scholarly journals Correlation between Renal Function and Common Risk Factors for Chronic Kidney Disease in a Healthy Middle-Aged Population: A Prospective Observational 2-Year Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e113263 ◽  
Author(s):  
Michiya Ohno ◽  
Fumiko Deguchi ◽  
Kumiko Izumi ◽  
Hirotoshi Ishigaki ◽  
Hiroshi Sarui ◽  
...  
2019 ◽  
pp. 29-38
Author(s):  
Hania Kassem ◽  
Bernard G. Jaar

Chronic kidney disease (CKD) represents a significant public health burden worldwide and several risk factors have been identified over the years; these have been well-described in the medical literature. Common risk factors such as diabetes mellitus and hypertension will be described in other chapters. While this chapter will focus mainly on CKD risk factors observed in developed countries, several of these are also observed in developing countries. It is now well-established that some risk factors are modifiable while others are non-modifiable. In this chapter, we will explore several of these non-modifiable risk factors in more detail, such as age, gender, race, family history, and low birth weight. But we will also discuss some of the modifiable risk factors such as kidney stones, obstructive sleep apnea, smoking, drugs (excluding NSAIDs), diet, obesity, metabolic syndrome, and hyperuricemia. We will provide a balanced and up to date review of the evidence linking these risk factors with CKD.


PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162782 ◽  
Author(s):  
Maria Alice Muniz Domingos ◽  
Silvia Regina Moreira ◽  
Luz Gomez ◽  
Alessandra Goulart ◽  
Paulo Andrade Lotufo ◽  
...  

2011 ◽  
Vol 38 (12) ◽  
pp. 2588-2597 ◽  
Author(s):  
SU-JIN MOON ◽  
SEUNG-KI KWOK ◽  
JI HYEON JU ◽  
KYUNG-SU PARK ◽  
SUNG-HWAN PARK ◽  
...  

Objective.Since chronic kidney disease (CKD) is closely associated with cardiovascular disease and mortality as well as endstage renal disease, prediction of progressive CKD is a clinically important issue. We investigated the independent risk factors for the development of CKD in patients with lupus nephritis (LN).Methods.The cohort included 322 Korean patients diagnosed with LN between 1985 and 2010. We retrospectively analyzed the clinical and laboratory indices, treatment response, the final renal function, and the biopsy findings. The timing and cumulative risk of developing CKD were identified by Kaplan-Meier methods. The independent risk factors for developing CKD were examined by univariate and multivariate Cox proportional hazards regression analyses.Results.The median followup time after the diagnosis of LN was 84 months. CKD occurs in 22% of the patients within 10 years after the diagnosis of LN. The probability of developing CKD was significantly associated with the onset time of LN (delayed-onset LN vs initial-onset LN; HR 2.904, p = 0.003), deteriorated renal function [an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 body surface area] at the onset of LN (HR 7.458, p < 0.001), relapse of LN after achieving remission (HR 2.806, p = 0.029), and resistance to induction therapy (HR 8.120, p < 0.001).Conclusion.Our results demonstrate that delayed-onset LN, a decreased eGFR at the time of LN onset, and the failure to achieve a sustained remission are predictors for the development of CKD in Korean patients with LN.


PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e14216 ◽  
Author(s):  
Iraj Najafi ◽  
Fatemeh Attari ◽  
Farhad Islami ◽  
Ramin Shakeri ◽  
Fatemeh Malekzadeh ◽  
...  

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