Analgesic use, parents’ clan, and coffee intake are three independent risk factors of chronic kidney disease in middle and elderly-aged population: a community-based study

Objective.Since chronic kidney disease (CKD) is closely associated with cardiovascular disease and mortality as well as endstage renal disease, prediction of progressive CKD is a clinically important issue. We investigated the independent risk factors for the development of CKD in patients with lupus nephritis (LN).Methods.The cohort included 322 Korean patients diagnosed with LN between 1985 and 2010. We retrospectively analyzed the clinical and laboratory indices, treatment response, the final renal function, and the biopsy findings. The timing and cumulative risk of developing CKD were identified by Kaplan-Meier methods. The independent risk factors for developing CKD were examined by univariate and multivariate Cox proportional hazards regression analyses.Results.The median followup time after the diagnosis of LN was 84 months. CKD occurs in 22% of the patients within 10 years after the diagnosis of LN. The probability of developing CKD was significantly associated with the onset time of LN (delayed-onset LN vs initial-onset LN; HR 2.904, p = 0.003), deteriorated renal function [an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 body surface area] at the onset of LN (HR 7.458, p < 0.001), relapse of LN after achieving remission (HR 2.806, p = 0.029), and resistance to induction therapy (HR 8.120, p < 0.001).Conclusion.Our results demonstrate that delayed-onset LN, a decreased eGFR at the time of LN onset, and the failure to achieve a sustained remission are predictors for the development of CKD in Korean patients with LN.

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Serum Albumin and High-Sensitivity C-reactive Protein are Independent Risk Factors of Chronic Kidney Disease in Middle-Aged Japanese Individuals: the Circulatory Risk in Communities Study

Journal of Atherosclerosis and Thrombosis ◽

10.5551/jat.33530 ◽

2016 ◽

Vol 23 (9) ◽

pp. 1089-1098 ◽

Cited By ~ 14

Author(s):

Sachimi Kubo ◽

Akihiko Kitamura ◽

Hironori Imano ◽

Renzhe Cui ◽

Kazumasa Yamagishi ◽

...

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Serum Albumin ◽

High Sensitivity ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Independent Risk Factors

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Presentation and outcomes of chronic kidney disease patients with COVID-19

Brazilian Journal of Nephrology ◽

10.1590/2175-8239-jbn-2021-0071 ◽

2021 ◽

Author(s):

Carolina Gonçalves Branco ◽

Inês Duarte ◽

Joana Gameiro ◽

Cláudia Costa ◽

Filipe Marques ◽

...

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Multivariate Analysis ◽

Kidney Disease ◽

Clinical Presentation ◽

Tertiary Care ◽

Kidney Injury ◽

Older Age ◽

Global Health Issue ◽

Independent Risk Factors

Abstract Introduction: COVID-19 is currently a global health issue and an important cause of mortality. Chronic kidney disease (CKD) is one of the risk factors for infection, morbidity and mortality by SARS-CoV-2. In our study, we aimed to evaluate the clinical presentation and outcomes of CKD patients with COVID-19, as well as identify predictors of mortality. Methods: This was a retrospective study of CKD patients admitted in a tertiary-care Portuguese hospital between March and August of 2020. Variables were submitted to univariate and multivariate analysis to determine factors predictive of in-hospital mortality. Results: 130 CKD patients were analyzed (median age 73.9 years, male 60.0%). Hypertension (81.5%), cardiovascular disease (36.2%), and diabetes (54.6%) were frequent conditions. Cough, dyspnea, fever and respiratory failure were also common. Almost 60% had anemia, 50% hypoalbuminemia, 13.8% hyperlactacidemia and 17% acidemia. Mean serum ferritin was 1531 µg/L, mean CRP 8.3 mg/dL and mean LDH 336.9 U/L. Most patients were treated with lopinavir/ritonavir, hydroxychloroquine or corticosteroids and only 2 with remdesivir. Eighty percent had acute kidney injury and 16.2% required intensive care unit admission. The 34 patients who died were older and more likely to have heart failure. They had higher neutrophils/lymphocytes ratio, ferritin, lactate, and LDH levels. Multivariate analysis identified an association between older age [OR 1.1 (CI 1.01-1.24), p=0.027], higher ferritin [OR 1.0 (CI 1.00-1.00), p=0.009] and higher LDH levels [OR 1.0 (CI 1.00-1.01), p=0.014] and mortality. Conclusion: In our cohort of CKD patients with COVID-19, older age, higher ferritin, and higher LDH levels were independent risk factors for mortality.

