scholarly journals Coagulation testing: Comparison of portable (CoaguChek® XS) and automated coagulation analyzer in healthy cats

2020 ◽  
Vol 13 (11) ◽  
pp. 2541-2545
Author(s):  
Sireeporn Tonthong ◽  
Jetsada Rungpupradit
Keyword(s):  
Small Volume ◽  
Oral Anticoagulants ◽  
Normal Range ◽  
Limits Of Agreement ◽  
Coagulation Testing ◽  
Testing Accuracy ◽  
Spearman’S Correlation ◽  
Coagulation Analyzer ◽  
Laboratory Analyzer ◽  
Good Agreement

Background and Aim: The CoaguChek® XS (CCX) is a portable coagulation analyzer that is widely used to monitor prothrombin time (PT) in human patients taking oral anticoagulants. It can also be reliably used for screening dogs when PT is in the normal range. Efficacy of the portable CCX coagulation analyzer was evaluated for testing PT in healthy cats and the normal range was established. Materials and Methods: Blood samples of 82 cats were collected from the jugular vein and PT was measured using both the CCX and an automated coagulation analyzer (ACA). Spearman's correlation was used to measure the strength and direction of association between the two analyzers, while limits of agreement were assessed utilizing Bland-Altman analysis. Results: Range of PT using the CCX was 10.1-14.1 s. Correlation between the two analyzers was moderate but significant (r=0.3465, p=0.0014). Mean difference between CCX-PT and ACA-PT was 1.624 s and standard deviation was 0.890 with 95.1% of the samples falling within the limits of agreement. Conclusion: The CCX is a portable, easy to use coagulation analyzer that requires a small volume of blood and gives results within 1 min. Results showed moderate correlation and good agreement with a standard automated laboratory analyzer. The CCX can be used for screening coagulation testing when PT is in the normal range for cats. However, testing accuracy of the CCX in abnormal PT cats should be further investigated before diagnostic coagulopathy applications.

scholarly journals Repeatability of automated measurements by a new anterior segment optical coherence tomographer and biometer and agreement with standard devices

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Domenico Schiano-Lomoriello ◽  
Kenneth J. Hoffer ◽  
Irene Abicca ◽  
Giacomo Savini
Keyword(s):  
Intraclass Correlation ◽  
Anterior Segment ◽  
Consecutive Series ◽  
Optical Coherence ◽  
Limits Of Agreement ◽  
Automated Measurements ◽  
Deviation Coefficient ◽  
Corneal Diameter ◽  
High Repeatability ◽  
Good Agreement

AbstractWe assess repeatability of automatic measurements of a new anterior segment optical coherence tomographer and biometer (ANTERION) and their agreement with those provided by an anterior segment-optical coherence tomography device combined with Placido-disk corneal topography (MS-39) and a validated optical biometer (IOLMaster 500). A consecutive series of patients underwent three measurements with ANTERION and one with MS-39. A subgroup of patients underwent biometry also with IOLMaster 500. Repeatability was assessed by means of within-subject standard deviation, coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was investigated with the 95% limits of agreement. Paired t-test and Wilcoxon matched-pairs test were performed to compare the measurements of the different devices. Repeatability of ANTERION measurements was high, with ICC > 0.98 for all parameters except astigmatism (0.963); all parameters apart from those related to astigmatism revealed a COV < 1%. Repeatability of astigmatism improved when only eyes whose keratometric astigmatism was higher than 1.0 D were investigated. Most measurements by ANTERION and MS-39 showed good agreement. No significant differences were found between measurements by ANTERION and IOLMaster, but for corneal diameter. ANTERION revealed high repeatability of automatic measurements and good agreement with both MS-39 and IOLMaster for most parameters.

Estimating Critical Speeds of Stepped Shafts with Flexible Bearings

1971 ◽  
Vol 8 (03) ◽  
pp. 327-333
Author(s):  
R. H. Salzman
Keyword(s):  
High Speed ◽  
Critical Speed ◽  
Design Stage ◽  
Normal Range ◽  
Critical Speeds ◽  
Stepped Shaft ◽  
Bearing Stiffness ◽  
Variable Support ◽  
Method Show ◽  
Good Agreement

This paper presents a semi-graphical approach for finding the first critical speed of a stepped shaft with finite bearing stiffness. The method is particularly applicable to high-speed turbine rotors with journal bearings. Using Rayleigh's Method and the exact solution for whirling of a uniform shaft with variable support stiffness, estimates of the lowest critical speed are easily obtained which are useful in the design stage. First critical speeds determined by this method show good agreement with values computed by the Prohl Method for the normal range of bearing stiffness. A criterion is also established for determining if the criticals are "bearing critical speeds" or "bending critical speeds," which is of importance in design. Discusser E. G. Baker

scholarly journals Development, Relative Validity and Reproducibility of the Aus-SDS (Australian Short Dietary Screener) in Adults Aged 70 Years and above

