scholarly journals Synthesis and Antimicrobial Activity of Some Novel 1,4-Dihydropyridine Trimer Derivatives

2019 ◽  
Vol 32 (2) ◽  
pp. 276-280
Author(s):  
D. Ashokkumar ◽  
M. Gopalakrishnan ◽  
G. Ramalingam
Keyword(s):  
Antimicrobial Activity ◽  
Acetic Acid ◽  
Low Cost ◽  
Antimicrobial Properties ◽  
Acid Catalyst ◽  
One Pot ◽  
Free Condition ◽  
Short Reaction Time ◽  
Solvent Free Condition ◽  
Dihydropyridine Derivatives

An efficient multi-component one pot synthesis of some novel bioactive 1,4-dihydropyridine derivatives from melamine using various aldehydes and 1,3-dicarbonyl compounds are reported. This reaction carried out microwave irradiation under solvent free condition using low cost and efficient acetic acid catalyst. The excellent futures of this method are eco-friendly, short reaction time and mild reaction condition. This method is convincing route for highly substituted dihydropyridine trimer synthesis. The synthesized dihydropyridine derivatives are screened for antimicrobial properties.

scholarly journals Synthesis, Molecular Docking and Antimicrobial Studies of Some Novel 1,4-Dihydropyridine Derivatives

2019 ◽  
Vol 31 (12) ◽  
pp. 2976-2980 ◽  
Author(s):  
D. Ashokkumar ◽  
G. Ramalingam ◽  
M. Gopalakrishnan
Keyword(s):  
Molecular Docking ◽  
Low Cost ◽  
Condensation Reaction ◽  
Antimicrobial Properties ◽  
Acid Catalyst ◽  
Docking Study ◽  
Molecular Docking Study ◽  
One Pot ◽  
Solvent Free Condition ◽  
Dihydropyridine Derivatives

Three components one pot synthesis of some novel triazole substituted 1,4-dihydropyridine compounds from the simple condensation reaction of ethyl acetoacetate, 4-amino triazole and aromatic aldehyde has been demonstrated using on low cost and efficient acetic acid catalyst in solvent free condition followed by microwave irradiation method. The newly synthesized 1,4-dihydropyridine compounds exhibit in excellent yield. The synthesized dihydropyridine derivatives are screened for antimicrobial properties and molecular docking study.

scholarly journals Synthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity

2019 ◽  
Vol 54 (1) ◽  
pp. 47-54
Author(s):  
K Akhter ◽  
K Jahan ◽  
ME Halim ◽  
S Shefa ◽  
S Rifat ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Diffusion Method ◽  
Nitrate Hexahydrate ◽  
One Pot ◽  
Disk Diffusion Method ◽  
Free Condition ◽  
Solvent Free Condition ◽  
Reaction Coupling

We report herein the use of nickel nitrate hexahydrate [Ni(NO3)2.6H2O] as a new catalyst for the one-pot Biginelli like reaction coupling of 1-phenyl thiourea, ethyl acetoacetate and aromatic aldehydes to afford the corresponding 1-phenyl-3,4-dihydropyrimidin-2(1H)-thiones under solvent free condition to avoid the usage of hazardous organic solvents. The synthesized compounds were evaluated for their antimicrobial activity by KIRBY-BAUER disk diffusion method. Most of the compounds showed good to moderate antimicrobial activity. Bangladesh J. Sci. Ind. Res.54(1), 47-54, 2019

Visible Light Assisted Hantzsch Reaction: Synthesis of Polycyclic Dihydropyridines

2019 ◽  
Vol 16 (8) ◽  
pp. 676-682
Author(s):  
Ankusab Noorahmadsab Nadaf ◽  
Kalegowda Shivashankar
Keyword(s):  
Reaction Time ◽  
Light Intensity ◽  
Ammonium Acetate ◽  
Low Cost ◽  
Aromatic Aldehydes ◽  
Light Irradiation ◽  
High Yield ◽  
Short Reaction Time ◽  
Green Protocol ◽  
Dihydropyridine Derivatives

The polycyclic dihydropyridine nucleus represents the heterocyclic system of invaluable core motifs with wide applications in chemical, biological and physical properties. Although this kind of compounds have been extensively synthesized by other groups, the synthesis of these compounds under CFL light intensity were not explored. The synthesis of polycyclic dihydropyridine derivatives were achieved through the reaction of 4-hydroxycoumarin, aromatic aldehydes and ammonium acetate under CFL light irradiation conditions. A series of polycyclic dihydropyridine derivatives were prepared under CFL light irradiation conditions with high yield, short reaction time, ambient condition and without the use of catalyst. The results displayed an efficient method for the synthesis of polycyclic dihydropyridine derivatives. Clean profile, short reaction time, low cost and use of CFL light intensity instead of catalyst making it a genuinely green protocol.

