Profil Sindrom Aspirasi Mekonium pada Bayi Baru Lahir di RSUD Dr. Soetrasno Rembang

Introduction: The presence of meconium in amniotic fluid occurs in 13% of live births in developing countries. This condition develops when the gestational age increases at delivery. Meconium aspiration syndrome occurs in 5% of newborns in meconium stained amniotic fluid. The aim of this study is to determine the profile of newborns who experience meconium aspiration syndrome (MAS) who are treated at Dr. Soetrasno Hospital, Rembang and its outcome.Methods: Prospective study, data were obtained from medical records of Dr. Soetrasno Hospital, Rembang during September to October 2018, on newborns with MAS.Results: Of 12 newborns with MAS were obtained, consisting of 7 (58.3%) male and 5 (41.7%) female. All cases were term infants (gestational age above 37 weeks) and normal birth weight (above 2500 grams). Based on the first minute APGAR score, there were 4 newborns had score 1 and 2, respectively (33.3%). Based on the fifth minute APGAR score, there were 7 newborns had score 3 (58.3%). The outcome of newborns with MAS were 7 alive (58.3%) and 5 died (41.7%).Conclusion: There were 12 newborns suffering from MAS (54.5%) of 22 babies hospitalized at the NICU dr. Soetrasno Hospital Rembang. All newborns with MAS were term infants and normal birth weight. There were 5 newborns with MAS which required invasive mechanical ventilation (intubation) and all died (41.7%).

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TO STUDY THE CLINICAL PROFILE OF MECONIUM ASPIRATION SYNDROME (MAS) IN NEONATES IN RELATION TO BIRTH WEIGHT, GESTATIONALAGE AND THEIR IMMEDIATE OUTCOME

10.36106/ijsr/9726593 ◽

2021 ◽

pp. 1-4

Author(s):

Mithilesh Kumar ◽

R. K. Sinha ◽

Debarshi Jana

Keyword(s):

Birth Weight ◽

Respiratory Distress ◽

Gestational Age ◽

Apgar Score ◽

Birth Asphyxia ◽

Meconium Aspiration Syndrome ◽

Clinical Profile ◽

Term Infants ◽

Cross Sectional ◽

Meconium Aspiration

Study the clinical profile of meconium aspiration syndrome (MAS) in neonates, in relation to birth weight, gestational age and their immediate outcome. Prospective observational cross sectional study. All preterm, term and post term infants, appropriate for gestational age with birth weight, delivered normally or by caesarean section or forceps, fulfilling all the inclusion criteria for MAS who were admitted to NICU, during the 9 months from January 2020 to September 2020 were included in the study. Over nine months' period, 574 neonates were admitted in NICU under that 312 neonates were in respiratory distress, out of which78 neonates were suffered with MAS. A detailed antenatal and natal history was elicited. Complications during delivery and details of resuscitation at birth, was done wherever required. Endo-tracheal intubation was done and bag and tube ventilation was given wherever needed. In MAS neonates, APGAR score at 1 minute and 5 minutes and gestational age was assessed with New Ballard’s score. A detailed clinical examination was carried out and respiratory distress was monitored by using Downes score system. Score > 6 was taken as an indication for assisted ventilation. 574 babies were admitted to NICU during the study period and out of them 312 were with respiratory distress. During the study period 78 (25%) babies had MAS. Conservative management was given to 59 cases (75.64%) and only 19 cases (24.36%) needed artificial ventilation, where indication was birth asphyxia, acute respiratory failure or other complications like pneumothorax. Out of 19 ventilated babies, 15 babies died and 4 babies survived and were discharged in good health. Conclusions: 1.Increased incidence of meconium aspiration syndrome was associated with increase in the gestational age (more in term and post term neonate, birth weight > 2.5kgs, 2. Highest mortality was associated with thick meconium and with low APGAR score at 5 minutes.

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Perinatal Outcome Associated with Meconium Stained Amniotic Fluid In Pregnancy

Journal of Paediatric Surgeons of Bangladesh ◽

10.3329/jpsb.v4i2.23937 ◽

2015 ◽

Vol 4 (2) ◽

pp. 44-49 ◽

Cited By ~ 1

Author(s):

Nasrin Begum ◽

Sharmeen Mahmood ◽

Salma Akhter Munmun ◽

MS Haque ◽

KN Nahar ◽

...

