Faculty Opinions recommendation of The epidemiology of lymphangioleiomyomatosis in Japan: a nationwide cross-sectional study of presenting features and prognostic factors.

BACKGROUND Breast carcinoma is the most well-known malignancy in women. Different predictive and prognostic factors, for example, estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptor (Her2neu), and Ki67 could inuence breast carcinoma behaviour, yet to date no authoritative connection has been set up among them and breast carcinoma subtypes. In this way present study was done to determine the interrelationships of these predictive and prognostic factors for breast carcinoma. METHODS In this cross sectional study, a total of 50 lumpectomy, modied radical mastectomy specimens of diagnosed carcinoma breast were included in this study. The histopathological grading of the breast carcinoma was performed by Nottingham modication of the Bloom Richardson grading system. All the cases went through immunohistochemistry for ER, PR, Her2neu and Ki67 expression. Association of ER, PR, Her2neu and Ki67 with different histomorphology was established. RESULTS The ER positivity was signicantly lower in tumors >5 cm size whereas Ki67was signicantly increased with increased tumor size. The ER positivity was signicantly lower in high grade tumors as compared to low grade tumors. The positive ER, PR, Her2neu and Ki67 were comparable in between premenopausal and post-menopausal age groups CONCLUSION The present study concludes that ER, PR show inverse while ki67 showed a direct relationship with the tumor grade. Correlation of histomorphology of breast tumor and Her2neu status could not be established.

Download Full-text

Prognostic Factors Influencing the Selection of Bevacizumab Combined With Chemotherapy in Patients With HER2-Negative Metastatic Breast Cancer in Routine Clinical Practice. Oncosur-Avalox: Observational Cross-Sectional Study

Annals of Oncology ◽

10.1016/s0923-7534(20)32906-9 ◽

2012 ◽

Vol 23 ◽

pp. ix125

Author(s):

L. Manso ◽

R. Perez-Carrion ◽

J.I. Chacon Lopez-Muniz ◽

A. García Palomo ◽

E. Galve Calvo ◽

...

Keyword(s):

Breast Cancer ◽

Prognostic Factors ◽

Metastatic Breast Cancer ◽

Metastatic Breast ◽

Cross Sectional Study ◽

Routine Clinical Practice ◽

Sectional Study ◽

Cross Sectional ◽

Factors Influencing ◽

Selection Of

Download Full-text

The epidemiology of lymphangioleiomyomatosis in Japan: A nationwide cross-sectional study of presenting features and prognostic factors

Respirology ◽

10.1111/j.1440-1843.2007.01101.x ◽

2007 ◽

Vol 12 (4) ◽

pp. 523-530 ◽

Cited By ~ 62

Author(s):

Mie HAYASHIDA ◽

Kuniaki SEYAMA ◽

Yoshikazu INOUE ◽

Keisaku FUJIMOTO ◽

Keishi KUBO ◽

...

Keyword(s):

Prognostic Factors ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Expression of CK-19 in Papillary Thyroid Carcinoma and Its Association with Prognostic Factors - A Cross-Sectional Study

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2021/174 ◽

2021 ◽

Vol 10 (11) ◽

pp. 813-818

Author(s):

Revathy V.J. ◽

Sarath Kumar A

Keyword(s):

Prognostic Factors ◽

Lymph Node ◽

Papillary Thyroid Carcinoma ◽

Lymph Node Metastasis ◽

Tumour Size ◽

Cross Sectional Study ◽

Papillary Thyroid ◽

Sectional Study ◽

Cross Sectional ◽

Node Metastasis

BACKGROUND Papillary thyroid carcinomas (PTC) are the most common carcinomas of the thyroid. Diagnosis of PTC is with its distinct nuclear features. Prognosis of PTC is favourable but can also be aggressive as demonstrated by its recurrence. So, we wanted to improve the present diagnostic tools to identify cases with aggressive course. Immunohistochemistry (IHC) markers which are thought to be useful are CK-19 and CD56. METHODS This is a cross sectional study, done in the Department of Pathology, Government Medical College, Thiruvananthapuram from January 2018 to May 2019. Histopathology slides were prepared from 80 samples, IHCs performed, and the data was analysed using statistical software SPSS version 23.0. RESULTS The classic variant was the most common. In the study, predominant population was below 45 years. There was a female predominance and majority of cases had a tumour size of more than 1 cm. 23.8 % of the cases showed lymph node metastasis. On evaluating CK-19 expression in PTC, 98.75 % showed a positive expression, but there was no association between CK-19 expression and factors like age, gender, tumour size, and lymph node metastasis. 96.3 % of cases showed a loss of expression of CD56. CONCLUSIONS Both CK-19 and CD56 can be used together as markers for PTC including all their variants but CK-19 cannot be used to assess the prognosis of PTC as no association was identified in the study between the expression of CK-19 and prognostic factors. KEY WORDS Papillary Thyroid Carcinoma, Immunohistochemistry

