scholarly journals Plasma levels of leucocyte elastase-generated cross linked fibrin degradation products (E-XDP) are elevated in chronic venous disease

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261073
Author(s):  
Helen Sinabulya ◽  
Angela Silveira ◽  
Lena Blomgren ◽  
Joy Roy
Keyword(s):  
Reference Group ◽  
Degradation Products ◽  
Chronic Venous Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Venous Disease ◽  
Fibrin Degradation Products ◽  
Leucocyte Elastase ◽  
History Of ◽  
Ceap Classification ◽  
Independent Association

Patients with chronic venous disease (CVD) have elevated levels of leucocyte elastase (LE) released from the activation of leucocytes. In acute deep venous thrombosis (DVT), LE can degrade fibrin from the thrombus resulting in cross-linked fibrin degradation products (E-XDP) being released into the bloodstream. In patients with CVD the levels and significance of circulating E-XDP are unknown. We aimed to investigate the association between plasma E-XDP concentration and severity of CVD. Levels of E-XDP were quantified with a specific enzyme-linked immunosorbent assay (ELISA) in plasma from 142 consecutively recruited CVD patients (mean age 64 years, (range 23–89), 81 were females and 61 males). Patients were also divided into three groups based on CVD severity using the C-class of the Clinical-Etiological-Anatomical-Pathophysiological (CEAP) classification, with C 0–1 class as the reference group, C 2–3 as the second group and C 4–6 as the third group with the most severely affected patients. We found significantly elevated levels of E-XDP in patients with C 4–6 compared with patients with C 0–1 (p = 0.007) and increased with increasing disease severity across the groups (p = 0.02). Significant independent association was observed between levels of E-XDP and the classes C 4–6 after adjustment for age and sex (p < 0.05), but the association was no longer significant after further adjustment for use of statins, use of anticoagulants and history of DVT (p = 0.247). This exploratory study shows that E-XDP levels are elevated in patients with CVD, encouraging further studies on the role of E-XDP in CVD.

Static foot disorders: a major risk factor for chronic venous disease?

2011 ◽  
Vol 27 (1) ◽  
pp. 13-18 ◽  
Author(s):  
J-F Uhl ◽  
M Chahim ◽  
F-A Allaert
Keyword(s):  
Risk Factor ◽  
Daily Practice ◽  
Chronic Venous Disease ◽  
Venous Stasis ◽  
Venous Disease ◽  
Prolonged Standing ◽  
Flat Feet ◽  
Study Population ◽  
Ceap Classification ◽  
Standardized Measurement

Objective To study the relationship between the static foot disorders (SFDs) and chronic venous disease (CVD). Material and methods A retrospective study of 824 feet in unselected 412 patients seen by one phlebologist using a standardized record form. A complete clinical, aetiological, anatomical and pathological elements (CEAP) classification was determined. Alleged venous symptoms were recorded using a 10-point visual analogue scale and scored using a customized questionnaire. A standardized measurement of the Djian-Annonier angle was used to quantify and identify the presence of any static disorder of the foot. Results There were 156 men (37.8%) and 256 women (62.2%) who were included in this study. A majority of patients (59.3%) had a CEAP classification of C3 or greater. Static disorders of the feet were found to be very common in the study population: 137 feet were hollow feet (16.6%) and 120 flat feet (14.5%). Thus, 31% of all of the feet had some form of SFD. A significant correlation was found between the incidence of SFD and body mass index ( P < 0.01), the presence of symptoms ( P<0.001) and prolonged standing during the day (>5 hours, P < 0.05). The severity of the CVD, represented by the CEAP clinical classes, was also found to be very significantly related to the SFD ( P < 0.001). This correlation was found to be independent of age. Conclusion Static disorders of the foot can be considered as an important risk factor that negatively affects CVD. In daily practice, it is often underestimated. This emphasizes the crucial importance of the detection of SFD during the clinical exam of all CVD patients. Correction of static disorders of the feet will improve symptoms due to the SFD, as well as those related to venous stasis. These results can easily be explained by improvement of foot pump efficacy during walking.

Prevalence and presentation of chronic venous disease in Pakistan: a multicentre study

2013 ◽  
Vol 28 (2) ◽  
pp. 74-79 ◽  
Author(s):  
A F A Khan ◽  
R Chaudhri ◽  
M A Ashraf ◽  
M S Mazaffar ◽  
S Zawar-ul-Imam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary Care Physicians ◽  
Significant Risk ◽  
Cross Sectional Study ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Cross Sectional ◽  
Blood Clots ◽  
History Of ◽  
Study Population

Our objective was to study the prevalence and clinical pattern of chronic venous disease (CVD) in the Pakistani population. This was a multicentre cross-sectional study in which 100 primary care physicians examined 3000 subjects. The study population was aged 18–95 years (mean ± SD = 39 ± 13.2) comprised 47.4% women and 52.6% men. The prevalence of CVD was 34.8%, being significantly higher ( P < 0.04) among men (36.4%) than women (33.0%). The maximum prevalence was of C3 (36.7%), followed by C2 (15.8%). The most frequent symptom was pain in the legs (59.2%) followed by heavy legs (42.7%) and night cramps (34.4%). The prevalence of symptoms increased with age but was similarly distributed between men and women. Family history of CVD, blood clots in veins and lack of exercise were significant risk factors. The roles of age or gender as risk factors could not be established. In conclusion, the prevalence and presentation of CVD in Pakistan is similar to most other countries.

