scholarly journals Clinical outcomes following intra-articular injection of autologous adipose-derived mesenchymal stem cells for the treatment of osteoarthritis in dogs characterized by weight-bearing asymmetry

2021 ◽  
Vol 10 (10) ◽  
pp. 650-658
Author(s):  
Anita Sanghani-Kerai ◽  
Cameron Black ◽  
Shuliang Oliver Cheng ◽  
Laura Collins ◽  
Nadine Schneider ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Platelet Rich Plasma ◽  
Statistical Significance ◽  
Weight Bearing ◽  
Combined Treatment ◽  
Joint Disease ◽  
The Impact

Aims This study investigates the effects of intra-articular injection of adipose-derived mesenchymal stem cells (AdMSCs) and platelet-rich plasma (PRP) on lameness, pain, and quality of life in osteoarthritic canine patients. Methods With informed owner consent, adipose tissue collected from adult dogs diagnosed with degenerative joint disease was enzymatically digested and cultured to passage 1. A small portion of cells (n = 4) surplus to clinical need were characterized using flow cytometry and tri-lineage differentiation. The impact and degree of osteoarthritis (OA) was assessed using the Liverpool Osteoarthritis in Dogs (LOAD) score, Modified Canine Osteoarthritis Staging Tool (mCOAST), kinetic gait analysis, and diagnostic imaging. Overall, 28 joints (25 dogs) were injected with autologous AdMSCs and PRP. The patients were followed up at two, four, eight, 12, and 24 weeks. Data were analyzed using two related-samples Wilcoxon signed-rank or Mann-Whitney U tests with statistical significance set at p < 0.05. Results AdMSCs demonstrated stem cell-like characteristics. LOAD scores were significantly lower at week 4 compared with preinjection (p = 0.021). The mCOAST improved significantly after three months (p = 0.001) and six months (p = 0.001). Asymmmetry indices decreased from four weeks post-injection and remained significantly lower at six months (p = 0.025). Conclusion These improvements in quality of life, reduction in pain on examination, and improved symmetry in dogs injected with AdMSCs and PRP support the effectiveness of this combined treatment for symptom modification in canine OA for six months. Cite this article: Bone Joint Res 2021;10(10):650–658.

scholarly journals Effectiveness of individual and group interventions for people with type 2 diabetes

2015 ◽  
Vol 23 (2) ◽  
pp. 200-207 ◽  
Author(s):  
Maria Fernanda Manoel Imazu ◽  
Barbara Nascimento Faria ◽  
Guilherme Oliveira de Arruda ◽  
Catarina Aparecida Sales ◽  
Sonia Silva Marcon
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Group Intervention ◽  
Statistical Significance ◽  
Self Care ◽  
Educational Interventions ◽  
The Individual ◽  
The Impact

OBJECTIVE: to compare the effectiveness of two educational interventions used by a healthcare provider in the monitoring of individuals with type 2 diabetes mellitus (T2DM), regarding knowledge of the disease, impact on quality of life and adoption of self-care actions. METHODS: comparative, longitudinal, prospective study performed with 150 subjects with type 2 diabetes, analyzed according to the type of participation in the program (individual and/or group). Participants of the individual intervention (II) received nursing consultations every six months and those of the group intervention (GI) took part in weekly meetings for three months. Data were collected through four questionnaires: Identification questionnaire, Problem Areas in Diabetes Questionnaire (PAID), Summary of Diabetes Self-Care Activities Questionnaire (SDSCA) and the Diabetes Knowledge Scale (DKN-A). Data were analyzed using the Friedman and Mann Whitney tests, considering a statistical significance of p ≤ 0.05. RESULTS: there was an increase in knowledge about the disease in the II (p<0.003) and GI (p<0.007), with reduction of the impact on the quality of life in the II (p<0.007) and improvement in self-care actions in the GI (p<0.001). CONCLUSION: in both intervention models improvements were observed in the indicators, over the six month monitoring period.

scholarly journals Mesenchymal Stem Cells: A New Choice for Nonsurgical Treatment of OA? Results from a Bayesian Network Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Ziqin Cao ◽  
Yajia Li ◽  
Fuqiang Gao ◽  
Ren Wu ◽  
Pengcheng Dou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pain Relief ◽  
Bayesian Network ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Joint Disease ◽  
Functional Improvement ◽  
Cochrane Library ◽  
Long Term Treatment

