Low Body Mass Index Is an Important Risk Factor for Low Bone Mass and Increased Bone Loss in Early Postmenopausal Women

The objective was to study the independent relationships of body mass index and endogenous estradiol to cortical bone mineral density and the rate of cortical bone loss at the radius in healthy early postmenopausal women. Fifty-one healthy early postmenopausal women (aged 58–66 years) participated. The women were a subset of a population participating in a 10-year longitudinal study to elucidate the influence of dietary calcium on the rate of cortical bone loss. Cortical bone mineral density at the radius, body weight and body height were measured annually (1979–89). Concentrations of sex steroids were measured in serum samples collected during the last year of follow-up (1989). Endogenous estradiol levels, although significantly positively correlated with body mass index, were not independently related to bone mass indices of the radius. Body mass index, on the other hand, was found to be positively related to cortical bone mineral density and negatively to the rate of bone loss, even after adjustments had been made for confounding factors. Our results suggest that the level of total estradiol is not an important determinant of cortical bone mass indices in healthy early postmenopausal women. Other factors of overweight such as mechanical loading may be important.

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Sclareol prevents ovariectomy-induced bone loss in vivo and inhibits osteoclastogenesis in vitro via suppressing NF-κB and MAPK/ERK signaling pathways

Food & Function ◽

10.1039/c9fo00206e ◽

2019 ◽

Vol 10 (10) ◽

pp. 6556-6567 ◽

Cited By ~ 5

Author(s):

Haiming Jin ◽

Zhenxuan Shao ◽

Qingqing Wang ◽

Jiansen Miao ◽

Xueqin Bai ◽

...

Keyword(s):

Bone Loss ◽

Bone Mass ◽

Postmenopausal Women ◽

Postmenopausal Osteoporosis ◽

Bone Quality ◽

Progressive Disease ◽

Erk Signaling ◽

Low Bone Mass

Postmenopausal osteoporosis (PMO) is a progressive disease occurring in elderly postmenopausal women that is characterized by low bone mass and impaired bone quality.

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479: Low body mass index (BMI) is a risk factor for increased markers of acute inflammation among early preterm births (PTB)

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2009.10.645 ◽

2009 ◽

Vol 201 (6) ◽

pp. S180

Author(s):

Tamula Patterson ◽

Suzanne Cliver ◽

Ona Faye-Petersen ◽

Robert Goldenberg ◽

William Andrews

Keyword(s):

Body Mass Index ◽

Risk Factor ◽

Body Mass ◽

Acute Inflammation ◽

Preterm Births ◽

Low Body Mass Index

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Effect of BMI(Body Mass Index) on BMD (Bone Mineral Density) in Postmenopausal Women

Journal of Dhaka Medical College ◽

10.3329/jdmc.v28i1.45758 ◽

2020 ◽

Vol 28 (1) ◽

pp. 60-66

Author(s):

Tabassum Ghani ◽

Subinoy Krishna Paul ◽

Afrina Begum ◽

Noorjahan ◽

Mandira Sarkar ◽

...

Keyword(s):

Bone Mineral Density ◽

Body Mass Index ◽

Bone Loss ◽

Postmenopausal Women ◽

Body Mass ◽

Bone Mineral ◽

Significant Positive Correlation ◽

Mineral Density ◽

Positive Correlation ◽

Medical College

Menopause is commonly associated with rapid bone loss and this bone loss manifests as a significant decrease in bone mineral density (BMD). Body weight or body mass index is the most important factor which influences BMD. Aim of this study was to evaluate the association between BMI and BMD in post menopausal women. Also to measure the correlation between age, duration of menopause, weight with BMD. This cross-sectional study was undertaken in the Department of Obstetrics and Gynaecology in Dhaka Medical College Hospital, Dhaka from January, 2012 to December, 2012. The study included women of 50 to 70 years who had menopause with three or more parity. Total 100 women were evaluated by history taking, physical examination and laboratory investigation (BMD).The results showed that there was significant positive correlation between BMI and BMD value of L1-4 and total femur (Pearson‘s coefficient was +0.285, P<0.01 and +.350, P<.001). There was also significant positive correlation between weight and T- score of L1-4 (r =+ .482, P<.01) and Total femur (r = +.513, P< .01). In addition, significant negative correlation was found between BMD with age and duration of menopause. It can be concluded that in postmenopausal women as the BMI decreases bone mineral density also decreases. So, adequate weight and BMI necessary for the prevention of osteoporosis. J Dhaka Medical College, Vol. 28, No.1, April, 2019, Page 60-66

