Predictors of neonatal sepsis in public referral hospitals, Northwest Ethiopia: A case control study

Abstract Background Neonatal sepsis is one of the leading causes of neonatal morbidity and mortality. Despite implementing of different preventive interventions, the burden of neonatal sepsis is reporting in different areas of Ethiopia. For further interventions, identifying its determinants is found to be crucial. Objective This study aimed to identify determinants of neonatal sepsis in the Northwest part of Ethiopia. Methods Unmatched case-control study was conducted among 246 neonates admitted in neonatal intensive care unit, Northwest Ethiopia. Study participants were selected from February 1st to March 30th 2018. Data was collected through face to face interview and review of neonates’ medical records using pretested structured questionnaire. Data was entered into Epi Data version 4.2.0.0 and further transferred to SPSS statistical software version 25 for analysis. All independent variables with p-value < 0.25 in Bivariable analysis were entered into multivariable logistic regression analysis. Finally, variables with p-value < 0.05 were considered as determinants of neonatal sepsis. Results A total of 82 cases and 164 controls were included in this study. Neonates with gestational age < 37 weeks [AOR = 6.90; 95% CI (2.76, 17.28)], premature rupture of membrane [AOR = 2.81; 95% CI (1.01, 7.79)], not crying immediately at birth and have received resuscitation at birth [AOR = 2.85; 95% CI (1.09, 7.47)] were found to be predictors of neonatal sepsis. Conclusions and recommendations Premature rupture of membrane was found to be obstetric-related determinant of neonatal sepsis. Gestational age < 37 weeks, not crying immediately at birth, and have received resuscitation at birth were found to be neonatal-related risk factors of neonatal sepsis. Infection prevention strategies need to be strengthening and/or implementing by providing especial attention for the specified determinants.

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Inflammatory and oxidative parameters in cord blood as diagnostic of early-onset neonatal sepsis: A case-control study

Pediatric Critical Care Medicine ◽

10.1097/pcc.0b013e318198b0e3 ◽

2009 ◽

Vol 10 (4) ◽

pp. 467-471 ◽

Cited By ~ 30

Author(s):

Ana Carolina Cancelier ◽

Fabricia Petronilho ◽

Adalisa Reinke ◽

Larissa Constantino ◽

Roberta Machado ◽

...

Keyword(s):

Cord Blood ◽

Neonatal Sepsis ◽

Early Onset ◽

Case Control Study ◽

Case Control ◽

Control Study

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Determinants of Health Facility Delivery in Northwest Ethiopia: A Community-Based Case-Control Study

International Journal of General Medicine ◽

10.2147/ijgm.s300178 ◽

2021 ◽

Vol Volume 14 ◽

pp. 993-1001

Author(s):

Tadesse Guadu Delele ◽

Gashaw Andargie Biks ◽

Solomon Mekonnen Abebe ◽

Zemene Tigabu Kebede

Keyword(s):

Health Facility ◽

Case Control Study ◽

Case Control ◽

Northwest Ethiopia ◽

Facility Delivery ◽

Determinants Of Health ◽

Health Facility Delivery ◽

Community Based ◽

Control Study

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Obesity in young age is a risk factor for preeclampsia: a facility based case-control study, northwest Ethiopia

BMC Pregnancy and Childbirth ◽

10.1186/s12884-016-1029-2 ◽

2016 ◽

Vol 16 (1) ◽

Cited By ~ 6

Author(s):

Mulualem Endeshaw ◽

Fantu Abebe ◽

Solomon Worku ◽

Lalem Menber ◽

Muluken Assress ◽

...

Keyword(s):

Risk Factor ◽

Case Control Study ◽

Case Control ◽

Northwest Ethiopia ◽

Young Age ◽

Control Study

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Assessment of Factors Associated with Malnutrition among Under Five Years Age Children at Machakel Woreda, Northwest Ethiopia: A Case Control Study

Journal of Nutrition & Food Sciences ◽

10.4172/2155-9600.1000256 ◽

2014 ◽

Vol 04 (01) ◽

Cited By ~ 6

Author(s):

Bantamen G Belaynew W

Keyword(s):

Case Control Study ◽

Case Control ◽

Northwest Ethiopia ◽

Under Five ◽

Factors Associated ◽

Control Study

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Determinants of Implanon Discontinuation among Women Who Use Implanon at Bahir Dar Town Health Institutions, Northwest Ethiopia, 2019: A Case-Control Study

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/9048609 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Tsegaw Yehuala ◽

Ergoye Melese ◽

Kassawmar Angaw Bogale ◽

Baye Dagnew

Keyword(s):