scholarly journals A Case of Bilateral Retinal Hemorrhage with Cotton Wool Spot Following Viper Bite

2015 ◽  
Vol 14 (3) ◽  
pp. 297-298
Author(s):  
Subhasis Jana ◽  
Saumen Kumar Chaudhuri ◽  
Purban Ganguly ◽  
Sumi Ghorai
Keyword(s):  
Degradation Products ◽  
Medical Science ◽  
Retinal Hemorrhage ◽  
Fundus Examination ◽  
Cotton Wool ◽  
Retinal Hemorrhages ◽  
Cotton Wool Spots ◽  
Fibrin Degradation Products ◽  
History Of

A 38 years male, admitted in the department of Internal Medicine with a history of snake bite in his left lower leg during agriculture work. He was treated with anti snake venom after admission. He had history of dimness of vision in both eyes. On examination, swelling and subcutaneous hemorrhage was noted in his left leg. His best corrected visual acuity (BCVA) was 6/60 in the both eyes. Fundus examination with 90 D lens and Indirect Ophthalmoscopy of both eyes showed retinal hemorrhage with cotton wool spots. Blood tests revealed increased titers of D-dimer and fibrin degradation products. The patient was followed up regularly at 2 weeks interval and BCVA and Fundus examination was carried out. At the end of 10 weeks, retinal hemorrhages had significantly cleared in both eyes with improvement of vision in both eyes (BCVA of right eye at last follow-up 6/6 and left eye 6/9).Bangladesh Journal of Medical Science Vol.14(3) 2015 p.297-298

Venous thromboembolism – prevalence and risk factors in chronic venous disease patients

2016 ◽  
Vol 32 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Dalibor Musil ◽  
Markéta Kaletová ◽  
Jiří Herman
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Family History ◽  
Hormone Therapy ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Obese Patients ◽  
Obese People ◽  
History Of ◽  
The Impact

Aims This study was aimed to investigate the prevalence of venous thromboembolism in patients with chronic venous disease and the impact of some intrinsic and extrinsic risk factors. Methods A retrospective study on 641 outpatients (489 women) with primary chronic venous disease (C0–C6). The prevalence of venous thromboembolism was evaluated according to sex, age, BMI, the presence of ≥1 first-degree siblings diagnosed with venous thromboembolism, CEAP clinical class, smoking and the use of hormone therapy. Results Venous thromboembolism episodes occurred in 32 patients (5%) with no gender predominance (OR 1.49, 95% CI = 0.90–2.45; p = 0.146). There was no increased RR of venous thromboembolism in the age group 46–69 years compared with patients aged ≤45 years ( p = 0.350). In persons aged ≥70 years, the risk of venous thromboembolism was 3.2 times higher than in patients aged 46–69 years and 4.78 times higher than in patients aged ≤45 years. The risk of venous thromboembolism rose very significantly in obese compared with normostenic patients ( p = 0.002). There were significantly more venous thromboembolism episodes in patients with chronic venous insufficiency (55.3%) than patients with varicose veins (44.7%) ( p < 0.001). A family history of venous thromboembolism ( p = 0.12), smoking ( p = 0.905) and hormone therapy ( p = 0.326) were not associated with increased risk of venous thromboembolism. Smoking was a risk factor in obese patients ( p = 0.033), but the combination of obesity, smoking, estrogens in women did not increase the risk of venous thromboembolism. Conclusions The 5% prevalence of venous thromboembolism episodes in patients was comparable with the prevalence of venous thromboembolism in the general European population. Age ≥70 years and obesity were strongly associated with an occurrence of venous thromboembolism. Obese patients with chronic venous disease were at higher risk for venous thromboembolism than obese people in the general population. A family history of venous thromboembolism, smoking and estrogens alone or in combination were not revealed as significant risk factors.

A study to evaluate patterns of superficial venous reflux in patients with primary chronic venous disease

2014 ◽  
Vol 30 (7) ◽  
pp. 455-461 ◽  
Author(s):  
Mahim I Qureshi ◽  
Manj Gohel ◽  
Louise Wing ◽  
Andrew MacDonald ◽  
Chung S Lim ◽  
...  
Keyword(s):  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Chronic Venous Disease ◽  
Duplex Ultrasonography ◽  
Venous Disease ◽  
Venous Reflux ◽  
History Of ◽  
Primary Chronic Venous Disease ◽  
Saphenofemoral Junction ◽  
Vein Reflux

