scholarly journals Correlation of Vitamin D Status with Lipid Profile of Outpatient Department Attendees - A Cross Sectional Study in a Rural Tertiary Care Hospital of North Bengal, India

2021 ◽  
Vol 10 (35) ◽  
pp. 3012-3016
Author(s):  
Ritam Banerjee ◽  
Sandipan Datta ◽  
Arup Jyoti Rout
Keyword(s):  
Vitamin D ◽  
Lipid Profile ◽  
Indian Subcontinent ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Care Hospital ◽  
Vitamin D Status ◽  
Multinomial Regression ◽  
Serum Vitamin D ◽  
North Bengal

BACKGROUND Deficient or insufficient vitamin D status is found as a major chunk amongst all age groups all over the Indian subcontinent. Low levels of serum 25 (OH) D are associated with atherogenic lipid profile, and the resultant dyslipidemia is an important risk factor for cardiovascular disease and other atherosclerotic disorders in adults. As, not much literature was available on the deficiency of vitamin D and its effects, in the North Bengal region of West Bengal, India, this study was done to find out the association between vitamin D status and lipid profile of the participants and predict the risk of dislipidaemia with changes in vitamin D status. METHODS 430 medicine OPD attendees were selected for the study, interviewed after taking consent, blood parameters were examined and collected data were analysed for correlation and multinomial regression using SPSS v.25. RESULTS The mean value and standard deviation of serum 25 (OH) D level was found to be 21.53 ± 7.06 ng / ml. 35 % of vitamin D deficient subjects were found to be dyslipidemic. A negative correlation was observed between vitamin D status and total cholesterol & LDL status. While vitamin D status changed from “Sufficient” to “Deficient”, the chance of dyslipidemia increased by approximately 4.6 times. CONCLUSIONS Serum vitamin D influences largely the lipid profile of the study population. KEY WORDS Vitamin D, Serum 25 (OH) D, Dyslipidaemia, Cholesterol

scholarly journals The Association of Vitamin D Status with Lipid Profile and Inflammation Biomarkers in Healthy Adolescents

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 590 ◽  
Author(s):  
Amirhossein Yarparvar ◽  
Ibrahim Elmadfa ◽  
Abolghassem Djazayery ◽  
Zahra Abdollahi ◽  
Forouzan Salehi
Keyword(s):  
High School ◽  
Vitamin D ◽  
Lipid Profile ◽  
Negative Correlation ◽  
Serum Lipids ◽  
Serum Vitamin ◽  
Inflammatory Biomarkers ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: The association between vitamin D status and inflammatory biomarkers and lipid profile is not well known, especially in adolescents. Therefore, the aim of the current study is to investigate the association of vitamin D status with serum lipids and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, in male adolescents. Methods and materials: A sample of seventy-one high school male students, aged 17 years old, from a high school in Tehran were enrolled in the study. They were divided into four groups including group with serum vitamin D below 25 (ng/mL) (SVD < 25; n = 36), 25 and above (ng/mL) (SVD ≥ 25; n = 35), negative-hsCRP (n = 48), and positive-hsCRP (n = 23). Weight, height, body mass index, dietary intake, serum lipids, and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, were measured. Results: In the (SVD < 25) group, the serum level of TNFR-2 was significantly higher compared to that in the (SVD ≥ 25) group. There was a significant negative association between serum TNFR-2 and vitamin D levels in the whole sample. We found significant lower levels of IL-10 in positive-hsCRP group compared to the negative-hsCRP group. In addition, there was a significant negative correlation between the serum vitamin D level and hsCRP in both hsCRP groups. The HDL level was lower in the (SVD < 25) group compared to that in the (SVD ≥ 25) group. Finally, there was a negative correlation between the serum HDL and hsCRP levels in the positive-hsCRP subjects. Conclusion: Based on the findings it can be concluded that serum vitamin D affects HDL and inflammation status. Although serum levels of HDL and inflammation status are both predictors of metabolic syndrome and cardiovascular disease, further studies are needed to prove it, especially in adolescents.

scholarly journals Evaluation of vitamin D profile in juvenile idiopathic arthritis