Objective. Osteoarthritis (OA) is the most common degenerative joint disease, causing joint pain, stiffness, and even disability. Guidelines recommend intra-articular injections as an alternative treatment to relieve OA symptoms for patients who demonstrate poor tolerability or compliance to oral administration of drugs. Mesenchymal stem cells (MSCs) are a potential treatment for of OA. We conducted this network meta-analysis to comprehensively compare the efficacy and safety between hyaluronic acid (HA), corticosteroids (GCs), platelet-rich plasma (PRP), and MSCs. Design. Systematic review and Bayesian network meta-analysis. Data Sources. Relevant studies, published from January 2000 to January 2020, in the PubMed, Cochrane library, EMBASE, and CKNI databases. Methods. Bayesian network and conventional meta-analyses were conducted. Pain relief, functional improvement, improvement in joint stiffness, and risk of adverse effects (AEs) were assessed. Results. Twenty-five articles with 4642 patients were included. Overall, MSC therapy was the most effective treatment for pain relief (standardized mean difference compared with placebo = 3.61 , 95% CI [1.87 to 5.35]). Both MSC and PRP therapies improved every symptom of OA effectively and have an advantage over HA and GCs which are recommended by guidelines. MSCs, PRP, HA, and GCs are tolerated well for patients in long-term treatment of OA compared with placebo. Conclusions. The results show that MSCs relieve pain, stiffness, and dysfunction due to OA better than PRP, HA, and GCs and are not statistically correlated with greater safety concerns. More high-quality trials are needed to reconfirm the findings of this study, however, standardization of preparation of MSCs and PRP should be investigated in the future.

scholarly journals Social Media Usage: The Impact on Feelings of Depression or Loneliness

2017 ◽  
Author(s):  
Sarah Jensen
Keyword(s):  
Quality Of Life ◽  
Social Media ◽  
Statistical Significance ◽  
General Social Survey ◽  
Mental Illnesses ◽  
Significant Finding ◽  
Adequate Treatment ◽  
Media Usage ◽  
The Impact

Over the past decade, there has been a rapid growth of social media. Much of the problem lies with the new potential for constant social comparisons. Social media also adds a new layer of interaction that can occur anywhere, at any time, with anyone. This allows for a higher quantity of relationships, but strips the depth of these relationships. Does increased social media use affect quality of life? I hypothesize that the more social media sites a respondent is a member or regular user of, the more time he or she reports feeling depressed or lonely. I used a sample of 628 respondents as part of in-person interviews conducted by the 2016 General Social Survey. The results found that overall about 51 percent of the people claimed to feel depressed or lonely none of the time. Meaning that about half of respondents do feel depressed or lonely at least some of the time. The most statistically significant finding revealed that the higher ones income, the less one reports feeling depressed or lonely. However, the hypothesis must be rejected because there is no statistical significance between social media usage and quality of life. Social media site usage does not result in increased feelings of depression or loneliness. Based on the income results, does money buy happiness? Those of lower socio-economic class may not have access to proper medical care and therefore do not get adequate treatment for mental illnesses. Structural forces might be having a direct impact.

scholarly journals Impact of a patient-centered medical home demonstration on quality of life and patient activation for older adults with complex needs in Singapore

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Grace Sum ◽  
Soon Hoe Ho ◽  
Zoe Zon Be Lim ◽  
Junxing Chay ◽  
Mimaika Luluina Ginting ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Medical Home ◽  
Statistical Significance ◽  
Patient Activation ◽  
Patient Centered Medical Home ◽  
Patient Centered ◽  
Needs Satisfaction ◽  
The Impact ◽  
Eq Vas