Download Full-text

Identification of Ocular Trauma Pattern with Risk and Prognostic Factors in the North Bund Area of Shanghai

Journal of Ophthalmology & Clinical Research ◽

10.33140/jocr.05.02.05 ◽

2021 ◽

Vol 5 (2) ◽

Keyword(s):

Prognostic Factors ◽

Ocular Trauma ◽

Visual Outcome ◽

Cross Sectional Study ◽

Trauma Patients ◽

Eye Injury ◽

Sectional Study ◽

Cross Sectional ◽

The North ◽

Treatment Objective

Background: Ocular trauma is a leading cause of blindness. Identification of ocular trauma pattern is necessary for better ocular trauma prevention and treatment. Objective: The aim of this study is to identify ocular trauma pattern in the North Bund area of Shanghai. Methods: A retrospective cross-sectional study was conducted with 206 ocular trauma patients at Shanghai General Hospital. Results: A gender related ocular trauma pattern was identified that consists of several risk and prognostic factors. Of 206 ocular trauma patients, 182 patients were males (88.35%) and only 24 patients were females (11.65%). Males had significantly higher percentage of penetrating/intraocular foreign body injuries compared to females, which is associated with age and occupation. A significantly higher average monthly percentage of ocular trauma is observed in summer, suggesting that season change alters the risk of eye injury. Although proper treatments of complications are beneficial for patients, the visual outcome is determined by the location and size of injuries. Conclusion: We identified a gender related ocular trauma pattern with several risk and prognostic factors in the North Bund area of Shanghai.

Download Full-text

Prognostic Factors in Adolescent and Adult Patients With Acute Lymphoblastic Leukemia With Two Protocols of Chemotherapy: A Cross-Sectional Study

Clinical Lymphoma Myeloma & Leukemia ◽

10.1016/j.clml.2014.07.006 ◽

2015 ◽

Vol 15 (1) ◽

pp. e7-e14 ◽

Cited By ~ 4

Author(s):

Edilson Diogenes Pinheiro Junior ◽

Luis Fernando Pracchia ◽

Beatriz Beitler de Mauriño ◽

Gracia Aparecida Martinez ◽

Pedro Enrique Dorlhiac-Llacer ◽

...

Keyword(s):

Prognostic Factors ◽

Acute Lymphoblastic Leukemia ◽

Lymphoblastic Leukemia ◽

Cross Sectional Study ◽

Adult Patients ◽

Sectional Study ◽

Cross Sectional

Download Full-text

Wilms’ tumor 1 protein expression in embryonal and alveolar rhabdomyosarcoma and its association with clinical prognostic factors: a cross-sectional study

Medical Journal of Indonesia ◽

10.13181/mji.oa.193326 ◽

2020 ◽

Vol 29 (1) ◽

pp. 47-52

Author(s):

Aina Angelina ◽

Nurjati Chairani Siregar ◽

Riesye Arisanty

Keyword(s):

Prognostic Factors ◽

Tumor Size ◽

Wilms Tumor ◽

Pediatric Population ◽

Cross Sectional Study ◽

Alveolar Rhabdomyosarcoma ◽

Genetic Profile ◽

Sectional Study ◽

Cross Sectional ◽

Wilms Tumor 1

BACKGROUND Embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS) are the two major histological types commonly found in the pediatric population, which have different morphology and genetic profile. Wilms’ tumor 1 (WT1) is an antigen highly expressed in solid tumors, including rhabdomyosarcoma, and a potential immunotherapy target. Only a few studies have attempted to determine WT1 expression in rhabdomyosarcoma. This study was conducted to demonstrate WT1 expression in ERMS, ARMS and associate it with established prognostic factors. METHODS A cross-sectional study was conducted at the Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta using archival data from January 2011 to December 2017. 30 from 102 ERMS cases and 16 from 28 ARMS cases were included in this study. Data of age, tumor size, and location were collected. All cases were stained by WT1 immunohistochemistry. The expression was assessed semiquantitatively using histoscore (H-score) formula. An independent t-test was used to compare WT1 expression between ERMS and ARMS. Correlation analysis was used to evaluate the relationship between WT1 expression and prognostic factors. RESULTS All ERMS and ARMS cases expressed WT1 in diffuse, moderate to strong staining. ERMS show higher WT1 expression than ARMS (H-score 179.9 versus 149.5) (p = 0.014). Strong WT1 expression mostly found in patient age <20 years and non favourable location. Moderate WT1 expression mostly found in cases with tumor size >5 cm. CONCLUSIONS WT1 expression was higher in ERMS cases than in ARMS cases, which the expressions were similar in different age, tumor size, and location groups.

Download Full-text