2021 ◽  
Author(s):  
Madhumita Nandi ◽  
Md Abu Sayeed Mullick ◽  
Arnab Nandy ◽  
Moumita Samanta ◽  
Sumantra Sarkar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Juvenile Idiopathic Arthritis ◽  
Disease Activity ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Inactive Disease ◽  
Categorical Variables ◽  
Care Hospital ◽  
Serum Vitamin D ◽  
Activity Groups

ABSTRACT Objective To observe the association between serum vitamin D level and disease activity in juvenile idiopathic arthritis (JIA). Methods The observational study was conducted at a tertiary care hospital during 2017-2019. Patients suffered from JIA were recruited through purposive sampling which was stratified by the disease activity based on the Juvenile Arthritis Disease Activity Score 27 (JADAS27) criteria. Serum vitamin D was estimated alongside other laboratory parameters. The numerical and categorical variables were analysed with appropriate statistical tests. Results 40 subjects were studied where inactive disease was observed in nine subjects (22.5%), five subjects (12.5%) were found to be in low disease activity and moderate disease activity groups each, and twenty-one subjects (52.5%) had high disease activity. Considering the total sample size of the study, the mean (SD) JADAS27 score and serum vitamin D level were observed to be 12.02 (11.31) and 23.10 (5.93) respectively. A negative correlation was found between the JADAS27 score and serum vitamin D (r= -0.67). The corrected Chi-square test had revealed significant association between the status of serum vitamin-D and disease activity groups (=16.28; p &lt; .001). Conclusions In JIA, higher grade of disease activity was found to be significantly associated with lower serum vitamin D.

scholarly journals STUDY TO EVALUATE THE VITAMIN D SCENARIO IN AN INDIAN POPULATION

2021 ◽  
pp. 1-2
Author(s):  
Firdushi Begum ◽  
Papori Borah
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Clinical Laboratory ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Institute Of Medicine ◽  
Vitamin D Status ◽  
Endocrine Society ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Introduction : Till the 20th century deficiency of vitamin D which is synthesized in the skin upon exposure to UVB light was largely unknown. But today vitamin D deficiency has taken an epidemic form and is linked with many disease conditions. Several studies have put forward a very high prevalence of vitamin D deficiency among Indians of all age groups. Aims and objectives : To study the vitamin D status of people visiting a tertiary care centre in India. Materials and Methods : This is a prospective observational study conducted in the Biochemistry section of Central Clinical Laboratory of Gauhati Medical College & Hospital (GMCH). All the vitamin D reports generated in the laboratory for a period of 9 months were recorded and analysed to estimate the prevalence. Similar to other vitamin D studies, 20ng/ml was taken as the cut-off for vitamin D deficiency, 30ng/ml for insufficiency, and 30-100ng/ml as the normal vitamin D range. Results and Observations : In this study Vitamin D data of 1000 patients admitted in GMCH was analysed. Of them females outnumbered males (68.7% vs 31.3%). Of the 1000 vitamin D reports analysed 51.9% were found to be in the insufficient range, followed by 30.1% in the normal range. In 17.5% vitamin D levels were found to be deficient Vitamin D status was found to be lower in females as compared to males. 86.75% of females were either vitamin D deficient or insufficient and 71.88% of males were either deficient or insufficient. Conclusion : In this study 17.5% of study subjects had vitamin D level <20ng/ml, which may be considered as deficient, as per the Institute of Medicine(IOM) which considers a serum vitamin D value of 20 ng/ml as optimal. According to the U.S. Endocrine Society 30 ng/ml is optimal. Due to this variation the recommended daily intakes of this nutrient also vary.

scholarly journals Vitamin-D Deficiency among Psychiatric Outpatients Attending Tertiary Care Hospital

2020 ◽  
Vol 16 (4) ◽  
pp. 195-200
Author(s):  
Arati Thapa ◽  
Mukesh Karki ◽  
Aradhana Thapa
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Teaching Hospital ◽  
Psychiatric Illness ◽  
Psychiatric Patients ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Care Hospital ◽  
Medical Sciences ◽  
Serum Vitamin D