Abstract Background The first Patient-Centered Medical Home (PCMH) demonstration in Singapore was launched in November 2016, which aimed to deliver integrated and patient-centered care for patients with bio-psycho-social needs. Implementation was guided by principles of comprehensiveness, coordinated care, shared decision-making, accessible services, and quality and safety. We aimed to investigate the impact of implementing the PCMH in primary care on quality of life (QoL) and patient activation. Methods The study design was a prospective single-arm pre-post study. We applied the 5-level EuroQol 5-dimension (EQ-5D-5L) and Visual Analog Scale (EQ VAS) instruments to assess health-related QoL. The CASP-19 tool was utilised to examine the degree that needs satisfaction was fulfilled in the domains of Control, Autonomy, Self-realisation, and Pleasure. The 13-item Patient Activation Measure (PAM-13) was used to evaluate knowledge, skills and confidence in management of conditions and ability to self-care. Multivariable linear regression models with random intercepts were applied to examine the impact of the PCMH intervention on outcome measures at 3 months and 6 months post-enrolment, compared to baseline. Results We analysed 165 study participants enrolled into the PCMH from November 2017 to April 2020, with mean age 77 years (SD: 9.9). Within-group pre-post (6 months) EQ-5D-5L Index (β= -0.01, p-value = 0.35) and EQ VAS score (β=-0.03, p-value = 0.99) had no change. Compared to baseline, there were improvements in CASP-19 total score at 3 months (β = 1.34, p-value = 0.05) and 6 months post-enrolment (β = 1.15, p-value = 0.08) that were marginally out of statistical significance. There was also a significant impact of the PCMH on the CASP-19 Pleasure domain (β = 0.62, p = 0.03) at 6 months post-enrolment, compared to baseline. We found improved patient activation from a 15.2 % reduction in the proportion of participants in lower PAM levels, and a 23.4 and 16.7 % rise in proportion for higher PAM levels 3 and 4, respectively, from 3 months to 6 months post-enrolment. Conclusions Preliminary demonstration of the PCMH model shows evidence of improved needs satisfaction and patient activation, with potential to have a greater impact after a longer intervention duration.

scholarly journals Postoperative Quality of Life after Single-Visit Root Canal Treatment Performed with Reciprocating Shaping Systems: An Observational Study

2020 ◽  
Vol 11 (1) ◽  
pp. 273
Author(s):  
Stefania Multari ◽  
Mario Alovisi ◽  
Elio Berutti ◽  
Stefano Corbella ◽  
Silvio Taschieri ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Postoperative Pain ◽  
Root Canal ◽  
Statistical Significance ◽  
Primary Root ◽  
Root Canal Treatment ◽  
Single Visit ◽  
Alloy Properties ◽  
The Impact

Postoperative pain is a frequent complication of root canal treatment. It could worse patients’ quality of life (QoL) and it may be associated to several factors, including the shaping technique. The aim of the study was to compare the impact of WaveOne Gold (WOG) and WaveOne Classic (WOC) reciprocating instrumentation on postoperative QoL after single-visit primary root canal treatment. Healthy subjects with pulp necrosis on multirooted teeth were observed. Canal shaping was performed with WaveOne Gold Primary (n = 25) or WaveOne Classic Primary (n = 29) and canal filling was completed with a carrier-based technique. Mean and maximum scores for postoperative pain were assessed through a Visual Analogue Scale (VAS) and QoL indicators were evaluated with a self-assessment questionnaire based on a Likert scale. Postoperative pain curves were similar in both groups (mean pain p = 0.43; maximum pain p = 0.27) and quality of life indicators showed no significant differences (p > 0.05). There was a more favourable trend of QoL values in the WOG group, reaching statistical significance on day six posttreatment (p = 0.021). Within the limitations of the study, reciprocating instrumentation may have an impact on patients’ QoL, but the innovative geometrical and alloy properties of the WaveOne Gold seemed to induce a faster resolution of the postoperative symptoms.

scholarly journals The efficacy of intraarticular PRP, ozone and PRP + ozone injections in patients with osteoarthritis [abstract]

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Aysegül Ellialtioglu ◽  
Lale Yeprem
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Platelet Rich Plasma ◽  
Functional Independence ◽  
Joint Disease ◽  
Cartilage Tissue ◽  
Knee Oa ◽  
Surgical Methods ◽  
Anti Inflammatory