Keyword(s):

Birth Weight ◽

Amniotic Fluid ◽

Apgar Score ◽

Perinatal Outcome ◽

Perinatal Death ◽

Mode Of Delivery ◽

Neonatal Resuscitation ◽

Meconium Aspiration Syndrome ◽

Meconium Aspiration ◽

Meconium Stained Amniotic Fluid

Objectives: To evaluate perinatal outcome associated with meconium stained amniotic fluid in pregnant women.Methods: It was a prospective cross sectional study, conducted in the Department of Obstetrics and Gynecology in Bangabandhu Sheikh Mujib Medical University, Dhaka, from January 2013 to December 2013. Total 50 pregnant women admitted in the labour ward for delivery with meconium stained amniotic fluid were the study population. Singleton pregnancy of more than 34 weeks duration was included and pregnancy with APH, breech presentation, congenital malformation of fetus, IUD were excluded from the study. Out of 50 patients two did not provide all the information needed to analyze the data and hence were excluded. Outcome Variables were gestational age, antenatal checkup, medical diseases of mother (HTN, Diabetes mellitus, Heart disease), obstetric complication (oligohydramnios, prolonged labour), mode of delivery, neonatal details (weight of the baby in kg, APGAR scoring at 1 min & 5 min), neonatal resuscitation, admission in neonatal ICU(NICU), neonatal complications (RDS, MAS, Neonatal death).Results: Over half (52.1%) of the neonates needed resuscitation and 54.2% admitted in ICU. About 90% of the neonates had normal birth weight and only 10.4% were of low birth weight. 14.6% of the neonates developed meconium aspiration syndrome and 10.4% respiratory distress syndrome. Neonatal jaundice and neonatal sepsis were observed in 4.2% neonates each. Four neonates (8.3%) died early in the neonatal life, while 1 (2.1 %) was still-born. Low APGAR score (<7) at 1 and 5 minutes of birth was found in 64.7% and 52.9% of the cases respectively with thick meconium stained amniotic fluid as opposed to 25.8% and 16.1% of the cases respectively having thin meconium stained amniotic fluid (p = 0.008 and p = 0.007 respectively). Thick meconium was significantly associated with meconium aspiration syndrome (p = 0.003). Neonates needing immediate resuscitation and admission in ICU was staggeringly higher in the former group than those in the later group (p = 0.002). The incidence of perinatal death was significantly higher in patients with thick meconium stained amniotic fluid than that in patients with thin meconium ( p= 0.021).Conclusion: Meconium stained amniotic fluid was associated with low APGAR score, higher incidence of MAS, ICU admission and perinatal death.J. Paediatr. Surg. Bangladesh 4(2): 44-49, 2013 (July)

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Value of Neutrophil to Lymphocyte Ratio in Early Prediction of Meconium Aspiration Syndrome

Journal of Child Science ◽

10.1055/s-0040-1720958 ◽

2020 ◽

Vol 10 (01) ◽

pp. e207-e211

Author(s):

Suzan Gad ◽

Abeer Alkhalafawi ◽

Syed Raza ◽

Mervat Hesham ◽

Mohamed Sheta

Keyword(s):

Risk Factors ◽

Amniotic Fluid ◽

Apgar Score ◽

Significant Risk ◽

Meconium Aspiration Syndrome ◽

Neutrophil To Lymphocyte Ratio ◽

Meconium Aspiration ◽

Lymphocyte Ratio ◽

Meconium Stained Amniotic Fluid ◽

Minute Apgar Score

AbstractMeconium aspiration syndrome (MAS) is a serious neonatal condition. Prediction of MAS is challenging particularly in low-resource setting. Neutrophil to lymphocyte ratio (NLR) is a new simple index used for diagnosis of many inflammatory conditions. The present study was an attempt to determine whether NLR can predict the occurrence of MAS. The present study included 101 children with meconium-stained amniotic fluid. They comprised 22 patients who developed MAS and 79 neonates who didn't have the condition. All neonates were subjected to careful analysis of maternal and perinatal history in addition to thorough clinical assessment and radiological and laboratory evaluation. Blood samples from the umbilical cord were collected at birth and were used to obtain complete blood counts and C-reactive protein (CRP) assay. Univariate analysis revealed that elevated CRP levels, increased NLR, and 5-minute Apgar score of <7 were significant risk factors for the occurrence of MAS. Multivariate analysis revealed that low 5-minute Apgar score and increased NLR remained as significant risk factors of MAS. Receiver operating characteristic curve analysis showed good performance of NLR in prediction of MAS. NLR is useful in prediction of MAS in term neonates with meconium-stained amniotic fluid.