Abstract Background: Vitamin D deficiency is associated with various physical and mental illness. This study aimed to estimate the prevalence of vitamin D deficiency among patients with psychiatric illness who visited Psychiatry outpatient department of College of Medical Sciences and Teaching Hospital, Chitwan, Nepal and investigate association of vitamin D with clinical characteristics and psychiatric illness. Methods: A total of 129 who attended Psychiatry OPD of College of Medical Sciences and Teaching Hospital were enrolled over a period of 4 months after taking informed written consent. Psychiatric diagnoses were established by attending psychiatrists as part of the routine assessment using ICD 10/DCR criteria. Serum vitamin D was assessed by standard method. Data was analyzed using SPSS. Results: Among 129 participants, one hundred and seven patients (82.9%) showed vitamin D level below normal range. Thirty one (24%) had vitamin D deficiency, seventy six (58.9%) had vitamin D insufficiency and twenty two (17.1%) had normal vitamin D level. The mean level of vitamin D was 24.11± 10.19. However, there was no significant association noted between vitamin D state and socio demographic profile and psychiatric illness. Conclusions: We have found a high percentage of vitamin D deficiency among psychiatric patients in our study. Thus, screening for vitamin D deficiency should be considered as an important part of assessment of patients with major psychiatric illnesses.

scholarly journals UTERINE ATONY;

2014 ◽  
Vol 21 (06) ◽  
pp. 1117-1121
Author(s):  
Shazia Majid Khan ◽  
Mohammad Saeed ◽  
Ghulam Mustafa ◽  
Haq Dad Durrani
Keyword(s):  
Vitamin D ◽  
Blood Loss ◽  
Vitamin D Deficiency ◽  
Gestational Age ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Uterine Atony ◽  
Care Hospital ◽  
Chi Square ◽  
Serum Vitamin D

Background: Uterine atony is one of the causes of postpartum hemorrhage, resulting in increased maternal morbidity and mortality. Objective: To determine the association of low serum vitamin D level with uterine atony, among women delivering in a tertiary care hospital. Subjects and Methods: Study design: Case control Study. Setting: Gynae and Obstetrics department of Sheikh Zayed Medical College, Rahim Yar Khan. Duration: 1st January to 31st December, 2013. A total of 130 patients were recruited and grouped as A (Cases) including patients with uterine atony (100 patients) and group B (Controls) patients having no uterine atony (30 patients) after cesearean section or vaginal delivery and fulfilling the inclusion or exclusion criteria. The test for 25 OH vitamin D was performed on Elecsys 2010 Roche by using electrochemiluminescence technique. Oral informed consent was taken from all subjects and approval from institutional ethical committee was obtained. Chi square test was applied to compare atony and non atony groups in terms of presence or absence of vitamin D deficiency. The data was entered and analysed on SPSS version 17. Results: It was noted that those who have uterine atony 87% were having vitamin D deficiency or insufficiency as compared to 68% in group with no uterine atony. This difference was statistically significant. (p=0.02) so uterine atony was significantly associated with vitamin D deficiency or insufficiency. In atony group mean age was 25±4 years, gravida 2.64±1.2, gestational age, 37±1.2, blood loss 1032±400, and serum vitamin D level 15.9±6, ng/ml. In non atony group, group mean age was 26±3 years, gravida 2.7±1, gestational age, 38±.8, blood loss 309±92, and serum vitamin D level 23±9 ng/ml. The mean level of serum vitamin D level was significantly low (15.9±6 ng/ml) in atony group as compared to non atony group(23±9 ng/ml). Mean blood loss was significantly high (1032ml) in atony group as compared to non atony group (309ml). Conclusion: Our results revealed that low vitamin D level is strongly associated with uterine atony and hence is a risk factor for uterine atony.

scholarly journals Prevalence of Hypovitaminosis D in Patients Visiting a Tertiary Care Center in Chitwan, Nepal

2019 ◽  
Vol 15 (2) ◽  
pp. 84-92
Author(s):  
Kushal Bhattarai ◽  
Nilu Manandhar ◽  
Sarita Dhakal
Keyword(s):  
Vitamin D ◽  
Care Center ◽  
Tertiary Care ◽  
Large Body ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Demographic Variables ◽  
High Rate ◽  
Care Hospital ◽  
Serum Vitamin D

