−15±2.8 Kg,P<0.0001), and glycosylated hemoglobin (−1.6 ± 0.5%,P<0.0001) occurred, along with improvements in insulin sensitivity (HOMA-I;−2.8 ± 0.6,P<0.0001), lipid profile (total/HDL-cholesterol ratio−2.9±1.5,P<0.0001), systolic and diastolic blood pressure (−23±10and−16±8mm Hg,P<0.0001, resp.), and neck and lumbar T-scores (+0.5±0.15 gr/cm2,P<0.0001;+0.7±0.8,P<0.0001, resp.). Also, serum vitamin D (+14.0±1.3 ng/mL,P<0.01), TSH (− 0.9±0.3 mUI/mL,P<0.01), GH (0.74±0.2 ng/mL,P<0.0001), and IGF1 (105±11 ng/mL,P<0.01) levels changed in T-group but not in controls. Normalization of T levels in men with MS improved obesity, glycemic control, blood pressure, lipid profile, and bone mineral density compared with controls. Amelioration in hormonal parameters, that is, vitamin D, growth hormone, and thyrotropin plasma levels, were reported.

scholarly journals The Association of Vitamin D Status with Lipid Profile and Inflammation Biomarkers in Healthy Adolescents

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 590 ◽  
Author(s):  
Amirhossein Yarparvar ◽  
Ibrahim Elmadfa ◽  
Abolghassem Djazayery ◽  
Zahra Abdollahi ◽  
Forouzan Salehi
Keyword(s):  
High School ◽  
Vitamin D ◽  
Lipid Profile ◽  
Negative Correlation ◽  
Serum Lipids ◽  
Serum Vitamin ◽  
Inflammatory Biomarkers ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: The association between vitamin D status and inflammatory biomarkers and lipid profile is not well known, especially in adolescents. Therefore, the aim of the current study is to investigate the association of vitamin D status with serum lipids and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, in male adolescents. Methods and materials: A sample of seventy-one high school male students, aged 17 years old, from a high school in Tehran were enrolled in the study. They were divided into four groups including group with serum vitamin D below 25 (ng/mL) (SVD < 25; n = 36), 25 and above (ng/mL) (SVD ≥ 25; n = 35), negative-hsCRP (n = 48), and positive-hsCRP (n = 23). Weight, height, body mass index, dietary intake, serum lipids, and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, were measured. Results: In the (SVD < 25) group, the serum level of TNFR-2 was significantly higher compared to that in the (SVD ≥ 25) group. There was a significant negative association between serum TNFR-2 and vitamin D levels in the whole sample. We found significant lower levels of IL-10 in positive-hsCRP group compared to the negative-hsCRP group. In addition, there was a significant negative correlation between the serum vitamin D level and hsCRP in both hsCRP groups. The HDL level was lower in the (SVD < 25) group compared to that in the (SVD ≥ 25) group. Finally, there was a negative correlation between the serum HDL and hsCRP levels in the positive-hsCRP subjects. Conclusion: Based on the findings it can be concluded that serum vitamin D affects HDL and inflammation status. Although serum levels of HDL and inflammation status are both predictors of metabolic syndrome and cardiovascular disease, further studies are needed to prove it, especially in adolescents.

scholarly journals Analysis of serum level of 25-hydroxycholecalciferol, calcium and lipid profile in carcinoma breast

2019 ◽  
Vol 6 (9) ◽  
pp. 3204
Author(s):  
Sanjeev Saha ◽  
Bipin Kumar Singh ◽  
Kirti Singh ◽  
Rahul Khanna ◽  
Ram Niwas Meena
Keyword(s):  
Vitamin D ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Vitamin ◽  
Breast Diseases ◽  
Preventive Strategy ◽  
Serum Vitamin D ◽  
Healthy Control ◽  
The Mean ◽  
Lower Vitamin

