Relationship Between MC4R Gene Polymorphyism and Body Weight Trait in Beagle Dogs

Program pemuliaan ikan mas varietas Punten dilakukan dengan seleksi individu terhadap karakter bobot ikan. Pembentukan populasi dasar untuk kegiatan seleksi dilakukan dengan memijahkan secara massal induk ikan mas yang terdiri atas 20 induk betina dan 21 induk jantan yang dikoleksi dari daerah Punten, Kepanjen (delapan betina dan enam jantan), Kediri (tujuh betina dan 12 jantan), Sragen (27 betina dan 10 jantan), dan Blitar (15 betina dan 11 jantan). Larva umur 10 hari dipelihara selama empat bulan. Selanjutnya dilakukan penjarangan sebesar 50% dan benih dipelihara selama 14 bulan untuk dilakukan seleksi dengan panduan hasil sampling 250 ekor individu setiap populasi. Seleksi terhadap calon induk dilakukan saat umur 18 bulan pada populasi jantan dan betina secara terpisah dengan memilih berdasarkan 10% bobot ikan yang terbaik. Calon induk yang terseleksi kemudian dipelihara hingga matang gonad, kemudian dipilih sebanyak 150 pasang dan dipijahkan secara massal. Didapatkan respons positif dari hasil seleksi berdasarkan bobot ikan, yaitu 49,89 g atau 3,66% (populasi ikan jantan) dan 168,47 g atau 11,43% (populasi ikan betina). Nilai heritabilitas untuk bobot ikan adalah 0,238 (jantan) dan 0,505 (betina).Punten carp breeding programs were carried out by individual selection for body weight trait. The base population for selection activities were conducted by mass breeding of parent consisted of 20 female and 21 male collected from area Punten, eight female and six male (Kepanjen), seven female and 12 male (Kediri), 27 female and 10 male (Sragen), 15 female and 11 male (Blitar). Larvae 10 days old reared for four moths. Then after spacing out 50% of total harvest, the offspring reared for 14 months for selection activity based on the sampling of 250 individual each population. Selection of broodstock candidates performed since 18 months age on male and female populations separately by selecting based on 10% of fish with best body weight. Candidates selected broodstocks were then maintained until mature. In oder to produce the next generation 150 pairs were sets and held for mass spawning. The results revealed that selection response were positive, 49.89 g (3.66%) for male and 168.47 (11.43%) for female. Heritability for body weight is 0.238 (male) and 0.505 (female).

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Genetic Mapping of a Body Weight Trait in Chicken

Nihon Chikusan Gakkaiho ◽

10.2508/chikusan.71.130 ◽

2000 ◽

Vol 71 (2) ◽

pp. 130-136

Author(s):

Ken TATSUDA ◽

Kuninori FUJINAKA ◽

Toshinobu YAMASAKI

Keyword(s):

Body Weight ◽

Genetic Mapping ◽

Body Weight Trait ◽

Weight Trait

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Ultrastructural Changes in Articular Cartilages of Immature Beagle Dogs Dosed with Difloxacin, a Fluoroquinolone

Veterinary Pathology ◽

10.1177/030098589202900307 ◽

1992 ◽

Vol 29 (3) ◽

pp. 230-238 ◽

Cited By ~ 36

Author(s):

J. E. Burkhardt ◽

M. A. Hill ◽

J. J. Turek ◽

W. W. Carlton

Keyword(s):

Extracellular Matrix ◽

Body Weight ◽

Electron Micrographs ◽

Collagen Fibrils ◽

Ultrastructural Changes ◽

Pericellular Matrix ◽

Skeletally Immature ◽

Beagle Dogs ◽

Cross Sectional ◽

Articular Cartilages

The ultrastructural features of quinolone-induced arthropathy were studied in' the humeral and femoral heads of nine skeletally immature Beagle dogs (3 months old) that were dosed orally with difloxacin at 300 mg/kg body weight and euthanatized 24, 36, or 48 hours later in groups of three. Three age-matched dogs were given a placebo and euthanatized after 48 hours. Mitochondria in chondrocytes had significantly greater cross-sectional areas ( P < 0.05) in electron micrographs from dogs euthanatized after 48 hours of treatment than did those in other groups. There was also a significantly greater percentage of chondrocytes with swollen mitochondria in treated dogs than in the controls ( P < 0.05). These changes preceded the necrosis observed in some chondrocytes in the dogs of the 48-hour group. Disruption of extracellular matrix was first observed in the pericellular matrix of necrotic chondrocytes, indicating that this change was secondary to the changes in chondrocytes. Fissures within cartilages apparently resulted from the loss of the normal association of proteoglycans with collagen fibrils.

