scholarly journals Association between serum 25-hydroxyvitamin D and physical performance measures in middle-aged and old Japanese men and women: The Unzen study

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261639
Author(s):  
Michiko Uchiyama ◽  
Satoshi Mizukami ◽  
Kazuhiko Arima ◽  
Takayuki Nishimura ◽  
Yoshihito Tomita ◽  
...  
Keyword(s):  
Vitamin D ◽  
Physical Performance ◽  
Community Dwelling ◽  
Japanese Men ◽  
Men And Women ◽  
Chair Stand ◽  
Hydroxyvitamin D ◽  
Functional Reach ◽  
Old Japanese ◽  
25 Hydroxyvitamin D

Purpose Regarding epidemiological studies, the role of vitamin D in musculoskeletal functionality (muscle weakness and physical performance) among elderly people is still controversial. The purpose of the present study was to investigate the associations between 25-hydroxyvitamin D [25(OH)D] and physical performance among community-dwelling middle-aged and old Japanese men and women. Methods The subjects were community-dwelling 297 men and 415 women aged 50 years and over. Data on height (m) and weight (kg) were collected. Serum 25(OH)D, parathyroid hormone, calcium, and albumin levels were measured. Serum 25(OH)D was classified into deficiency group: < 20 ng/mL, insufficiency group: 20–30 ng/mL, and sufficiency group: ≧ 30 ng/mL. Physical performance was assessed by grip strength, chair stand time, and functional reach. Information on current smoking, alcohol drinking, regular exercise, any comorbidities (hypertension, heart disease, diabetes mellitus, lung disease, and stroke), and pain (lumbar and knee) was collected. Results Vitamin D deficiency and insufficiency based on serum 25(OH)D levels were observed in 15.2% and 56.9% of men and 52.0% and 43.6% of women, respectively. In men, higher serum 25(OH)D levels were associated with better grip strength (p for trend = 0.003), chair stand time (p for trend = 0.042), and functional reach (p for trend <0.001). On the other hand, these parameters were not associated with serum 25(OH)D levels in women. Conclusion A higher level of serum 25(OH)D was associated with better physical performance in men but not in women.

scholarly journals Associations of Serum 25-Hydroxyvitamin D with Physical Performance and Bone Health in Overweight and Obese Older Adults

2019 ◽  
Vol 16 (3) ◽  
pp. 509 ◽  
Author(s):  
Melissa Dang ◽  
Cat Shore-Lorenti ◽  
Lachlan McMillan ◽  
Jakub Mesinovic ◽  
Alan Hayes ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Physical Performance ◽  
Bone Health ◽  
Muscle Power ◽  
Bone Structure ◽  
Quantitative Computed Tomography ◽  
Community Dwelling ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Low vitamin D status commonly accompanies obesity, and both vitamin D deficiency and obesity have been associated with falls and fracture risk in older adults. We aimed to determine the associations of serum 25-hydroxyvitamin D (25(OH)D) concentrations with physical performance and bone health in community-dwelling, overweight and obese older men and women. Serum 25(OH)D concentrations were measured in 84 participants with body mass index ≥25 kg/m2 (mean ± SD age 62.4 ± 7.9 years; 55% women). Physical function was determined by short physical performance battery, hand grip and quadriceps strength, and stair climb power tests. Body composition and bone structure were assessed by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography, respectively. Mean ± SD 25(OH)D was 49.6 ± 17.7 nmol/L, and 50% of participants had low 25(OH)D (<50 nmol/L) levels. 25(OH)D concentrations were positively associated with quadricep strength and stair climb power in women (B = 0.15; 95% CI 0.02–0.27 kg and B = 1.07; 95% CI 0.12–2.03 W, respectively) but not in men. There were no associations between 25(OH)D and bone parameters in either sex after multivariable adjustment (all p > 0.05). Lower 25(OH)D concentrations are associated with poorer quadricep strength and muscle power in overweight and obese older women but not men.

scholarly journals Plasma 25-Hydroxyvitamin D Levels and Fracture Risk in a Community-Based Cohort of Elderly Men in Sweden

2010 ◽  
Vol 95 (6) ◽  
pp. 2637-2645 ◽  
Author(s):  
Håkan Melhus ◽  
Greta Snellman ◽  
Rolf Gedeborg ◽  
Liisa Byberg ◽  
Lars Berglund ◽  
...  
Keyword(s):  
Vitamin D ◽  
Uv Light ◽  
Winter Season ◽  
Community Dwelling ◽  
Reference Level ◽  
Blood Levels ◽  
Elderly Men ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
25 Hydroxyvitamin D