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The National Kidney Foundation of Illinois KidneyMobile: a mobile resource for community based screenings of chronic kidney disease and its risk factors

BMC Nephrology ◽

10.1186/s12882-018-1079-y ◽

2018 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Swati Lederer ◽

Laurie Ruggiero ◽

Nicole M. Sisen ◽

Nancy Lepain ◽

Kate Grubbs O’Connor ◽

...

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

National Kidney Foundation ◽

Community Based

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Community-Based Screening for Chronic Kidney Disease, Hypertension and Diabetes in Dharan

Journal of Nepal Medical Association ◽

10.31729/jnma.548 ◽

2013 ◽

Vol 52 (189) ◽

pp. 205-212 ◽

Cited By ~ 16

Author(s):

Sanjib Kumar Sharma ◽

Subodh Dhakal ◽

Lekhjung Thapa ◽

Anup Ghimire ◽

Rikesh Tamrakar ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Intervention Program ◽

Lifestyle Modification ◽

Fasting Blood Glucose ◽

Management Program ◽

Community Based ◽

Spot Urine

Introduction: Nepal cannot afford renal replacement therapy for End Stage Renal Disease due to lack of resources. Early diagnosis of Chronic Kidney Disease and its risk factors may reduce the need of renal replacement therapy.Methods:A community-based screening on, 3218 people ≥20 years were assessed by door-to-door survey in Dharan, Nepal. Health status, lifestyle habit, physical examination and blood pressure were evaluated. Spot urine was examined for proteins and glucose by dipstick. Fasting blood glucose and serum creatinine were measured in a subset of 1000 people and the prevalence of Chronic Kidney Disease was evaluated.Results: Overweight, obesity, hypertension, diabetes and proteinuria were found in 20%, 5.0%, 38.6%, 7.5%, and 5.1% respectively. In the subset group, Chronic Kidney Disease was detected in 10.6%. Multivariate analysis indicated age (P <0.0001) and diabetes (P = 0.027) as statistically significant predictors for Chronic Kidney Disease. Total of 848 patients entered the management program of lifestyle modification and pharmacologic intervention. Glycemic and blood pressure control was achieved in 60% and 72%, respectively. Regression or stabilization of proteinuria was reported in 52% of patients. Conclusions: Burden of Chronic Kidney Disease and cardiovascular risk factors are high in Dharan. Reasonable control of blood sugar, hypertension and proteinuria was achieved in this program. Findings indicate that activation a large prevention and intervention program to tackle Chronic Kidney Disease and Cardiovascular Disease in Nepal is needed.Keywords: chronic kidney disease; community-screening; diabetes; hypertension; intervention; Nepal.

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Effects of Coffee Intake on Incident Chronic Kidney Disease: A Community-Based Prospective Cohort Study

The American Journal of Medicine ◽

10.1016/j.amjmed.2018.05.021 ◽

2018 ◽

Vol 131 (12) ◽

pp. 1482-1490.e3 ◽

Cited By ~ 11

Author(s):

Jong Hyun Jhee ◽

Ki Heon Nam ◽

Seong Yeong An ◽

Min-Uk Cha ◽

Misol Lee ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Cohort Study ◽

Kidney Disease ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Community Based ◽

Coffee Intake ◽

Incident Chronic Kidney Disease

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AS-058 Chronic Kidney Disease was Independent Risk Factors on the Target Revascularization after Everolimus Eluting Stent Implantation

The American Journal of Cardiology ◽

10.1016/j.amjcard.2012.01.065 ◽

2012 ◽

Vol 109 (7) ◽

pp. S31

Author(s):

Makito Ozawa

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Stent Implantation ◽

Independent Risk Factors

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P0765RHEUMATOID ARTHRITIS AND CHRONIC KIDNEY DISEASE: DOES INFLAMMATION SAY IT ALL?

