scholarly journals Spectrum of Gestational Trophoblastic Disease Secondary to Dilation and Evacuation - Our Experience at a Tertiary Care Centre in Mullana, Ambala

2021 ◽  
Vol 10 (16) ◽  
pp. 1106-1113
Author(s):  
Akshat Kuchhal ◽  
Harneet Narula ◽  
Amit Jain ◽  
Shivangi Jain
Keyword(s):  
Wide Spectrum ◽  
Venous Malformation ◽  
Tertiary Care ◽  
Previous History ◽  
Gestational Trophoblastic Disease ◽  
Reproductive Age ◽  
Trophoblastic Disease ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases ◽  
History Of

BACKGROUND Gestational trophoblastic diseases have varying clinical presentations with certain diagnostic signs and symptoms. A strong correlation between gestational trophoblastic diseases (GTD) and a previous history of dilation & evacuation (D & E) has been documented in the limited available literature. We wanted to study the spectrum of gestational trophoblastic disease secondary to dilation & evacuation. METHODS A two-year study including all the females who were admitted to MMIMSR Hospital in view of suspicion of gestational trophoblastic disease was conducted with all having a common history of dilatation and evacuation in the recent past. RESULTS Through the analysis we saw the spectrum of GTD including partial mole, complete mole, invasive mole and choriocarcinoma, as well as its complications in the form of arterio-venous malformation (AVM). CONCLUSIONS The two-year experience suggests that dilatation and curettage may predispose a female of reproductive age group to develop gestational trophoblastic disease in the future. Hence, a high index of suspicion is necessary for timely diagnosis and intervention. The study further helped us understand the wide spectrum of the disease and its associated complications. KEY WORDS Abortion, AVM, Dilatation and Evacuation, GTD, GTN

scholarly journals Study of gestational trophoblastic diseases at a tertiary care hospital in India

2018 ◽  
Vol 7 (4) ◽  
pp. 1622
Author(s):  
Ramalingappa C. Antaratani ◽  
Shruthi M.
Keyword(s):  
Hydatidiform Mole ◽  
Local Population ◽  
Tertiary Care ◽  
Spontaneous Remission ◽  
Standard Of Care ◽  
Gestational Trophoblastic Disease ◽  
Care Hospital ◽  
Case Record ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases

Background: Gestational trophoblastic disease refers to the heterogeneous group of interrelated lesions that arises from abnormal proliferation of placental trophoblasts. GTNs are among the rare human tumours that can be cured even in the presence of widespread dissemination. Although GTNs commonly follow a molar pregnancy, they can occur after any gestational event, including induced or spontaneous abortion, ectopic pregnancy, or term pregnancy. The study was conducted to know the incidence of different types of gestational trophoblastic diseases in the local population and the percentage of people ultimately requiring chemotherapy.Methods: The retrospective analysis of case record of 124 women with a diagnosis of GTD admitted to Karnataka Institute of Medical Sciences Hubli between November 2008 to November 2017.Results: A total of 124 cases of GTD were reviewed. Hydatidiform mole was diagnosed in 91 patients; of those experienced spontaneous remission after evacuation. 04 patients had persistent gestational trophoblastic Neoplasia and 13 cases of invasive mole (GTN) 1 case of epitheloid trophoblastic tumors and 15 cases of choriocarcinoma 99 (80%) had low-risk GTN, 25 (20%) had high-risk GTN.Conclusions: Hydatidiform mole was found to be the most common form of gestational trophoblastic diseases. Majority of the cases got cured by simple surgical evacuation. During the course of our study some rare cases of gestational trophoblastic diseases were noted. Patients’ compliance for serial follow up is a highly challenging task in developing countries. Registration of women with GTD represents a minimum standard of care.

scholarly journals Morbidity and mortality of patients suffering from gestational trophoblastic diseases at the Clinic of gynecology and obstetrics, Clinical center of Serbia in the period from 2000 to 2007

2011 ◽  
Vol 64 (11-12) ◽  
pp. 579-582 ◽  
Author(s):  
Biljana Lazovic ◽  
Vera Milenkovic ◽  
Ljiljana Mirkovic
Keyword(s):  
Risk Factors ◽  
Gestational Trophoblastic Disease ◽  
Morbidity And Mortality ◽  
Trophoblastic Disease ◽  
Gynecology And Obstetrics ◽  
Heterogenous Group ◽  
Clinical Center ◽  
Trophoblastic Diseases ◽  
Potential Risk Factors ◽  
Gestational Trophoblastic Diseases