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Necrotizing Enterocolitis in the First 24 Hours of Life

PEDIATRICS ◽

10.1542/peds.73.4.476 ◽

1984 ◽

Vol 73 (4) ◽

pp. 476-480 ◽

Cited By ~ 2

Author(s):

Elizabeth H. Thilo ◽

Raul A. Lazarte ◽

Jacinto A. Hernandez

Keyword(s):

Birth Weight ◽

Necrotizing Enterocolitis ◽

Gestational Age ◽

Surgical Intervention ◽

Term Infants ◽

Large Size ◽

Disease Occurrence ◽

Near Term ◽

Degree Of Maturity ◽

Minute Apgar Score

Necrotizing enterocolitis (NEC) is commonly thought of as occuring in the sick premature infant, usually in the first one to two weeks of life. A review of NEC at the Children's Hospital of Denver over a 5-year period, found that 13 of 79 infants (16.1%) had onset of NEC during the first day of life. These infants were larger (mean birth weight 2,624 ± 849 g), more mature (mean gestational age 37.9 ± 2.5 weeks), and less asphyxiated as judged by Apgar scores (mean five-minute score 8.15 ± 1.07) than infants with onset of NEC after the first day of life (mean birth weight 1,519 ± 586 g, mean gestational age 32.0 ± 3.5 weeks, P < .001, and mean five-minute Apgar score 6.81 ± 1.84, P < .05). Despite their large size and degree of maturity, eight of these infants (62%) showed signs of respiratory distress; four (31%) were polycythemic; four (31%) had either a partial or double-volume exchange transfusion performed; and 11 (85%) were fed prior to developing NEC. Presenting signs of disease, occurrence of sepsis (31%), requirement for surgical intervention (62%), and mortality (30%) were similar for the two groups of infants. It is suggested that term and near-term infants who have significant illness after delivery be treated more like their premature counterparts with cautious introduction of feedings after an adequate period of stabilization.

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Heterogeneous Growth and Mental Development of Intrauterine Growth-Retarded Infants During the First 3 Years of Life

PEDIATRICS ◽

10.1542/peds.74.5.783 ◽

1984 ◽

Vol 74 (5) ◽

pp. 783-791 ◽

Cited By ~ 4

Author(s):

J. Villar ◽

V. Smeriglio ◽

R. Martorell ◽

C. H. Brown ◽

R. E. Klein

Keyword(s):

Birth Weight ◽

Total Sample ◽

Postnatal Growth ◽

Ponderal Index ◽

Normal Birth Weight ◽

Term Infants ◽

Developmental Patterns ◽

Intrauterine Growth ◽

Normal Birth ◽

Catch Up

Postnatal growth and development were studied in two groups of term infants with intrauterine growth retardation (IUGR) and one group of infants with normal birth weight up to 3 years of age (total sample, 205 infants). Infants with IUGR were classified as having low ponderal index (IUGR-LPI) or adequate ponderal index (IUGR-API). At birth, the two groups of infants with IUGR had similar birth weight, but length and head circumference measurements were significantly different. Overall, the IUGR-API infants remained lighter and shorter and had smaller head circumferences up to 30 months of age. The IUGR-LPI infants experienced catch-up growth in weight during the first months, because of greater fat deposition. At 24 months of age, the IUGR-API infants scored below the others on mental items. At 3 years of age the IUGR-API infants had the lowest values on seven of eight developmental measures and on the composite score; at these two time periods, the group with normal birth weight scored the highest, and the IUGR-LPI infants obtained intermediate values. It is concluded that infanst with IUGR tend to follow postnatal growth and developmental patterns that are associated with their physical characteristics at birth.

