scholarly journals The Subacute Neurotoxicity of Excess Pyridoxine HCl and Clioquinol (5-Chloro-7-Iodo-8-Hydroxyquinoline) in Beagle Dogs. II. Pathology

1981 ◽  
Vol 18 (6) ◽  
pp. 757-768 ◽  
Author(s):  
D. M. Hoover ◽  
W. W. Carlton
Keyword(s):  
Body Weight ◽  
Combined Treatment ◽  
Experimental Period ◽  
Nerve Fibers ◽  
Trigeminal Ganglia ◽  
Beagle Dogs ◽  
Pyridoxine Hydrochloride ◽  
Dorsal Funiculus ◽  
Treatment Groups ◽  
The Central Nervous System

The lesions caused by excess oral pyridoxine hydrochloride (150 mg/kg body weight/day) and clioquinol (200 mg/kg body weight/day), given individually and in combination to adult Beagle dogs, were evaluated. The experimental period was 100 to 112 days, except that four dogs in each of the clioquinol and combined-treatment groups were killed early because of severe debilitation or neurologic disease, and one dog given both compounds died on the third day of compound administration. Degenerative neurologic lesions had distribution specific for the compound given. Pyridoxine-treated dogs had lesions limited to tracts and nerves with neuronal bodies of their nerve fibers in the spinal and trigeminal ganglia. Clioquinol-treated dogs had neurologic lesions limited to the central nervous system. The most severe lesions were in the rostral dorsal funiculus and distal aspects of the optic nerve fibers, but minimal to mild degenerative changes also occurred in distal aspects of the corticospinal and spinocerebellar tracts. Dogs given both pyridoxine hydrochloride and clioquinol had a combination of the lesions in dogs given pyridoxine or clioquinol individually. Several dogs given clioquinol or pyridoxine plus clioquinol had extraneural lesions, including myocardial degeneration and thyroidal alterations.

scholarly journals Ultrastructural Lesions of Pyridoxine Toxicity in Beagle Dogs

1981 ◽  
Vol 18 (6) ◽  
pp. 769-777 ◽  
Author(s):  
D. M. Hoover ◽  
W. W. Carlton ◽  
C. K. Henrikson
Keyword(s):  
Spinal Cord ◽  
Body Weight ◽  
Beagle Dogs ◽  
Pyridoxine Hydrochloride ◽  
Dorsal Funiculus ◽  
Pathogenic Mechanisms ◽  
Ultrastructural Alterations ◽  
Myelin Sheaths ◽  
Leg Movements

Three adult Beagle dogs given pyridoxine hydrochloride orally at a dose of 150 mg/kg body weight/day for about 100 days developed ataxia and had spastic, dysmetric leg movements. Ultrastructural alterations in the dorsal funiculus of the spinal cord were degeneration and loss of axons and myelin, and secondary changes of the myelin sheaths. Possible pathogenic mechanisms of pyridoxine neurotoxicity are discussed.

Effect of chedu and mattha on growth performance of Murrah buffalo calves

2016 ◽  
Author(s):  
Ramesh Kumar ◽  
Sanjay Kumar ◽  
Jyoti Palod ◽  
Himani Tewari ◽  
Balwan Singh
Keyword(s):  
Body Weight ◽  
Health Status ◽  
Growth Performance ◽  
Research Work ◽  
Experimental Period ◽  
Control Group ◽  
Buffalo Calves ◽  
Early Puberty ◽  
Murrah Buffalo ◽  
Treatment Groups

The aim of the present study was to determine the effect of chedu and mattha on growth performance of Murrah buffalo calves. To assess the effect of chedu and mattha on growth rate, 20 growing buffalo calves of around 1 year of age and approximately of same weights were selected and were divided into 4 treatment groups having 5 animals in each group. The animals had access to ad libitum berseem hay as the basal roughage T0 (Control), T1 (Administration of mattha @ 2% of body weight with salt @ 0.5% of mattha), T2 (Application of chedu on their body @ 150 g per animal), T3 (Administration of mattha and application of chedu). Body weight of all buffalo calves was recorded at 15 days interval during the experimental period. From 75th day of experiment, significant effect (P<0.05) was observed in body weight, heart girth and height at withers of treatment groups as compared to control group whereas, body length and paunch girth showed significant effect (P<0.05) on 90th day of experiment. The results further indicated that use of chedu and mattha improved the health status of the calves and helped to attain a comparatively higher body weight and an early puberty. It can be concluded on the basis of findings of present research work that the use of chedu and mattha may be recommended for supplementation of calves’ diet, as it improves the health status of the calves and helps in the attainment of higher body weight and an early onset of puberty in the calves.

scholarly journals Ameliorative Effects of Ascorbic Acid and Allium sativum (Garlic) Ethanol Extract on Renal Parenchyma of Gentamicin-induced Nephropathic Rats

