The current market

2021 ◽  
Vol 23 (5) ◽  
pp. 29-30
Author(s):  
Karen Hart
Keyword(s):  
High Quality ◽  
New Entrants ◽  
Quality Childcare ◽  
Insight Into

There continues to be strong demand for the purchase of high-quality childcare businesses, both in terms of new entrants and existing nursery operators with plans to expand their portfolios. Here we have a snapshot insight into the current market.

scholarly journals The Gossypium stocksii genome as a novel resource for cotton improvement

2021 ◽  
Author(s):  
Corrinne E Grover ◽  
Daojun Yuan ◽  
Mark A Arick ◽  
Emma R Miller ◽  
Guanjing Hu ◽  
...  
Keyword(s):  
Genome Sequence ◽  
De Novo ◽  
Pest Resistance ◽  
Cotton Leaf ◽  
High Quality ◽  
Cotton Leaf Curl Virus ◽  
Cotton Species ◽  
Wild Cotton ◽  
Leaf Curl Virus ◽  
Insight Into

Abstract Cotton is an important textile crop whose gains in production over the last century have been challenged by various diseases. Because many modern cultivars are susceptible to several pests and pathogens, breeding efforts have included attempts to introgress wild, naturally resistant germplasm into elite lines. Gossypium stocksii is a wild cotton species native to Africa, which is part of a clade of vastly understudied species. Most of what is known about this species comes from pest resistance surveys and/or breeding efforts, which suggests that G. stocksii could be a valuable reservoir of natural pest resistance. Here we present a high-quality de novo genome sequence for G. stocksii. We compare the G. stocksii genome with resequencing data from a closely related, understudied species (G. somalense) to generate insight into the relatedness of these cotton species. Finally, we discuss the utility of the G. stocksii genome for understanding pest resistance in cotton, particularly resistance to cotton leaf curl virus.

The global elements of vital signs' assessment: a guide for clinical practice

2021 ◽  
Vol 30 (16) ◽  
pp. 956-962
Author(s):  
Malcolm Elliott
Keyword(s):  
Clinical Practice ◽  
Outcomes Research ◽  
Quality Care ◽  
Vital Signs ◽  
Clinical Judgement ◽  
Evidence Based ◽  
Valuable Insight ◽  
High Quality ◽  
Culture Tradition ◽  
Insight Into

The assessment of vital signs is critical for safe, high-quality care. Vital signs' data provide valuable insight into the patient's condition, including how they are responding to medical treatment and, importantly, whether the patient is deteriorating. Although abnormal vital signs have been associated with poor clinical outcomes, research has consistently found that vital signs' assessment is often neglected in clinical practice. Factors contributing to this include nurses' knowledge, clinical judgement, culture, tradition and workloads. To emphasise the importance of vital signs' assessment, global elements of vital signs' assessment are proposed. The elements reflect key principles underpinning vital signs' assessment and are informed by evidence-based literature.

Insight into the Al/N-GaN barrier property to realize high quality n-type Ohmic contact

2020 ◽  
Vol 818 ◽  
pp. 152855 ◽  
Author(s):  
Ting Wang ◽  
Zhihua Xiong ◽  
Juanli Zhao ◽  
Ning Wu ◽  
Kun Du ◽  
...  
Keyword(s):  
Ohmic Contact ◽  
Barrier Property ◽  
High Quality ◽  
Insight Into

Characterisation of V-type asteroids using phase-curves

2020 ◽  
Author(s):  
Dagmara Oszkiewicz ◽  
Keyword(s):  
Particle Size ◽  
Surface Properties ◽  
Absolute Magnitude ◽  
Phase Curve ◽  
Main Belt ◽  
Substantial Evidence ◽  
High Quality ◽  
Formation And Evolution ◽  
Phase Functions ◽  
Insight Into

<p>Characterisation of the V-type asteroid population may help to comprehend the planetesimal formation and evolution. Asteroid phase-curves are known to relate to surface properties such as asteroid taxonomy, surface roughness, particle size distribution, albedo and many others, providing insight into surface properties of the V-types.<br /><br />Gil-Hutton et al. (2017) showed that the basaltic asteroids display two distinct polarimetric behaviors, which they attributed to the regolith particle size. Considering that phase-curve parameters relate to surface and regolith properties, they may verify those distinct behaviors.<br /><br />We observed about 20 asteroids during around 250 nights (over 500 fragmental lightcurves) to obtain high quality phase curves. We fitted the standard H,G; H,G1,G2, and H, G12 phase functions, limiting them to physical solutions only. This greatly extends the sample of well determined phase-curves for the underrepresented V-types. For asteroids with data from multiple oppositions we used a simultaneous fit assuming the same slope parameters in all apparitions and different absolute magnitude values. From these data we also derived the G12* parameter to be used in single parameter phase functions recommended for fitting low quality photometry. We do not find substantial evidence for any clustering into distinct phase curve parameters groups as suggested by Gil-Hutton et al. 2017. Only one asteroid (2763 Jeans) shows an exceptionally high G2 value.<br /><br />Further work should be conducted to determine slope parameters of more V-types to further verify the division of V-type asteroids into two distinct groups. Obtaining phase curves of non-Vestoids (such as those in the mid and outer Main Belt) may also help clarify if the division into distinct V-type groups is due to particle size or mineralogical differences.</p>

scholarly journals Fish for the city: meta-analysis of archaeological cod remains and the growth of London's northern trade

