Clinicopathologic Features of Sporadic Colorectal Cancer with MLH1/MSH2 Loss of Expression - Reduced Likelihood of Metastases

: Colitis-associated colorectal cancer (CAC) remains a critical complication of ulcerative colitis (UC) with mortality of approximately 15%, which makes early CAC diagnosis crucial. The current standard of surveillance, with repetitive colonoscopies and histological testing of biopsied mucosa samples is burdensome and expensive, and therefore less invasive methods and reliable biomarkers are needed. Significant progress has been made thanks to continuous extensive research in this field, however no clinically relevant biomarker has been established so far. This review of the current literature presents the genetic and molecular differences between CAC and sporadic colorectal cancer and covers progress made in the early detection of CAC carcinogenesis. It focuses on biomarkers under development, which can be easily tested in samples of body fluids or breath and, once made clinically available, will help to differentiate between progressors (UC patients who will develop dysplasia) from non-progressors and enable early intervention to decrease the risk of cancer development.

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Tracking the Antibody Immunome in Sporadic Colorectal Cancer by Using Antigen Self-Assembled Protein Arrays

Cancers ◽

10.3390/cancers13112718 ◽

2021 ◽

Vol 13 (11) ◽

pp. 2718

Author(s):

María González-González ◽

José María Sayagués ◽

Luis Muñoz-Bellvís ◽

Carlos Eduardo Pedreira ◽

Marcello L. R. de Campos ◽

...

Keyword(s):

Colorectal Cancer ◽

Clinical Utility ◽

Genetic Alterations ◽

Western World ◽

Sporadic Colorectal Cancer ◽

Protein Arrays ◽

Humoral Immune ◽

Cellular Processes ◽

Healthy Donors ◽

Associated Proteins

Sporadic Colorectal Cancer (sCRC) is the third leading cause of cancer death in the Western world, and the sCRC patients presenting with synchronic metastasis have the poorest prognosis. Genetic alterations accumulated in sCRC tumor cells translate into mutated proteins and/or abnormal protein expression levels, which contribute to the development of sCRC. Then, the tumor-associated proteins (TAAs) might induce the production of auto-antibodies (aAb) via humoral immune response. Here, Nucleic Acid Programmable Protein Arrays (NAPPArray) are employed to identify aAb in plasma samples from a set of 50 sCRC patients compared to seven healthy donors. Our goal was to establish a systematic workflow based on NAPPArray to define differential aAb profiles between healthy individuals and sCRC patients as well as between non-metastatic (n = 38) and metastatic (n = 12) sCRC, in order to gain insight into the role of the humoral immune system in controlling the development and progression of sCRC. Our results showed aAb profile based on 141 TAA including TAAs associated with biological cellular processes altered in genesis and progress of sCRC (e.g., FSCN1, VTI2 and RPS28) that discriminated healthy donors vs. sCRC patients. In addition, the potential capacity of discrimination (between non-metastatic vs. metastatic sCRC) of 7 TAAs (USP5, ML4, MARCKSL1, CKMT1B, HMOX2, VTI2, TP53) have been analyzed individually in an independent cohort of sCRC patients, where two of them (VTI2 and TP53) were validated (AUC ~75%). In turn, these findings provided novel insights into the immunome of sCRC, in combination with transcriptomics profiles and protein antigenicity characterizations, wich might lead to the identification of novel sCRC biomarkers that might be of clinical utility for early diagnosis of the tumor. These results explore the immunomic analysis as potent source for biomarkers with diagnostic and prognostic value in CRC. Additional prospective studies in larger series of patients are required to confirm the clinical utility of these novel sCRC immunomic biomarkers.

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S2054 A Novel Mouse Model of Sporadic Colorectal Cancer

Gastroenterology ◽

10.1016/s0016-5085(08)61424-9 ◽

2008 ◽

Vol 134 (4) ◽

pp. A-305-A-306

Author(s):

Kenneth Hung ◽

Larissa Georgeon Richard ◽

Alexandra Kunin ◽

Umar Mahmood ◽

Raju Kucherlapati

Keyword(s):

Colorectal Cancer ◽

Mouse Model ◽

Sporadic Colorectal Cancer

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Identification of preneoplastic lesions as mucin-depleted foci in patients with sporadic colorectal cancer

Cancer Science ◽

10.1111/j.1349-7006.2011.02125.x ◽

2011 ◽

Vol 103 (1) ◽

pp. 144-149 ◽

Cited By ~ 13

Author(s):

Eiji Sakai ◽

Takamitsu Morioka ◽

Eiji Yamada ◽

Hidenori Ohkubo ◽

Takuma Higurashi ◽

...

