scholarly journals Optimal dynamic control approach in a multi-objective therapeutic scenario: Application to drug delivery in the treatment of prostate cancer

2018 ◽  
Vol 14 (4) ◽  
pp. e1006087 ◽  
Author(s):  
Itziar Irurzun-Arana ◽  
Alvaro Janda ◽  
Sergio Ardanza-Trevijano ◽  
Iñaki F. Trocóniz
2016 ◽  
Vol 30 (3) ◽  
pp. 470-491
Author(s):  
Yingdong Lu ◽  
Mayank Sharma ◽  
Mark S. Squillante ◽  
Bo Zhang

Motivated by applications in areas such as cloud computing and information technology services, we consider GI/GI/1 queueing systems under workloads (arrival and service processes) that vary according to one discrete time scale and under controls (server capacity) that vary according to another discrete time scale. We take a stochastic optimal control approach and formulate the corresponding optimal dynamic control problem as a stochastic dynamic program. Under general assumptions for the queueing system, we derive structural properties for the optimal dynamic control policy, establishing that the optimal policy can be obtained through a sequence of convex programs. We also derive fluid and diffusion approximations for the problem and propose analytical and computational approaches in these settings. Computational experiments demonstrate the benefits of our theoretical results over standard heuristics.


2017 ◽  
Vol 18 (11) ◽  
Author(s):  
Rohit R. Bhosale ◽  
H. V. Gangadharappa ◽  
Umme Hani ◽  
Riyaz Ali M. Osmani ◽  
Rudra Vaghela ◽  
...  

2021 ◽  
Vol 18 ◽  
Author(s):  
Raja Murugesan ◽  
Sureshkumar Raman

: At present treatment methods for cancer are limited, partially due to the solubility, poor cellular distribution of drug molecules and, the incapability of drugs to annoy the cellular barriers. Carbon nanotubes (CNTs) generally have excellent physio-chemical properties, which include high-level penetration into the cell membrane, high surface area and high capacity of drug loading by in circulating modification with bio-molecules, project them as an appropriate candidate to diagnose and deliver drugs to prostate cancer (PCa). Additionally, the chemically modified CNTs which have excellent 'Biosensing' properties therefore makes it easy for detecting PCa without fluorescent agent and thus targets the particular site of PCa and also, Drug delivery can accomplish a high efficacy, enhanced permeability with less toxic effects. While CNTs have been mainly engaged in cancer treatment, a few studies are focussed on the diagnosis and treatment of PCa. Here, we detailly reviewed the current progress of the CNTs based diagnosis and targeted drug delivery system for managing and curing PCa.


2017 ◽  
Vol 408 ◽  
pp. 164-173 ◽  
Author(s):  
O. Bashari ◽  
B. Redko ◽  
A. Cohen ◽  
G. Luboshits ◽  
G. Gellerman ◽  
...  

2018 ◽  
Vol 18 (8) ◽  
pp. 5171-5191 ◽  
Author(s):  
Soundararajan Hema ◽  
Selvarathinam Thambiraj ◽  
Dhesingh Ravi Shankaran

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