Background: Breast cancer (BC) is one of the major surgical problems in India, particularly in younger females. There are conflicting reports regarding the association between the serum lipid profiles, vitamin D, calcium and BC. The objective of the study was to measure the serum vitamin D, calcium and lipid profile levels in BC, benign breast diseases (BBD) and healthy control (HC), and compared these variables with clinico-pathological parameters in BC patients.Methods: Forty histologically confirmed invasive BC, 20 BBD patients and 20 healthy individuals taken as controls were enrolled for estimation of serum lipid profile, calcium and vitamin D. The study variables were compared with all three groups. In BC group, the levels were also compared with clinico-pathological parameters.Results: The mean age of subjects in BC, BBD and HC group was 48.88±11.33, 31.10±3.93 and 36.30±5.97 years respectively. The levels of serum cholesterol, triglyceride, HDL, LDL, VLDL and calcium was significantly increased and vitamin D was significantly decreased in BC patients as compared with BBD and HC group (p<0.001). On comparing lipid profile, calcium and vitamin D in receptor positive BC patients and triple negative BC patients, only serum HDL and serum calcium was significantly high in receptor positive BC patients (p=0.047 and p=0.041).Conclusions: Our findings suggest that lower vitamin D level and higher calcium and lipid profile level could be an important etiopathological factor in the causation of BC. Correction of these factors could be used as a prophylactic and preventive strategy in the population against BC.

scholarly journals Correlation of Vitamin D Status with Lipid Profile of Outpatient Department Attendees - A Cross Sectional Study in a Rural Tertiary Care Hospital of North Bengal, India

2021 ◽  
Vol 10 (35) ◽  
pp. 3012-3016
Author(s):  
Ritam Banerjee ◽  
Sandipan Datta ◽  
Arup Jyoti Rout
Keyword(s):  
Vitamin D ◽  
Lipid Profile ◽  
Indian Subcontinent ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Care Hospital ◽  
Vitamin D Status ◽  
Multinomial Regression ◽  
Serum Vitamin D ◽  
North Bengal

BACKGROUND Deficient or insufficient vitamin D status is found as a major chunk amongst all age groups all over the Indian subcontinent. Low levels of serum 25 (OH) D are associated with atherogenic lipid profile, and the resultant dyslipidemia is an important risk factor for cardiovascular disease and other atherosclerotic disorders in adults. As, not much literature was available on the deficiency of vitamin D and its effects, in the North Bengal region of West Bengal, India, this study was done to find out the association between vitamin D status and lipid profile of the participants and predict the risk of dislipidaemia with changes in vitamin D status. METHODS 430 medicine OPD attendees were selected for the study, interviewed after taking consent, blood parameters were examined and collected data were analysed for correlation and multinomial regression using SPSS v.25. RESULTS The mean value and standard deviation of serum 25 (OH) D level was found to be 21.53 ± 7.06 ng / ml. 35 % of vitamin D deficient subjects were found to be dyslipidemic. A negative correlation was observed between vitamin D status and total cholesterol & LDL status. While vitamin D status changed from “Sufficient” to “Deficient”, the chance of dyslipidemia increased by approximately 4.6 times. CONCLUSIONS Serum vitamin D influences largely the lipid profile of the study population. KEY WORDS Vitamin D, Serum 25 (OH) D, Dyslipidaemia, Cholesterol

scholarly journals EFFECTS OF TAMOXIFEN OR LETROZOLE ON LIPID PROFILE, VITAMIN D AND ESTRADIOL SERUM LEVELS IN OBESE POSTMENOPAUSAL WOMAN WITH BREAST CANCER

2017 ◽  
Vol 9 (2) ◽  
pp. 142
Author(s):  
Haeder Abdulhafith Al-biati ◽  
Ahmed Salih Sahib ◽  
Anwar Noori Mahmood
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Lipid Profile ◽  
Blood Sugar ◽  
Disease Onset ◽  
Serum Vitamin ◽  
Normal Weight ◽  
Serum Estradiol ◽  
Obese Women ◽  
Serum Vitamin D