Sulfated polyborate: a new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction

2016 ◽  
Vol 40 (12) ◽  
pp. 10412-10417 ◽  
Author(s):  
Chetan K. Khatri ◽  
Deelip S. Rekunge ◽  
Ganesh U. Chaturbhuj
Keyword(s):  
Biginelli Reaction ◽  
Solvent Free ◽  
Synthetic Methodology ◽  
One Pot ◽  
Free Condition ◽  
Sulfated Polyborate ◽  
Highly Efficient ◽  
Excellent Yield ◽  
Solvent Free Condition

A highly efficient and improved synthetic methodology for the preparation of 3,4-dihydropyrimidin-2(1H)-one derivatives in good to excellent yield via Biginelli reaction of β-ketoesters/β-diketone, urea/thiourea and various aldehydes using new, efficient and recyclable sulfated polyborate catalyst under the solvent-free condition is reported.

scholarly journals Regioselective Green Synthesis and Antimicrobial properties of full fused non mixed Heterocyclic Systems

2017 ◽  
Vol 13 (2) ◽  
pp. 6006-6020
Author(s):  
Amira A. El-Sayed ◽  
Maher El-HAshash ◽  
Sameh Rizk
Keyword(s):  
Antimicrobial Activity ◽  
Green Synthesis ◽  
Elemental Analysis ◽  
Spectroscopic Data ◽  
Heterocyclic Compounds ◽  
Antimicrobial Properties ◽  
One Pot ◽  
One Pot Synthesis ◽  
Electrophilic Reagents

One pot synthesis and reaction of triazinthione and triazinohydrazide derivatives with different electrophilic reagents in ordered to synthesis of some interesting non-mixed heterocyclic compounds. Structures of thiazolotriazine, triazolotriazine, pyrimidinyltriazine, and triazinotriazine derivatives were established via spectroscopic data and elemental analysis. The synthesized compounds were screened for their antimicrobial activity.

scholarly journals Green approach for synthesis of bioactive Hantzsch 1,4-dihydropyridine derivatives based on thiophene moiety via multicomponent reaction

2017 ◽  
Vol 4 (6) ◽  
pp. 170006 ◽  
Author(s):  
M. G. Sharma ◽  
D. P. Rajani ◽  
H. M. Patel
Keyword(s):  
Antifungal Activity ◽  
Multicomponent Reaction ◽  
Breast Tumour ◽  
Ceric Ammonium Nitrate ◽  
One Pot ◽  
Solvent Free Condition ◽  
Green Approach ◽  
Short Period ◽  
Dihydropyridine Derivatives

A novel green and efficient one-pot multicomponent reaction of dihydropyridine derivatives was reported as having good to excellent yield. In the presence of the catalyst ceric ammonium nitrate (CAN), different 1,3-diones and same starting materials as 5-bromothiophene-2-carboxaldehyde and ammonium acetate were used at room temperature under solvent-free condition for the Hantzsch pyridine synthesis within a short period of time. All compounds were evaluated for their in vitro antibacterial and antifungal activity and, interestingly, we found that 5(b–f) show excellent activity compared with Ampicillin, whereas only the 5e compound shows excellent antifungal activity against Candida albicans compared with griseofulvin. The cytotoxicity of all compounds has been assessed against breast tumour cell lines (BT-549), but no activity was found. The X-ray structure of one such compound, 5a , viewed as a colourless block crystal, corresponded accurately to a primitive monoclinic cell.

One-pot three-component synthesis of bis(indolyl)methanes under solvent-free condition using heteropoly-11-tungsto-1-vanadophosphoric acid supported on natural clay as catalyst

2017 ◽  
Vol 47 (9) ◽  
pp. 913-927 ◽  
Author(s):  
Karuppaiah Selvakumar ◽  
Thangamariyappan Shanmugaprabha ◽  
Ramamoorthy Annapoorani ◽  
Ponnusamy Sami
Keyword(s):  
Solvent Free ◽  
Natural Clay ◽  
One Pot ◽  
Free Condition ◽  
Solvent Free Condition
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