Introduction. Gestational trophoblastic disease is a heterogenous group of diseases with malignant potential. The aim of this retrospective study was to evaluate potential risk factors in pathogenesis of gestational trophoblastic disease, its morbidity and mortality as well as treatment results. Method. We investigated 82 patients who were treated at the University Clinic of Gynecology and Obstetrics Clinical Center of Serbia from Jan 1st 2000 to Dec 31st 2007. The data were collected from their hospital charts and referred to gynecological anamnesis, diagnosis, protocols of operated patients, diagnosis, histopathological findings, decisions of expert team for trophoblastic disease and hospital discharge. Results. The incidence was 1.5 per 1000 deliveries. The most frequent finding was hydatiform mole (59.8%). The patients were treated by chemotherapy and surgery. All patients survived. Conclusion. The maternal age and a larger number deliveries and abortions are risk factors for gestational trophoblastic disease. The incidence in our clinic is approximately equal to the incidence in western countries in this period.

scholarly journals Gestational Trophoblastic Disease-induced Thyroid Storm

2019 ◽  
Vol 3 (4) ◽  
pp. 409-412
Author(s):  
Carly Blick ◽  
Kraftin Schreyer
Keyword(s):  
Vaginal Bleeding ◽  
The United States ◽  
Gestational Trophoblastic Disease ◽  
Definitive Treatment ◽  
Thyroid Storm ◽  
Trophoblastic Disease ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases ◽  
Life Threatening ◽  
Life Threatening Complication

In the United States, gestational trophoblastic diseases (GTD), including molar pregnancies, occur in 121 out of 100,000 pregnancies.1 Many patients with GTD may develop hyperthyroidism. GTD-induced thyroid storm is a rare but life-threatening complication of GTD.2 Once patients are hemodynamically stable, the mainstay of definitive treatment is evacuation of the mole.3 We present a case of molar pregnancy-induced thyroid storm presenting as vaginal bleeding, fever, and tachycardia.

scholarly journals Clinical study of gestational trophoblastic disease in a tertiary care hospital

2020 ◽  
Vol 9 (7) ◽  
pp. 2964
Author(s):  
Jayashree Mulik ◽  
Archana Choudhary
Keyword(s):  
Histopathological Examination ◽  
Hydatidiform Mole ◽  
Tertiary Care ◽  
Gestational Trophoblastic Disease ◽  
Care Hospital ◽  
Complete Mole ◽  
Trophoblastic Diseases ◽  
Study Centre ◽  
Gestational Trophoblastic Diseases ◽  
Chest X Ray

Background: Gestational trophoblastic diseases (GTDs) had been associated with significant morbidity and mortality till recently. Wide variation in incidences have been reported worldwide. The present study was planned with the objective of determination of incidence, assessment of risk factors, clinical presentation, management protocols and outcomes in GTD cases in Indian population at a tertiary care centre.Methods: All the diagnosed cases of GTD reporting to study centre during study period of 1.5 years were included. Detailed history taking, examination and relevant investigations (Hb%, blood grouping, thyroid functions, serum ß-hCG, USG and chest X-ray) were undertaken. Suction and evacuation were done for all patients as primary mode of management and samples were sent for histopathological examination. Comprehensive follow ups were done, including weekly ß-hCG until normal for 3 consecutive weeks followed by monthly determination until the levels were normal for 6 consecutive months.Results: Total 22 cases out of 19500 deliveries were diagnosed as GTD (incidence rate-1.13/1000 deliveries). Mean age was 23.64±3.89 years with 50% participants being primigravida. The commonest symptom after amenorrhea 22 (100%) was bleeding per-vaginum 15 (68.2%). Maximum cases were of complete hydatidiform mole histopathology 16 (72.73%), USG 19 (86.4%). Clinical characteristics were statistically comparable between patients of complete mole and partial mole. Out of 22 cases, 1 (4.5%) was diagnosed as GTN.Conclusions: Early diagnosis and treatment along with regular follow up is the key in GTD. There is need to establish a centralized disease specific registry in future.

scholarly journals Pancreatic and Hepatic Metastasis of an Undiagnosed Choriocarcinoma: An Exceptional Cause of Haemoperitoneum in Young Women – Report of a Rare Case