<p><strong>Objective: </strong>Obesity is associated with both increased breast cancer risk and poorer prognosis after disease onset. Women who are obese continue to have higher levels of estrogen than women of normal weight even after treatment with hormone-suppressing drugs, raising the possibility that they might benefit from modification or changes to their treatment. The aim of this work was to study the effect of letrozole compared to tamoxifen on serum estradiol and, vitamine D and metabolic profile in Iraqi obese postmenopausal women with breast cancer.</p><p><strong>Methods: </strong>A hospital-based case-control study was carried out at Baquba teaching hospital, Diyala, Iraq. The analyzed variables were: age, lipid profile including total cholesterol; triglycerides, HDL-C, blood sugar, estradiol, and serum vit D. Descriptive statistics and testing of hypothesis were used for the analysis using mean±SD test P≤0.05.<strong> </strong></p><p><strong>Results: </strong>Lipid profile, serum estradiol showed significant variability among the studied group in this study and serum vit D show significant differences between groups in postmenopausal obese with breast cancer taking tamoxifen.</p><p><strong>Conclusion: </strong>Treatment of obese women with breast cancer with tamoxifen or letrozole had neglected effects on metabolic parameters including lipid profile and blood sugar, both agents decrease serum estradiol level in treated patients, and most importantly, the significant positive effect of tamoxifen on serum vitamin D level compared to negative effect of aromatase inhibitor drug letrozole.</p>

scholarly journals Serum Vitamin D Affected Type 2 Diabetes though Altering Lipid Profile and Modified the Effects of Testosterone on Diabetes Status

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 90
Author(s):  
Lulu Wang ◽  
Xue Liu ◽  
Jian Hou ◽  
Dandan Wei ◽  
Pengling Liu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Lipid Profile ◽  
Serum Vitamin ◽  
Density Lipoprotein ◽  
Interactive Effects ◽  
Lipoprotein Cholesterol ◽  
Serum Vitamin D ◽  
Diabetes Status

Numerous studies have investigated the associations between serum vitamin D or testosterone and diabetes; however, inconsistencies are observed. Whether there is an interaction between vitamin D and testosterone and whether the lipid profile (total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)) mediates the association between vitamin D and diabetes is unclear. To investigate the effect of vitamin D and testosterone on impaired fasting glucose (IFG) or type 2 diabetes mellitus (T2DM), 2659 participants from the Henan Rural Cohort were included in the case-control study. Generalized linear models were utilized to estimate associations of vitamin D with IFG or T2DM and interactive effects of vitamin D and testosterone on IFG or T2DM. Principal component analysis (PCA) and mediation analysis were used to estimate whether the lipid profile mediated the association of vitamin D with IFG or T2DM. Serum 25(OH)D3, 25(OH)D2, and total 25(OH)D levels were negatively correlated with IFG (odds ratios (ORs) (95% confidence intervals (CIs)): 0.99 (0.97, 1.00), 0.85 (0.82, 0.88), and 0.97 (0.96, 0.98), respectively). Similarity results for associations between serum 25(OH)D2 and total 25(OH)D with T2DM (ORs (95%CIs): 0.84 (0.81, 0.88) and 0.97 (0.96, 0.99)) were observed, whereas serum 25(OH)D3 was negatively correlated to T2DM only in the quartile 2 (Q2) and Q3 groups (both p < 0.05). The lipid profile, mainly TC and TG, partly mediated the relationship between 25(OH)D2 or total 25(OH)D and IFG or T2DM and the proportion explained was from 2.74 to 17.46%. Furthermore, interactive effects of serum 25(OH)D2, total 25(OH)D, and testosterone on T2DM were observed in females (both p for interactive <0.05), implying that the positive association between serum testosterone and T2DM was vanished when 25(OH)D2 was higher than 10.04 ng/mL or total 25(OH)D was higher than 40.04 ng/mL. Therefore, ensuring adequate vitamin D levels could reduce the prevalence of IFG and T2DM, especially in females with high levels of testosterone.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Relationship Between Nutrient Intake and Vitamin D Status in Osteoporotic Women

2007 ◽  
Vol 77 (6) ◽  
pp. 376-381 ◽  
Author(s):  
de Souza Genaro ◽  
de Paiva Pereira ◽  
de Medeiros Pinheiro ◽  
Szejnfeld ◽  
Araújo Martini
Keyword(s):  
Vitamin D ◽  
Mineral Metabolism ◽  
Sodium Intake ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Dietary Records

Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (≥ 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 μ g/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.

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