Effect of Fracture on Bone Turnover Markers: A Longitudinal Study Comparing Marker Levels Before and After Injury in 113 Elderly Women

2007 ◽  
Vol 22 (8) ◽  
pp. 1155-1164 ◽  
Author(s):  
Kaisa K Ivaska ◽  
Paul Gerdhem ◽  
Kristina Åkesson ◽  
Patrick Garnero ◽  
Karl J Obrant
2013 ◽  
Author(s):  
Fratzl-Zelman Nadja ◽  
Nawrot-Wawrzyniak Kamilla ◽  
Misof Barbara ◽  
Panczyk-Tomaszewska Malgorzata ◽  
Ziolkowska Helena ◽  
...  

2008 ◽  
Vol 83 (6) ◽  
pp. 388-392 ◽  
Author(s):  
Silvano Adami ◽  
Davide Gatti ◽  
Ombretta Viapiana ◽  
Carmelo Erio Fiore ◽  
Ranuccio Nuti ◽  
...  

2015 ◽  
Vol 100 (4) ◽  
pp. 1460-1468 ◽  
Author(s):  
Anna Darelid ◽  
Martin Nilsson ◽  
Jenny M. Kindblom ◽  
Dan Mellström ◽  
Claes Ohlsson ◽  
...  

2018 ◽  
Vol 18 (08) ◽  
pp. 1840027 ◽  
Author(s):  
JINZE QIN ◽  
XIAOXU RONG ◽  
GUOXING ZHU ◽  
YU JIANG

Objective: To study the effects of square dance on bone mineral density (BMD) and bone turnover markers in patients with postmenopausal osteoporosis. Methods: Fifty postmenopausal women (aging 45–60) with osteoporosis were randomly assigned to a research group and a control group. The patients in the research group received 600[Formula: see text]mg of calcium combined with square dance (5 times a week, 30 to 60 minutes each time) for 6 months while those in the control group only received 600[Formula: see text]mg of calcium. BMD, changes in bone turnover markers and bone pain were assessed before and after the treatment. Results: (1) After the 6-month treatment, BMD of L[Formula: see text] and the femoral neck significantly increased in the research group ([Formula: see text]). No significant change was observed in BMD of the Ward’s region. BMD in the control group did not change significantly ([Formula: see text]). (2) No significant difference was found in serum levels of calcium, phosphorus and alkaline phosphatase between the two groups both before and after the treatment ([Formula: see text]). Serum levels of P1NP had a significant increase, while [Formula: see text]-CTX’s level did not change significantly. (3) The bone pain in both groups has been effectively relieved. The pain in the research group was relieved significantly compared to the control group. Conclusions: By improving the BMD and relieving the pain, square dancing can exert positive effects on women with postmenopausal osteoporosis. Square dancing may become a feasible strategy for osteoporosis prevention and treatment.


2010 ◽  
Vol 29 (2) ◽  
pp. 71-80 ◽  
Author(s):  
Simona Jurkovic Mlakar ◽  
Josko Osredkar ◽  
Janez Prezelj ◽  
Janja Marc

Recently, oxidative stress has been suggested as participating in the development of osteoporosis. Glutathione peroxidase 1 (GPX1) is one of antioxidant enzymes responsible for the defence of cells against oxidative damage and thus for protection against age related diseases such as osteoporosis.The aim of present study was to associate genetic variances of GPX1 enzyme with bone mineral density (BMD) and biochemical bone turnover markers and to show the influence of antioxidative defence system in genetics of osteoporosis.We evaluated 682 Slovenian subjects: 571 elderly women and 111 elderly men. All subjects were genotyped for the presence ofGPX1gene polymorphisms Pro198Leu and polyAla region. BMD and biochemical markers were also measured. General linear model analysis, adjusted to height, and (one-way) analysis of variance were used to assess differences between the genotype.and haplotype subgroups, respectively.The significant or borderline significant associations were found between the polyAla or the Pro198Leu polymorphisms and total hip BMD (0.018; 0.023, respectively), femoral neck BMD (0.117; 0.026, respectively) and lumbar spine BMD (0.032; 0.086, respectively), and with biochemical bone turnover markers such as plasma osteocalcin (0.027; 0.025, respectively) and serum C-terminal telopeptide of type I collagen concentrations (0.114; 0.012, respectively) in whole group. Haplotype analysis revealed that the 6-T haplotype is associated significantly with low BMD values (p> 0.025) at all measured locations of the skeleton, and with high plasma osteocalcin concentrations (p= 0.008).This study shows for the first time that the polymorphisms polyAla and Pro198Leu of theGPX1gene, individually and in combination, are associated with BMD and therefore may be useful as genetic markers for bone disease. Moreover, it implies the important contribution of the oxidative stress to pathogenesis of osteoporosis.


Bone ◽  
2003 ◽  
Vol 33 (4) ◽  
pp. 606-613 ◽  
Author(s):  
Susana N Zeni ◽  
Carlos R Ortela Soler ◽  
Araceli Lazzari ◽  
Laura López ◽  
Marisa Suarez ◽  
...  

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