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Capromorelin oral solution (ENTYCE®) increases food consumption and body weight when administered for 4 consecutive days to healthy adult Beagle dogs in a randomized, masked, placebo controlled study

BMC Veterinary Research ◽

10.1186/s12917-016-0925-z ◽

2016 ◽

Vol 13 (1) ◽

Cited By ~ 8

Author(s):

Bill Zollers ◽

Linda Rhodes ◽

Ernst Heinen

Keyword(s):

Body Weight ◽

Food Consumption ◽

Healthy Adult ◽

Oral Solution ◽

Controlled Study ◽

Beagle Dogs

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Cobalt Protoporphyrin Regulates Body Weight in Beagle Dogs: Induction of Weight Loss in Normal Animals of Stable Adult Weight

Pharmacology ◽

10.1159/000138834 ◽

1991 ◽

Vol 43 (2) ◽

pp. 96-105 ◽

Cited By ~ 11

Author(s):

Richard A. Galbraith ◽

Attallah Kappas

Keyword(s):

Weight Loss ◽

Body Weight ◽

Beagle Dogs ◽

Adult Weight ◽

Cobalt Protoporphyrin

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The SNPs of Melanocortin 4 Receptor (MC4R) Associated with Body Weight in Beagle Dogs

Experimental Animals ◽

10.1538/expanim.63.73 ◽

2014 ◽

Vol 63 (1) ◽

pp. 73-78 ◽

Cited By ~ 9

Author(s):

Ruixia Zeng ◽

YiBo Zhang ◽

Peng Du

Keyword(s):

Body Weight ◽

Beagle Dogs ◽

Melanocortin 4 Receptor

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Relative Serum Antiplasmin Levels in Normal and Hemophilic Dogs Treated with Choline

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649359 ◽

1972 ◽

Vol 27 (02) ◽

pp. 220-227

Author(s):

D McDonald ◽

Blanche Jackson ◽

H. B Boudreaux ◽

R. B Myers

Keyword(s):

Body Weight ◽

Factor Viii ◽

Human Serum ◽

Low Temperatures ◽

Enzyme Preparation ◽

Peroral Administration ◽

Beagle Dogs ◽

Canine Serum ◽

Significant Change

SummaryPeroral administration of choline in relatively high dosage (300 or 600 mg choline dihydrogen citrate per 17-20 lb body weight, 4 times daily) caused no significant change in serum antiplasmin activity of either normal or factor VIII-deficient beagle dogs. Also, no alteration in antiplasmin level was found to be associated with the hemophilic state.Canine serum antiplasmins are stable at low temperatures. Like human antiplasmins, they appear to have two major components which differ conspicuously in stability at 60° C.Other data presented in this paper show that crude plasmin readily obtained from human serum euglobulins provides an enzyme preparation suitable for screening antiplasmin levels of sera by the caseinolytic method.

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Ultrastructural Lesions of Pyridoxine Toxicity in Beagle Dogs

Veterinary Pathology ◽

10.1177/030098588101800607 ◽

1981 ◽

Vol 18 (6) ◽

pp. 769-777 ◽

Cited By ~ 13

Author(s):

D. M. Hoover ◽

W. W. Carlton ◽

C. K. Henrikson

Keyword(s):

Spinal Cord ◽

Body Weight ◽

Beagle Dogs ◽

Pyridoxine Hydrochloride ◽

Dorsal Funiculus ◽

Pathogenic Mechanisms ◽

Ultrastructural Alterations ◽

Myelin Sheaths ◽

Leg Movements

Three adult Beagle dogs given pyridoxine hydrochloride orally at a dose of 150 mg/kg body weight/day for about 100 days developed ataxia and had spastic, dysmetric leg movements. Ultrastructural alterations in the dorsal funiculus of the spinal cord were degeneration and loss of axons and myelin, and secondary changes of the myelin sheaths. Possible pathogenic mechanisms of pyridoxine neurotoxicity are discussed.

