scholarly journals Light Emitting Diode Mediated Photobiomodulation Therapy in Orthodontics - A Review of Contemporary Literature

2021 ◽  
Vol 10 (32) ◽  
pp. 2672-2679
Author(s):  
Akanksha Naresh Kumar ◽  
Vikrant Jadhav ◽  
Rashmi Jawalekar ◽  
Pankaj Akhare ◽  
Harish Atram ◽  
...  
Keyword(s):  
Light Emitting Diodes ◽  
Tooth Movement ◽  
Root Resorption ◽  
Light Therapy ◽  
Photobiomodulation Therapy ◽  
Biologically Active ◽  
Therapeutic Effects ◽  
Maxillary Expansion ◽  
Light Emitting

BACKGROUND Photobiomodulation is an emerging area of medical and dental science that has gained attention in numerous clinical fields with the advent of new generational light - emitting diodes (LEDs), as evident in the extent of published scientific literature in recent years. The rationale behind LED - mediated photobiomodulation therapy (LPT) is that at certain biologically active wavelengths, LEDs have shown to have therapeutic effects at the cellular and subcellular levels and are an efficient alternative photon source after lasers, along with their numerous benefits. Subsequent to favourable in-vitro, animal and recently human clinical trials, considerable attention has been garnered towards the promising applications and the integration of LPT with traditional therapeutic protocols, including in orthodontics. Originally started and accepted as a modality in acceleration of tooth movement, pain management and increasing the bone remodelling rate and quality, the advancements in this therapeutic technology have created new avenues in the treatment of temporomandibular disorders, root resorption, bone consolidation during maxillary expansion and distraction osteogenesis, as well as for improvement in miniscrew stability. Since it is non-invasive, easy to perform and user friendly with reported efficacy, an established consensus of wavelengths and parameters with respect to guidance for clinical use will go a long way in enabling the successful achievement of numerous objectives. This review article of published research intends to evaluate the adjunctive applications of LPT within orthodontic treatment at several levels along with the underlying mechanism, parameters and reported outcomes. KEY WORDS Photobiomodulation Therapy, Light Emitting Diodes, LED - Mediated Phototherapy, Low Level Light Therapy, NIR-LED, Light Accelerated Orthodontics

scholarly journals Application of Light-Emitting Diodes for Improving the Nutritional Quality and Bioactive Compound Levels of Some Crops and Medicinal Plants

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1477
Author(s):  
Woo-Suk Jung ◽  
Ill-Min Chung ◽  
Myeong Ha Hwang ◽  
Seung-Hyun Kim ◽  
Chang Yeon Yu ◽  
...  
Keyword(s):  
Plant Growth ◽  
In Vitro Culture ◽  
Light Emitting Diodes ◽  
Photosynthetic Pigment ◽  
Antioxidant Properties ◽  
Light Sources ◽  
Light Emitting ◽  
Cell Defense ◽  
Led Irradiation

Light is a key factor that affects phytochemical synthesis and accumulation in plants. Due to limitations of the environment or cultivated land, there is an urgent need to develop indoor cultivation systems to obtain higher yields with increased phytochemical concentrations using convenient light sources. Light-emitting diodes (LEDs) have several advantages, including consumption of lesser power, longer half-life, higher efficacy, and wider variation in the spectral wavelength than traditional light sources; therefore, these devices are preferred for in vitro culture and indoor plant growth. Moreover, LED irradiation of seedlings enhances plant biomass, nutrient and secondary metabolite levels, and antioxidant properties. Specifically, red and blue LED irradiation exerts strong effects on photosynthesis, stomatal functioning, phototropism, photomorphogenesis, and photosynthetic pigment levels. Additionally, ex vitro plantlet development and acclimatization can be enhanced by regulating the spectral properties of LEDs. Applying an appropriate LED spectral wavelength significantly increases antioxidant enzyme activity in plants, thereby enhancing the cell defense system and providing protection from oxidative damage. Since different plant species respond differently to lighting in the cultivation environment, it is necessary to evaluate specific wavebands before large-scale LED application for controlled in vitro plant growth. This review focuses on the most recent advances and applications of LEDs for in vitro culture organogenesis. The mechanisms underlying the production of different phytochemicals, including phenolics, flavonoids, carotenoids, anthocyanins, and antioxidant enzymes, have also been discussed.

ERYTHROSINE AS A PHOTOSENSITIZER FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY WITH BLUE LIGHT-EMITTING DIODES – AN IN VITRO STUDY

2021 ◽  
pp. 102445
Author(s):  
Marcela Leticia Leal Gonçalves ◽  
Elaine Marcílio Santos ◽  
Ana Cláudia Muniz Renno ◽  
Anna Carolina Ratto Tempestini Horliana ◽  
Matheus de Almeida Cruz ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Blue Light ◽  
Light Emitting Diodes ◽  
In Vitro Study ◽  
Vitro Study ◽  
Antimicrobial Photodynamic Therapy ◽  
Light Emitting

scholarly journals Cell-Penetrating Peptide and siRNA-Mediated Therapeutic Effects on Endometriosis and Cancer In Vitro Models