Abstract Context: Blood levels of 25-hydroxyvitamin D [25(OH)D] is the generally accepted indicator of vitamin D status, but no universal reference level has been reached. Objective: The objective of the study was to determine the threshold at which low plasma 25(OH)D levels are associated with fractures in elderly men and clarify the importance of low levels on total fracture burden. Design and Participants: In the Uppsala Longitudinal Study of Adult Men, a population-based cohort (mean age, 71 yr, n = 1194), we examined the relationship between 25(OH)D and risk for fracture. Plasma 25(OH)D levels were measured with high-pressure liquid chromatography-mass spectrometry. Setting: The study was conducted in the municipality of Uppsala in Sweden, a country with a high fracture incidence. Main Outcome Measure: Time to fracture was measured. Results: During follow-up (median 11 yr), 309 of the participants (26%) sustained a fracture. 25(OH)D levels below 40 nmol/liter, which corresponded to the fifth percentile of 25(OH)D, were associated with a modestly increased risk for fracture, multivariable-adjusted hazard ratio 1.65 (95% confidence interval 1.09–2.49). No risk difference was detected above this level. Approximately 3% of the fractures were attributable to low 25(OH)D levels in this population. Conclusions: Vitamin D insufficiency is not a major cause of fractures in community-dwelling elderly men in Sweden. Despite the fact that cutaneous synthesis of previtamin D during the winter season is undetectable at this northern latitude of 60°, only one in 20 had 25(OH)D levels below 40 nmol/liter, the threshold at which the risk for fracture started to increase. Genetic adaptations to limited UV light may be an explanation for our findings.

Vitamin D Supplementation and Physical Performance in Adolescent Swimmers

2015 ◽  
Vol 25 (4) ◽  
pp. 317-325 ◽  
Author(s):  
Gal Dubnov-Raz ◽  
Netachen Livne ◽  
Raanan Raz ◽  
Avner H. Cohen ◽  
Naama W. Constantini
Keyword(s):  
Vitamin D ◽  
Physical Performance ◽  
Swimming Performance ◽  
Vitamin D Insufficiency ◽  
Sport Performance ◽  
Vitamin D Supplementation ◽  
Performance Variables ◽  
Hydroxyvitamin D ◽  
Before And After ◽  
25 Hydroxyvitamin D

It is hypothesized that vitamin D insufficiency in athletes might negatively affect sport performance. The objective of this study was to examine the effect of vitamin D3 supplementation on physical performance of adolescent swimmers with vitamin D insufficiency. Fifty-three adolescent competitive swimmers with vitamin D insufficiency (serum 25-hydroxyvitamin-D concentrations (25(OH)D)<30ng/ml, mean 24.2 ± 4.8ng/ml) were randomized to receive 2,000IU/day of vitamin D3 or placebo for 12 weeks. Swimming performance at several speeds, arm-grip strength, and one-legged balance, were measured before and after supplementation. The age-adjusted changes in performance variables during the study were compared between groups. 25(OH) D concentrations at study end were significantly higher in the vitamin group compared with the placebo group (29.6 ± 6.5ng/ml vs. 20.3 ± 4.2ng/ml, p < .001), yet only 48% of the vitamin group became vitamin D sufficient with this dosing. No between-group differences were found in the changes of the performance variables tested. No significant differences in performance were found between participants that became vitamin D sufficient, and those who did not. No significant correlation was found between the change in serum 25(OH)D and ageadjusted balance, strength or swimming performance at study end. Vitamin D3 supplementation that raised serum 25(OH)D concentrations by a mean of 9.3ng/ml above placebo in adolescent swimmers with vitamin D insufficiency, did not improve physical performance more than placebo.

Population vitamin D stores are increasing in Tasmania and this is associated with less BMD loss over 10 years

2021 ◽  
Author(s):  
Michael Thompson ◽  
Dawn Aitken ◽  
Saliu Balogun ◽  
Flavia Cicuttini ◽  
Graeme Jones
Keyword(s):  
Vitamin D ◽  
Lumbar Spine ◽  
Vitamin D Deficiency ◽  
Cohort Analysis ◽  
Sun Exposure ◽  
Community Dwelling ◽  
Longitudinal Change ◽  
Hydroxyvitamin D ◽  
Supplement Use ◽  
25 Hydroxyvitamin D