Family Planning ◽

Side Effects ◽

Case Control Study ◽

Health Sector ◽

Case Control ◽

Northwest Ethiopia ◽

Bahir Dar ◽

Limited Information ◽

Health Institutions ◽

Control Study

Background. Implanon is a long-acting reversible contraceptive method that is 99% effective in preventing unintended pregnancy. Despite its effectiveness, the rate of Implanon discontinuation is high. In Ethiopia, there is limited information about determinants of Implanon discontinuation. Therefore, this study aimed to identify the determinants of Implanon discontinuation among women who used Implanon at Bahir Dar town health institutions. Methods. We employed an unmatched case-control study to find out the determinants of Implanon discontinuation at Bahir Dar town health institutions from March to June 2019 using the multistage stratified sampling technique to select study participants. Cases were women who had discontinued Implanon before completion of 3 years, and controls were women who had removed Implanon at the date of appointment (3 years). A pretested, structured questionnaire with face-to-face interviews was used. Binary logistic regression was performed to identify determinants of Implanon discontinuation. In the final model, variables with a p value of <0.05 were considered significant at 95% confidence interval and the strength of association was measured using odds ratio. Results. Primary education (AOR = 0.104, 95% CI (0.02–0.48)), secondary education (AOR = 0.48, 95% CI (0.24–0.952)), women who have no child (AOR = 2.04, 95% CI (1.2–3.4)), women who had no discussion with their partner (AOR = 2.2, 95% CI (1.39–3.57)), mass counseling (AOR = 3.5, 95% CI (1.75–7.01)), women who had no counseling about side effects (AOR = 1.7, 95% CI (1.07–2.07)), women who experienced side effects (AOR = 2.2, 95% CI (1.4–3.4)), and purpose of family planning use (AOR = 2.5, 95% CI (1.14–4.8)) were determinants of Implanon discontinuation. Conclusion. Implanon discontinuation is attributed by multifactorial involvement. Women’s educational status, nulliparity, no counseling, not informed of side effects, and no partner discussion are significant factors. Health sector stakeholders need to tailor counseling services at individual level to bolster family planning utilization until the desired time.

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Determinants of Preterm Birth among Women Who Gave Birth in Amhara Region Referral Hospitals, Northern Ethiopia, 2018: Institutional Based Case Control Study

International Journal of Pediatrics ◽

10.1155/2020/1854073 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Abebayehu Melesew Mekuriyaw ◽

Muhabaw Shumye Mihret ◽

Ayenew Engida Yismaw

Keyword(s):

Preterm Birth ◽

Case Control Study ◽

Case Control ◽

Multiple Gestation ◽

Northern Ethiopia ◽

Amhara Region ◽

Premature Rupture ◽

Referral Hospitals ◽

Multivariable Analyses ◽

Control Study

Background. Preterm birth refers to a birth of a baby before 37 completed weeks of gestation and after fetal viability. It is now the leading cause of new born deaths. Although identifying its common risk factors is mandatory to decrease preterm birth and thereby neonatal deaths, there was a dearth of studies in the study area. Objective. The aim of this study was to identify determinants of preterm birth among women who gave birth in Amhara region referral hospitals, Northwest Ethiopia, 2018. Method. An institutional based case-control study was conducted from September 01 to December 01/2018. A total of 405 mothers (135 cases and 270 controls) were included in the study. Multistage sampling technique was employed. Data were collected using structured questionnaire through face to face interview and checklist via Chart review. Data were entered into Epi Info version 7 and export to Statistical Package for Social Sciences (SPSS) version 20 for analysis. Descriptive statics like mean, frequency and percentage was used to describe the characteristics of participants. Both bivariable and multivariable analyses were carried out. Variable having p-value <0.05 in binary logistic regression were the candidate for multivariable analyses. Finally, the statistical significance of the study was claimed based on the Adjusted Odds Ratio (AOR) with 95% Confidence Interval (CI) and its p-value <0.05. Result. The result of multivariable analysis show that mothers with no formal education (AOR = 2.24; 95% CI: 1.28, 3.91), history of abortion (AOR = 2.92; 95% CI: 1.3, 6.4), multiple gestation (AOR = 4.1; 95% CI: 1.7, 9.8), hemoglobin level <11 gm/dl (AOR = 2.75; 95% CI: 1.11, 7.31), premature rupture of membrane (AOR = 6.4; 95% CI: 3.23, 12.7) and pregnancy induced hypertension (AOR = 4.74; 95% CI: 2.49, 9.0) had statistically significant association with experiencing preterm birth. Conclusion and Recommendation. Most of the determinants of preterm birth found to be modifiable. Thus, putting emphasis for prevention of obstetric and gynecologic complications such as anemia, premature rupture of membrane and abortion would decrease the incidence of preterm birth. Moreover, strengthening Information Communication Education about prevention of preterm birth was recommended.

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