2016 ◽  
Vol 9 (3) ◽  
pp. 633-638 ◽  
Author(s):  
Nishat Fatema ◽  
Neeru Vinod Arora ◽  
Fatma Majid Al Abri ◽  
Yaseer Muhammad Tareq Khan
Keyword(s):  
Hepatic Metastasis ◽  
Rare Case ◽  
Previous History ◽  
Gestational Trophoblastic Disease ◽  
Reproductive Age ◽  
Childbearing Age ◽  
Women Of Reproductive Age ◽  
Positive Pregnancy Test ◽  
History Of ◽  
The Right

Haemoperitoneum in women of reproductive age usually suggests either ruptured ectopic pregnancy or ruptured ovarian cysts. Metastatic choriocarcinoma is considered the least common cause of haemoperitoneum in women of childbearing age. We report a rare case of pancreatic and hepatic metastasis of choriocarcinoma in a young, 30-year-old female who had delivered 10 months prior at term gestation with no previous history of gestational trophoblastic disease or molar pregnancy. She had a short history of fever and pain in the right hypochondrium, with findings of hypovolaemic shock due to intraperitoneal haemorrhage. Unfortunately, the patient expired with massive uncontrolled bleeding from liver metastasis despite 2 emergency laparotomies within 12 h. This case report is an apt reminder to clinicians to include metastatic choriocarcinoma on the list of differential diagnoses for haemoperitoneum with a positive pregnancy test in women of reproductive age to diagnose early and to avoid life-threatening consequences.

scholarly journals GESTATIONAL TROPHOBLASTIC DISEASES;

2012 ◽  
Vol 19 (02) ◽  
pp. 159-161
Author(s):  
SYED MEHMOOD HASSAN ◽  
SHOAIB NAYYER I HASHM ◽  
BUSHRA AYAZ ◽  
Faisal Rashid Lodhi ◽  
Kanwal Sohail
Keyword(s):  
Hydatidiform Mole ◽  
Age Groups ◽  
Gestational Trophoblastic Disease ◽  
Trophoblastic Disease ◽  
Complete Mole ◽  
Trophoblastic Diseases ◽  
Partial Mole ◽  
Gestational Trophoblastic Diseases ◽  
Data Source ◽  
Naval Hospital

Objective: The study was carried out to evaluate the frequency and types of gestational. Trophoblastic diseases (GTD) inendometrial curettings received for histopathology examination. Data Source: Pathology Department, Shifa Naval Hospital Karachi. Design ofStudy: It was a Retrospective Descriptive Observational study. Setting: Department of Pathology, Pakistan Naval Ship; Shifa Naval HospitalKarachi. Period: From 2009 till 2010. Material & Methods: A total of 170 cases of endometrial curettage were examined. All specimensreceived with a diagnosis of product of conceptions (POC) or with the clinical suspicion of a gestational trophoblastic disease were included.Results: It was observed that partial mole identified in 57.1 % cases followed by complete mole 21.4%, choriocarcinoma 14.2% and placentalsite Trophoblastic disease 7.1% cases. Nearly half of the cases were diagnosed as having a gestational trophoblastic disease; these were fromthe age groups of 26-30 years followed by 21-25 years. Conclusions: Hydatidiform mole is the commonest gestational trophoblastic disease.Most complete moles are detected clinically but partial moles are misdiagnosed as abortions therefore all cases of abortions should be sent forhistopathological examinations.

scholarly journals An invasive mole with pulmonary metastases in a 55-year-old postmenopausal Syrian woman: a case report and review of the literature

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Sawsan Ismail ◽  
Karen Mikhael ◽  
Nehad Salloum ◽  
Zuheir Alshehabi
Keyword(s):  
Emergency Department ◽  
Postmenopausal Women ◽  
Clinical Laboratory ◽  
Pulmonary Metastases ◽  
Diagnostic Methods ◽  
Reproductive Age ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases ◽  
History Of ◽  
Invasive Mole