Abstract Introduction Vitamin D deficiency is a common, modifiable determinant of musculoskeletal health. There are limited data that examine the longitudinal change in population 25-hydroxyvitamin D (25(OH)D) and none that evaluate the long-term skeletal outcomes of longitudinal vitamin D status. Methods Prospective cohort analysis of community-dwelling adults aged 50-80 years who had 25(OH)D assessed by radioimmunoassay and BMD by DXA at baseline (n=1096), 2.5 (n=870) and 10 (n=565) years. Sun exposure was quantified by questionnaire and supplement use at clinic review. 25(OH)D &lt;50nmol/L was considered deficient. Participants were provided with their 25(OH)D results. Results Over 10 years 25(OH)D increased (52.2 ± 17.0 to 63.5 ± 23.6 nmol/L, p&lt;0.001). Participants with baseline deficiency had larger 25(OH)D increases than baseline sufficient participants (19.2 ± 25.3 vs 1.6 ± 23.3 nmol/L, p&lt;0.001). Longitudinal change in 25(OH)D was associated with baseline summer (β=1.46, p&lt;0.001) and winter (β=1.29, p=0.003) sun exposure, change in summer (β=1.27, p=0.002) and winter (β=1.47, p&lt;0.001) sun exposure and vitamin D supplement use (β=25.0 – 33.0, p&lt;0.001). Persistent vitamin D sufficiency was associated with less BMD loss at the femoral neck (β=0.020, p=0.027), lumbar spine (β=0.033, p=0.003) and total hip (β=0.023, p=0.021) compared to persistent vitamin D deficiency. Achieving vitamin D sufficiency was associated with less BMD loss at the lumbar spine (β=0.045, p&lt;0.001) compared to persistent vitamin D deficiency. Conclusions Population 25(OH)D concentration increased due to a combination of increased sun exposure and supplement use. Maintaining or achieving vitamin D sufficiency was associated with less BMD loss over 10 years.

scholarly journals Annual high-dose vitamin D3and mental well-being: randomised controlled trial

2011 ◽  
Vol 198 (5) ◽  
pp. 357-364 ◽  
Author(s):  
Kerrie M. Sanders ◽  
Amanda L. Stuart ◽  
Elizabeth J. Williamson ◽  
Felice N. Jacka ◽  
Seetal Dodd ◽  
...  
Keyword(s):  
Mental Health ◽  
Vitamin D ◽  
Depressive Symptoms ◽  
Controlled Trial ◽  
Well Being ◽  
Community Dwelling ◽  
High Dose ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Mental Well Being

BackgroundEpidemiological evidence supports a relationship between vitamin D and mental well-being, although evidence from large-scale placebo-controlled intervention trials is lacking.AimsTo examine if vitamin D supplementation has a beneficial effect on mood in community-dwelling older women; if a single annual large dose of vitamin D has a role in the prevention of depressive symptoms; and if there is an association between serum 25-hydroxyvitamin D levels and mental health.MethodA double-blind, randomised, placebo-controlled trial of women aged 70 or older (the Vital D Study: ISRCTN83409867 and ACTR12605000658617). Participants were randomly assigned to receive 500 000 IU vitamin D3(cholecalciferol) orally or placebo every autumn/winter for 3–5 consecutive years. The tools utilised at various time points were the General Health Questionnaire, the 12-item Short Form Health Survey, the Patient Global Impression–Improvement scale and the WHO Well-Being Index. Serum 25-hydroxyvitamin D levels were measured in a subset of 102 participants.ResultsIn this non-clinical population, no significant differences between the vitamin D and placebo groups were detected in any of the measured outcomes of mental health. Serum 25-hydroxyvitamin D levels in the vitamin D group were 41% higher than the placebo group 12 months following their annual dose. Despite this difference, scores from the questionnaires did not differ. Furthermore, there was no interaction between those on antidepressant/anxiety medication at baseline and the treatment groups.ConclusionsThe lack of improvement in indices of mental well-being in the vitamin D group does not support the hypothesis that an annual high dose of vitamin D3is a practical intervention to prevent depressive symptoms in older community-dwelling women.

scholarly journals Vitamin D Status Predicts Physical Performance and Its Decline in Older Persons

2007 ◽  
Vol 92 (6) ◽  
pp. 2058-2065 ◽  
Author(s):  
Ilse S. Wicherts ◽  
Natasja M. van Schoor ◽  
A. Joan P. Boeke ◽  
Marjolein Visser ◽  
Dorly J. H. Deeg ◽  
...  
Keyword(s):  
Vitamin D ◽  
Physical Performance ◽  
Performance Test ◽  
Longitudinal Design ◽  
Individual Performance ◽  
Cross Sectional ◽  
Men And Women ◽  
Hydroxyvitamin D ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study

