Visible Light Assisted Hantzsch Reaction: Synthesis of Polycyclic Dihydropyridines

2019 ◽  
Vol 16 (8) ◽  
pp. 676-682
Author(s):  
Ankusab Noorahmadsab Nadaf ◽  
Kalegowda Shivashankar
Keyword(s):  
Reaction Time ◽  
Light Intensity ◽  
Ammonium Acetate ◽  
Low Cost ◽  
Aromatic Aldehydes ◽  
Light Irradiation ◽  
High Yield ◽  
Short Reaction Time ◽  
Green Protocol ◽  
Dihydropyridine Derivatives

The polycyclic dihydropyridine nucleus represents the heterocyclic system of invaluable core motifs with wide applications in chemical, biological and physical properties. Although this kind of compounds have been extensively synthesized by other groups, the synthesis of these compounds under CFL light intensity were not explored. The synthesis of polycyclic dihydropyridine derivatives were achieved through the reaction of 4-hydroxycoumarin, aromatic aldehydes and ammonium acetate under CFL light irradiation conditions. A series of polycyclic dihydropyridine derivatives were prepared under CFL light irradiation conditions with high yield, short reaction time, ambient condition and without the use of catalyst. The results displayed an efficient method for the synthesis of polycyclic dihydropyridine derivatives. Clean profile, short reaction time, low cost and use of CFL light intensity instead of catalyst making it a genuinely green protocol.

scholarly journals A Green Protocol for the Synthesis of α-Amino Phosphonates Catalyzed by Orange Peel Powder

2021 ◽  
Vol 11 (1) ◽  
pp. 3175-3180
Keyword(s):  
Reaction Time ◽  
Orange Peel ◽  
Aromatic Aldehydes ◽  
High Yield ◽  
Short Reaction Time ◽  
Green Protocol ◽  
Dimethyl Phosphite ◽  
Amino Phosphonates

A simple and green protocol has been developed for the synthesis of α-aminophosphonates from different substituted aromatic aldehydes, aniline and dimethyl phosphite in the presence of orange peel powder (OPP) as a natural catalyst under reflux conditions. The main advantages of this method are the high yield of product, simple workup procedure, short reaction time and easily available catalyst.

New Crown Ether-Based Ionic Liquids as a Green and Versatile Organocatalyst for Three-Component Synthesis of 1,5-Dihydropyrano[2,3- c]chromene Derivatives

2020 ◽  
Vol 17 (3) ◽  
pp. 240-245
Author(s):  
Iman Mohammadzadeh ◽  
Ali Asadipour ◽  
Abbas Pardakhty ◽  
Mehdi Abaszadeh
Keyword(s):  
Ionic Liquids ◽  
Reaction Time ◽  
Crown Ether ◽  
Reaction Medium ◽  
Aromatic Aldehydes ◽  
High Yield ◽  
The Novel ◽  
Green Method ◽  
Short Reaction Time ◽  
Three Component Reaction

A simple and green method for the synthesis of 1,5-dihydropyrano[2,3-c]chromene derivatives has been reported by three-component reaction of aromatic aldehydes, malononitrile, and 3-hydroxycoumarin in the presence of a series of novel crown ether-based ionic liquids (CE-based ILs) in H2O/EtOH (1:1), under the reflux conditions. The novel CE-based ILs have been synthesized by 18-crown-6 or dibenzo 18-crown-6 chelated with sodium benzenesulfinate derivatives and used as a green and environmental organocatalyst. This method has some advantages such as the aqueous reaction medium, stable catalysts, cleaner reaction profiles and high yield of products in short reaction time.

