scholarly journals Wilms’ tumor 1 protein expression in embryonal and alveolar rhabdomyosarcoma and its association with clinical prognostic factors: a cross-sectional study

2020 ◽  
Vol 29 (1) ◽  
pp. 47-52
Author(s):  
Aina Angelina ◽  
Nurjati Chairani Siregar ◽  
Riesye Arisanty
Keyword(s):  
Prognostic Factors ◽  
Tumor Size ◽  
Wilms Tumor ◽  
Pediatric Population ◽  
Cross Sectional Study ◽  
Alveolar Rhabdomyosarcoma ◽  
Genetic Profile ◽  
Sectional Study ◽  
Cross Sectional ◽  
Wilms Tumor 1

BACKGROUND Embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS) are the two major histological types commonly found in the pediatric population, which have different morphology and genetic profile. Wilms’ tumor 1 (WT1) is an antigen highly expressed in solid tumors, including rhabdomyosarcoma, and a potential immunotherapy target. Only a few studies have attempted to determine WT1 expression in rhabdomyosarcoma. This study was conducted to demonstrate WT1 expression in ERMS, ARMS and associate it with established prognostic factors. METHODS A cross-sectional study was conducted at the Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta using archival data from January 2011 to December 2017. 30 from 102 ERMS cases and 16 from 28 ARMS cases were included in this study. Data of age, tumor size, and location were collected. All cases were stained by WT1 immunohistochemistry. The expression was assessed semiquantitatively using histoscore (H-score) formula. An independent t-test was used to compare WT1 expression between ERMS and ARMS. Correlation analysis was used to evaluate the relationship between WT1 expression and prognostic factors. RESULTS All ERMS and ARMS cases expressed WT1 in diffuse, moderate to strong staining. ERMS show higher WT1 expression than ARMS (H-score 179.9 versus 149.5) (p = 0.014). Strong WT1 expression mostly found in patient age <20 years and non favourable location. Moderate WT1 expression mostly found in cases with tumor size >5 cm. CONCLUSIONS WT1 expression was higher in ERMS cases than in ARMS cases, which the expressions were similar in different age, tumor size, and location groups.

scholarly journals Prevalence of gout and asymptomatic hyperuricemia in the pediatric population: a cross-sectional study of a Japanese health insurance database

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Shuichi Ito ◽  
Tomoko Torii ◽  
Akihiro Nakajima ◽  
Takeshi Iijima ◽  
Hiroshi Murano ◽  
...  
Keyword(s):  
Uric Acid ◽  
Health Insurance ◽  
Pediatric Population ◽  
Gouty Arthritis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Insurance Claims ◽  
Cross Sectional ◽  
Total Prevalence ◽  
Health Insurance Claims

Abstract Background Although gout is rare in children, chronic sustained hyperuricemia can lead to monosodium urate deposits progressing to gout, just as in adults. This study assessed prevalence and characteristics of gout and asymptomatic hyperuricemia, and incidence of gouty arthritis in the pediatric population, using data from Japanese health insurance claims. The diagnosis and treatment of pediatric gout and hyperuricemia were analyzed, and specific characteristics of those patients were assessed. Since Japanese guidelines recommend treatment with uric acid lowering drugs for asymptomatic hyperuricemia as well as for gout, these data were also used to investigate the real-world use of uric acid lowering drugs in a pediatric population. Methods This cross-sectional study was based on a 2016–2017 Japanese health insurance claims database, one of the largest epidemiology claims databases available in Japan, which included 356,790 males and 339,487 females 0–18 years of age. Outcomes were measured for prevalence, patient characteristics, treatment with uric acid lowering drugs for gout and asymptomatic hyperuricemia, and prevalence and incidence of gouty arthritis. Because uric acid can be elevated by some forms of chemotherapy, data from patients under treatment for malignancies were excluded from consideration. Results Total prevalence of gout and asymptomatic hyperuricemia in 0–18 year-olds was 0.040% (276/696,277 patients), with gout prevalence at 0.007% (48/696,277) and asymptomatic hyperuricemia at 0.033% (228/696,277). Prevalence of gout and asymptomatic hyperuricemia was highest in adolescent males, at 0.135% (176/130,823). The most common comorbidities for gout and asymptomatic hyperuricemia were metabolic syndrome at 42.8% (118/276) and kidney disease at 34.8% (96/276). Of the patients diagnosed with gout or asymptomatic hyperuricemia, 35.1% (97/276) were treated with uric acid lowering drugs. Gouty arthritis developed in 43.8% (21/48) of gout patients during the study, at an incidence of 0.65 flares/person-year. Conclusions Even the pediatric population could be affected by asymptomatic hyperuricemia, gout, and gouty arthritis, and uric acid lowering drugs are being used in this population even though those drugs have not been approved for pediatric indications. Such off-label use may indicate a potential need for therapeutic agents in this population. Trial registration UMIN000036029.