2020 ◽  
pp. 1-8
Author(s):  
Dayo Rotimi Omotoso ◽  
Joy Motunrayo Olajumoke
Keyword(s):  
Ascorbic Acid ◽  
Body Weight ◽  
Allium Sativum ◽  
Combined Treatment ◽  
Ethanol Extract ◽  
Renal Tissue ◽  
Renal Parenchyma ◽  
Histopathological Changes ◽  
Treatment Groups ◽  
Tissue Weight

To assess ameliorative effects of Ascorbic acid (AA) and Allium sativum ethanol extract (ASEE) on renal parenchyma of gentamicin-induced nephropathic rats. Thirty Wistar rats (weighing between 180-205 g) were randomly divided into five groups (A-E).  These include Group A administered with 0.9% Normal Saline (0.5 ml/kg body weight (b.w.)), Group B administered with gentamicin (GM, 200 mg/kg b.w.) intraperitoneally (i.p.), Group C administered with GM (200 mg/kg b.w.) i.p. and AA (200 mg/kg b.w.) orally, Group D administered with GM (200 mg/kg b.w.) i.p. and ASEE (200 mg/kg b.w.) orally and Group E administered with GM (200 mg/kg b.w.) i.p. and AA (200 mg/kg b.w.) orally and ASEE (200 mg/kg b.w.) orally. All administrations were done once daily for a period of ten (10) days. The body weight of study animals was recorded at the beginning and end of study period. After the study period, renal tissue of study animals was harvested, weighed, processed, stained using H & E technique. Stained sections were examined under microscope for histopathological changes within the renal parenchyma and were scored using image-J software. The results of this study showed that exposure to GM results into significant (P < 0.05) reduction in body and renal tissue weight. However, therapeutic exposure to AA and ASEE either as individual or combined treatment regimen culminated into relatively null body and renal tissue weight loss among treatment groups C-E. In addition, exposure to GM precipitates prominent histopathological changes within renal parenchyma of study animals.  As observed with body and renal tissue weight changes, treatment with AA and ASEE also comparatively ameliorate GM-induced nephropathy within renal parenchyma of study animals in treatment groups. The findings of this study therefore showed that AA and ASEE exhibit ameliorative effect on the renal parenchyma of gentamicin-induced nephropathic rats either as distinct or combined treatment regimen.

scholarly journals A NOTE ON CONCENTRATE: LEGUME HAY RATIO IN FATTENING YANKASA SHEEP

1987 ◽  
Vol 14 ◽  
pp. 135-137
Author(s):  
C. A. M. Lakpini ◽  
I. F. Adu
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Dry Matter ◽  
Experimental Period ◽  
Dry Matter Intake ◽  
Feedlot Performance ◽  
Treatment Groups ◽  
Group A ◽  
Group D ◽  
Effect Of Feeding

Twenty Yankasa rams, about 1.5 years and weighing between 20 and 25kg. were randomly alloted to four treatment groups of 5 animals each. The groups were used to study the effect of feeding concentrate and groundnut haulms in the ratio of 0:1 (A); 1:1 (B); 1:3 (C); 3:1 (D) on feedlot performance. All animals were fed at 4% of body weight in individual pens through the 86 day experimental period. Total dry matter intake was significantly (P<0.05) highest for Group D and lowest for Group A. It costs least to feed Group A animals but cost of feed per weight gain was least for Group D. Liveweight gain was highest for Group D, which utilized feed most efficiently.   

scholarly journals Effect of Phytase Supplementation on the Performance of Babcock-380 Layer Hens

2021 ◽  
Vol 1 (1) ◽  
pp. 36-41
Author(s):  
MD. Ruhul Amin ◽  
Elliyana Nadia Hamidi
Keyword(s):  
Body Weight ◽  
Egg Production ◽  
Egg Size ◽  
Basal Diet ◽  
Experimental Period ◽  
Egg Mass ◽  
Egg Weight ◽  
Treatment Groups ◽  
Microbial Phytase ◽  
Production Group

 In order to examine the effect of phytase supplementation in the diet of laying hen this experiment was conducted with 30 commercial hybrid Babcock-380 layers of 73 weeks of age. The hens were grouped into 3 treatment groups and given microbial phytase (Rena Phytase 400) at levels 2.5, 1.5 and 0 (control) g/kg feed in addition to their basal diet (110 g commercial pellet/day). Records on egg production/group/day, egg mass weight/day, body weight of hens at the end of experimental period were taken and analysed. Results revealed that hen house egg production (HHEP) and egg weight (EW) varied (p<0.05) among the treatment groups but level of phytase did not affect (p<0.05) body weight of hens. Both HHEP and EW were in order of 2.5>1.5>0 g/kg feed phytase group and all the means were significantly (p<0.05) different from each other within treatment groups. Microbial phytase supplementation in layer ration proved to be beneficial in terms of egg production and egg size even after 72 weeks of age of hens. Layer farms in Malaysia can use this technology to earn more profit.

