scholarly journals Estimation of benzathine penicillin G demand for congenital syphilis elimination with adoption of dual HIV/syphilis rapid diagnostic tests in eleven high burden countries

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256400
Author(s):  
Sapan Shah ◽  
Surbhi Garg ◽  
Katherine Heath ◽  
Obiageli Ofili ◽  
Yashika Bansal ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Congenital Syphilis ◽  
Scale Up ◽  
Penicillin G ◽  
Benzathine Penicillin ◽  
Adequate Treatment ◽  
Treatment Coverage ◽  
Hiv Test ◽  
Screening Coverage ◽  
Syphilis Screening

Background WHO recommends use of rapid dual HIV/syphilis tests for screening pregnant women (PW) during antenatal care to prevent mother-to-child transmission. Scale-up of testing implies a need to accurately forecast and procure benzathine penicillin (BPG) to treat the additionally identified PW with syphilis. Methods Country-reported ANC coverage, PW syphilis screening and treatment coverage values in 2019 were scaled linearly to EMTCT targets by 2030 (constant increasing slope from 2019 figures to 95% in 2030) for 11 focus countries. Antenatal syphilis screening coverage was substituted with HIV screening coverage to estimate potential contribution of rapid dual HIV/syphilis tests in identifying additional PW with syphilis. BPG demand was calculated for 2019–2030 accordingly. Results The estimated demand for BPG (in 2.4 million unit vials) using current maternal syphilis prevalence and treatment coverage will increase from a baseline of 414,459 doses in 2019 to 683,067 doses (+65%) in 2021 assuming immediate replacement of single HIV test kits with rapid dual HIV/syphilis tests for these 11 countries. Continued scale up of syphilis screening and treatment coverage to reach elimination coverage of 95% will result in an estimated demand increase of 160%, (663,969 doses) from 2019 baseline for a total demand of 1,078,428 BPG doses by 2030. Conclusions Demand for BPG will increase following adoption of rapid dual HIV/syphilis test kits due to increases in maternal diagnoses of syphilis. To eliminate congenital syphilis, MNCH clinical programs will need to synergize with disease surveillance programs to accurately forecast BPG demand with scale up of antenatal syphilis screening to ensure adequate treatment is available for pregnant women diagnosed with syphilis.

Elimination of mother-to-child transmission of syphilis: Is it a reality in Nigeria by 2020?

2017 ◽  
Vol 46 (8) ◽  
pp. 794-797 ◽  
Author(s):  
Daniel A. Adeyinka ◽  
Babayemi O. Olakunde ◽  
Chamberline E. Ozigbu ◽  
Emmanuel A. Agogo ◽  
Mercy Morka ◽  
...  
Keyword(s):  
Antenatal Care ◽  
Pregnant Women ◽  
Congenital Syphilis ◽  
Scale Up ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Treatment Coverage ◽  
Syphilis Screening ◽  
Maternal Syphilis ◽  
Mother To Child

Background: Congenital syphilis is a global health problem, yet it has received little attention in recent years. Despite cost-effective syphilis screening and treatment, it continues to contribute hugely to perinatal morbidity and mortality worldwide. Aims: To determine the prevalence and treatment coverage trend for syphilis among pregnant women in the national prevention of mother-to-child transmission programme in Nigeria and to evaluate progress towards the elimination of congenital syphilis in the country. Methods: A retrospective analysis of validated national health sector performance data on pregnant women attending antenatal care at prevention of mother-to-child transmission clinics from 2013 to 2016 in Nigeria. Results: The proportion of new antenatal care attendees who annually received serological testing for syphilis increased from 12.2% in 2013 to 16.3% in 2016 (p-trend<0.0001). Although the prevalence of maternal syphilis decreased from 3.2% in 2013 to 1.4% in 2016 (p-trend<0.0001), the syphilis treatment coverage during pregnancy has decreased from 71.3% in 2013 to 54.9% in 2016 (p-trend<0.0001). Conclusions: Maternal syphilis screening and treatment in Nigeria are inadequate to meet the elimination aspirations. A rapid scale-up of antenatal care syphilis screening and treatment are crucial to averting an epidemic in Nigeria by 2020.

scholarly journals 53Women with syphilis notification in pregnant women who lose their baby, belém/pa, 2017 and 2018