Background: As documented by a large body of evidences, Hypovitaminosis D prevails both in the general and the hospitalized populations. We conducted this study to determine the prevalence of hypovitaminosis D amongst the patients visiting a tertiary care hospital and compare the rate gender-wise, across different categories of socio-demographic variables. Methods: It was a cross-sectional study (retrospective chart review) based on the hospital registry of patients at College of Medical Sciences and Teaching Hospital, Bharatpur, Chitwan, Nepal. From the registry, we retrieved the socio-demographic variables (age, gender, ethnicity and season) along with serum vitamin D (25-hydroxy-cholecalciferol) concentrations of the study subjects from January 2015 to August 2018, for our analysis. Hypovitaminosis D was defined as serum vitamin D <30 ng/mL (insufficiency: 20-30ng/mL and deficiency: <20 ng/mL). Results: The overall prevalence of hypovitaminosis D was 70.7% (insufficiency: 35.9% and deficiency: 34.8%), 72.4% (females), 64.2% (males), 76.3% (first age-quartile), 74.5% (miscellaneous ethnic group), and 73.9% (Spring). Females had higher prevalence rates of hypovitaminosis D (and lower median serum 25-hydroxy-cholecalciferol lev-els) as compared to males, in overall participants, and those under each category of age, ethnicity and season (except Winter). Conclusions: The greater prevalence of hypovitaminosis D in the females than the males in the face of high rate in the overall hospital-visiting clearly calls for necessary strategies in the form of further studies and judicious prescription of supplementary vitamin D in the target population.

scholarly journals Vitamin D: A Silent Cofactor for Allergic Rhinitis

2019 ◽  
Vol 27 (2) ◽  
pp. 107-112
Author(s):  
Rabi Hembrom ◽  
Somnath Patra ◽  
Rupam Sinha ◽  
Indranil Sen ◽  
Satadal Mandal ◽  
...  
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Blood Eosinophil ◽  
Cell Mediated Immunity ◽  
Care Hospital ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Low Serum

Introduction   Allergic rhinitis affects around 50% of atopies in India. Vitamin D is related to both humoral and cell mediated immunity and its receptors are found in inflammatory mediators. This study was conducted to assess any possible association between Allergic rhinitis and serum Vitamin D. Materials and Methods A cross sectional study was conducted amongst 41patients with Allergic rhinitis as per ARIA guidelines attending the Otolaryngology outpatient Department of a peripheral tertiary care hospital. Vitamin D levels were assessed in patients with allergic rhinitis in terms of serum Ig-E level and absolute blood eosinophil count (ABEC). Results Among 41 patients, 31 patients (75.6%) had deficiency of vitamin D with mean Vitamin D level of 14.87±1.56ng/ml (normal vitamin D level-30-100ng/ml and low <20ng/ml), mean serum Ig-E level was 1040±303.83Iu/ml (normal-1.90-170 IU/ml by CLIA method) and mean ABEC 1226.77±397.89 (normal-30-350/ml). Conclusion Low serum Vitamin D is common in Allergic rhinitis patients. Low serum Vitamin D seems to be a significant cofactor in aetiopathogenesis of Allergic rhinitis in most of the cases.

scholarly journals VITAMIN D AND HSCRP LEVELS AMONG INSULIN RESISTANT PATIENTS IN A TERTIARY CARE HOSPITAL AT KOLKATA.

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Kaushik Kar ◽  
Satwika Sinha
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
High Sensitivity ◽  
Model Assessment ◽  
Care Hospital ◽  
Serum Vitamin D ◽  
Insulin Resistant ◽  
Homeostatic Model Assessment

Vitamin D deficiency probably takes a part in the development of insulin resistance. Insulin resistance also markedly affects the obese population. High-sensitivity C-reactive protein is a sensitive marker of subclinical inflammation and strongly predicts increased risks of insulin resistance. In this study, 123 obese persons were selected, and homeostatic model assessment (HOMA-IR) was measured in them. Serum Vitamin D and hsCRP were also measured in all participants. Among participants with HOMA-IR >2.7, significantly higher BMI, serum hsCRP and lower vitamin D were observed; Keywords: Obesity, BMI, HOMA-IR, Vitamin D, hsCRP.

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