scholarly journals The sequential feeding of growing chickens

1975 ◽  
Vol 34 (1) ◽  
pp. 113-118 ◽  
Author(s):  
R. M. Gous ◽  
J. J. Du Preez
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Fish Meal ◽  
Experimental Period ◽  
Sole Source ◽  
Control Group ◽  
Sunflower Meal ◽  
Fasting Period ◽  
Treatment Groups ◽  
Feeding And Fasting

1. Male chickens, 1 week old, were fed alternately for 6 or 12 h periods with diets complementary in their amino acid composition. The isonitrogenous, isoenergetic diets were based on fish meal or sunflower meal as the sole source of protein, or fish meal–sunflower meal (40:60, w/w); each diet contained 120 g crude protein/kg. Other groups of chickens were given these diets ad lib.Net protein utilization (NPU) values obtained after a 1-week experimental period indicated that sequential feeding for both 6 and 12 h resulted in significantly improved responses compared with chickens given the same diets ad lib. These results suggested that the two protein sources, although provided at separate times, could complement each other.2. In certain treatments there was a 6 or 12 h fasting period between feeding periods to reduce the effect of nutrients from the previous period.3. For alternate feeding and fasting periods of 6 h with the combined diet, food intake and gain in body-weight were both significantly reduced compared with the corresponding values for the combined diet fed ad lib. The NPU value was virtually the same for both treatments. For 12 h periods of alternate feeding and fasting the gain in body-weight was only just significantly lower than that for the control group (combined diet fed ad lib.), but the NPU value was highly significantly better than that for the control group.4. For the treatments which included 6 and 12 h fasting periods between the two singleprotein diets, the food intake and gain in body-weight were significantly lower compared with the treatment groups given alternate feeding and fasting periods of either 6 or 12 h with the combined diet. The NPU values for the two groups given 12 h alternate feeding and fasting periods differed significantly, whereas the NPU values for the two groups given 6 h feeding and fasting periods were the same.

The Subacute Neurotoxicity of Excess Pyridoxine HCl and Clioquinol (5-Chloro-7-Iodo-8-Hydroxyquinoline) in Beagle Dogs. I. Clinical Disease

1981 ◽  
Vol 18 (6) ◽  
pp. 745-756 ◽  
Author(s):  
D. M. Hoover ◽  
W. W. Carlton
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Experimental Period ◽  
Treated Group ◽  
Neurologic Disease ◽  
Beagle Dogs ◽  
Nitrogen Concentrations ◽  
Leukocyte Counts ◽  
Support Body Weight ◽  
Leg Movements

The clinical and clinicopathologic effects of excess oral pyridoxine hydrochloride (150 mg/kg body weight/day) and clioquinol (200 mg/kg body weight/day) alone and in combination were evaluated in adult Beagle dogs over an experimental period of approximately 100 days. Anorexia and loss of body weight occurred in the first weeks of the trial period in each treatment group, but was most severe in dogs given both compounds. Dogs in each treatment group (10 of 10 pyridoxine-treated dogs, 6 of 13 clioquinol-treated dogs and 12 of 13 pyridoxine plus clioquinol-treated dogs) developed neurologic disease, manifested principally by ataxia. Pyridoxine-treated dogs had proprioceptive loss involving both fore- and hindquarters, characterized by stiff, spastic, dysmetric leg movements. In clioquinol-treated dogs, dysmetric leg movements were accompanied by failure to support body weight in the hindquarters, but similar forelimb involvement occurred in severely affected dogs. The neurologic disease in dogs given both compounds varied; signs in some dogs resembled those of affected dogs of the pyridoxine-treated group, and in others, those in the clioquinol-treated group. Erythrocyte counts, hemoglobin concentrations and packed cell volumes were reduced in dogs in each treatment group and were lowest in dogs given both compounds. Plasma protein was mildly reduced in dogs given pyridoxine or pyridoxine plus clioquinol. Few or no differences were present in the leukocyte counts, blood urea nitrogen concentrations, in activities of serum alanine aminotransferase and aspartate aminotransferase, and in concentrations of sodium, chloride or potassium in treated dogs as compared to control dogs.

scholarly journals Predicting the effects of body fatness on food intake and performance of sheep

2007 ◽  
Vol 97 (6) ◽  
pp. 1206-1215 ◽  
Author(s):  
Bert J. Tolkamp ◽  
Jonathan M. Yearsley ◽  
Iain J. Gordon ◽  
Andrew W. Illius ◽  
John R. Speakman ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Experimental Period ◽  
Energetic Efficiency ◽  
Final Body Weight ◽  
Body Fatness ◽  
Treatment Groups ◽  
Condition Score ◽  
And Performance ◽  
Parameter Values