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The Dietary Composition of Women Who Delivered Healthy Full-Term Infants, Preterm Infants, and Full-Term Infants Who Were Small for Gestational Age

Biological Research For Nursing ◽

10.1177/1099800414556529 ◽

2014 ◽

Vol 17 (5) ◽

pp. 495-502 ◽

Cited By ~ 4

Author(s):

Rafał Bobiński ◽

Monika Mikulska ◽

Hanna Mojska ◽

Izabela Ulman-Włodarz

Keyword(s):

Gestational Age ◽

Small For Gestational Age ◽

Full Term ◽

Normal Birth Weight ◽

Term Infants ◽

Clinical Issue ◽

Normal Birth ◽

Appropriate For Gestational Age ◽

The Impact ◽

Gestational Duration

The impact of diet on the health of pregnant women remains an unresolved clinical issue. The aim of this study was to determine and compare the dietary intake of mothers who gave birth to full-term infants whose sizes were appropriate for gestational age (AGA), preterm birth (PTB) infants, and full-term infants who were small for gestational age (SGA). Of the 103 women who participated, 50 gave birth to AGA infants, 30 gave birth to PTB infants, and 23 gave birth to SGA infants. The composition of each woman’s diet was analyzed using a questionnaire completed 3 days postchildbirth. Findings revealed a number of differences between the groups. The percentage of energy obtained from fat and the calcium and lactose intake was all highest in Group AGA. The largest number of differences in intake of fatty acids (FAs) was observed among short- and medium-chain FAs. Lower levels of C4:0, C6:0, C8:0, C10:0, and C14:0 were observed in the diets of women in Group PTB than in Group AGA. C18:0 intake was also lower in Group PTB than in Group AGA. The reduced short-, medium-, and long-chain FA intake by women in Group PTB also affected the total saturated FA intake, which was lowest in that group. These findings suggest that, even in mothers giving birth to children with only slight deviations from normal birth weight or normal gestational duration, differences in diet can be identified, particularly regarding FA content, which may affect the health of the newborn.

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Meconium Stained Amniotic Fluid – A Potential Predictor Of Meconium Aspiration Syndrome

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v28i1.1397 ◽

1970 ◽

Vol 28 (1) ◽

pp. 3-6 ◽

Cited By ~ 2

Author(s):

P Swain ◽

A Thapalial

Keyword(s):

Amniotic Fluid ◽

Apgar Score ◽

Multiple Logistic Regression Analysis ◽

Univariate Analysis ◽

Significant Risk ◽

Neonatal Morbidity ◽

Meconium Aspiration Syndrome ◽

Meconium Aspiration ◽

Prolonged Labour ◽

Meconium Stained Amniotic Fluid

Objective: To identify potential predictors of Meconium Aspiration Syndrome (MAS) in pregnancies complicated by meconium-stained amniotic fluid (MSAF) & to review the incidence, morbidity and mortality of Meconium Aspiration Syndrome (MAS). Methods: In the period of 2003 to 2006,175 pregnancies with thick meconium-stained AF were delivered; of these, 15 neonates developed MAS and 160 did not. The two groups were compared retrospectively according to maternal findings, pregnancy outcome, and neonatal complications, using univariate analysis (P < 0.05 considered significant) and stepwise multiple logistic regression analysis to identify independent significant factors for prediction of MAS. Results: Incidence of MSAF was 13.97% and that of MAS was 8.57%. All deliveries associated with thick MSAF had developed MAS. 40% mothers were associated with PROM & prolonged labour. Most common & significant risk factors associated with MAS were increased gestational age, increased cesarean section (LSCS) & low Apgar scores at 1 minute and 5 minute. Mortality rate was 6.66% & mechanical ventilation was used in only 1(6.66%) case. Conclusion: MAS are associated with higher incidence of LSCS, lower 1 minute & 5 minute Apgar score & higher gestational weeks. 40% mothers were associated with PROM & prolonged labour. The neonatal morbidity & mortality is significantly more frequent in relation to thick meconium stained amniotic fluid. Specific delivery room resuscitation procedure, early diagnosis & proper management can prevent development of MAS as well as morbidity & mortality. Key words: Meconium Stained Amniotic Fluid, Meconium Aspiration Syndrome and Apgar Score. DOI = 10.3126/jnps.v28i1.1397 J. Nepal Paediatr. Soc. Vol.28(1) p.3-6

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Executive Functions of Six-Year-Old Boys with Normal Birth Weight and Gestational Age

PLoS ONE ◽

10.1371/journal.pone.0036502 ◽

2012 ◽

Vol 7 (4) ◽

pp. e36502 ◽

Cited By ~ 23

Author(s):

Desiree Yee-Ling Phua ◽

Anne Rifkin-Graboi ◽

Seang-Mei Saw ◽

Michael J. Meaney ◽

Anqi Qiu

Keyword(s):