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0765 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Marina Sofia Rodrigues Reis ◽

Pedro Salvador ◽

Ana Marta Gomes ◽

Sara Beça ◽

João Carlos Fernandes

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Cardiovascular Events ◽

Estimated Glomerular Filtration Rate ◽

Mortality And Morbidity ◽

American College Of Rheumatology ◽

Increase Risk ◽

Independent Risk Factors ◽

The Mean

Abstract Background and Aims Rheumatoid arthritis (RA) increase risk of developing chronic kidney disease (CKD), but it is unknow which risk factors contributes to CKD in this population. This study aims to determine predictors for the development of CKD in RA patients. Method A retrospective study was conducted in 106 patients with RA followed at a sub-specialized internal medicine appointment between January 2007 and December 2017. RA was defined according to the American College of Rheumatology criteria and CKD was defined as an estimated glomerular filtration rate less than 60mL/min/ 1.73m2 or presence of abnormalities of urinary sediment for 3 months. Results The mean age was 61 ± 12.83 years, and 67.9% (n=72) were female. The prevalence of CKD was 20.8% (n=22). Renal disease had multifactorial etiology in 20 patients, and one case of ANCA negative glomerulonephritis and other of diabetic nephropathy. Individuals with RA and CKD were older, presented more cardiovascular disease, diabetes and hypertension. There was no statistically significant association between gender and the presence of CKD (p = 0.131). Age (p = 0.031) and diabetes (p = 0.031) were independent risk factors for development of CKD in RA patients. RA duration in patients with CKD (8, 4-13) was not statistically different from RA duration in non-CKD patients (7.50, 4,75 – 12,25), (p=0.890). Conclusion Patients with RA and CKD had higher incidence of cardiovascular events, diabetes and hypertension which are a major cause of mortality and morbidity in this group. The presence of diabetes mellitus that often arise as an adverse effect of drugs used in the treatment of RA, significantly increased the risk of developing CKD. Otherwise, RA duration didn’t represent a risk factor for developing CKD. Thus, it is important to control diabetes, particularly glucocorticoid-induced diabetes to prevent development of CKD in AR patients.

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Assessment of Renal Function and Risk Factors for Chronic Kidney Disease in Patients With Peripheral Arterial Disease

Angiology ◽

10.1177/0003319716686876 ◽

2017 ◽

Vol 68 (9) ◽

pp. 776-781 ◽

Cited By ~ 2

Author(s):

Xi-Bei Jia ◽

Xi-Hua Hou ◽

Qiu-Bo Ma ◽

Xiao-Wen Cai ◽

Yi-Ran Li ◽

...

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Renal Function ◽

Kidney Disease ◽

Peripheral Arterial Disease ◽

Arterial Disease ◽

High Risk Population ◽

High Prevalence ◽

Independent Risk Factors ◽

Peripheral Arterial

Chronic kidney disease (CKD) and peripheral arterial disease (PAD) share common risk factors. We assessed renal function and the prevalence of CKD in patients with PAD and investigated the characteristics of the risk factors for CKD in this population. Renal function of 421 patients with PAD was evaluated. Among the participants, 194 (46.1%) patients had decreased estimated glomerular filtration rate (eGFR). The prevalence of CKD was much higher among patients with PAD. Hypertension (odds ratios [ORs] 2.156, 95% confidence interval [CI] 1.413-3.289, P < .001), serum uric acid (OR 3.794, 95% CI 2.220-6.450, P < .001), and dyslipidemia (OR 1.755, 95% CI 1.123-2.745, P = .014) were significantly associated with CKD and the independent risk factors for CKD in patients with PAD. CKD is common and has a high prevalence in a population with PAD. Patients with PAD may be considered as a high-risk population for CKD. Recognition and modification of risk factors for CKD might beneficially decrease CKD incidence and improve prognosis in patients with PAD.

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