Tyrosine-Selective Bioconjugation with Iminoxyl Radicals

2020 ◽  
Author(s):  
Katsuya Maruyama ◽  
Takashi Ishiyama ◽  
Yohei Seki ◽  
Kounosuke Oisaki ◽  
Motomu Kanai
Keyword(s):  
Reaction Time ◽  
Steric Hindrance ◽  
Room Temperature ◽  
Water Soluble ◽  
Light Irradiation ◽  
Sodium Ascorbate ◽  
Iminoxyl Radical ◽  
Short Reaction Time ◽  
Modified Peptides ◽  
The Stability

A novel Tyr-selective protein bioconjugation using the water-soluble persistent iminoxyl radical is described. The conjugation proceeded with high Tyr-selectivity and short reaction time under biocompatible conditions (room temperature in buffered media under air). The stability of the conjugates was tunable depending on the steric hindrance of iminoxyl. The presence of sodium ascorbate and/or light irradiation promoted traceless deconjugation, restoring the native Tyr structure. The method is applied to the synthesis of a protein-dye conjugate and further derivatization to azobenzene-modified peptides.

scholarly journals A Simple and Green Protocol for 2H-Indazolo[2,1-b]phthalazine-triones Using Grinding Method

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Xiao-chuan Jia ◽  
Jing Li ◽  
Yu Ding ◽  
Bin Zhang ◽  
Na Wang ◽  
...  
Keyword(s):  
Reaction Time ◽  
Sulfonic Acid ◽  
Catalytic Amount ◽  
Solvent Free ◽  
Short Reaction Time ◽  
Green Protocol ◽  
Simple Operation ◽  
Grinding Method ◽  
Toluene Sulfonic Acid ◽  
High Yields

A robust, facile, and solvent-free route for the three-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones in the presence of a catalytic amount ofp-toluene sulfonic acid utilizing grinding has been developed. Short reaction time, simple operation, and high yields are the advantages of this protocol.

scholarly journals Green synthesis of 2-aryl-4-phenyl-quınazolıne derıvatives promoted by lactıc acıd

2017 ◽  
Vol 36 (2) ◽  
pp. 223 ◽  
Author(s):  
Belgheis Adrom ◽  
Nourallah Hazeri ◽  
Malek Taher Maghsoodlou ◽  
Mojtaba Lashkari ◽  
Maryam Fatahpour
Keyword(s):  
Lactic Acid ◽  
Reaction Time ◽  
Green Synthesis ◽  
Ammonium Acetate ◽  
Simple Procedure ◽  
Environmentally Benign ◽  
Synthetic Method ◽  
Short Reaction Time ◽  
Quinazoline Derivatives ◽  
Work Up

An environmentally benign three-component synthetic method is described for the construction of 2-aryl-4-phenylquinazoline derivatives from the reaction between aldehydes, ammonium acetate, and 2-aminobenzophenone in the presence of lactic acid in a solvent-less media. The benefits of the reaction were good yields, a simple procedure, simple starting materials short reaction time, easy work-up, and cleaner reaction profiles.

scholarly journals Microwave Assisted One Pot Synthesis of 3,4-Dihydropyrano[c]chromene Derivatives using [Emim]OH Ionic Liquid as Novel Catalyst

2019 ◽  
Vol 31 (4) ◽  
pp. 829-833
Author(s):  
D.S. Bhagat ◽  
S.G. Pande ◽  
M.V. Katariya ◽  
R.P. Pawar ◽  
P.S. Kendrekar
Keyword(s):  
Ionic Liquid ◽  
Reaction Time ◽  
High Yield ◽  
Reaction Conditions ◽  
One Pot ◽  
Short Reaction Time ◽  
Aryl Aldehydes ◽  
Microwave Assisted ◽  
Novel Catalyst ◽  
Work Up

One-pot efficient protocol to the synthesis of 2-amino-5-oxo-4,5-dihydropyrano(3,2-c)chromene-3-carbonitrile derivatives via condensation of various aryl aldehydes, dicyanomethane and 4-hydroxycoumarin in presence of Emim hydroxide as an excellent homogeneous liquid catalyst. The key advantages of this methodology are mild reaction conditions, novel catalyst, short reaction time, eco-friendly, easy work-up procedure and high yield of isolation of derivatives.

scholarly journals Clauson Kaas Pyrrole Synthesis Catalyzed by Acidic Ionic Liquid under Microwave Irradiation

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Feray Aydogan ◽  
Cigdem Yolacan
Keyword(s):  
Ionic Liquid ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Product Formation ◽  
High Yield ◽  
Pyrrole Derivatives ◽  
Short Reaction Time ◽  
Acidic Ionic Liquid ◽  
Clean Product

A new procedure to synthesize the N-substituted pyrrole derivatives by Clauson Kaas reaction catalyzed by acidic ionic liquid under microwave irradiation was developed. This procedure provides several advantages such as high yield, clean product formation, and short reaction time.