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1618
Author(s):  
Kristina Kiisholts ◽  
Kaido Kurrikoff ◽  
Piret Arukuusk ◽  
Ly Porosk ◽  
Maire Peters ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Cellular Proliferation ◽  
Expression Patterns ◽  
In Vitro Models ◽  
Cell Penetrating Peptides ◽  
Biologically Active ◽  
Therapeutic Effects ◽  
Cell Penetrating ◽  
Proliferation And Invasion

Gene therapy is a powerful tool for the development of new treatment strategies for various conditions, by aiming to transport biologically active nucleic acids into diseased cells. To achieve that goal, we used highly potential delivery vectors, cell-penetrating peptides (CPPs), as oligonucleotide carriers for the development of a therapeutic approach for endometriosis and cancer. Despite marked differences, both of these conditions still exhibit similarities, like excessive, uncoordinated, and autonomous cellular proliferation and invasion, accompanied by overlapping gene expression patterns. Thus, in the current study, we investigated the therapeutic effects of CPP and siRNA nanoparticles using in vitro models of benign endometriosis and malignant glioblastoma. We demonstrated that CPPs PepFect6 and NickFect70 are highly effective in transfecting cell lines, primary cell cultures, and three-dimensional spheroids. CPP nanoparticles are capable of inducing siRNA-specific knockdown of therapeutic genes, ribonucleotide reductase subunit M2 (RRM2), and vascular endothelial growth factor (VEGF), which results in the reduction of in vitro cellular proliferation, invasion, and migration. In addition, we proved that it is possible to achieve synergistic suppression of endometriosis cellular proliferation and invasion by combining gene therapy and hormonal treatment approaches by co-administering CPP/siRNA nanoparticles together with the endometriosis-drug danazol. We suggest a novel target, RRM2, for endometriosis therapy and as a proof-of-concept, we propose a CPP-mediated gene therapy approach for endometriosis and cancer.

Acute effects of photobiomodulation therapy (PBMT) combining laser diodes, light-emitting diodes, and magnetic field in exercise capacity assessed by 6MST in patients with COPD: a crossover, randomized, and triple-blinded clinical trial

2018 ◽  
Vol 34 (4) ◽  
pp. 711-719 ◽  
Author(s):  
Eduardo Foschini Miranda ◽  
Welton Alves Diniz ◽  
Marcos Vinicius Nogueira Gomes ◽  
Marcelo Ferreira Duarte de Oliveira ◽  
Paulo de Tarso Camillo de Carvalho ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Clinical Trial ◽  
Exercise Capacity ◽  
Light Emitting Diodes ◽  
Laser Diodes ◽  
Photobiomodulation Therapy ◽  
Acute Effects ◽  
Light Emitting

Effect of Light-emitting Diodes on Growth of in vitro Propagules in Gerbera hybrida

2012 ◽  
Vol 20 (4) ◽  
pp. 233-237 ◽  
Author(s):  
Min-Kyung Kwon ◽  
◽  
Hyo Hoon Nam ◽  
Jeon Joong Sung ◽  
Jea Ha Lim
Keyword(s):  
Light Emitting Diodes ◽  
Gerbera Hybrida ◽  
Light Emitting ◽  
Effect Of Light

scholarly journals A 3-D evaluation of transverse dentoalveolar changes and maxillary first molar root length after rapid or slow maxillary expansion in children

2019 ◽  
Vol 24 (3) ◽  
pp. 79-87 ◽  
Author(s):  
Helder Baldi Jacob ◽  
Gerson Luiz Ulema Ribeiro ◽  
Jeryl D. English ◽  
Juliana da Silva Pereira ◽  
Mauricio Brunetto
Keyword(s):  
Root Length ◽  
Root Formation ◽  
Tooth Movement ◽  
Root Resorption ◽  
Root Apex ◽  
Cone Beam ◽  
Maxillary Expansion ◽  
Bone Thickness ◽  
Significant Difference ◽  
Bone Changes

ABSTRACT Objective: The objective of the present study was to conduct a randomized clinical trial comparing the effects of rapid maxillary expansion (RME) and slow maxillary expansion (SME). Maxillary permanent first molar root length and tooth movement through the alveolus were studied using cone-beam computed tomography (CBCT). Methods: Subjects with maxillary transverse deficiencies between 7 and 10 years of age were included. Using Haas-type expanders, children were randomly assigned to two groups: RME (19 subjects, mean age of 8.60 years) and SME (13 subjects, mean age of 8.70 years). Results: Buccal cortical, buccal bone thicknesses and dentoalveolar width decreased in both groups. In the RME group the greatest decrease was related to distal bone thickness (1.26 mm), followed by mesial bone thickness (1.09 mm), alveolar width (0.57 mm), and the buccal cortical (0.19 mm). In the SME group the mesial bone thickness decreased the most (0.87 mm) and the buccal cortical decreased the least (0.22 mm). The lingual bone thickness increased in the RME and SME groups (0.56 mm and 0.42 mm, respectively). The mesial root significantly increased in the RME group (0.52 mm) and in the SME group (0.40 mm), possibly due to incomplete root apex formation at T1 (prior to installation of expanders). Conclusions: Maxillary expansion (RME and SME) does not interrupt root formation neither shows first molar apical root resorption in juvenile patients. Although slightly larger in the RME group than SME group, both activation protocols showed similar buccal bone thickness and lingual bone thickness changes, without significant difference; and RME presented similar buccal cortical bone changes to SME.

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