BACKGROUND: Osteoarthritis (OA) is the most common form of arthritis and some joints are predisposed more than others. The prevalence of OA increases with age and it represents the major problem for functional impairment in older patients. PURPOSE: This study was performed to determine efficiency of ozone + PRP (platelet rich plasma) injections on pain in patients with knee osteoarthritis. MATERIAL and METHODS: 102 patients with the diagnosis of OA according to the criteria of the American College of Rheumatology were enrolled in this study. Patients were randomized into three equal groups (34 patients each group). Patients in the first group were treated with intra-articular injections of ozone 2 times/week, with 10 ?g/ml ozone, 5ml in volume for a total of 12 times . Patients in the second group were treated with intra-articular injections of PRP + ozone (10 ?g/ml ozone, 5 ml volume) once a week for a total of 3 times. Patients in the third group were treated only with PRP injections once a week for a total of 3 times. The pain levels of patients were measured with visual analog scale (VAS).We chose the patients with VAS score 5 and above. The improvement strength has been evaluated according to Clinical Global image scale. RESULTS: In a retrospective study, Evaluation of the Clinical Global impression scale in the intra-articular injection of all patients (102 patients in total); 36 males and 66 females of 102 patients were found to have an average age of 56.11. The stress subscale of the 34 patients who had only ozone injections decreased from 5.17 to the healing scale of 2.91 In the 34 patients who received Ozone + PRP combination, the stress subscale decreased from 5,.14 to the healing scale 1.52. In the 34 patients who had only PRP, the subscale of stress subscale decreased from 4.9 to the healing scale 1.85. When the mean recovery scores were evaluated, it was 2.26 in the ozone alone group, 3.62 in the ozone + PRP combination and 3.06 in the PRP patients only. The recovery scores of the patients who received the ozone + PRP combination were significantly better than ozone or PRP injections alone. No side effects were observed during and after the treatments. DISCUSSION: OA is a degenerative joint disease that increases with age and causes pain and disability to significantly impair an individual's quality of life. It is considered to be an organ disease that affects cartilage destruction and changes in the subchondral bone, and all the joints and tissues around the joint. Pathologically, destruction and loss of articular cartilage, subchondral sclerosis and osteophyte formation are often accompanied by synovial inflammation and destruction of other structures that support joint. The loss of pain and functioning impairs the patient to a wide variety of treatment seeking, but unfortunately there are no medical or physical methods that have proven scientifically and proven to be effective in humans to prevent joint cartilage degradation and therefore all treatment approaches are aimed at relieving symptomatic pain and minimizing functional deficits . The goal of treatment in knee OA should be to control pain, to preserve and correct joint functions, to provide functional independence and to improve quality of life. In order to achieve these goals, knee OA therapy should include non pharmacologic, pharmacologic and if necessary, surgical methods. Treatment should be tailored to each patient. Non-steroidal anti-inflammatory (NSAID) drugs are thought to be the standard treatment for OA in many cases but many patients are not able to tolerate these drugs or are exposed to side effects, while only analgesics are adequate in some patients. As we have seen in the study above; ozone or PRP injections alone can be used for the patients with knee OA but the results of Ozone + PRP injections in knee OA reduced the pain more than the ozone and PRP injections alone. This might be because of the anti inflammatory effect of ozone has been supported by the release of the growth factors from the platelets in PRP. Therefore we can add ozone + PRP injections to patients who has OA without hesitation in additional to the classical treatment . For further studies we can use Major Autohemotherapy for regeneration in addition to the injections of ozone, PRP, Ozone + PRP. CONCLUSION: The combination of ozone + PRP offers the best results compared with PRP or ozone alone. We could not get any biopsy from the cartilage so we could not show the healing or changes of the cartilage according to the decrease of pain and the increase of quality of life. For further studies we could include biopsy and the measurement of inflammatory and anti inflammatory markers from the cartilage tissue before and after treatment.

scholarly journals The quality of life - an indicator for assessing the recovery program in patients diagnosed with degenerative disorders

2020 ◽  
pp. 88-94
Author(s):  
Elisabeta ANTONESCU ◽  
Maria TOTAN ◽  
Sînziana Călina SILIȘTEANU
Keyword(s):  
Quality Of Life ◽  
Family Environment ◽  
Muscle Tone ◽  
Statistical Significance ◽  
Demographic Data ◽  
Joint Disease ◽  
Important Symptom ◽  
Recovery Treatment ◽  
Recovery Program