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Effect of body mass, body mass index (BMI) on bone formation and effect of body mass index on bone turnover and bone mass in postmenopausal women

Bone ◽

10.1016/j.bone.2010.09.309 ◽

2010 ◽

Vol 47 ◽

pp. S448

Author(s):

Qun Cheng ◽

Huilin Li ◽

Jiemin Gan ◽

Xiaoying Zhu ◽

Han-min Zhu

Keyword(s):

Body Mass Index ◽

Bone Formation ◽

Bone Mass ◽

Bone Turnover ◽

Postmenopausal Women ◽

Body Mass

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Low body mass index is a risk factor forimpaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(03)00630-2 ◽

2003 ◽

Vol 42 (2) ◽

pp. 256-263 ◽

Cited By ~ 46

Author(s):

Yukihito Higashi ◽

Shota Sasaki ◽

Keigo Nakagawa ◽

Masashi Kimura ◽

Kensuke Noma ◽

...

Keyword(s):

Oxidative Stress ◽

Nitric Oxide ◽

Body Mass Index ◽

Risk Factor ◽

Body Mass ◽

Low Body Mass Index ◽

And Oxidative Stress

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Low body mass index as a risk factor of moderate to severe oral mucositis in oral cancer patients with radiotherapy

Supportive Care in Cancer ◽

10.1007/s00520-012-1620-7 ◽

2012 ◽

Vol 20 (12) ◽

pp. 3373-3377 ◽

Cited By ~ 9

Author(s):

Nobue Saito ◽

Yutaka Imai ◽

Takashi Muto ◽

Toshimi Sairenchi

Keyword(s):

Body Mass Index ◽

Risk Factor ◽

Oral Cancer ◽

Cancer Patients ◽

Body Mass ◽

Oral Mucositis ◽

Oral Cancer Patients ◽

Low Body Mass Index ◽

Severe Oral Mucositis

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Effect of L-citrulline, L-leucine, and multicomponent exercises on body compositions, physical activity, and amino acid concentrations in older Japanese women with low body mass index: A randomized double-blind placebo-controlled study

10.21203/rs.3.rs-311313/v1 ◽

2021 ◽

Author(s):

Mijin Kim ◽

Hiroko Isoda ◽

Tomohiro Okura

Keyword(s):

Physical Activity ◽

Body Mass Index ◽

Body Composition ◽

Body Weight ◽

Amino Acid ◽

Bone Mass ◽

Older Women ◽

Body Mass ◽

Low Body Mass Index ◽

Amino Acid Concentrations

Abstract Background: The intake of citrulline (CIT) and leucine (LEU) can stimulate protein synthesis. However, the efficacy of the combined intervention of CIT and LEU intake with exercise on body composition and physical activity (PA) remains unclear. This study aimed to investigate the combined effect of CIT and LEU intake and weight-bearing exercises (WBE) and square stepping exercise (SSE) for 20 weeks on body composition, PA, and amino acid concentration in older women with low body mass index (BMI) (16 to 21 kg/m 2 ). Methods: A total of 23 participants practiced WBE and SSE once a week for 75 minutes and were administered supplement (Ex + CIT·LEU group: CIT 0.8 g and LEU 1.6 g; Ex + Placebo group: 3.5 g carbohydrate) twice a day for 20 weeks. Body composition was measured using dual-energy X-ray absorptiometry. PA, including leisure-time, household, and occupational PA, was assessed using the Physical Activity Scale for the Elderly. Amino acid concentrations in the blood were analyzed by high-performance liquid chromatography.Results: Significant interactions were observed in the body weight, BMI, lean mass, body mass, household and total PA, tyrosine, and phenylalanine. The within-group analysis showed that tyrosine of post-intervention measurement (Post) significantly in both groups ( p < 0.05). Body weight, BMI, lean mass, body mass, household PA, total PA, and phenylalanine of Post increased significantly in the Ex + CIT·LEU group ( p < 0.05). Additionally, significant positive correlations were observed between the intake rate of supplements and bone mass ( r = 0.80) and between the practice rate of WBE at home and bone mineral density ( r = 0.66) in the Ex + CIT·LEU group. Conclusion: Our findings suggest that the intake of CIT and LEU, with the practice of WBE and SSE, could improve body weight, muscle mass, bone mass, and PA in older women with low BMI, which may prevent sarcopenia and frailty.Trial registration: UMIN000022385. Registered 20 May 2016, https://upload.umin.ac.jp/cgi-open-39 bin/ctr/ctr.cgi?function=brows&action=brows&recptno=R000025797&type=summary&language=J

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