SiC Platelets Synthesized by Powder-Heating Technique

2007 ◽  
Vol 336-338 ◽  
pp. 939-941
Author(s):  
Yong Qiang Meng ◽  
Zhi Min Bai ◽  
Chang Hong Dai ◽  
Bao Bao Zhang
Keyword(s):  
Silicon Carbide ◽  
Reaction Time ◽  
Carbon Black ◽  
Raw Materials ◽  
Low Cost ◽  
Average Diameter ◽  
New Method ◽  
Conventional Heating ◽  
High Yield ◽  
Sio2 Powder

A new method for producing silicon carbide platelets with low cost and high yield was introduced. The silicon carbide platelets were synthesized by powder-heating techniques with carbon black and SiO2 powder as raw materials and CoCl2 as catalyst. The starting mixtures were heated at a temperature in the range of 1800-2000°C for the duration of about 2-4h to produce substantially completely unagglomerated silicon carbide platelets with a thickness of 5-20μm and the average diameter of 50-200μm. Compared to the conventional heating, the powder-heating technique is advantageous of less investment on equipment, easy to manufacture and convenient to operate. Furthermore, it is very suitable for realizing the scaled production because of the lower synthesizing temperature, shorter reaction time and greater output.

An ultrasound-assisted solvent and catalyst-free synthesis of structurally diverse pyrazole centered 1,5-disubstituted tetrazoles via one-pot four-component reaction

2021 ◽  
Vol 19 ◽  
Author(s):  
Suman Swami ◽  
Rahul Shrivastava ◽  
Neelam Sharma ◽  
Arunava Agarwala ◽  
Ved Prakash Verma ◽  
...  
Keyword(s):  
Reaction Time ◽  
Ultrasound Irradiation ◽  
Amide Bond ◽  
High Yield ◽  
Spectroscopic Techniques ◽  
Mass Analysis ◽  
One Pot ◽  
Green Protocol ◽  
Ultrasound Assisted ◽  
Solvent Free Reaction

Abstract: 1,5-Disubstituted tetrazoles are vital drug-like scaffold usually encountered as valuable bioisosteres of cis-amide bond. In this article, we reported synthesis of some novel medicinally relevant pyrazole centered 1,5-disubstituted tetrazoles using ultrasound irradiation via a one-pot 4-C reaction from various pyrazole originated aldehyde, amine, isocyanide, and sodium azide. All the synthesized derivatives were characterized by IR, 1H NMR, 13C NMR, spectroscopic techniques, and mass analysis. This ultrasound-assisted green protocol has several advantages like mild reaction condition, high yield, catalyst and solvent-free reaction protocol, 15 minutes reaction time and easy workup.

DMAP-catalyzed Efficient and Convenient Approach for the Synthesis of 3,3′-(Arylmethylene)bis(2-Hydroxynaphthalene-1,4-Dione) Derivatives

2021 ◽  
Vol 16 (9) ◽  
pp. 1934578X2110458
Author(s):  
Le Nhat Thuy Giang ◽  
Dang Thi Tuyet Anh ◽  
Hoang Thi Phuong ◽  
Nguyen Ha Thanh ◽  
Nguyen Thi Quynh Giang ◽  
...  
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
Basic Catalyst ◽  
Reaction Conditions ◽  
Efficient Procedure ◽  
Short Reaction Time ◽  
Convenient Approach ◽  
First Time

For the first time the 4-dimethylaminopyridine (DMAP) catalyzed straightforward and efficient procedure has been developed for the synthesis of 3,3′-(arylmethylene) bis(2-hydroxynaphthalene-1,4-dione) derivatives starting from lawsone (2-hydroxy-1,4-naphthoquinone) and a variety of (hetero)aromatic aldehydes in ethanol under microwave irradiation. Three of nine synthesized compounds are new. This method provides notable advantages over existing procedures including use of non-traditional basic catalyst and environmentally benign solvent, mild reaction conditions, excellent yields, short reaction time and simple workup.

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