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1436 ◽  
Author(s):  
Adelle M. Gadowski ◽  
Tracy A. McCaffrey ◽  
Stephane Heritier ◽  
Andrea J. Curtis ◽  
Natalie Nanayakkara ◽  
...  
Keyword(s):  
Daily Intake ◽  
Kappa Statistic ◽  
Food Groups ◽  
Cohen’S Kappa ◽  
Relative Validity ◽  
Cohen's Kappa ◽  
Spearman’S Correlation ◽  
Acceptable Agreement ◽  
Dietary Screener ◽  
Good Agreement

The aim of this study was to assess the relative validity and reproducibility of a six-item Australian Short Dietary Screener (Aus-SDS). The Aus-SDS assessed the daily intake of core food groups (vegetables, fruits, legumes and beans, cereals, protein sources and dairy sources) in 100 Australians (52 males and 48 females) aged ≥70 years. Relative validity was assessed by comparing intakes from the Aus-SDS1 with an average of three 24-h recalls (24-HRs), and reproducibility using two administrations of the Aus-SDS (Aus-SDS1 and Aus-SDS2). Cohen’s kappa statistic between the Aus-SDS1 and 24-HRs showed moderate to good agreement, ranging from 0.44 for fruits and dairy to 0.64 for protein. There was poor agreement for legume intake (0.12). Bland–Altman plots demonstrated acceptable limits of agreement between the Aus-SDS1 and 24-HRs for all food groups. Median intakes obtained from Aus-SDS1 and Aus-SDS2 did not differ. For all food groups, Cohen’s kappa statistic ranged from 0.68 to 0.89, indicating acceptable agreement between the Aus-SDS1 and Aus-SDS2. Spearman’s correlation coefficient between Aus-SDS1 and 24-HRs across all food groups ranged from 0.64 for fruit to 0.83 for protein. We found the Aus-SDS to be a useful tool in assessing daily intake of core food groups in this population.

Comparison of the TOFscan and the TOF-Watch SX during Recovery of Neuromuscular Function

2018 ◽  
Vol 129 (5) ◽  
pp. 880-888 ◽  
Author(s):  
Glenn S. Murphy ◽  
Joseph W. Szokol ◽  
Michael J. Avram ◽  
Steven B. Greenberg ◽  
Torin D. Shear ◽  
...  
Keyword(s):  
Neuromuscular Blockade ◽  
Spontaneous Recovery ◽  
Three Dimensional ◽  
Tracheal Extubation ◽  
Neuromuscular Function ◽  
Neuromuscular Monitoring ◽  
Limits Of Agreement ◽  
Train Of Four ◽  
Good Agreement

Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Quantitative neuromuscular monitoring is required to ensure neuromuscular function has recovered completely at the time of tracheal extubation. The TOFscan (Drager Technologies, Canada) is a new three-dimensional acceleromyography device that measures movement of the thumb in multiple planes. The aim of this observational investigation was to assess the agreement between nonnormalized and normalized train-of-four values obtained with the TOF-Watch SX (Organon, Ireland) and those obtained with the TOFscan during recovery from neuromuscular blockade. Methods Twenty-five patients were administered rocuronium, and spontaneous recovery of neuromuscular blockade was allowed to occur. The TOFscan and TOF-Watch SX devices were applied to opposite arms. A preload was applied to the TOF-Watch SX, and calibration was performed before rocuronium administration. Both devices were activated, and train-of-four values were obtained every 15 s. Modified Bland–Altman analyses were conducted to compare train-of-four ratios measured with the TOFscan to those measured with the TOF-Watch SX (when train-of-four thresholds of 0.2 to 1.0 were achieved). Results Bias and 95% limits of agreement between the TOF-Watch SX and the TOFscan at nonnormalized train-of-four ratios between 0.2 and 1.0 were 0.021 and −0.100 to 0.141, respectively. When train-of-four measures with the TOF-Watch SX were normalized, bias and 95% limits of agreement between the TOF-Watch SX and the TOFscan at ratios between 0.2 and 1.0 were 0.015 and −0.097 to 0.126, respectively. Conclusions Good agreement between the TOF-Watch SX with calibration and preload application and the uncalibrated TOFscan was observed throughout all stages of neuromuscular recovery.