Adipose tissue produces signals that can have a profound effect on many physiological functions, including energy expenditure and food intake. The hypothesis that variation in food intake of sheep resulting from differences in animal fatness can be predicted from effects of animal fatness on energetic efficiency was subjected to three tests. First, an existing food intake model was adapted to account for effects of animal fatness, as estimated by condition score, on food intake. Parameter values were derived from data obtained with two of five treatment groups of an experiment where ewe lambs were fed either chopped hay or pelleted concentrates. The model predicted the intake of the remaining three treatment groups satisfactorily. The energy intake model was subsequently extended with a protein module based upon a Gompertz curve to simulate changes in body weight and condition score. The model predicted these changes satisfactorily for most treatment groups during the experimental period of 50 weeks. In a last test, the final body weights and body lipid contents of animals fed either hay or concentrates for a period of 3 years were predicted. The predictions for final body weight (77 or 118 kg) and lipid content in the empty body (26 or 58 %) were within the range of expectations for sheep with access to hay or concentrates, respectively. The biological implications of the hypothesis that body fatness acts upon voluntary intake via its effects on energetic efficiency are discussed.

scholarly journals Effects of the Hydrolysable Oak Tannins on the Quail Performance

2016 ◽  
Vol 4 (12) ◽  
pp. 1085
Author(s):  
Mesut Karaman ◽  
Trefa Kamal M. Azize ◽  
Mehmet Sait Ekinci
Keyword(s):  
Body Weight ◽  
Mortality Rate ◽  
Conversion Efficiency ◽  
Body Weight Gain ◽  
Control Diet ◽  
Experimental Period ◽  
Feed Conversion ◽  
Treatment Groups ◽  
Live Body Weight ◽  
Different Levels

In the present study effects of different levels of hydrolyzed oak tannin on Japanese quail, live body weight and live body weight gain, food intake, food conversion efficiency and mortality rate were investigated. Therefore, a total of 240 quails were weighed and divided into 4 treatment groups each with 3 replicates containing 20 birds and reared in flat for 42 days as experimental period. While one of the groups was fed control diet with no additives (0% tannin A), other groups were fed with the different percentages of tannin on their diets, which are 0.5% (B), 1.0% (C), 1.5% (D) respectively. It has been observed that Japanese quails that fed the oak tannin containing diet had slower growth rate and poorer feed conversion efficiency and high mortality rate than birds fed with a tannin-free diet.

scholarly journals Sophorolipid protects against early-weaning syndrome by improving the gut microenvironment in early-weaned piglets

2022 ◽  
Vol 18 (1) ◽  
Author(s):  
Min-Jin Kwak ◽  
Sun-Woo Choi ◽  
Yong-Soon Choi ◽  
Hanbae Lee ◽  
Kwang-Youn Whang
Keyword(s):  
Body Weight ◽  
Average Daily Gain ◽  
Experimental Period ◽  
Control Group ◽  
Defense System ◽  
Weaned Piglets ◽  
Fatty Acid Production ◽  
Treatment Groups ◽  
Weaning Stress ◽  
Mucin Layer

Abstract Background In animals, weaning stress is the first and most critical stress. Weaning can negatively affect the growth performance of animals physically, psychologically, and pathologically. Our previous studies on the HT-29 cell line and early-weaned rats demonstrated that adequate sophorolipid (SPL) supplementation in feed could enhance the mucin-producing and wound healing capacities of the gut defense system by modulating gut microbiota. Methods We conducted an experiment with one hundred forty 21-day-old early weaned piglets (L x Y x D). They were allocated into 4 treatment and 7 replications (4 pigs per pen) according to their initial body weight. Body weight and feed intake were measured biweekly during experimental period. After 6 weeks, 28 pigs were randomly selected and sacrificed to collect plasma, jejunum, and cecal content samples. Results Dietary SPL supplementation at 5 and 10 mg/kg quadratically increased the average daily gain during the experimental period in the treatment groups when compared with the control group. The albumin levels of piglets fed with the SPL supplemented diet were downregulated to the normal range. Moreover, in feed, SPL supplementation at 5 and 10 mg/kg improved jejunal histological indices and gene expression levels related to mucin secretion and local inflammation markers. Consistent with these results, adequate SPL supplementation (5 and 10 mg/kg) increased the population of Prevotella, a beneficial bacterium, and its short-chain fatty acid production in the ceca of piglets. Conclusions The occurrence of diarrhea after weaning in piglets could be reduced by feeding a 10 ppm of SPL supplemented diet which improves the gut defense system by improving the microbial population and enhancing mucin layer integrity.

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