Introduction. Osteoarthritis is a chronic joint disease, a progressive non-inflammatory arthropathy-type. Globally, around 1.7 billion people are affected by musculoskeletal and rheumatic diseases, which indicates an increase in the last 20 years of around 45%. Material and method. The objectives of the treatment of patients diagnosed with osteoarthritis were: decreasing the pain, increasing joint mobility, muscle strength, trophic and muscle tone, increasing the quality of life and reintegration into the social and family environment. Demographic data and the functional status were assessed using the VAS scale, the WOMAC scale, the QOL scale. Results and discussions. The pain, the most important symptom in osteoarthritis, was diminished in the patients from the group, the evaluation on the VAS scale, but also on the WOMAC scale has showed the value reduction and the statistical significance of this decrease. The quality of life in the group patients after the application of the complex recovery treatment, especially of the kinetotherapy program. Conclusions. The application of the individualized recovery treatment and adapted to the age group has allowed the improvement of the values of the parameters of pain, rigidity, functional capacity. The recovery of patients aged 55-65 is important to ensure the percentage of professionally active persons, to reduce medical costs, as well as those generated by absenteeism, and the socio-professional reintegration of these patients.

scholarly journals Ultrasound guided platelet rich plasma injections for post-traumatic greater occipital neuralgia: a randomized controlled pilot study

2021 ◽  
Author(s):  
Jacqueline Stone ◽  
Tak S. Fung ◽  
Matthew Machan ◽  
Christina Campbell ◽  
Rodney Li Pi Shan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pilot Study ◽  
Adverse Events ◽  
Normal Saline ◽  
Platelet Rich Plasma ◽  
Occipital Neuralgia ◽  
Greater Occipital Nerve ◽  
Post Traumatic ◽  
The Impact

Abstract Background: Post-traumatic headaches (PTH) are a common sequalae of TBI and greatly impact patient function and quality of life. Post-traumatic greater occipital neuralgia (GON) is a type of post-traumatic headache. Conventional treatment includes steroid/anesthetic injections which typically alleviate pain but have a short duration of effect. Platelet rich plasma (PRP) is an emerging biological treatment for numerous degenerative disorders, including peripheral nerve disorders. The primary aim of this pilot study is to evaluate whether a randomized control trial of PRP for the treatment of GON in patients with post-traumatic headaches is feasible in regard to recruitment, adherence, retention, and adherence and adverse events. Exploratory aims includes improvement in pain, function and quality of life in patients with post-traumatic GON receiving PRP compared to steroid/anesthetic and normal saline injections. Methods: Thirty adults (over 18 years of age) with post-traumatic GON will be randomized into one of three groups: 1) autologous PRP injection 2) steroid/anesthetic injection (standard care) or 3) placebo injection with normal saline. Injections will be performed to the greater occipital nerve under ultrasound guidance by a trained physician. Daily headache intensity and frequency data will be collected pre-injection and for the duration of the study period. Feasibility will be defined as greater than 30% recruitment, 70% completion of intervention, 70% retention and less than 2 minor adverse events. Exploratory outcomes will be explored using the (HIT-6; a valid and reliable 6-item questionnaire for assessment of the impact of headaches across different diagnostic groups of headaches (42, 43)) and the quality of life in following brain injury questionnaire (QOILIBRI). Discussion: This pilot study will be the first to evaluate the feasibility of PRP as a potential treatment of GON in patients with post-traumatic headache. Trial Registration: ClinicalTrials.gov - NCT04051203 (registered August 9, 2019), available at https://clinicaltrials.gov/ct2/show/NCT04051203?cond=greater+occipital+neuralgia&draw=2&rank=1

Autologous platelet-rich plasma (PRP) in chronic penile lichen sclerosus: the impact on tissue repair and patient quality of life

2017 ◽  
Vol 49 (4) ◽  
pp. 573-580 ◽  
Author(s):  
Francesco Casabona ◽  
Ilaria Gambelli ◽  
Federica Casabona ◽  
Pierluigi Santi ◽  
Gregorio Santori ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Tissue Repair ◽  
Platelet Rich Plasma ◽  
Lichen Sclerosus ◽  
Autologous Platelet Rich Plasma ◽  
The Impact ◽  
Autologous Platelet
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