scholarly journals Mathematical modeling of the hematocrit influence on cerebral blood flow in preterm infants

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261819
Author(s):  
Irina Sidorenko ◽  
Varvara Turova ◽  
Esther Rieger-Fackeldey ◽  
Ursula Felderhoff-Müser ◽  
Andrey Kovtanyuk ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Preterm Infants ◽  
Blood Viscosity ◽  
Intraventricular Hemorrhage ◽  
Clinical Care ◽  
Diagnostic Tools ◽  
Vessel Resistance

Premature birth is one of the most important factors increasing the risk for brain damage in newborns. Development of an intraventricular hemorrhage in the immature brain is often triggered by fluctuations of cerebral blood flow (CBF). Therefore, monitoring of CBF becomes an important task in clinical care of preterm infants. Mathematical modeling of CBF can be a complementary tool in addition to diagnostic tools in clinical practice and research. The purpose of the present study is an enhancement of the previously developed mathematical model for CBF by a detailed description of apparent blood viscosity and vessel resistance, accounting for inhomogeneous hematocrit distribution in multiscale blood vessel architectures. The enhanced model is applied to our medical database retrospectively collected from the 254 preterm infants with a gestational age of 23–30 weeks. It is shown that by including clinically measured hematocrit in the mathematical model, apparent blood viscosity, vessel resistance, and hence the CBF are strongly affected. Thus, a statistically significant decrease in hematocrit values observed in the group of preterm infants with intraventricular hemorrhage resulted in a statistically significant increase in calculated CBF values.

Alterations in Cerebral Blood Flow in Preterm Infants with Intraventricular Hemorrhage

PEDIATRICS ◽  
1981 ◽  
Vol 68 (6) ◽  
pp. 763-769
Author(s):  
Laura R. Ment ◽  
Richard A. Ehrenkranz ◽  
Robert C. Lange ◽  
Peter T. Rothstein ◽  
Charles C. Duncan
Keyword(s):  
Computed Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Ct Scan ◽  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Mean Value ◽  
Germinal Matrix ◽  
The Mean ◽  
Xenon 133

Xenon-133 inhalation hemispheric cerebral blood flow (HCBF) determinations at one to two days and four to six days postnatally and at 37 weeks postconceptual age have been correlated with computed tomography (CT) scan and autopsy findings in 15 preterm infants weighing less than 1,250 gm at birth. Ten of these infants had germinal matrix hemorrhages (GMH) or intraventricular hemorrhages (IVH). Although HCBF obtained at one to two days showed no mean difference between the GMH/IVH group and the nonhemorrhage infants, hemispheric flow ratios showed significant discrepancies in the GMH/IVH group. In addition, in four of five patients in whom the hemorrhage appeared asymmetric on CT scan, the side of higher flow correlated with the hemorrhage. At four to six days HCBF showed a lower mean value in the GMH/IVH patients than in the nonhemorrhage patients and differences in the interhemispheric ratios in the GMH/IVH group persisted. There were no differences in the mean HCBF values or hemispheric ratios between the two groups of infants at 37 weeks postconceptual age.

scholarly journals Whole blood viscosity parameters and cerebral blood flow.

Stroke ◽  
1982 ◽  
Vol 13 (3) ◽  
pp. 296-301 ◽  
Author(s):  
J Grotta ◽  
R Ackerman ◽  
J Correia ◽  
G Fallick ◽  
J Chang
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Whole Blood Viscosity

Effect of CO2 and 100% O2 on cerebral blood flow in preterm infants

1980 ◽  
Vol 48 (3) ◽  
pp. 468-472 ◽  
Author(s):  
F. A. Leahy ◽  
D. Cates ◽  
M. MacCallum ◽  
H. Rigatto
Keyword(s):  
Carbon Dioxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Preterm Infants ◽  
Cerebral Circulation ◽  
Pressure Change ◽  
Venous Occlusion ◽  
Co2 Sensitivity ◽  
Important Regulator ◽  
Carbon Dioxide Pressure

To determine 1) the effect of arterial CO2 change on the neonatal cerebral circulation and 2) whether 100% O2 would produce significant decrease in cerebral blood flow (CBF), we studied 24 preterm infants to explain the late (5 min) hyperventilation observed in them during hyperoxia. Of these, 12 were studied before and during inhalation of 2-3% CO2 and 12 before and during the inhalation of 100% O2. We measured CBF by a modification of the venous occlusion plethysmography technique and found that CBF increased 7.8% per Torr alveolar carbon dioxide pressure change and that it decreased 15% with 100% O2. These findings suggest that 1) CO2 is an important regulator of CBF in the perterm infant, 2) CBF-CO2 sensitivity in these infants may be greater than in adult subjects, 3) 100% O2 reduced CBF significantly, and 4) a decrease in CBF during administration of 100% O2 may be at least partially responsible for the increase in ventilation with hyperoxia.

Influence of Sleep State and Respiratory Pattern on Cyclical Fluctuations of Cerebral Blood Flow Velocity in Healthy Preterm Infants

Neonatology ◽  
1996 ◽  
Vol 69 (6) ◽  
pp. 357-367 ◽  
Author(s):  
Virender K. Rehan ◽  
Carlos A. Fajardo ◽  
Zia Haider ◽  
Ruben E. Alvaro ◽  
Donald B. Gates ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Velocity ◽  
Preterm Infants ◽  
Blood Flow Velocity ◽  
Cerebral Blood Flow Velocity ◽  
Respiratory Pattern ◽  
Sleep State ◽  
Cyclical Fluctuations
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