A CROSS SECTIONAL STUDY OF BREAST CANCER HISTOMORPHOLOGY AND ITS CORRELATION WITH ER/PR, HER 2NEU AND KI-67 EXPRESSION IN A TERTIARY CARE HOSPITAL AT KANPUR

2021 ◽  
pp. 9-12
Author(s):  
Mahendra Singh ◽  
Shobha Dwivedi ◽  
Yukteshwar Mishra ◽  
Sakshi Tripathi
Keyword(s):  
Prognostic Factors ◽  
Breast Carcinoma ◽  
Tertiary Care ◽  
Radical Mastectomy ◽  
Cross Sectional Study ◽  
Low Grade ◽  
Care Hospital ◽  
Sectional Study ◽  
Ki 67 ◽  
Cross Sectional

BACKGROUND Breast carcinoma is the most well-known malignancy in women. Different predictive and prognostic factors, for example, estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptor (Her2neu), and Ki67 could inuence breast carcinoma behaviour, yet to date no authoritative connection has been set up among them and breast carcinoma subtypes. In this way present study was done to determine the interrelationships of these predictive and prognostic factors for breast carcinoma. METHODS In this cross sectional study, a total of 50 lumpectomy, modied radical mastectomy specimens of diagnosed carcinoma breast were included in this study. The histopathological grading of the breast carcinoma was performed by Nottingham modication of the Bloom Richardson grading system. All the cases went through immunohistochemistry for ER, PR, Her2neu and Ki67 expression. Association of ER, PR, Her2neu and Ki67 with different histomorphology was established. RESULTS The ER positivity was signicantly lower in tumors >5 cm size whereas Ki67was signicantly increased with increased tumor size. The ER positivity was signicantly lower in high grade tumors as compared to low grade tumors. The positive ER, PR, Her2neu and Ki67 were comparable in between premenopausal and post-menopausal age groups CONCLUSION The present study concludes that ER, PR show inverse while ki67 showed a direct relationship with the tumor grade. Correlation of histomorphology of breast tumor and Her2neu status could not be established.

scholarly journals Differential Impacts of Caries Classification in Children and Adults: A Comparison of ICDAS and DMF-T

2016 ◽  
Vol 27 (6) ◽  
pp. 761-766 ◽  
Author(s):  
Rosa Ana Melgar ◽  
Joanna Tatith Pereira ◽  
Patrícia Blaya Luz ◽  
Fernando Neves Hugo ◽  
Fernando Borba de Araujo
Keyword(s):  
Pediatric Population ◽  
Clinical Care ◽  
Population Level ◽  
Target Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Epidemiological Surveys ◽  
Dmft Index ◽  
Cavitated Lesions