Antiquity ◽  
2014 ◽  
Vol 88 (340) ◽  
pp. 516-530 ◽  
Author(s):  
David C. Orton ◽  
James Morris ◽  
Alison Locker ◽  
James H. Barrett
Keyword(s):  
Quantitative Analysis ◽  
Food Supply ◽  
Meta Analysis ◽  
Northern Europe ◽  
Black Death ◽  
High Quality ◽  
Changing Patterns ◽  
The Impact ◽  
The City ◽  
Insight Into

The growth of medieval cities in Northern Europe placed new demands on food supply, and led to the import of fish from increasingly distant fishing grounds. Quantitative analysis of cod remains from London provides revealing insight into the changing patterns of supply that can be related to known historical events and circumstances. In particular it identifies a marked increase in imported cod from the thirteenth century AD. That trend continued into the fifteenth and sixteenth centuries, after a short downturn, perhaps attributable to the impact of the Black Death, in the mid fourteenth century. The detailed pattern of fluctuating abundance illustrates the potential of archaeological information that is now available from the high-quality urban excavations conducted in London and similar centres during recent decades.

scholarly journals Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 979 ◽  
Author(s):  
Justin M. Rectenwald ◽  
Shiva Krishna Reddy Guduru ◽  
Zhao Dang ◽  
Leonard B. Collins ◽  
Yi-En Liao ◽  
...  
Keyword(s):  
Structure And Function ◽  
Cellular Phenotype ◽  
Chemical Probes ◽  
Target Class ◽  
High Quality ◽  
Histone Tails ◽  
Post Translational Modifications ◽  
Chromatin Dynamics ◽  
And Function ◽  
Insight Into

Chromatin structure and function, and consequently cellular phenotype, is regulated in part by a network of chromatin-modifying enzymes that place post-translational modifications (PTMs) on histone tails. These marks serve as recruitment sites for other chromatin regulatory complexes that ‘read’ these PTMs. High-quality chemical probes that can block reader functions of proteins involved in chromatin regulation are important tools to improve our understanding of pathways involved in chromatin dynamics. Insight into the intricate system of chromatin PTMs and their context within the epigenome is also therapeutically important as misregulation of this complex system is implicated in numerous human diseases. Using computational methods, along with structure-based knowledge, we have designed and constructed a focused DNA-Encoded Library (DEL) containing approximately 60,000 compounds targeting bi-valent methyl-lysine (Kme) reader domains. Additionally, we have constructed DNA-barcoded control compounds to allow optimization of selection conditions using a model Kme reader domain. We anticipate that this target-class focused approach will serve as a new method for rapid discovery of inhibitors for multivalent chromatin reader domains.

scholarly journals Formation Conditions and 40Ar/39Ar Age of the Gem-Bearing Boqueirão Granitic Pegmatite, Parelhas, Rio Grande do Norte, Brazil

Minerals ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 233 ◽  
Author(s):  
Strmić Palinkaš ◽  
Palinkaš ◽  
Neubauer ◽  
Scholz ◽  
Šoštarić ◽  
...  
Keyword(s):  
Fluid Inclusion ◽  
Melt Inclusions ◽  
Fluid Phase ◽  
Granitic Pegmatite ◽  
Northeast Brazil ◽  
High Quality ◽  
Late Cambrian ◽  
Formation Conditions ◽  
Zone Ii ◽  
Insight Into

The Boqueirão granitic pegmatite, alias Alto da Cabeça pegmatite, is situated in Borborema Pegmatitic Province (BPP) in Northeast Brazil. This pegmatitic province hosts globally important reserves of tantalum and beryllium, as well as significant quantities of gemstones, including aquamarine, morganite, and the high-quality turquoise-blue “Paraíba Elbaite”. The studied lithium-cesium-tantalum Boqueirão granitic pegmatite intruded meta-conglomerates of the Equador Formation during the late Cambrian (502.1 ± 5.8 Ma; 40Ar/39Ar plateau age of muscovite). The pegmatite exhibits a typical zonal mineral pattern with four defined zones (Zone I: muscovite, tourmaline, albite, and quartz; Zone II: K-feldspar (microcline), quartz, and albite; Zone III: perthite crystals (blocky feldspar zone); Zone IV: massive quartz). Huge individual beryl, spodumene, tantalite, and cassiterite crystals are common as well. Microscopic examinations revealed that melt inclusions were entrapped simultaneously with fluid inclusions, suggesting the magmatic–hydrothermal transition. The magmatic–hydrothermal transition affected the evolution of the pegmatite, segregating volatile compounds (H2O, CO2, N2) and elements that preferentially partition into a fluid phase from the viscous silicate melt. Fluid inclusion studies on microcline and associated quartz combined with microthermometry and Raman spectroscopy gave an insight into the P-T-X characteristics of entrapped fluids. The presence of spodumene without other LiAl(SiO3)2 polymorphs and constructed fluid inclusion isochores limited the magmatic–hydrothermal transition at the gem-bearing Boqueirão granitic pegmatite to the temperature range between 300 and 415 °C at a pressure from 1.8 to 3 kbar.

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