Birth Weight ◽

Executive Functions ◽

Gestational Age ◽

Normal Birth Weight ◽

Normal Birth

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Determinan Kematian Neonatal Dini di RSUD Dr. Achmad Mochtar Bukittinggi

Kesmas National Public Health Journal ◽

10.21109/kesmas.v2i3.264 ◽

2007 ◽

Vol 2 (3) ◽

pp. 99

Author(s):

Efriza Efriza

Keyword(s):

Health Care ◽

Birth Weight ◽

Low Birth Weight ◽

Apgar Score ◽

Neonatal Death ◽

Health Care Facilities ◽

Care Process ◽

Normal Birth Weight ◽

Early Neonatal Death ◽

Normal Birth

Berdasarkan data SDKI 2002-2003 angka kematian neonatal di Indonesia adalah 20 per 1000 kelahiran hidup. Sebagian besar kematian neonatal terjadi pada saat neonatal dini ketika bayi berumur 0-7 hari. Penelitian ini bertujuan untuk mengetahui berbagai faktor yang mempengaruhi kematian neonatal dinidi RSUD Dr. Achmad Mochtar Bukittinggi tahun 2001-2005. Penelitian yang dilakukan pada sumber data sekunder rekam medik ibu dan bayi ini menggunakan disain studi kasus kontrol. Sampel dihitung dengan rumus ukursan sampel minimal kasus kontrol. Kasus. adalah bayi yang lahir hidup dan meninggal pada periode neonatal dini (0-7 hari) dan kontrol adalah bayi yang lahir hidup dan bertahan hidup pada periode neonatal dini. Jumlah kasus (93i) dan kontrol (392) ditentukan dengan rasio 1:4 untuk meningkatkan power penelitian Metoda analisis yang digunakan adalah analisis regresi logistik. Hasil penelitian menunjukkan kejadian kematian neonatal dini dipengaruhi oleh umur kehamilan, nilai apgar 1 menit setelah lahir, nilai apgar 5 menit setelah lahir dan berat lahir setelah dikontrol oleh variabel komplikasi kehamilan atau persalinan, rujukan, kelas perawatan, jenis persalinan, pendidikan ibu dan paritas. Bayi berat lahir sangat rendah (<1500 gram) berisiko untuk mati pada periode neonatal dini 59 kali lebih besar daripada bayi berat lahir normal. Sedangkan bayi beratlahir rendah (<2500 gram) berisiko mati pada periode neonatal dini 6 kali lebih besar daripada bayi berat lahir normal (³ 2500 gram). Antisipasi kematian neonatal dini perlu penanganan sejak kehamilan (ANC) sampai persalinan. Kerjasama pusat pelayanan dasar dengan pusat pelayanan ditingkat atas,persalinan di rumah sakit didampingi oleh dokter anak, pengkajian alat, tenaga, standar pelayanan dan mengoperasikan NICU (Neonatal Intensif Care Unit).Kata kunci : Kematian neonatal dini, faktor risikoAbstractThe Indonesia Demographic and Health Survey (SDKI) 2002-2003 reported neonatal death rate in Indonesia of 20 per 1000 live birth. Most of the neonatal death occurred early, that is in the age of infant of 0-7 days. This study aimed at knowing factors influencing early nenonatal detah in Dr Achmad MochtarHospital Bukittinggi in the year 2001-2005. The study used medical records of mother and infant as secondary data source and was designed as a casecontrol study. Cases were infants born alive and died during the early neonatal period (0-7 days), and controls were infants born and stay alive during thatperiod. Number of cases was 93 and control was 392 subjects was calculated on 1:4 ratio to increase the study power. Analysis method used was logistic regression analysis. The results show that early neonatal death was influenced by gestational age, Apgar score 1 minute after birth, Apgar score 5 minuteafter birth and birth weight after controlled by pregnancy or delivery complication, referral, health care class, type of delivery, mother’s education, and parity variables. Infants with very low birth weight (<1500 grams) have 59 times greater risk of early neonatal death compared to those of normal birth weight. While those with low birth weight (<2500 grams) have 6 times greater risk compared to normal birth weight infants. To anticipate the occurrence of early neonatal death there is a need to intervene since pregnancy (through ANC) until delivery. There is also a need to foster the collaboration between different levels of health care facilities, delivery assistance by specialist in the hospital level, and to standardize health care process including Neonatal Intensive Care Unit (NICU) implementation.Keywords : Early neonatal death, risk factors

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