scholarly journals The Association of Mycobacterium avium subsp. paratuberculosis with Inflammatory Bowel Disease

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148731 ◽  
Author(s):  
Verlaine J. Timms ◽  
George Daskalopoulos ◽  
Hazel M. Mitchell ◽  
Brett A. Neilan
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mycobacterium Avium ◽  
Bowel Disease ◽  
Mycobacterium Avium Subsp ◽  
Inflammatory Bowel ◽  
Mycobacterium Avium Subsp Paratuberculosis

scholarly journals Analysis of publications on paratuberculosis from 1995 to 2009 with emphasis on the period from 2005 to 2009

2010 ◽  
Vol 55 (No. 2) ◽  
pp. 43-54 ◽  
Author(s):  
M. Kaevska ◽  
K. Hruska
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Mycobacterium Avium ◽  
Bowel Disease ◽  
Web Of Science ◽  
Descriptive Data ◽  
Funding Agencies ◽  
Inflammatory Bowel ◽  
Number Of Publications ◽  
The Web

The importance of paratuberculosis, an infectious bowel disease of ruminants, and Crohn’s disease, a type of inflammatory bowel disease in humans with suspected links with <I>Mycobacterium avium</I> subsp. <I>paratuberculosis</I>, is evident from the steadily increasing number of publications on these topics. Data from the Web of Science databases were analysed by authors, institutions, countries and funding agencies, involved in research. A summary of the descriptive data for the most frequently cited publications are presented here.

scholarly journals Presence of Mycobacterium avium subsp. paratuberculosis (MAP) in Brazilian patients with inflammatory bowel diseases and in controls

2015 ◽  
Vol 134 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Isabel Azevedo Carvalho ◽  
David Germano Gonçalves Schwarz ◽  
Pricila Aparecida Grasse Pietralonga ◽  
Ana Carolina Silva Faria ◽  
Isis Freitas Espechit Braga ◽  
...  
Keyword(s):  
Mycobacterium Avium ◽  
Bacterial Load ◽  
Cross Sectional Study ◽  
Mycobacterium Avium Subsp ◽  
Control Group ◽  
Cross Sectional ◽  
Qrt Pcr ◽  
Ffpe Samples ◽  
Inflammatory Bowel ◽  
Mycobacterium Avium Subsp Paratuberculosis

CONTEXT AND OBJECTIVE: Mycobacterium avium subsp. paratuberculosis (MAP) has attracted the interest of researchers because of similarities between paratuberculosis and Crohn's disease (CD). The aim of this study was to evaluate the frequency of MAP through cultures, histology and polymerase chain reaction (PCR) on intestinal biopsies from Brazilian CD patients. Quantitative real time PCR (qRT-PCR) was performed on positive samples. DESIGN AND SETTING: Analytical cross-sectional study with control group at two federal universities. METHODS: Fresh samples were collected from 25 patients; five with CD, eight with ulcerative colitis (UC) and 12 controls with non-inflammatory bowel disease (nIBD). Formalin-fixed paraffin-embedded (FFPE) samples from 143 patients were also collected: 44 CD, 49 UC and 56 nIBD. RESULTS: None of the fresh samples was positive for MAP. Five FFPE samples (one CD, two UC and two nIBD) and three fresh samples (one in each group) were positive through IS900-PCR. qRT-PCR was performed on these eight samples. Among the FFPE samples, there were 192.12 copies/μl in the CD group, 72.28 copies/μl in UC and 81.43 copies/μl in nIBD. Among the fresh samples, there were 432.99 copies/μl, 167.92 copies/μl and 249.73 copies/μl in the CD, UC and nIBD groups, respectively. The highest bacterial load was in the CD group. CONCLUSION: This study does not provide evidence for a role of MAP in the etiology of CD, although MAP DNA was detected in all three patient groups. This is the first report of MAP presence in human intestinal biopsies in Brazil.

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