Ambient Air Pollution and Occurrence of Multiple Sclerosis Relapses

Abstract The effects of air pollutants on autoimmune diseases are gaining increasing attention. At present, no studies have conducted systemic review and meta-analysis on ambient air pollution and multiple sclerosis (MS). In this paper, literature was collected in order to explore whether there was a connection between air pollutants and MS or not. Through electronic literature search, literature related to our research topic was collected in Cochrane Library, Embase and Pubmed till August 18, 2020 according to certain criteria. Pooled risk estimate and 95% confidence intervals (95%CI) were calculated by random-effect model analysis. After removing copies, browsing titles and abstracts and reading full text, 6 studies were finally included. The results showed that only particulate matter (PM) with aerodynamic diameter ≤10 (PM10) was related to MS (pooled HR=1.058, 95% CI=1.050-1.066), and no correlation was found between other pollutants and MS. There was no publication bias, and the heterogeneity analysis results were stable. PM is correlated with the disease MS, while other pollution is not connected with MS. More literature results need to be included to meta-analysis results for further study.

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Ambient air pollution and multiple sclerosis: a systematic review

Reviews on Environmental Health ◽

10.1515/reveh-2020-0079 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Mohammad Amin Farahmandfard ◽

Ahmad Naghibzadeh-Tahami ◽

Narges Khanjani

Keyword(s):

Multiple Sclerosis ◽

Systematic Review ◽

Air Pollution ◽

Search Strategy ◽

Meta Analysis ◽

Ambient Air ◽

Ambient Air Pollution ◽

Significant Relation ◽

Exclusion Criteria ◽

Key Word

Abstract Objectives Some studies have shown that environmental risk factors, including air pollution, might be related to the incidence or recurrence of multiple sclerosis (MS). This systematic review was conducted to investigate the relation between air pollution and MS. Methods A systematic search was conducted in PubMed, Scopus, Science Direct, Embase, and Web of Science; until January 2020 with no restrictions. The search strategy was conducted with air pollution key words such as CO, PM2.5, PM10, SO2, and NO2, for exposure and the key word “Multiple sclerosis” as the outcome. Results Eventually, after applying the inclusion and exclusion criteria, 17 articles were included. The methodologies and outcomes reported were heterogeneous and different metrics had been used in the results; therefore conducting a meta-analysis was not possible. Eight studies had analyzed the relation between particulate matter (PM) and the prevalence or relapse of MS and had observed a significant relation. NO2 and NOx were associated with recurrence or prevalence of MS in three studies. But, in three cohort studies, no association was observed between air pollution and recurrence or occurrence of MS. Conclusions The results of this systematic review show that outdoor air pollution, especially PM and nitrogen oxides might be related to the prevalence or relapse of MS.

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STATISTICAL METHODS FOR THE ASSESSMENT OF AIR POLLUTION OF JHANSI CITY, UTTAR PRADESH, INDIA

FLORA AND FAUNA ◽

10.33451/florafauna.v24i1pp187-196 ◽

2018 ◽

Vol 24 (1) ◽

Author(s):

V. S. CHAUHAN ◽

BHANUMATI SINGH ◽

SHREE GANESH ◽

JAMSHED ZAIDI

Keyword(s):

Air Pollution ◽

Uttar Pradesh ◽

Ambient Air ◽

Ambient Air Pollution ◽

Base Line ◽

Multivariate Statistical ◽

Large Cities ◽

Governmental Organizations ◽

Non Governmental Organizations ◽

The Status

Studies on air pollution in large cities of India showed that ambient air pollution concentrations are at such levels where serious health effects are possible. This paper presents overview on the status of air quality index (AQI) of Jhansi city by using multivariate statistical techniques. This base line data can help governmental and non-governmental organizations for the management of air pollution.

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