Abstract Background Invasive mole is a subtype of gestational trophoblastic neoplasms (GTNs) that usually develops from the malignant transformation of trophoblastic tissue after molar evacuation. Invasive moles mostly occur in women of reproductive age, while they are extremely rare in postmenopausal women. Case presentation We present the case of a 55-year-old postmenopausal Syrian woman who was admitted to the emergency department at our hospital due to massive vaginal bleeding for 10 days accompanied by constant abdominal pain with diarrhea and vomiting. Following clinical, laboratory and radiological examination, total hysterectomy with bilateral salpingo-oophorectomy was performed. Histologic examination of the resected specimens revealed the diagnosis of an invasive mole with pulmonary metastases that were diagnosed by chest computed tomography (CT). Following surgical resection, the patient was scheduled for combination chemotherapy. However, 2 weeks later the patient was readmitted to the emergency department due to severe hemoptysis and dyspnea, and later that day the patient died in spite of resuscitation efforts. Conclusion Although invasive moles in postmenopausal women have been reported previously, we believe our case is the first reported from Syria. Our case highlights the difficulties in diagnosing invasive moles in the absence of significant history of gestational trophoblastic diseases. The present study further reviews the diagnostic methods, histological characteristics and treatment recommendations.

scholarly journals Correlation of ultrasound imaging with histopathological findings in gestational trophoblastic disease

2020 ◽  
Vol 7 (3) ◽  
pp. 41-46
Author(s):  
Pooja Jaiswal ◽  
Shreejana Shrestha ◽  
Yogita Dwa ◽  
Sagun Manandhar
Keyword(s):  
Ultrasound Imaging ◽  
Imaging Modality ◽  
Retrospective Chart Review ◽  
Gestational Trophoblastic Disease ◽  
Chi Square ◽  
Histopathological Findings ◽  
Trophoblastic Disease ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases ◽  
Invasive Mole

Introduction: Gestational trophoblastic diseases include a spectrum of pregnancy-related diseases caused by abnormal proliferation of the placenta.  The main aim of this study was to correlate ultrasound imaging with histopathological findings. Method: This is the retrospective chart review of findings of transabdominal ultrasonography in clinically suspected gestational trophoblastic diseases which were confirmed by histopathology after the evacuation of a product of conception during 3 years from 2016 to 2019 at Patan Hospital, Patan Academy of Health Sciences Nepal. The accuracy of sonography was correlated with histopathological findings and analyzed by Fisher’s Exact or Pearson’s Chi-square tests. The study was approved ethically. Result:  Among 155 clinically suspected gestational trophoblastic diseases, ultrasonography was accurate in 141(91.0%) and confirmed by histopathology; 14(9.0%) were non-molar miscarriages. In 141 histologically confirmed trophoblastic disease, 110(71.0 %) were partial mole, 15(9.7%) complete mole, 12(7.7%) invasive mole and 3(1.9 %) persistent mole, and 1(0.6%) choriocarcinoma. Snowstorm appearance and absence of fetus were statistically significant ultrasonography findings. Conclusion:  The ultrasound is a reliable non-invasive first-line imaging modality for the diagnosis of gestational trophoblastic diseases and had an accuracy of 91% as confirmed by histopathology in this study.

scholarly journals A clinicopathological study of gestational trophoblastic disease in a tertiary care centre of southern Assam

2021 ◽  
Vol 9 (4) ◽  
pp. 1169
Author(s):  
Sailendra K. Thakuria ◽  
Monoj K. Deka ◽  
Shah A. Sheikh
Keyword(s):  
Histopathological Examination ◽  
Wide Spectrum ◽  
Tertiary Care ◽  
First Trimester ◽  
Gestational Trophoblastic Disease ◽  
Cross Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Trophoblastic Disease ◽  
Increased Risk

Background: Gestational trophoblastic disease (GTD) covers a wide spectrum of benign and malignant conditions that arise from pregnancies with abnormal trophoblastic tissue development. It is a source of significant morbidity as well as increased risk of mortality from their complications if not identified and treated early enough. Our study aimed at the various clinicopathological features of GTDs along with their prevalence in a tertiary care centre.Methods: It was a retrospective cross-sectional study conducted over a period of 3 years from January 2017 to December 2019. All GTD cases were retrieved from department registries and analysed.Results: Out of 60 diagnosed cases of GTDs, 57 cases (95%) were Hydatiform mole. Invasive mole and choriocarcinoma were 2 cases (3%) and 1 cases (2%) respectively. Age ranged from 18-37 years. The most commonly affected age group was 20-25 years with 33 cases (55%). Most cases were presented in the first trimester presenting with bleeding per vagina. The majority of GTD cases belonged to blood group A and 50,000-<1,00,000 mlU/mL beta HCG level.Conclusions: Histopathological examination is helpful for confirmation of diagnosis.It is very important to follow up of such patients for early diagnosis of malignant trophoblastic tumors.

Sign in / Sign up

Export Citation Format

Share Document