Serum Iron Determination

1956 ◽  
Vol 2 (3) ◽  
pp. 175-183 ◽  
Author(s):  
George R Kingsley ◽  
Gloria Getchell
Keyword(s):  
Serum Iron ◽  
Isoamyl Alcohol ◽  
Photometric Measurement ◽  
Normal Range ◽  
Iron Determination ◽  
Acid Hydrolysate ◽  
Dry Ashing ◽  
Reproducible Method ◽  
Good Agreement ◽  
Ferrous Complex

Abstract 1. A sensitive, reproducible method for serum iron determination has been developed employing extraction of serum acid hydrolysate with isoamyl alcohol and development of a highly colored ferrous complex of 4,7-diphenyl-1, 1O-phenanthroline for quantitative photometric measurement of iron. 2. The method gives good recoveries and also good agreement with the dry-ashing procedure. 3. A normal range of 120-200 µg./100 ml. (average 160) for the female and 125-238 µg./100 ml. (average 182) for the male for serum iron was obtained by the method.

Validation of a New Small-Volume Sodium Citrate Collection Tube for Coagulation Testing in Critically Ill Patients with Coagulopathy

2018 ◽  
Vol 64 (06/2018) ◽  
Author(s):  
Elisabeth Adam ◽  
Kai Zacharowski ◽  
Gudrun Hintereder ◽  
Florian Raimann ◽  
Patrick Meybohm
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Sodium Citrate ◽  
Small Volume ◽  
Coagulation Testing ◽  
Collection Tube

On the Inclusion of Sliding Kinematical Effects on the Biodynamical Modeling of Symmetrical Lifting Activities

2009 ◽  
Author(s):  
Mohammed M. Hassan ◽  
E. M. Bakr ◽  
A. A. Hegazy
Keyword(s):  
Present Model ◽  
Compressive Force ◽  
Dynamic Responses ◽  
Normal Range ◽  
Body Postures ◽  
Symmetric Lifting ◽  
Angular Velocities ◽  
Severe Back Pain ◽  
Vast Range ◽  
Good Agreement

In this paper, A new biodynamical model was developed with the objective of analyzing the dynamic responses of the human back during the exertion of symmetric lifting activities. More emphasis was placed on the study of the lumbosacral disc located between the fifth lumbar and first sacral vertebrae (L5/S1). The present model accounts for the sliding components of velocity and acceleration as well as the Coriolis acceleration in the kinematical equations of the human back. The inclusion of those terms has enabled a more accurate computation of the generated sliding effect of the flexible disc as well as the change in its height and width which normally occurs during the gross body rotation of the back. This has turned to have a significant effect on the resulting compressive force applied at the L5/S1 region. A computer model was developed in this study to automate the biodynamical simulation processes for workers of different genders and for a vast range of body postures. Results indicated that the inclusion of the sliding components of velocity and acceleration do actually have a significant effect on the whole range of lifting activities in which an angular velocity exceeding 24 degree/sec is employed. Results obtained in this paper were compared with the experimental and computational (simulated) results of recent relevant publications. The comparison shows that there are good agreements between the results for angular velocities exceeding 24 degree/second, which is known as the normal range of operation in lifting activities. Results obtained in this paper were in good agreement with NIOSH action and maximum limits which make it reliable for use as a guideline to help workers in industry to avoid hostile lifting activities and bring to attention an early warning to avoid engaging industrial labors with postures leading to severe back pain problems.

Problematic Aspects Of Synthetic Peptide Substrate Assays For Coagulation Parameters

1981 ◽  
Author(s):  
Hary L Messmore ◽  
Jawed Fareed ◽  
Jeanine M Walenga ◽  
Judith M Kniffin ◽  
Edward W Bermes
Keyword(s):  
Serine Protease ◽  
Oral Anticoagulants ◽  
Substrate Inhibition ◽  
Poor Correlation ◽  
Factor X ◽  
Amidolytic Activity ◽  
Peptide Substrates ◽  
New Era ◽  
Molecular Variants ◽  
Coagulation Testing