Objective This study assessed patterns of superficial reflux in patients with primary chronic venous disease. Methods Retrospective review of all patient venous duplex ultrasonography reports at one institution between 2000 and 2009. Legs with secondary, deep or no superficial reflux were excluded. Results In total, 8654 limbs were scanned; 2559 legs from 2053 patients (mean age 52.3 years) were included for analysis. Great saphenous vein reflux predominated (68%), followed by combined great saphenous vein/small saphenous vein reflux (20%) and small saphenous vein reflux (7%). The majority of legs with competent saphenofemoral junction had below-knee great saphenous vein reflux (53%); incompetent saphenofemoral junction was associated with combined above and below-knee great saphenous vein reflux (72%). Isolated small saphenous vein reflux was associated with saphenopopliteal junction incompetence (61%), although the majority of all small saphenous vein reflux limbs had a competent saphenopopliteal junction (57%). Conclusion Superficial venous reflux does not necessarily originate from a saphenous junction. Large prospective studies with interval duplex ultrasonography are required to unravel the natural history of primary chronic venous disease.

How specific are venous symptoms for diagnosis of chronic venous disease?

2014 ◽  
Vol 29 (9) ◽  
pp. 580-586 ◽  
Author(s):  
SK Van der Velden ◽  
NH Shadid ◽  
PJ Nelemans ◽  
A Sommer
Keyword(s):  
Arterial Disease ◽  
Cross Sectional Study ◽  
Lower Limbs ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Disease Group ◽  
Cross Sectional ◽  
Ultrasound Findings ◽  
Ceap Classification ◽  
Peripheral Arterial

Objective The objective of this study is to evaluate whether and which ‘venous’ symptoms are characteristic for patients affected with chronic venous disease compared to patients with other diseases of the lower limbs (e.g. arthrosis, peripheral arterial disease, spinal disc herniation). Methods A cross-sectional study was performed to compare the frequency of venous symptoms among 76 patients with chronic venous disease and reflux and 74 patients with other diseases of the legs without reflux. The VEINES-Sym of the VEINES-QOL/Sym questionnaire was used to evaluate the frequency of symptoms. Demographic, clinical classification and ultrasound findings were also noted. Results A total of 122 patients were included for analysis (response rate of 87%). Presence of venous symptoms was slightly more often reported in the chronic venous disease group than in the non-chronic venous disease group, but differences were small and statistically non-significant. Severity of chronic venous disease as classified by the CEAP classification was not associated with higher proportions of patients reporting symptoms than in non-chronic venous disease patients, except for swelling ( p = .016) and itching ( p = .007) in C3-C6 patients. The largest difference between the chronic venous disease and non-chronic venous disease group was observed for the time of the day at which symptoms were most intense; patients with chronic venous disease were more likely to experience symptoms at the end of the day ( p < .001). Conclusions The small differences in prevalence of reported ‘venous’ symptoms between chronic venous disease patients and patients with other diseases of the legs suggest that these symptoms may be less specific for patients with chronic venous disease and refluxing veins than is usually assumed.

FIBRIIOLYTIC ACTIVITY II THE IITBISIVE CARE PATIEIT

1987 ◽  
Author(s):  
L J Garcia Frade ◽  
L Landin ◽  
A Garcia Avello ◽  
J L Bavarro ◽  
L J Creighton ◽  
...  
Keyword(s):  
Critically Ill ◽  
Immunosorbent Assay ◽  
Critically Ill Patients ◽  
Degradation Products ◽  
Enzyme Linked Immunosorbent Assay ◽  
Clotting Time ◽  
Fibrin Degradation Products ◽  
Coagulation Abnormalities ◽  
Fibrin Plate ◽  
Tissue Plasminogen

Critically ill patients have been described to have blood coagulation abnormalities that predispose to bleeding and thrombosis.We have studied plasminogen activators (fibrin plate, enzyme-linked Immunosorbent assay using polyclonalantibodies for t-PA), X-oligomers fibrin fragments (using monoclonal antibodies in an enzyme-linked immunosorbent assay), octant i pi asmin, antithrombtai III and fibronectin (Laurel1 innaunoeleetrophoretic technique), fibrinogen (thrombin timeassay), plateLets count, kaolln-cephalin clotting time and prothrombin time on admission to the intensive care unit and sequentially after 24 and 48 hours in 39 adult patients: Adult respiratory distress syndrome (ARDS) (n:6), Trauma (n:12), Sepsis (n:8), and Miscellanea (n:13).A decrease in tissue plasminogen activator (ng/ml)(p<0.001, p<0.05, p<0.01, p<0.05, respectively in the four groups), associated to an increase in the earliest form of cross-linked fibrin degradation products, X-Oligomers concentration (ng/ml) (p<0.01), indicatethat fibrindeposition and fibrinolytic exhaustion is a widespread situation in the ICU patients. Fibronectin was significantly reduced (p<0.001) in ARDS and Sepsis patients, low fibronectin levels were related to prognosis (p<0.01).These findings suggest.that critically ill patients, must be evaluated in respect to fibrinolysis and supported when necessary with prophylactic treatment.

Sign in / Sign up

Export Citation Format

Share Document