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The Subacute Neurotoxicity of Excess Pyridoxine HCl and Clioquinol (5-Chloro-7-Iodo-8-Hydroxyquinoline) in Beagle Dogs. I. Clinical Disease

Veterinary Pathology ◽

10.1177/030098588101800605 ◽

1981 ◽

Vol 18 (6) ◽

pp. 745-756 ◽

Cited By ~ 18

Author(s):

D. M. Hoover ◽

W. W. Carlton

Keyword(s):

Body Weight ◽

Treatment Group ◽

Experimental Period ◽

Treated Group ◽

Neurologic Disease ◽

Beagle Dogs ◽

Nitrogen Concentrations ◽

Leukocyte Counts ◽

Support Body Weight ◽

Leg Movements

The clinical and clinicopathologic effects of excess oral pyridoxine hydrochloride (150 mg/kg body weight/day) and clioquinol (200 mg/kg body weight/day) alone and in combination were evaluated in adult Beagle dogs over an experimental period of approximately 100 days. Anorexia and loss of body weight occurred in the first weeks of the trial period in each treatment group, but was most severe in dogs given both compounds. Dogs in each treatment group (10 of 10 pyridoxine-treated dogs, 6 of 13 clioquinol-treated dogs and 12 of 13 pyridoxine plus clioquinol-treated dogs) developed neurologic disease, manifested principally by ataxia. Pyridoxine-treated dogs had proprioceptive loss involving both fore- and hindquarters, characterized by stiff, spastic, dysmetric leg movements. In clioquinol-treated dogs, dysmetric leg movements were accompanied by failure to support body weight in the hindquarters, but similar forelimb involvement occurred in severely affected dogs. The neurologic disease in dogs given both compounds varied; signs in some dogs resembled those of affected dogs of the pyridoxine-treated group, and in others, those in the clioquinol-treated group. Erythrocyte counts, hemoglobin concentrations and packed cell volumes were reduced in dogs in each treatment group and were lowest in dogs given both compounds. Plasma protein was mildly reduced in dogs given pyridoxine or pyridoxine plus clioquinol. Few or no differences were present in the leukocyte counts, blood urea nitrogen concentrations, in activities of serum alanine aminotransferase and aspartate aminotransferase, and in concentrations of sodium, chloride or potassium in treated dogs as compared to control dogs.

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The Subacute Neurotoxicity of Excess Pyridoxine HCl and Clioquinol (5-Chloro-7-Iodo-8-Hydroxyquinoline) in Beagle Dogs. II. Pathology

Veterinary Pathology ◽

10.1177/030098588101800606 ◽

1981 ◽

Vol 18 (6) ◽

pp. 757-768 ◽

Cited By ~ 15

Author(s):

D. M. Hoover ◽

W. W. Carlton

Keyword(s):

Body Weight ◽

Combined Treatment ◽

Experimental Period ◽

Nerve Fibers ◽

Trigeminal Ganglia ◽

Beagle Dogs ◽

Pyridoxine Hydrochloride ◽

Dorsal Funiculus ◽

Treatment Groups ◽

The Central Nervous System

The lesions caused by excess oral pyridoxine hydrochloride (150 mg/kg body weight/day) and clioquinol (200 mg/kg body weight/day), given individually and in combination to adult Beagle dogs, were evaluated. The experimental period was 100 to 112 days, except that four dogs in each of the clioquinol and combined-treatment groups were killed early because of severe debilitation or neurologic disease, and one dog given both compounds died on the third day of compound administration. Degenerative neurologic lesions had distribution specific for the compound given. Pyridoxine-treated dogs had lesions limited to tracts and nerves with neuronal bodies of their nerve fibers in the spinal and trigeminal ganglia. Clioquinol-treated dogs had neurologic lesions limited to the central nervous system. The most severe lesions were in the rostral dorsal funiculus and distal aspects of the optic nerve fibers, but minimal to mild degenerative changes also occurred in distal aspects of the corticospinal and spinocerebellar tracts. Dogs given both pyridoxine hydrochloride and clioquinol had a combination of the lesions in dogs given pyridoxine or clioquinol individually. Several dogs given clioquinol or pyridoxine plus clioquinol had extraneural lesions, including myocardial degeneration and thyroidal alterations.

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