With the advent of synthetic chromogenic and fluorogenic peptide substrates, coagulation testing has entered a new era. We have evaluated amidolytic assays for prothrombin, factor X, prekallikrein; prothrombin time (PT) and partial thromboplastin time (PTT) equivalent assays. Factor X is quantitated after activating with Russell’s viper venom with Xa specific substrates. In normals a good correlation is obtained between the coagulant and amidolytic assays (r=0.91, n=50), a poor correlation is reported in patients with liver disease and those treated with oral anticoagulants (r=0.76, n=50). Prothrombin is quantitated using ecarin, staphylocoagulase and phospholipid/Ca+2 as activators. The decarboxy glutamic forms of factor X and II should be compared in the coagulant and amidolytic assays to establish their equivalency. Although PT and PTT equivalent assays using amidolytic assays have been proposed, substrate inhibition of Xa generated during activation and other serine protease have not been fully explored, Dextran activated prekallikrein assay requires adequate level (≥ 50%) of Hageman factor. Heparin is quantitated in absolute terms and do not reflect clinical anticoagulation. In the antiplasmin assay, plasmin preparations cannot be used unless standardized in biochemical terms. Thrombins are standardized in terms of NIH U/ml and contain non-clotting molecular variants with amidolytic activity; therefore thrombin be best standardized in amidolytic terms for these assays. Certain serine protease-inhibitor complexes retain the amidolytic activity while losing their biologic activity, therefore a study on the amidolytic properties of these complexes is warranted. Standardization of the amidolytic method is almost nonexistent and claims for their bioequivalency to the existing clotting assays require support data. While synthetic substrate offers certain advantages, their application should be assessed critically and their limitations determined.

Cobas Integra: clinical laboratory instrument with continuous and random-access capabilities

1995 ◽  
Vol 41 (12) ◽  
pp. 1751-1760 ◽  
Author(s):  
S M Palmer ◽  
R A Kaufman ◽  
S J Salamone ◽  
J Blake-Courtney ◽  
W Bette ◽  
...  
Keyword(s):  
Drugs Of Abuse ◽  
Clinical Laboratory ◽  
Random Access ◽  
Diagnostic Systems ◽  
Therapeutic Drugs ◽  
Specific Proteins ◽  
Assay Precision ◽  
Laboratory Analyzer ◽  
Specific Reagent ◽  
Good Agreement

Abstract The Cobas Integra from Roche Diagnostic Systems is a new clinical laboratory analyzer with continuous and random-access features for routine chemistries, specific proteins, electrolytes, hormones, therapeutic drugs, and drugs of abuse. The system maintains 68 test-specific reagent cassettes on board, along with multiple ion-selective electrodes (ISEs) for electrolyte determinations. This gives the Cobas Integra the capability of analyzing as many as 72 analytes without having to load additional reagents. We describe the basic analyzer configuration and the subsystems for absorbance, fluorescence polarization, and ISE measurements. Performance characteristics for precision, methods comparison, and on-board stability are given for assays representative of the various test groups. The 29 Cobas Integra tests evaluated in the present study show good agreement (r &gt; or = 0.98 and slopes generally 0.90 to 1.12) with the respective methods available on either the Olympus AU5000, Hitachi 911 or 717, Behring BNA, or Abbott TDx systems. Total assay precision (CV) ranged from 0.8% to 8.5%, and calibration curves were stable for as long as 20 weeks. Test throughput, which is dependent on pipetting sequence, was determined to be up to 600 tests per hour without ISE and up to 750 tests per hour with ISE; the time to first result was 2.0-10.0 min.

scholarly journals Comparison of Anterior Segment Measurements with Scheimpflug/Placido Photography-Based Topography System and IOLMaster Partial Coherence Interferometry in Patients with Cataracts

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Jinhai Huang ◽  
Na Liao ◽  
Giacomo Savini ◽  
Fangjun Bao ◽  
Ye Yu ◽  
...  
Keyword(s):  
Prospective Study ◽  
Anterior Chamber ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Corneal Astigmatism ◽  
Partial Coherence ◽  
Poor Agreement ◽  
Limits Of Agreement ◽  
Partial Coherence Interferometry ◽  
Good Agreement

Purpose. To assess the consistency of anterior segment measurements obtained using a Sirius Scheimpflug/Placido photography-based topography system (CSO, Italy) and IOLMaster partial coherence interferometry (Carl Zeiss Meditec, Germany) in eyes with cataracts.Methods. A total of 90 eyes of 90 patients were included in this prospective study. The anterior chamber depth (ACD), keratometry (K), corneal astigmatism axis, and white to white (WTW) values were randomly measured three times with Sirius and IOLMaster. Concordance between them was assessed by calculating 95% limits of agreement (LoA).Results. The ACD and K taken with the Sirius were statistically significantly higher than that taken with the IOLMaster; however, the Sirius significantly underestimated the WTW values compared with the IOLMaster. Good agreement was found for Km and ACD measurements, with 95% LoA of −0.20 to 0.54 mm and −0.16 to 0.34 mm, respectively. Poor agreement was observed for astigmatism axis and WTW measurements, as the 95% LoA was −23.96 to 23.36° and −1.15 to 0.37 mm, respectively.Conclusion. With the exception of astigmatism axis and WTW, anterior segment measurements taken by Sirius and IOLMaster devices showed good agreement and may be used interchangeably in patients with cataracts.

Sign in / Sign up

Export Citation Format

Share Document