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Josué Costa ◽  
Rute Leila dos Reis Flores ◽  
Veronilce Borges da Silva ◽  
Eula Oliveira Santos das Neves ◽  
Carlos Gustavo Paes Barreto da Cruz ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Information System ◽  
Pregnant Women ◽  
Fetal Death ◽  
Congenital Syphilis ◽  
Transmission Rate ◽  
Treponema Pallidum ◽  
Penicillin G ◽  
Transmitted Infection ◽  
Adequate Treatment

Abstract Background Syphilis is a chronic systemic infectious disease that is subject to acute outbreaks and latency periods when left untreated. It is an infectious disease produced by a bacteria, Treponema pallidum, of predominantly sexual transmission. The inclusion of syphilis in pregnancy as a sexually transmitted infection with compulsory notification is justified by its high prevalence rate and high vertical transmission rate, which ranges from 30% to 100% without adequate treatment. Congenital syphilis is a result of the hematogenous spread of Treponema pallidum, an untreated or inadequately treated pregnant woman, through the placenta, which causes miscarriages or child and fetal deaths. Our objective was to draw an epidemiological profile of women, living in Belém / PA, notified by syphilis during pregnancy and who developed infant or fetal death in 2017 and 2018. Methods This is a descriptive epidemiological study. Two information systems were used, the Mortality Information System (MIS) and the Notification Record Information System (NRIS). At MIS, all child and fetal deaths of residents of Belém in 2017 and 2018 were selected. In NRIS, we selected all cases of pregnant women notified by syphilis in 2017 and 2018, also resident in the municipality. Subsequently, the two banks were compared to verify whether pregnant women notified for syphilis evolved with infant or fetal death. Data were analyzed according to age, race, education, gestational period, length of treatment of pregnant women, whether the partner was treated and the type of death of the children. Results We found 32 women with reports of syphilis in pregnant women, of whom 81% developed fetal death and 19% had infant death. 63% were between 20 and 29 years old, 88% were brown, 75% were in the third trimester of pregnancy when they were notified, 25% had incomplete elementary school and 25% had incomplete high school. 72% were treated with 7,200,000 IU of Penicillin G Benzathine. 59% of cases were not performed in the treatment of the partner. Conclusions Most of these women are young, poorly educated, and despite appropriate treatment, their partners have not been treated and may have been reinfected and passed on the infection to their children. Key messages Syphilis in pregnant women; Hild and fetal death

Factors associated with congenital syphilis: A retrospective study in Jiangxi Province, China

2021 ◽  
pp. 095646242110521
Author(s):  
Zhihua Wan ◽  
Yuling Tao ◽  
Huan Zhang ◽  
Yang Hu ◽  
Kuanyong Shu
Keyword(s):  
Regression Analysis ◽  
Retrospective Study ◽  
Pregnant Women ◽  
Congenital Syphilis ◽  
Jiangxi Province ◽  
Multivariable Logistic Regression Analysis ◽  
Syphilis Infection ◽  
Adequate Treatment ◽  
Maternal Characteristics ◽  
Increased Risk

Background There are a lack of studies about factors influencing congenital syphilis (CS) in economically underdeveloped areas, such as Jiangxi Province, China. Methods A retrospective study was conducted based on the information system of prevention of mother-to-child transmission of syphilis management in Jiangxi Province, China. Pregnant women with syphilis infection who delivered ≥28 gestational weeks and registered in this system from 1 January 2013 to 2030 June 2018 were enrolled. Maternal characteristics and treatment regimens associated with CS were evaluated using multivariable regression analysis. Results 1196 syphilis infected mothers and their 1207 infants were included in the analyses, and 116 infants were diagnosed with CS, providing an overall incidence of 9.61% (116/1207). Multivariable logistic regression analysis showed that increasing maternal age was barely associated with the risk of CS (adjusted odds ratio (aOR) = 0.97, 95% CI, 0.93–1.00, p = .047). Women with a high nontreponemal serum test titer (≥1:8) had a 126% increased risk of delivering an infant with CS than those with a low titer (<1:8) (aOR = 2.26, 95% CI, 1.51–3.39, p < .001). The risk for CS decreased significantly in infants born to mothers receiving adequate treatment than those receiving no treatment (aOR = 0.36, 95% CI, 0.21–0.61, p < .001). Conclusions Adequate treatment is critical for the prevention of CS. Further strategies focusing on early diagnosis and adequate treatment among syphilis infected pregnant women, particularly among those with younger age and high nontreponemal titer, should be strengthened to prevent CS.