Abstract Context: Vitamin D deficiency is common among older people and can cause mineralization defects, bone loss, and muscle weakness. Objective: The aim of this study was to investigate the association of serum 25-hydroxyvitamin D (25-OHD) concentration with current physical performance and its decline over 3 yr among elderly. Design: The study consisted of a cross-sectional and longitudinal design (3-yr follow-up) within the Longitudinal Aging Study Amsterdam. Setting: An age- and sex-stratified random sample of the Dutch older population was used. Other Participants: Subjects included 1234 men and women (aged 65 yr and older) for cross-sectional analysis and 979 (79%) persons for longitudinal analysis. Main Outcome Measure(s): Physical performance (sum score of the walking test, chair stands, and tandem stand) and decline in physical performance were measured. Results: Serum 25-OHD was associated with physical performance after adjustment for age, gender, chronic diseases, degree of urbanization, body mass index, and alcohol consumption. Compared with individuals with serum 25-OHD levels above 30 ng/ml, physical performance was poorer in participants with serum 25-OHD less than 10 ng/ml [regression coefficient (B) = −1.69; 95% confidence interval (CI) = −2.28; −1.10], and with serum 25-OHD of 10–20 ng/ml (B = −0.46; 95% CI = −0.90; −0.03). After adjustment for confounding variables, participants with 25-OHD less than 10 ng/ml and 25-OHD between 10 and 20 ng/ml had significantly higher odds ratios (OR) for 3-yr decline in physical performance (OR = 2.21; 95% CI = 1.00–4.87; and OR = 2.01; 95% CI = 1.06–3.81), compared with participants with 25-OHD of at least 30 ng/ml. The results were consistent for each individual performance test. Conclusions: Serum 25-OHD concentrations below 20 ng/ml are associated with poorer physical performance and a greater decline in physical performance in older men and women. Because almost 50% of the population had serum 25-OHD below 20 ng/ml, public health strategies should be aimed at this group.

Association of plasma 25-hydroxyvitamin D with physical performance in physically active children

2016 ◽  
Vol 41 (11) ◽  
pp. 1124-1128 ◽  
Author(s):  
Ikram Bezrati ◽  
Raouf Hammami ◽  
Mohamed Kacem Ben Fradj ◽  
Domenico Martone ◽  
Johnny Padulo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Physical Performance ◽  
Vertical Jump ◽  
Performance Testing ◽  
Skeletal Muscle Function ◽  
Cross Sectional ◽  
Physically Active ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Vitamin D is thought to regulate skeletal muscle function and boost physical performance. The aim of this study was to assess the relationship between vitamin D and physical performance in physically active children. This cross-sectional study included 125 children who practice football as a leisure activity. Plasma 25-hydroxyvitamin D (25-OHD) was assessed using a chemiluminescence immunoassay method. Vitamin D inadequacy was defined as 25-OHD < 20 ng/mL. Physical performance testing included measurements of muscle strength (maximal isometric contraction), jumping ability (vertical jump, standing broad jump, triple hop test), linear sprint (10 m and 20 m), and agility (9 × 4-m shuttle run). Plasma 25-OHD concentrations were positively correlated with muscle strength (r = 0.539; p < 0.001), vertical jump (r = 0.528; p < 0.001), and standing broad jump (r = 0.492; p < 0.001) but inversely correlated with sprint performance (r = –0.539; p < 0.001). In multivariate analysis models, plasma 25-OHD concentrations were associated with each physical performance parameter independently of age, maturity status, body mass index, fat mass, and protein and calcium intakes. In conclusion, a low plasma 25-OHD level was associated with decreased muscle strength, agility, and jumping and sprinting abilities in physically active children. Vitamin D inadequacy may limit exercise performance. Further research should verify whether correction of vitamin D deficiency enhances physical performance.

Proposal and Validation of a Quick Question to Rate the Influence of Sun Exposure in Geriatric Epidemiological Studies on Vitamin D

2012 ◽  
Vol 82 (6) ◽  
pp. 412-416 ◽  
Author(s):  
Cédric Annweiler ◽  
Anne-Marie Schott ◽  
Olivier Beauchet
Keyword(s):  
Vitamin D ◽  
Sun Exposure ◽  
Hypovitaminosis D ◽  
Epidemiological Studies ◽  
Community Dwelling ◽  
Ultraviolet B ◽  
The Sun ◽  
Hydroxyvitamin D ◽  
Simple Question ◽  
25 Hydroxyvitamin D

Background: Vitamin D is synthesized in the skin under the action of solar ultraviolet-B radiation. The objective of this study was to determine whether a simple question exploring sun exposure (“When weather is nice, do you stay more than 15 minutes exposed to the sun (face and hands uncovered) between 11am and 3pm?”) could be associated with serum 25-hydroxyvitamin D status among 751 older community-dwelling women (mean age, 80.2 ± 3.5 years). Methods: Two groups were distinguished based on the binary “Yes” versus “No” answer. Hypovitaminosis D was defined as serum 25-hydroxyvitamin D < 30 ng/mL. Results: Fewer women with hypovitaminosis D answered “Yes” to the question on sun exposure (p = 0.042). Answering “Yes” was inversely associated with hypovitaminosis D (OR = 0.56, p = 0.049) after adjustment for demographic characteristics and exogenous sources of vitamin D, with a positive predictive value of 88 %. Conclusion: This simple question may reflect the sun’s influence on vitamin D status and identify older community-dwellers with hypovitaminosis D.

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