Abstract The aim of this study was to describe and compare findings regarding the prevalence and severity of dental caries when using ICDAS and DMFT/dmft in an epidemiological study with children and their mothers. This cross-sectional study evaluated 150 preschoolers and their mothers. Data were collected with ICDAS and then transformed into DMFT/dmft. ICDAS scores related to caries were analyzed according to three different cut-off-points: CP1 (0-healthy/1-6-caries), CP2 (0-1-healthy/2-6-caries) and CP3 (0-2-healthy/3-6-caries), representing the D/d of DMFT/dmft. ICDAS codes regarding restorations, except sealants, were considered the F/f and the code 97 as the M/m of DMFT/dmft index. Prevalence of caries and its severity with ICDAS were 92%, 84% and 31.3% in children and 97.3%, 96.6% and 80% in adults according to CP1/CP2/CP3, respectively. Admitting CP3 as the standard for data transformation of ICDAS in DMFT/dmft, it was observed that DMFT/dmft index would underestimate 60% of non-cavitated lesions in children and 16.6% in adults. The DMFT/dmft underestimated the presence of disease to disregard non-cavitated lesions for the pediatric population evaluated. The choice of which is the best index for epidemiological surveys will depend on the purpose of the research and the target population: if it is to estimate the needs of the population to determine clinical care in children and adults, the DMFT/dmft may be sufficient. However, if the objective is to have a more comprehensive diagnosis of caries at the population level in order to develop preventive strategies, to halt and reverse the disease, the detection of non-cavitated-lesions becomes important, mainly in young children.

scholarly journals The family role in children׳s sleep disturbances: Results from a cross-sectional study in a Portuguese Urban pediatric population

Sleep Science ◽  
2015 ◽  
Vol 8 (3) ◽  
pp. 108-114 ◽  
Author(s):  
Andreia Luís Martins ◽  
Petra Chaves ◽  
Ana Luísa Papoila ◽  
Helena Cristina Loureiro
Keyword(s):  
Sleep Disturbances ◽  
Pediatric Population ◽  
Cross Sectional Study ◽  
Family Role ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Family

The epidemiology of lymphangioleiomyomatosis in Japan: A nationwide cross-sectional study of presenting features and prognostic factors

Respirology ◽  
2007 ◽  
Vol 12 (4) ◽  
pp. 523-530 ◽  
Author(s):  
Mie HAYASHIDA ◽  
Kuniaki SEYAMA ◽  
Yoshikazu INOUE ◽  
Keisaku FUJIMOTO ◽  
Keishi KUBO ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Expression of CK-19 in Papillary Thyroid Carcinoma and Its Association with Prognostic Factors - A Cross-Sectional Study

2021 ◽  
Vol 10 (11) ◽  
pp. 813-818
Author(s):  
Revathy V.J. ◽  
Sarath Kumar A
Keyword(s):  
Prognostic Factors ◽  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Tumour Size ◽  
Cross Sectional Study ◽  
Papillary Thyroid ◽  
Sectional Study ◽  
Cross Sectional ◽  
Node Metastasis

BACKGROUND Papillary thyroid carcinomas (PTC) are the most common carcinomas of the thyroid. Diagnosis of PTC is with its distinct nuclear features. Prognosis of PTC is favourable but can also be aggressive as demonstrated by its recurrence. So, we wanted to improve the present diagnostic tools to identify cases with aggressive course. Immunohistochemistry (IHC) markers which are thought to be useful are CK-19 and CD56. METHODS This is a cross sectional study, done in the Department of Pathology, Government Medical College, Thiruvananthapuram from January 2018 to May 2019. Histopathology slides were prepared from 80 samples, IHCs performed, and the data was analysed using statistical software SPSS version 23.0. RESULTS The classic variant was the most common. In the study, predominant population was below 45 years. There was a female predominance and majority of cases had a tumour size of more than 1 cm. 23.8 % of the cases showed lymph node metastasis. On evaluating CK-19 expression in PTC, 98.75 % showed a positive expression, but there was no association between CK-19 expression and factors like age, gender, tumour size, and lymph node metastasis. 96.3 % of cases showed a loss of expression of CD56. CONCLUSIONS Both CK-19 and CD56 can be used together as markers for PTC including all their variants but CK-19 cannot be used to assess the prognosis of PTC as no association was identified in the study between the expression of CK-19 and prognostic factors. KEY WORDS Papillary Thyroid Carcinoma, Immunohistochemistry

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