scholarly journals Congenital Syphilis Like Many Years Ago

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Giulia Brighi ◽  
Giorgia Farneti ◽  
Antonella Marangoni ◽  
Elisabetta Tridapalli ◽  
Iria Neri ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
Pregnant Women ◽  
Premature Infant ◽  
21St Century ◽  
Congenital Syphilis ◽  
Neonatal Infection ◽  
Adequate Therapy ◽  
Syphilis Screening

This case concerns a premature infant with typical signs of congenital syphilis born to an untreated foreign mother. Syphilis prevalence in pregnant women has been rising in Italy since the beginning of the 21st century, mainly due to immigration. A correct antenatal syphilis screening and consequent adequate therapy of pregnant woman are fundamental to prevent the neonatal infection.

scholarly journals Syphilis Notifications and the Triggering Processes for Vertical Transmission: A Cross-Sectional Study

2020 ◽  
Vol 17 (3) ◽  
pp. 984 ◽  
Author(s):  
Samara Isabela Maia de Oliveira ◽  
Cecília Olívia Paraguai de Oliveira Saraiva ◽  
Débora Feitosa de França ◽  
Marcos Antônio Ferreira Júnior ◽  
Libna Helen de Melo Lima ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Vertical Transmission ◽  
Professional Training ◽  
Congenital Syphilis ◽  
Cross Sectional Study ◽  
Epidemiological Surveillance ◽  
Concomitant Treatment ◽  
Sectional Study ◽  
Cross Sectional ◽  
Adequate Treatment

Syphilis is a disease that is found all over the world that causes damaging effects to the fetus through vertical transmission. This study aimed to analyze the processes that trigger the vertical transmission of syphilis through gestational and congenital syphilis notifications. It is a cross-sectional study. The sample totaled 129 notifications of syphilis in pregnant women and 132 notifications of congenital syphilis in the city of Natal, from 2011 to 2015. Data were obtained from the Information System for Disease Notification. The Chi-square, Student’s and Fisher’s tests were used to verify associations of interest. Diagnosis of maternal syphilis was predominant in the third trimester of pregnancy. Only 1.6% of the pregnant women were registered with an adequate treatment regimen, of these 16.3% had the concomitant treatment with their partners. Of the affected children, 78.8% were registered as asymptomatic. The factors that trigger vertical transmission are related to the late diagnosis of the pregnant woman and sexual partner(s) and the deficiencies in clinical/therapeutic management in relation to the phase of the disease. Strategies of professional training should be adopted to notify and expand the provision of information for epidemiological surveillance, aiming to strengthen care, reduce vertical transmission and enable the continuous analysis of this problem.

scholarly journals Syphilis screening and treatment in pregnant women in Kinshasa, Democratic Republic of the Congo and in Lusaka, Zambia: a cross-sectional study

2017 ◽  
Vol 1 ◽  
pp. 13 ◽  
Author(s):  
Mabel Berrueta ◽  
Maria Luisa Cafferata ◽  
Musaku Mwenechanya ◽  
Dalau Nkamba Mukadi ◽  
Fernando Althabe ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Democratic Republic ◽  
Congenital Syphilis ◽  
Preterm Births ◽  
Health Providers ◽  
Syphilis Infection ◽  
Cross Sectional ◽  
Republic Of The Congo ◽  
Syphilis Screening ◽  
The Impact