Keyword(s):

Colorectal Cancer ◽

Sporadic Colorectal Cancer ◽

Preneoplastic Lesions

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Distinct BRAF (V600E) and KRAS Mutations in High Microsatellite Instability Sporadic Colorectal Cancer in African Americans

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-08-1029 ◽

2009 ◽

Vol 15 (4) ◽

pp. 1155-1161 ◽

Cited By ~ 46

Author(s):

Krishan Kumar ◽

Hassan Brim ◽

Francis Giardiello ◽

Duane T. Smoot ◽

Mehdi Nouraie ◽

...

Keyword(s):

Colorectal Cancer ◽

African Americans ◽

Microsatellite Instability ◽

Braf V600e ◽

Sporadic Colorectal Cancer ◽

Kras Mutations

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Long-Term Outcome and Prognostic Factors of Sporadic Colorectal Cancer in Young Patients

Medicine ◽

10.1097/md.0000000000003641 ◽

2016 ◽

Vol 95 (19) ◽

pp. e3641 ◽

Cited By ~ 11

Author(s):

Tae Jun Kim ◽

Eun Ran Kim ◽

Sung Noh Hong ◽

Dong Kyung Chang ◽

Young-Ho Kim

Keyword(s):

Colorectal Cancer ◽

Prognostic Factors ◽

Young Patients ◽

Sporadic Colorectal Cancer ◽

Term Outcome ◽

Long Term Outcome

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Cancer risk and overall survival in mismatch repair proficient hereditary non-polyposis colorectal cancer, Lynch syndrome and sporadic colorectal cancer

Familial Cancer ◽

10.1007/s10689-013-9683-2 ◽

2013 ◽

Vol 13 (1) ◽

pp. 109-119 ◽

Cited By ~ 9

Author(s):

Pilar Garre ◽

Lorena Martín ◽

Inmaculada Bando ◽

Alicia Tosar ◽

Patricia Llovet ◽

...

Keyword(s):

Colorectal Cancer ◽

Overall Survival ◽

Cancer Risk ◽

Lynch Syndrome ◽

Mismatch Repair ◽

Sporadic Colorectal Cancer

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A Comparative Study of Epidemiology, Clinicopathologic Features and Outcome of Colorectal Cancer Patients between Ain Shams University Hospitals and Luxor International Hospital

QJM ◽

10.1093/qjmed/hcab103.005 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Tarek Hussein Kamel ◽

Amr Lotfy Farag ◽

Dr/Sherif Hassanin Ahmed ◽

Chresteen Talaat Samy Hanna

Keyword(s):

Colorectal Cancer ◽

Comparative Study ◽

Disease Free Survival ◽

University Hospital ◽

Treatment Modalities ◽

Clinicopathologic Features ◽

Free Survival ◽

Significant Difference ◽

Group A ◽

Group B

Abstract Background Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world. It is the third most common malignancy after lung & breast and the fourth leading cause of cancer-related deaths worldwide, accounting for approximately 1,400,000 new cases and about 700,000 deaths worldwide. Objectives The aim of this retrospective study is to compare the epidemiology, clinicopathologic features, different treatment modalities and outcomes regarding disease free survival (DFS), progression free survival (PFS) & overall survival (OS) of colorectal cancer disease between cases presented to Ain shams university hospital & to Luxor international hospital in 3 consecutive years. Patients and Methods The study is retrospective comparative study. Clinical oncology department in Ain Shams University Hospital and Luxor International Hospital. The data Collected from January 2013 to December 2015. This study analyzed hospital records of patients who diagnosed with colorectal cancer (CRC) and allocated into two groups: Group A: CRC patients presented to Ain-Shams University Hospital from January 2013 to December 2015, group B: CRC patients presented to Luxor International Hospital from January 2013 to December 2015. Results There was no statistically significant difference regarding age parameter in LIH when compared to ASU, but the study was consistent with higher incidence in patients who were aged more than forty- accounted about 70.5% in all CRC cases. Cases less than 40 years old, in group A were 35.2%, while in Group B were 23.5%. Even there was no statistically significant difference but it may be attributable to more westernization in Lower Egypt. Other explanation may be due to decreased low socioeconomic status and different lifestyle factors in more developing region what increase risk of colorectal cancer. Among our cases, there is no statistically significant difference regarding gender between the two hospitals. Both sexes almost were affected equally, females appeared to be at a slightly higher risk of developing CRC cancer with current prevalence 1.3:1 in ASU group, and 1.1:1 in LIH group. Conclusion The need to increase awareness about CRC in Egypt especially upper Egypt, is recommended. An awareness campaign should be performed to promote detection of CRC at its earliest and most curable stage by recognizing early symptoms and enabling early referrals for colonoscopy. Those at higher risk should be offered more intensive surveillance. Similarity of the data from different centers suggests that this is the picture of colorectal cancer typical of Egypt.

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