Background: Congenital syphilis is associated with perinatal deaths, preterm births and congenital malformations. Low rates of syphilis screening during pregnancy and treatment of those found seropositive have been reported in the Democratic Republic of the Congo (DRC) and Zambia. We report the rates on antenatal syphilis screening, the seroprevalence of syphilis infection, and the frequency of antibiotic treatment in pregnant women screened positive for syphilis during their attendance at antenatal care (ANC) clinics in Kinshasa, DRC and Lusaka, Zambia. Methods: Women attending their first ANC were enrolled consecutively during a 9-month period in 16 and 13 ANC clinics in Kinshasa and Lusaka respectively, in the context of the baseline period of a cluster trial. Study personnel collected data on women’s characteristics, the syphilis screening practices, the test results, and the frequency of treatment, that were done under routine ANC conditions and registered in the clinic records. Results: 4,153 women in Kinshasa and 18,097 women in Lusaka were enrolled. The frequency of screening at the first visit was 59.7% (n= 2,479) in Kinshasa, and 27.8% (n=5,025) in Lusaka. Screening test availability varied. In the periods in which tests were available the screening rates were 92.8% in Kinshasa and 52.0% in Lusaka. The frequency of women screened seropositive was 0.4% (n=10) in Kinshasa and 2.2% (n=109) in Lusaka. Respectively, 10% (n=1) and 11.9% (n= 13) among seropositive women received treatment at the first visit. Conclusions: The results of the study show that screening for syphilis in pregnancy is not universal even when supplies are available. Our ongoing trial will evaluate the impact of a behavioral intervention on changing health providers’ practices to increase screening and treatment rates when supplies are available.

scholarly journals Epidemiological profile of patients with congenital and gestational syphilis in a city in the State of São Paulo, Brazil

2019 ◽  
Vol 19 (4) ◽  
pp. 865-872
Author(s):  
Taiza Maschio-Lima ◽  
Iara Lúcia de Lima Machado ◽  
João Paulo Zen Siqueira ◽  
Margarete Teresa Gottardo Almeida
Keyword(s):  
Pregnant Women ◽  
Ecological Study ◽  
Congenital Syphilis ◽  
Sao Paulo ◽  
World Health ◽  
São Paulo ◽  
Adequate Treatment ◽  
Live Births ◽  
Epidemiological Profile ◽  
Health Organization

Abstract Objectives: to assess the epidemiological profile of congenital and syphilis during pregnancy in residents of São José do Rio Preto in São Paulo State. Methods: ecological study of the epidemiological profile of patients with congenital and gestational syphilis, based on the Sistema de Informação de Agravos de Notificação (Information System for Notifiable Diseases) from 2007 to 2016. Results: there were 396 cases of syphilis reported in pregnant women and 290 of congenital syphilis. In 2016, the rate of detecting syphilis in pregnant women was 13.2 cases/1,000 live births, while congenital syphilis the incidence rate was 6.5 cases/1,000 live births. For gestational syphilis, 54% of the diagnosis was performed in 2nd or 3rd trimester and 85% were reported at the primary care. Adequate treatment for pregnant women occurred in 96% of the notifications with 52% of partners treated. In congenital syphilis, 82% of the mothers underwent prenatal care. However, 94% of the pregnant women were treated inadequately while 82% of the partners did not receive any treatment. Conclusions: there has been an increase in the number of cases of gestational syphilis in pregnant women and a decrease in the cases of congenital syphilis from 2014. These results showed that the goal of 0.5 case/1,000 live births proposed by World Health Organization is still far from being achieved in this city.

scholarly journals Treatment evaluation to improve preventing mother to child transmission among women with syphilis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Tian Gong ◽  
Yan Shao ◽  
Juning Liu ◽  
Qianlan Wu ◽  
Rong Xu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Retrospective Analysis ◽  
Pregnancy Outcomes ◽  
Benzathine Penicillin ◽  
Child Transmission ◽  
Early Screening ◽  
Ceftriaxone Sodium ◽  
Screening Coverage ◽  
Suzhou City ◽  
Mother To Child

AbstractThe aim of this study was to evaluate the effectiveness of preventing mother to child syphilis transmission to improve pregnancy outcomes. We performed a retrospective analysis of municipal databases of mother-to-child syphilis transmission. Pregnant women with syphilis were included. Group specific pregnancy outcomes were analyzed according to treatment. A total of 28 pregnant women were diagnosed with syphilis in 2012; 321 were diagnosed with syphilis in 2018. A prevalence of 0.14% was observed amongst pregnant women in Suzhou city from 2012–2018. Primary treatments included benzathine penicillin, ceftriaxone sodium or erythromycin when patients were allergic to Benzathine penicillin. The treatment coverage was 81.57%, and only 52.86% of pregnant women were adequately treated. Adverse pregnant outcomes were higher amongst untreated women. Expanding early screening coverage and promoting treatment were key to improving pregnancy outcomes amongst women with syphilis.

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